CN112842979A - Washing-free hand sanitizer with antibacterial and moisturizing functions and preparation method thereof - Google Patents
Washing-free hand sanitizer with antibacterial and moisturizing functions and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a no-clean hand sanitizer with antibacterial and moisturizing functions and a preparation method thereof, and on one hand, the no-clean hand sanitizer with the antibacterial and moisturizing functions comprises aloe extract, plant essential oil, glycerol, nano silver ion solution, nano copper oxide powder, nano titanium dioxide powder, ceramide, a thickening agent, a bacteriostatic agent, a surfactant, vitamin E and deionized water, wherein the bacteriostatic agent comprises quaternary ammonium salt and hexamethylenetetramine, and the ratio of the quaternary ammonium salt to the hexamethylenetetramine is 1-3: 10; the no-clean hand sanitizer provided by the invention has good cleaning effect, is far beyond the conventional alcohol gel type no-clean hand sanitizer sold on the aspects of moisture retention and irritation, and is obviously superior to the existing alcohol gel type no-clean hand sanitizer in antibacterial effect by adopting the antibacterial agent prepared by combining the quaternary ammonium salt and the hexamethylenetetramine.
Description
Technical Field
The invention relates to the field of daily chemical cleaning products, in particular to a no-clean hand sanitizer with antibacterial and moisturizing functions and a preparation method thereof.
Background
In 1977, a manual soap manufacturer named robert tyler invented a hand soap product similar to the hand soap product, namely, a hand soap was placed in a disposable, beautiful container and a pump was added to the container, which was welcomed after the product was put on the market. In the end of 1979, taylor designed a smaller bottle and lower selling price for this product named "soft soap" and sold it as a commodity in grocery and drug stores. In addition, he insists on putting it with a bar soap, so that the customer understands that it can replace unsightly traditional soap bars. In China, the hand washing products are also subjected to the varieties of kerosene, gasoline, washing powder, soap, perfumed soap and hand washing solution, and compared with the traditional absorption products, the hand washing solution has the advantages of strong practicability, more diversified components, full utilization, less waste, avoidance of cross contamination and the like.
As a novel hand sanitizer, the no-clean hand sanitizer is not required to be cleaned by clean water when in use, and only a proper amount of product is required to be smeared on hands and continuously rubbed for a period of time, and then the hands are wiped by towels, paper towels and the like.
However, most of the existing wash-free hand sanitizer contains gel type medical alcohol as a main component, has strong volatility, can accelerate the water loss of skin, makes the skin dry and tight, and has poor bacteriostatic effect.
Disclosure of Invention
The invention aims to provide a no-clean hand sanitizer with antibacterial and moisturizing functions and a preparation method thereof, so as to solve the problems in the background technology.
To achieve the above object, in one aspect, the present invention provides:
a no-clean hand sanitizer with antibacterial and moisturizing functions comprises the following raw materials: aloe extract, plant essential oil, glycerol, nano silver ion solution, nano copper oxide powder, nano titanium dioxide powder, ceramide, thickening agent, bacteriostatic agent, surfactant, vitamin E and deionized water.
As a further scheme of the invention: the material is prepared from the following raw materials in percentage by weight: 0.5-2.0% of aloe extract, 2.0-6.0% of plant essential oil, 5.0-12.0% of glycerol, 3.0-5.0% of nano silver ion solution, 0.5-2.0% of nano copper oxide powder, 0.5-2.0% of nano titanium dioxide powder, 0.2-1.5% of ceramide, 0.5-2.0% of thickening agent, 2.0-4.0% of bacteriostatic agent, 5.0-10.0% of surfactant, 0.1-1.0% of vitamin E and the balance of deionized water.
As a further scheme of the invention: the material is prepared from the following raw materials in percentage by weight: 1.5% of aloe extract, 4.0% of plant essential oil, 8.0% of glycerol, 3.5% of nano silver ion solution, 1.0% of nano copper oxide powder, 1.5% of nano titanium dioxide powder, 0.8% of ceramide, 1.5% of thickening agent, 3.0% of bacteriostatic agent, 6.0% of surfactant, 0.8% of vitamin E and the balance of deionized water.
As a further scheme of the invention: the bacteriostatic agent comprises quaternary ammonium salt and hexamethylenetetramine, and the ratio of the quaternary ammonium salt to the hexamethylenetetramine is 1-3: 10.
