CN114392209A - Hand sanitizer with long-acting sterilization effect - Google Patents
Hand sanitizer with long-acting sterilization effect Download PDFInfo
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- CN114392209A CN114392209A CN202111641000.6A CN202111641000A CN114392209A CN 114392209 A CN114392209 A CN 114392209A CN 202111641000 A CN202111641000 A CN 202111641000A CN 114392209 A CN114392209 A CN 114392209A
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- hand sanitizer
- starch
- polysaccharide
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- 238000004659 sterilization and disinfection Methods 0.000 title abstract description 18
- 230000001954 sterilising effect Effects 0.000 title abstract description 17
- 230000000694 effects Effects 0.000 title abstract description 15
- 239000008187 granular material Substances 0.000 claims abstract description 39
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 33
- 239000005017 polysaccharide Substances 0.000 claims abstract description 33
- 229920002472 Starch Polymers 0.000 claims abstract description 29
- 239000008107 starch Substances 0.000 claims abstract description 29
- 235000019698 starch Nutrition 0.000 claims abstract description 29
- -1 dodecyl dipropylene triamine Chemical compound 0.000 claims abstract description 18
- 239000002994 raw material Substances 0.000 claims abstract description 13
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims abstract description 9
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims abstract description 9
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims abstract description 9
- 229930182490 saponin Natural products 0.000 claims abstract description 9
- 150000007949 saponins Chemical class 0.000 claims abstract description 9
- 239000000341 volatile oil Substances 0.000 claims abstract description 9
- 150000004676 glycans Chemical class 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 20
- 238000002156 mixing Methods 0.000 claims description 16
- 229920000881 Modified starch Polymers 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000004368 Modified starch Substances 0.000 claims description 10
- 235000019426 modified starch Nutrition 0.000 claims description 10
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims description 8
- 244000269722 Thea sinensis Species 0.000 claims description 8
- 230000000844 anti-bacterial effect Effects 0.000 claims description 8
- 239000008120 corn starch Substances 0.000 claims description 8
- 229910000077 silane Inorganic materials 0.000 claims description 8
- 239000000725 suspension Substances 0.000 claims description 8
- 230000008878 coupling Effects 0.000 claims description 7
- 238000010168 coupling process Methods 0.000 claims description 7
- 238000005859 coupling reaction Methods 0.000 claims description 7
- 239000012153 distilled water Substances 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 235000001674 Agaricus brunnescens Nutrition 0.000 claims description 4
- 229920002261 Corn starch Polymers 0.000 claims description 4
- 229920001218 Pullulan Polymers 0.000 claims description 4
- 239000004373 Pullulan Substances 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 4
- 238000000227 grinding Methods 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 235000019423 pullulan Nutrition 0.000 claims description 4
- 229920001503 Glucan Polymers 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 244000052769 pathogen Species 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 2
- 241001122767 Theaceae Species 0.000 abstract 1
- 238000005406 washing Methods 0.000 description 3
- 229920002307 Dextran Polymers 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to the field of chemical industry of daily necessities, and discloses a hand sanitizer with a long-acting sterilization effect, which comprises the following raw materials in percentage by weight: 2-3 parts of butanediol, 1-1.5 parts of tea saponin, 1-1.5 parts of isopropyl myristate, 0.5-0.8 part of dodecyl dipropylene triamine, 0.1-0.3 part of starch granules, 0.1-0.3 part of alkyl polysaccharide and 0.05-0.1 part of essential oil. The invention has the advantages that the sterilization effect is more durable, and the sterilization effect is better after daily use, thereby reducing the chance that pathogens are infected in the gap between the hands which can not be washed or washed twice, and having higher application value.
Description
Technical Field
The invention relates to the field of chemical industry of daily necessities, in particular to a hand sanitizer with a long-acting sterilization effect.
Background
Although the conventional hand sanitizer can meet the daily hand sterilization requirements of people, the sterilization effect lasts for a short time, in daily life, various objects, especially palm parts, of a human body usually need to be relieved frequently, pathogens are easy to be re-infected, and the sterilization effect of the effective sterilization components remained after hand washing gradually decreases along with the daily contact of the objects in a short time, so that the sterilization and disinfection effects are lost, and therefore, the hand washing is required to be carried out regularly so as to keep the hands clean. There is a need to develop a novel hand sanitizer which has better sterilization effect, can meet the needs of daily life to a certain extent and improves the sterilization lasting effect.
