CN113311163A - Cleaning method of detection pool - Google Patents
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- CN113311163A CN113311163A CN202010120098.XA CN202010120098A CN113311163A CN 113311163 A CN113311163 A CN 113311163A CN 202010120098 A CN202010120098 A CN 202010120098A CN 113311163 A CN113311163 A CN 113311163A
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- 238000001514 detection method Methods 0.000 title claims abstract description 149
- 238000004140 cleaning Methods 0.000 title claims abstract description 69
- 238000000034 method Methods 0.000 title claims abstract description 27
- 239000003085 diluting agent Substances 0.000 claims abstract description 62
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 51
- 238000007599 discharging Methods 0.000 claims abstract description 24
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 24
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 24
- 238000005406 washing Methods 0.000 claims description 59
- 239000007788 liquid Substances 0.000 claims description 39
- 238000002791 soaking Methods 0.000 claims description 35
- 238000012360 testing method Methods 0.000 claims description 14
- 239000003219 hemolytic agent Substances 0.000 claims description 13
- 238000005259 measurement Methods 0.000 claims description 8
- 239000012491 analyte Substances 0.000 claims description 4
- 230000002378 acidificating effect Effects 0.000 claims description 3
- 238000009792 diffusion process Methods 0.000 abstract description 5
- 239000000243 solution Substances 0.000 description 20
- 238000003556 assay Methods 0.000 description 13
- 230000000694 effects Effects 0.000 description 7
- 102000004338 Transferrin Human genes 0.000 description 5
- 108090000901 Transferrin Proteins 0.000 description 5
- 239000012581 transferrin Substances 0.000 description 5
- 108010074051 C-Reactive Protein Proteins 0.000 description 4
- 102100032752 C-reactive protein Human genes 0.000 description 4
- 102000014702 Haptoglobin Human genes 0.000 description 4
- 108050005077 Haptoglobin Proteins 0.000 description 4
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- 239000012895 dilution Substances 0.000 description 4
- 108060003951 Immunoglobulin Proteins 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
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- 102000007584 Prealbumin Human genes 0.000 description 2
- 108010071690 Prealbumin Proteins 0.000 description 2
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- 108010050122 alpha 1-Antitrypsin Proteins 0.000 description 2
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- 238000011010 flushing procedure Methods 0.000 description 2
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- 230000004048 modification Effects 0.000 description 2
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- 102000004411 Antithrombin III Human genes 0.000 description 1
- 108090000935 Antithrombin III Proteins 0.000 description 1
- 208000019838 Blood disease Diseases 0.000 description 1
- 108010028780 Complement C3 Proteins 0.000 description 1
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Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
Abstract
The invention provides a cleaning method of a detection pool, wherein the detection pool is used for accommodating an object to be detected comprising specific protein for determining the specific protein; when the determination in the detection pool is finished, firstly, the detection pool is cleaned in the early stage; and pushing a determination reagent to the detection pool, and discharging the determination reagent after the determination reagent is soaked in the detection pool for a first preset time to complete the cleaning of the detection pool, wherein the determination reagent is used for determining the object to be detected next time in the detection pool. The invention uses the measuring reagent used for measuring the object to be measured next time instead of the diluent or the cleaning solution to soak the detection pool, thereby avoiding the possible diffusion of the cleaning solution and the measuring reagent used for measuring the object to be measured next time and not influencing the result of the next detection.
Description
Technical Field
The invention relates to the field of detection instruments, in particular to a cleaning method of a detection pool.
Background
The conventional specific protein analysis comprises two steps of detection and cleaning, wherein the detection is only responsible for the accuracy of a single result, and the cleaning ensures the consistency of results of multiple measurements and the service life of a reaction tank; therefore, effective cleaning of specific protein detection systems is one of the core indicators for comprehensive evaluation of a specific protein analysis system. The prior technical scheme on the market has the following defects: firstly, a traditional biochemical analyzer uses a sampling needle to add cleaning fluid or discharge waste liquid, so that dead corners are not cleaned; secondly, a flow colorimetric scheme is used, a reaction tank and a colorimetric tank need to be cleaned respectively, an intermediate pipeline is designed, a sampling needle is cleaned, the number of involved links is large, and any problem can cause poor results; thirdly, a reaction and detection integrated pool scheme is adopted, a plurality of inlets are common, and if the liquid level is below the inlets, part of the liquid cannot be washed; if the liquid level is above the inlet, diffusion will occur; and fourthly, soaking the sample in the last step by using diluent, wherein unclean discharge can affect the next detection result.