In another aspect, the present invention further provides:
a preparation method of a no-clean hand sanitizer with antibacterial and moisturizing functions is used for preparing the no-clean hand sanitizer, and comprises the following steps:
the method comprises the following steps: weighing raw materials of aloe extract, plant essential oil, glycerol, nano silver ion solution, nano copper oxide powder, nano titanium dioxide powder, ceramide, thickening agent, bacteriostatic agent, surfactant, vitamin E and deionized water;
step two: introducing deionized water accounting for 50-70% of the total mass into a container, and heating;
step three: adding the bacteriostatic agent into the container, and uniformly stirring;
step four: uniformly mixing the nano silver ion solution, the nano copper oxide powder and the nano titanium dioxide powder into the balance of deionized water;
step five: placing Aloe extract, plant essential oil, glycerol, surfactant, vitamin E, and ceramide in the container, cooling, and stirring;
step six: and (3) putting the thickening agent into the container for multiple times, introducing the rest of deionized water into the container for multiple times, and uniformly stirring.
Step seven: and cooling the mixture in the container to room temperature to obtain the no-clean hand sanitizer.
As a further scheme of the invention: the heating mode in the second step is constant temperature heating in a water area, and the heating temperature is 60-75 ℃.
As a further scheme of the invention: and the stirring temperature in the fifth step is 45-60 ℃, the stirring speed is 80-150r/min, and the stirring time is 20-45 min.
As a further scheme of the invention: in the sixth step, the thickener is placed for 3-5 times, the interval time is 5-15min each time, and the rest deionized water is added into the container in several times at intervals.
As a still further scheme of the invention: and after the thickening agent and the balance of deionized water are completely added into the container, continuously stirring for 20-45 min.
Compared with the prior art, the invention has the beneficial effects that:
the no-clean hand sanitizer provided by the invention has good cleaning effect, is far beyond the conventional alcohol gel type no-clean hand sanitizer sold on the aspects of moisture retention and irritation, and is obviously superior to the existing alcohol gel type no-clean hand sanitizer in antibacterial effect by adopting the antibacterial agent prepared by combining the quaternary ammonium salt and the hexamethylenetetramine.
The invention has the functions of astringing, softening, moisturizing, diminishing inflammation and bleaching the skin by adding the aloe extract into the no-clean hand sanitizer. It also has effects in relieving sclerosis and keratinization, and improving scar; the glycerin is used as a common humectant, has hygroscopicity and water retention property, and has good moisture retention effect; ceramide has good effect of repairing skin barrier and enhancing skin tolerance, has good affinity to skin due to being one of the components in the skin, has titanium dioxide and excellent anti-ultraviolet effect, can provide good sun protection, and enables the skin to look more delicate, white and smooth.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention discloses a no-clean hand sanitizer with antibacterial and moisturizing functions, which comprises aloe extract, plant essential oil, glycerin, nano silver ion solution, nano copper oxide powder, nano titanium dioxide powder, ceramide, a thickening agent, a bacteriostatic agent, a surfactant, vitamin E and deionized water.
The bacteriostatic agent comprises quaternary ammonium salt and hexamethylenetetramine, and the ratio of the quaternary ammonium salt to the hexamethylenetetramine is 1-3: 10.
A preparation method of a no-clean hand sanitizer with antibacterial and moisturizing functions is used for preparing the no-clean hand sanitizer, and comprises the following steps:
the method comprises the following steps: weighing raw materials of aloe extract, plant essential oil, glycerol, nano silver ion solution, nano copper oxide powder, nano titanium dioxide powder, ceramide, thickening agent, bacteriostatic agent, surfactant, vitamin E and deionized water;
step two: introducing deionized water accounting for 50-70% of the total mass into a container, and heating;
step three: adding the bacteriostatic agent into the container, and uniformly stirring;
step four: uniformly mixing the nano silver ion solution, the nano copper oxide powder and the nano titanium dioxide powder into the balance of deionized water;
step five: placing Aloe extract, plant essential oil, glycerol, surfactant, vitamin E, and ceramide in the container, cooling, and stirring;
step six: and (3) putting the thickening agent into the container for multiple times, introducing the rest of deionized water into the container for multiple times, and uniformly stirring.
Step seven: and cooling the mixture in the container to room temperature to obtain the no-clean hand sanitizer.
The heating mode in the second step is constant temperature heating in a water area, and the heating temperature is 60-75 ℃.
And the stirring temperature in the fifth step is 45-60 ℃, the stirring speed is 80-150r/min, and the stirring time is 20-45 min.