Disclosure of Invention
The invention provides a hand sanitizer with a long-acting sterilization effect, aiming at the defects that the prior art is no longer available, the hand sanitizer is easy to lose efficacy through daily life, and a better continuous sterilization effect cannot be achieved.
In order to achieve the purpose, the invention can adopt the following technical scheme:
a hand sanitizer with long-acting bactericidal effect comprises the following raw materials in percentage by weight: 2-3 parts of butanediol, 1-1.5 parts of tea saponin, 1-1.5 parts of isopropyl myristate, 0.5-0.8 part of dodecyl dipropylene triamine, 0.1-0.3 part of starch granules, 0.1-0.3 part of alkyl polysaccharide and 0.05-0.1 part of essential oil;
mixing the starch granules, alkyl polysaccharide and essential oil, stirring uniformly, heating to 50-60 ℃, keeping for 1-2 hours, and standing for more than 24 hours for later use; and (3) adding dodecyl dipropylene triamine, butanediol, tea saponin and isopropyl myristate into the mixture of the starch granules in sequence, stirring at room temperature after each addition, standing for not less than 2 hours, adding the raw materials, mixing the raw materials, and standing to obtain a finished product.
Further, the starch granules adopt corn starch or modified starch.
Further, the starch granules are a mixture of silane coupling modified starch granules and polysaccharide or a mixture of corn starch and polysaccharide.
Further, the starch granules have a diameter of no more than 50 microns.
Further, the starch granules are prepared by the following method: mixing silane coupling modified starch or corn starch with distilled water to obtain a suspension, performing jet cavitation treatment on the suspension, standing for 1-2 hours for gelatinization, drying and grinding for later use; mixing the polysaccharide and the granules, and stirring to fully mix to obtain the starch granules.
Further, the polysaccharide comprises the following components in percentage by weight: 1 part of cellulose, 1 part of glucan, 1 part of pullulan and 1 part of mushroom polysaccharide, wherein the water content of the mixture is not less than 40 percent by weight.
The invention has the following remarkable technical effects:
the sterilization effect is more durable, and the sterilization effect is still better after daily use, so that the chance that pathogens are infected in the gap between the hands which cannot be washed or twice is reduced.
Detailed Description
The present invention will be described in further detail with reference to examples.
Example 1
Preparing the following raw materials in percentage by weight: 2 parts of butanediol, 1 part of tea saponin, 1 part of isopropyl myristate, 0.5 part of dodecyl dipropylene triamine, 0.1 part of starch granules, 0.1 part of alkyl polysaccharide and 0.05 part of essential oil; mixing the starch granules, alkyl polysaccharide and essential oil, stirring uniformly, heating to 50 ℃, keeping for 1-2 hours, and standing for more than 24 hours for later use; and (3) adding dodecyl dipropylene triamine, butanediol, tea saponin and isopropyl myristate into the mixture of the starch granules in sequence, stirring at room temperature after each addition, standing for not less than 2 hours, adding the raw materials, mixing the raw materials, and standing to obtain a finished product.
The starch granules adopt a mixture of silane coupling modified starch granules and polysaccharide, and the polysaccharide comprises the following components in percentage by weight: the mixture of 1 part cellulose, 1 part dextran, 1 part pullulan and 1 part mushroom polysaccharide is generally added with distilled water to prepare paste, then stirred and mixed, the mixture of the polysaccharides is dried, and the water content of the polysaccharides is not lower than 40% by weight through drying. Mixing silane coupling modified starch or corn starch with distilled water to obtain a suspension, performing jet cavitation treatment on the suspension, standing for 1-2 hours for gelatinization, drying and grinding for later use; mixing the polysaccharide and the granules, stirring to fully mix the polysaccharide and the granules to obtain starch granules, wherein the diameter of the finished starch granules is not more than 50 microns.
Example 2
Preparing the following raw materials in percentage by weight: 3 parts of butanediol, 1.5 parts of tea saponin, 1.5 parts of isopropyl myristate, 0.8 part of dodecyl dipropylene triamine, 0.3 part of starch granules, 0.3 part of alkyl polysaccharide and 0.1 part of essential oil; mixing and stirring the starch granules, the alkyl polysaccharide and the essential oil uniformly, heating to 50 ℃, keeping for 1-2 hours, and standing for more than 24 hours for later use; and (3) adding dodecyl dipropylene triamine, butanediol, tea saponin and isopropyl myristate into the mixture of the starch granules in sequence, stirring at room temperature after each addition, standing for not less than 2 hours, adding the raw materials, mixing the raw materials, and standing to obtain a finished product.