Disclosure of Invention
In view of the above, the present disclosure is directed to solving at least one of the problems in the prior art. To this end, the present application provides a method for cleaning a detection cell, comprising:
the detection pool is used for accommodating an object to be detected comprising a specific protein for determining the specific protein, and the cleaning method of the detection pool comprises the following steps:
providing a detection pool;
when the determination in the detection pool is finished, firstly, the detection pool is cleaned in the early stage;
and pushing a determination reagent to the detection pool, and discharging the determination reagent after the determination reagent is soaked in the detection pool for a first preset time to complete the cleaning of the detection pool, wherein the determination reagent is used for determining the object to be detected next time in the detection pool.
In one embodiment of this application, the measuring cell includes cylinder and the conical surface body of interconnect and intercommunication the cylinder with the junction of conical surface body is equipped with the inlet.
In one embodiment of the present application, the "discharging the assay reagent after the assay reagent is soaked in the detection cell for a first preset time" includes:
and after the detection pool is soaked by the determination reagent for a first preset time, emptying the detection pool.
In one embodiment of the present application, the performing of the preliminary washing on the detection cell includes:
and pushing a cleaning solution to the detection pool, and discharging the cleaning solution after the cleaning solution is used for washing and soaking the detection pool for a second preset time.
In one embodiment of the present application, the "washing the detection cell with the washing liquid for a second preset time and then discharging the washing liquid" includes:
and after the cleaning solution is used for washing and soaking the detection pool for a second preset time, emptying the detection pool.
In an embodiment of this application, to detect the pond propelling movement washing liquid, with the washing liquid is right after detecting the pond and washing and soaking the second preset time after with the washing liquid discharge, it still includes to detect the pond and wash earlier stage:
and pushing a first diluent to the detection pool, and discharging the first diluent after the detection pool is washed and soaked for a third preset time by using the first diluent.
In one embodiment of the present application, the "washing and soaking the detection cell with the first diluent for a third preset time before discharging the first diluent" includes:
and after the first diluent is used for washing and soaking the detection pool for a third preset time, emptying the detection pool.
In an embodiment of this application, to the first diluent of inspection cell propelling movement, it is right to use first diluent the inspection cell washes after soaking the diluent discharge after the third preset time, it still includes to right the inspection cell washs earlier stage:
and pushing a second diluent to the detection pool, and discharging the second diluent after the second diluent washes and soaks the detection pool for a fourth preset time.
In one embodiment of the present application, the "washing and soaking the detection cell with the second diluent for a fourth preset time before discharging the second diluent" includes: and after the second diluent is used for washing and soaking the detection pool for a fourth preset time, emptying the detection pool.
In one embodiment of the present application, the first diluent and the second diluent are the same.
In an embodiment of the present application, the fourth preset time is greater than the third preset time.
In one embodiment of the present application, when the measuring reagent is immersed in the measuring cell, the liquid level of the measuring reagent in the measuring cell is higher than the liquid level of the measuring cell in the reagent used in the preliminary washing.
In one embodiment of the present application, the cleaning solution is an alkaline or acidic cleaning solution.
In one embodiment of the present application, the assay reagent is a hemolytic agent for the assay of a specific protein.
The beneficial effect of this application: the invention uses the measuring reagent used for measuring the object to be measured next time instead of the diluent or the cleaning solution to soak the detection pool, thereby avoiding the possible diffusion of the cleaning solution and the measuring reagent used for measuring the object to be measured next time and not influencing the result of the next detection.
Drawings
Fig. 1 is a flowchart of a method for cleaning a detection cell according to an embodiment of the present invention.
Fig. 2 is a detection cell according to an embodiment of the present invention.
Fig. 3 is a sub-flowchart of step 200 in fig. 1.
Detailed Description
While the following is a description of the preferred embodiments of the present invention, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention.
Referring to fig. 1, an embodiment of the present invention provides a method for cleaning a detection cell, in which the detection cell is used for accommodating an analyte including a specific protein for determining the specific protein. The method for cleaning the detection cell includes step S100, step S200 and step S300. The detailed procedure is as follows.
Step S100, providing a detection pool. The detection cell provided in this step means a detection cell having a residual detection substance or detection solution after the end of the last measurement or a detection cell that has never been used.
And step S200, after the determination in the detection pool is finished, firstly, cleaning the detection pool in the early stage. The early wash may wash away most of the residual material or residual solution. For a test cell that has never been used, i.e., a new test cell, the method of the preliminary washing may be different from that of the previous test cell that has been used last.