In the sixth step, the thickener is placed for 3-5 times, the interval time of each time is 5-15min, and the rest deionized water is added into the container in several times at intervals.
And after the thickening agent and the balance of deionized water are completely added into the container, continuously stirring for 20-45 min.
Example 1:
weighing the following raw materials in percentage by mass: 1.8% of aloe extract, 3% of plant essential oil, 10% of glycerol, 3% of nano silver ion solution, 0.8% of nano copper oxide powder, 1.2% of nano titanium dioxide powder, 1.1% of ceramide, 1.0% of thickening agent, 4.0% of bacteriostat, 8.0% of surfactant, 0.8% of vitamin E and the balance of deionized water, wherein the components of the antibacterial agent are benzalkonium chloride and hexamethylenetetramine, and the ratio of the components is 2: 10.
introducing deionized water accounting for 50-70% of the total mass into a container, and heating to 60-75 ℃ in a water bath;
adding the bacteriostatic agent into the container, and uniformly stirring;
uniformly mixing the nano silver ion solution, the nano copper oxide powder and the nano titanium dioxide powder into the rest deionized water;
placing Aloe extract, plant essential oil, glycerol, surfactant, vitamin E, and ceramide into the container, cooling to 45-60 deg.C, stirring at 80-150r/min for 20-45 min;
and (3) putting the thickening agent into the container for 3 times, wherein the interval time is 10min each time, introducing the rest amount of deionized water into the container for two intervals, stirring uniformly, and continuously stirring for 20-45min after the thickening agent and the rest amount of deionized water are completely added into the container.
Example 2:
weighing the following raw materials in percentage by mass: 1.5% of aloe extract, 4.0% of plant essential oil, 8.0% of glycerol, 3.5% of nano silver ion solution, 1.0% of nano copper oxide powder, 1.5% of nano titanium dioxide powder, 0.8% of ceramide, 1.5% of thickening agent, 3.0% of bacteriostatic agent, 6.0% of surfactant, 0.8% of vitamin E and the balance of deionized water, wherein the antibacterial agent comprises the following components of decyldimethylammonium bromide and hexamethylenetetramine in a ratio of 2: 10.
introducing deionized water accounting for 50-70% of the total mass into a container, and heating to 60-75 ℃ in a water bath;
adding the bacteriostatic agent into the container, and uniformly stirring;
uniformly mixing the nano silver ion solution, the nano copper oxide powder and the nano titanium dioxide powder into the rest deionized water;
placing Aloe extract, plant essential oil, glycerol, surfactant, vitamin E, and ceramide into the container, cooling to 45-60 deg.C, stirring at 80-150r/min for 20-45 min;
putting the thickening agent into the container for 4 times, wherein the interval time is 10min each time, introducing the rest amount of deionized water into the container for two intervals, stirring uniformly, and continuously stirring for 20-45min after the thickening agent and the rest amount of deionized water are completely added into the container.
Example 3:
weighing the following raw materials in percentage by mass: 1.8% of aloe extract, 3.0% of plant essential oil, 6.0% of glycerol, 5.0% of nano silver ion solution, 1.5% of nano copper oxide powder, 1.0% of nano titanium dioxide powder, 1.5% of ceramide, 2.0% of thickening agent, 3.0% of bacteriostatic agent, 5.0% of surfactant, 0.5% of vitamin E and the balance of deionized water, wherein the antibacterial agent comprises the following components of decyldimethylammonium bromide and hexamethylenetetramine in a ratio of 2: 10.
introducing deionized water accounting for 50-70% of the total mass into a container, and heating to 60-75 ℃ in a water bath;
adding the bacteriostatic agent into the container, and uniformly stirring;
uniformly mixing the nano silver ion solution, the nano copper oxide powder and the nano titanium dioxide powder into the rest deionized water;
placing Aloe extract, plant essential oil, glycerol, surfactant, vitamin E, and ceramide into the container, cooling to 45-60 deg.C, stirring at 80-150r/min for 20-45 min;
putting the thickening agent into the container for 4 times, wherein the interval time is 10min each time, introducing the rest amount of deionized water into the container for two intervals, stirring uniformly, and continuously stirring for 20-45min after the thickening agent and the rest amount of deionized water are completely added into the container.