The starch granules adopt a mixture of silane coupling modified starch granules and polysaccharide, and the polysaccharide comprises the following components in percentage by weight: the mixture of 1 part cellulose, 1 part dextran, 1 part pullulan and 1 part mushroom polysaccharide is generally added with distilled water to prepare paste, then stirred and mixed, the mixture of the polysaccharides is dried, and the water content of the polysaccharides is not lower than 40% by weight through drying. Mixing silane coupling modified starch or corn starch with distilled water to obtain a suspension, performing jet cavitation treatment on the suspension, standing for 1-2 hours for gelatinization, drying and grinding for later use; mixing the polysaccharide and the granules, stirring to fully mix the polysaccharide and the granules to obtain starch granules, wherein the diameter of the finished starch granules is not more than 50 microns.
Test example:
the hand sanitizer obtained in the above examples 1 and 2 is kept stand for 72 hours for observation, is relatively stable, and has no obvious layering, a proper amount of palm is taken for kneading, the viscosity is moderate, the hand sanitizer left on the palm can be dried in a short time after being uniformly coated, and the palm has no obvious strange feeling.
1 ml of the hand washing liquid obtained in the above examples 1 and 2 is uniformly smeared on a palm, and washed by water flows for 20 seconds, 30 seconds and 40 seconds respectively, wherein the flow rate of the water flow is 0.66 m/s, and the sterilization rates of staphylococcus aureus and escherichia coli are respectively tested after 2 hours, and respectively reach 98%, 97.7 and 96%; 98.2%, 97.5% and 96%, and has good bactericidal effect.
In summary, the above-mentioned embodiments are only preferred embodiments of the present invention, and all equivalent changes and modifications made in the claims of the present invention should be covered by the claims of the present invention.
Claims (6)
1. The hand sanitizer with the long-acting bactericidal effect is characterized by comprising the following raw materials in percentage by weight: 2-3 parts of butanediol, 1-1.5 parts of tea saponin, 1-1.5 parts of isopropyl myristate, 0.5-0.8 part of dodecyl dipropylene triamine, 0.1-0.3 part of starch granules, 0.1-0.3 part of alkyl polysaccharide and 0.05-0.1 part of essential oil;
mixing the starch granules, alkyl polysaccharide and essential oil, stirring uniformly, heating to 50-60 ℃, keeping for 1-2 hours, and standing for more than 24 hours for later use; and (3) adding dodecyl dipropylene triamine, butanediol, tea saponin and isopropyl myristate into the mixture of the starch granules in sequence, stirring at room temperature after each addition, standing for not less than 2 hours, adding the raw materials, mixing the raw materials, and standing to obtain a finished product.
2. The hand sanitizer with long-acting bactericidal effect according to claim 1, wherein the starch granules are corn starch or modified starch.
3. The hand sanitizer with long-acting bactericidal effect according to claim 1, wherein the starch granules are a mixture of silane-coupled modified starch granules and polysaccharides or a mixture of corn starch and polysaccharides.
4. The hand sanitizer with long-acting bactericidal effect according to claim 1, wherein the starch granules have a diameter of not more than 50 μm.
5. The hand sanitizer with long-acting bactericidal effect according to claim 3, wherein the starch granules are prepared by the following method: mixing silane coupling modified starch or corn starch with distilled water to obtain a suspension, performing jet cavitation treatment on the suspension, standing for 1-2 hours for gelatinization, drying and grinding for later use; mixing the polysaccharide and the granules, and stirring to fully mix to obtain the starch granules.
6. The hand sanitizer with long-acting bactericidal effect according to claim 5, wherein the polysaccharide comprises the following components in percentage by weight: 1 part of cellulose, 1 part of glucan, 1 part of pullulan and 1 part of mushroom polysaccharide, wherein the water content of the mixture is not less than 40 percent by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111641000.6A CN114392209A (en) | 2021-12-29 | 2021-12-29 | Hand sanitizer with long-acting sterilization effect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111641000.6A CN114392209A (en) | 2021-12-29 | 2021-12-29 | Hand sanitizer with long-acting sterilization effect |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114392209A true CN114392209A (en) | 2022-04-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111641000.6A Pending CN114392209A (en) | 2021-12-29 | 2021-12-29 | Hand sanitizer with long-acting sterilization effect |
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2021
- 2021-12-29 CN CN202111641000.6A patent/CN114392209A/en active Pending
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Application publication date: 20220426 |