And step S300, pushing the determination reagent to the detection pool, discharging the determination reagent after the determination reagent is soaked in the detection pool for a first preset time, and finishing cleaning the detection pool, wherein the determination reagent is used for determining the object to be detected next time by the detection pool. The measuring reagent used for measuring the object to be measured next time is used for soaking instead of the diluent or the cleaning solution, so that the possible diffusion of the cleaning solution and the measuring reagent used for measuring the object to be measured next time is avoided, and the result of the next detection is not influenced.
In the present application, the assay reagent is preferably a hemolytic agent for assay of a specific protein. For example, the analyte to be measured in the next measurement is a specific protein, the measurement reagent for the specific protein is a hemolytic agent, after the detection chamber is cleaned, the hemolytic agent is pushed into the detection chamber, and after the detection chamber is soaked with the hemolytic agent for a first preset time, the hemolytic agent is discharged, thereby completing the cleaning of the detection chamber. Because the hemolytic agent is a determination reagent for detecting the specific protein by using the detection cell next time, even if a small amount of hemolytic agent is not discharged after the last soaking, the small amount of hemolytic agent does not influence the next detection result, and the detection accuracy can be further improved.
In the present application, specific proteins include, but are not limited to, the following.
Immunoglobulin: IgG, IgM, IgA and complement C3, complement C4 series.
Detecting specific proteins of rheumatism and rheumatoid series: antistreptolysin (ASO), Rheumatoid Factor (RF), C-reactive protein (CRP).
Specific proteins of the urine trace protein series: urinary micro-protein (MA), urinary Transferrin (TRU), urinary immunoglobulin (IgU), alpha 1-microglobulin (A1M), beta 2-microglobulin (beta 2 MG).
Specific proteins of the acute inflammatory series: c-reactive protein (CRP), alpha 1-acid glycoprotein (AAG), Haptoglobin (HPT), cuprammonium protein (CER), alpha 1-antitrypsin (AAT).
Specific proteins of the nutritional profile: albumin (ALB), Prealbumin (PAB), Transferrin (TRF).
Specific proteins of the blood disease detection index series: transferrin (TRF), Haptoglobin (HPT), Ferritin (FER), antithrombin-III (AT 3).
Referring to FIG. 2, in a further embodiment, the detecting cell 10 includes a cylindrical body 100 and a conical body 200 connected and communicated with each other, and a liquid inlet 300 is provided at the connection position of the cylindrical body 100 and the conical body 200. The purpose of this is to optimize the liquid flow line entering the test cell 10, i.e. to be able to achieve both horizontal and vertical cleaning in the test cell 10. If the liquid inlet 300 is arranged above the cylinder 100, when the liquid level of the cleaning liquid is lower than the liquid inlet, the part between the liquid level and the liquid inlet can not be soaked, so that the cleaning effect can not be ensured; if the liquid level is increased to cover the liquid inlet, a new problem is caused, namely that a plurality of reagents can diffuse, so that the next result analysis is influenced. In the present application, the above-mentioned problem can be avoided by disposing the liquid inlet 300 at the junction of the cylinder 100 and the conical body 200. Specifically, the central axis of the liquid inlet 300 is flush with the boundary between the cylinder 100 and the conical body 200. In the present application, the number of the liquid inlets 300 is preferably one, so that the reagents in the liquid inlets 300 can be prevented from being cross-diffused, and the cleaning effect can be further improved, compared with the plurality of liquid inlets 300. It should be noted that the cleaning method of the present application is also applicable to detection cells having other structural shapes.
In a further embodiment, the step of "discharging the assay reagent after the assay reagent soaks the detection cell for the first preset time" in the step S300 includes emptying the detection cell after the assay reagent soaks the detection cell for the first preset time. Namely, the assay reagent is completely discharged from the detection cell, thereby further improving the detection accuracy.
In a further embodiment, in the step S200, performing a previous washing on the detection cell includes step S210.
And step S210, pushing the cleaning solution to the detection pool, washing and soaking the detection pool by the cleaning solution for a second preset time, and then discharging the cleaning solution. In this step, most of the detection reagent or analyte remaining in the previous detection is washed and discharged with a washing solution. In the present application, the cleaning liquid is preferably an alkaline or acidic cleaning liquid.
In a further embodiment, the step of discharging the cleaning solution after washing and soaking the detection pool with the cleaning solution for a second preset time includes the step of emptying the detection pool after washing and soaking the detection pool with the cleaning solution for the second preset time. Namely, the cleaning liquid is completely discharged out of the detection pool, so that the detection precision is further improved.
In a further embodiment, after step S210, the pre-washing of the detection cell further comprises step S220.
Step S220, pushing the first diluent to the detection pool, washing and soaking the detection pool for a third preset time by using the first diluent, and then discharging the first diluent. In this step, the test cell is further rinsed with a first diluent.