Example 4:
weighing the following raw materials in percentage by mass: 0.8% of aloe extract, 5.5% of plant essential oil, 9.5% of glycerol, 3.5% of nano silver ion solution, 0.8% of nano copper oxide powder, 1.3% of nano titanium dioxide powder, 0.5% of ceramide, 1.5% of thickening agent, 4.0% of bacteriostatic agent, 8.0% of surfactant, 0.8% of vitamin E and the balance of deionized water.
Introducing deionized water accounting for 50-70% of the total mass into a container, and heating to 60-75 ℃ in a water bath;
adding the bacteriostatic agent into the container, and uniformly stirring;
uniformly mixing the nano silver ion solution, the nano copper oxide powder and the nano titanium dioxide powder into the rest deionized water;
placing Aloe extract, plant essential oil, glycerol, surfactant, vitamin E, and ceramide into the container, cooling to 45-60 deg.C, stirring at 80-150r/min for 20-45 min;
putting the thickening agent into the container for 4 times, wherein the interval time is 10min each time, introducing the rest amount of deionized water into the container for two intervals, stirring uniformly, and continuously stirring for 20-45min after the thickening agent and the rest amount of deionized water are completely added into the container.
Comparative example 1:
this comparative example differs from example 2 in that: the raw material formula does not contain nano silver ion solution.
Comparative example 2:
this comparative example differs from example 2 in that: the raw material formula does not contain the nano-scale copper oxide powder.
Comparative example 3:
this comparative example differs from example 2 in that: the formula of the material does not contain nano silver ion solution and nano copper oxide powder.
Comparative example 4:
this comparative example differs from example 2 in that: the antibacterial agent comprises the following components of decyldimethylammonium bromide and hexamethylenetetramine in a ratio of 1: 10.
comparative example 5:
this comparative example differs from example 2 in that: the antibacterial agent contains hexamethylenetetramine.
Comparative examples 6, 7:
two commercially available alcohol gel type wash-free hand cleaners are respectively selected.
And (3) performance testing:
test 1:
sensory testing; randomly selecting 20 volunteers with the ages of 18-35 as testing personnel, and scoring each type of wash-free hand sanitizer according to cleanliness, moisture retention and irritation after use, wherein the full score is 10, and the test results are shown in table 1:
| cleanliness | Moisture retention | Irritation property | |
| Example 1 | 7.52 | 8.37 | 4.48 |
| Example 2 | 7.48 | 8.46 | 4.36 |
| Example 3 | 7.44 | 8.29 | 4.42 |
| Example 4 | 7.56 | 8.31 | 4.47 |
| Comparative example 1 | 7.51 | 8.43 | 4.35 |
| Comparative example 2 | 7.49 | 8.07 | 4.55 |
| Comparative example 3 | 7.53 | 8.12 | 4.28 |
| Comparative example 4 | 7.47 | 8.49 | 4.29 |
| Comparative example 5 | 7.52 | 8.45 | 4.42 |
| Comparative example 6 | 6.92 | 4.74 | 7.88 |
| Comparative example 7 | 7.13 | 4.94 | 7.37 |
TABLE 1
And (3) testing 2:
testing the change rate of the moisture content of the skin cutin; randomly selecting 50 volunteers aged 18-35 years as test persons, washing hands and wiping for 5 minutes, selecting a test area with 3 x 3cm at the center of the back of the hand, measuring the water content of the horny layer of the test part by using a skin water measuring probe, taking an average value of 5 measurements, performing the skin horny layer water content test again after half an hour, wherein the test results are shown in table 2,
TABLE 2
And (3) testing:
testing the bacteriostatic performance; according to GB15979-2002 hygienic Standard for Disposable sanitary articles appendix C4 bacteriostasis test method for dissolution antibacterial (bacteriostatic) products, Escherichia coli (ATCC8739), Staphylococcus aureus (ATCC6538) and Candida albicans (ATCC10231) suspension liquid are respectively taken to react with a sample (diluted 10 times) for 30s (conventional hand washing time), bacteriostasis rate calculation is carried out after culture treatment, and the bacteriostasis performance is detected, wherein the results are shown in Table 3:
TABLE 3
As can be seen from the test results shown in tables 1 to 3, the no-clean hand sanitizer provided by the embodiments of the present invention has certain advantages in terms of cleanliness, moisture retention and irritation after use, and particularly exceeds the conventional alcohol gel type no-clean hand sanitizer sold on the market in terms of moisture retention and irritation, and meanwhile, the no-clean hand sanitizer provided by the embodiments of the present invention has good bacteriostatic ability.
As can be seen from the data in the table, the addition of the nano silver ion solution and the nano copper oxide powder in the formula can obviously improve the bacteriostatic effect of the no-clean hand sanitizer, and meanwhile, the nano copper oxide powder has a promoting effect on the moisture retention performance of the no-clean hand sanitizer.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes, modifications, equivalents, improvements and the like can be made therein without departing from the spirit and scope of the invention.
Claims (9)
1. The washing-free hand sanitizer with the antibacterial and moisturizing functions is characterized by comprising the following raw materials: aloe extract, plant essential oil, glycerol, nano silver ion solution, nano copper oxide powder, nano titanium dioxide powder, ceramide, thickening agent, bacteriostatic agent, surfactant, vitamin E and deionized water.
2. The no-clean hand sanitizer with antibacterial and moisturizing functions of claim 1 is prepared from the following raw materials in percentage by weight: 0.5-2.0% of aloe extract, 2.0-6.0% of plant essential oil, 5.0-12.0% of glycerol, 3.0-5.0% of nano silver ion solution, 0.5-2.0% of nano copper oxide powder, 0.5-2.0% of nano titanium dioxide powder, 0.2-1.5% of ceramide, 0.5-2.0% of thickening agent, 2.0-4.0% of bacteriostatic agent, 5.0-10.0% of surfactant, 0.1-1.0% of vitamin E and the balance of deionized water.
3. The no-clean hand sanitizer with antibacterial and moisturizing functions of claim 1 is prepared from the following raw materials in percentage by weight: 1.5% of aloe extract, 4.0% of plant essential oil, 8.0% of glycerol, 3.5% of nano silver ion solution, 1.0% of nano copper oxide powder, 1.5% of nano titanium dioxide powder, 0.8% of ceramide, 1.5% of thickening agent, 3.0% of bacteriostatic agent, 6.0% of surfactant, 0.8% of vitamin E and the balance of deionized water.
4. The no-clean hand sanitizer with antibacterial and moisturizing functions of claim 1, wherein: the bacteriostatic agent comprises quaternary ammonium salt and hexamethylenetetramine, and the ratio of the quaternary ammonium salt to the hexamethylenetetramine is 1-3: 10.
5. A preparation method of a no-clean hand sanitizer with antibacterial and moisturizing functions, which is used for preparing the no-clean hand sanitizer as claimed in any one of claims 1 to 4, and is characterized by comprising the following steps:
the method comprises the following steps: weighing raw materials of aloe extract, plant essential oil, glycerol, nano silver ion solution, nano copper oxide powder, nano titanium dioxide powder, ceramide, thickening agent, bacteriostatic agent, surfactant, vitamin E and deionized water;
step two: introducing deionized water accounting for 50-70% of the total mass into a container, and heating;
step three: adding the bacteriostatic agent into the container, and uniformly stirring;
step four: uniformly mixing the nano silver ion solution, the nano copper oxide powder and the nano titanium dioxide powder into the balance of deionized water;
step five: placing Aloe extract, plant essential oil, glycerol, surfactant, vitamin E, and ceramide into the container, cooling, and stirring;
step six: and (3) putting the thickening agent into the container for multiple times, introducing the rest of deionized water into the container for multiple times, and uniformly stirring.
Step seven: and cooling the mixture in the container to room temperature to obtain the no-clean hand sanitizer.
6. The preparation method of the no-clean hand sanitizer with antibacterial and moisturizing functions as claimed in claim 5, wherein the preparation method comprises the following steps: the heating mode in the second step is constant temperature heating in a water area, and the heating temperature is 60-75 ℃.
7. The preparation method of the no-clean hand sanitizer with antibacterial and moisturizing functions as claimed in claim 5, wherein the preparation method comprises the following steps: and the stirring temperature in the fifth step is 45-60 ℃, the stirring speed is 80-150r/min, and the stirring time is 20-45 min.
8. The preparation method of the no-clean hand sanitizer with antibacterial and moisturizing functions as claimed in claim 5, wherein the preparation method comprises the following steps: in the sixth step, the thickener is placed for 3-5 times, the interval time of each time is 5-15min, and the rest deionized water is added into the container in several times at intervals.
9. The preparation method of the no-clean hand sanitizer with antibacterial and moisturizing functions as claimed in claim 5, wherein the preparation method comprises the following steps: and after the thickening agent and the balance of deionized water are completely added into the container, continuously stirring for 20-45 min.
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