In a further embodiment, the "rinsing and soaking the detection cell with the first diluent for a third preset time and then discharging the first diluent" includes draining the detection cell after rinsing and soaking the detection cell with the first diluent for the third preset time. Namely, the first diluent is completely discharged out of the detection cell, so as to further improve the detection precision.
In a further embodiment, after step S220, the pre-washing of the detection cell further comprises step S230.
And step S230, pushing a second diluent to the detection pool, washing and soaking the detection pool for a fourth preset time by using the second diluent, and then discharging the second diluent. And the second diluent is used for washing the detection pool again, so that the cleaning effect is further improved.
In a further embodiment, the "rinsing and soaking the detection cell with the second diluent for a fourth preset time and then discharging the second diluent" includes draining the detection cell after rinsing and soaking the detection cell with the second diluent for the fourth preset time. I.e. the second diluent is completely discharged from the detection cell, so as to further improve the detection precision.
In a further embodiment, the first and second dilutions are the same. In other embodiments, the first and second dilutions may be different, but preferably, the second dilution washes better than the first dilution in terms of washing efficiency.
In a further embodiment, the fourth predetermined time is greater than the third predetermined time. Namely, the time for flushing and soaking by using the second diluent is longer than that for flushing and soaking by using the first diluent, so that the cleaning effect is improved. In other embodiments, when there is a limit to the cleaning time, the fourth preset time may be set to be equal to the third preset time, so as to ensure the cleaning effect while ensuring the cleaning efficiency.
In a further embodiment, in step 300, the liquid level of the assay reagent in the detection cell is higher than the liquid level of the reagent used in the previous washing when the assay reagent is immersed in the detection cell. If the last washing of the previous washing is the above step S230, the liquid level at which the measurement reagent is pushed into the detection cell is higher than the liquid level at which the second diluent is washed and soaked in the detection cell in step S300, so that the second diluent remaining in the previous washing can be sufficiently soaked, and the influence of the second diluent on the measurement effect can be reduced.
In the present application, the washing of the detection cell includes four times of washing, including three times of washing in the previous stage and the last washing of the measurement reagent. The method specifically comprises the following steps: for the first time, washing and soaking for the first time by using a cleaning solution; secondly, washing and soaking by using the first diluent; thirdly, washing and soaking by using the second diluent again; fourth, the next assay reagent (e.g., hemolytic agent) is used for soaking. On one hand, the cleaning and the emptying are carried out for multiple times, so that the cleaning effect is enhanced; on the other hand, the hemolytic agent is finally used for soaking instead of the diluent, so that the possible diffusion of the cleaning liquid and the hemolytic agent is avoided, and the result of the next detection is not influenced.
The above examples only show some embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (14)
1. A method for washing a detection cell for receiving an analyte including a specific protein for measurement of the specific protein, comprising:
providing a detection pool;
when the determination in the detection pool is finished, firstly, the detection pool is cleaned in the early stage;
and pushing a determination reagent to the detection pool, and discharging the determination reagent after the determination reagent is soaked in the detection pool for a first preset time to complete the cleaning of the detection pool, wherein the determination reagent is used for determining the object to be detected next time in the detection pool.
2. The method for cleaning the detection tank, according to claim 1, wherein the detection tank comprises a cylindrical body and a conical body which are connected and communicated with each other, and a liquid inlet is provided at the joint of the cylindrical body and the conical body.
3. The method for washing a measuring cell according to claim 1, wherein said "discharging the measuring reagent after the measuring reagent is soaked in the measuring cell for a first predetermined time" comprises:
and after the detection pool is soaked by the determination reagent for a first preset time, emptying the detection pool.
4. The method for washing a test cell according to claim 1, wherein the pre-washing the test cell comprises:
and pushing a cleaning solution to the detection pool, and discharging the cleaning solution after the cleaning solution is used for washing and soaking the detection pool for a second preset time.
5. The method for washing a detection cell according to claim 4, wherein said "draining the washing liquid after washing and soaking the detection cell with the washing liquid for a second predetermined time" comprises:
and after the cleaning solution is used for washing and soaking the detection pool for a second preset time, emptying the detection pool.
6. The method for cleaning the detection pool according to claim 4, wherein the step of pushing a cleaning solution to the detection pool, and after the cleaning solution is discharged after the detection pool is washed and soaked with the cleaning solution for a second preset time, the step of performing the early-stage cleaning on the detection pool further comprises:
and pushing a first diluent to the detection pool, and discharging the first diluent after the detection pool is washed and soaked for a third preset time by using the first diluent.
7. The method for washing a test cell according to claim 6, wherein the discharging the first diluent after washing and soaking the test cell with the first diluent for a third predetermined time comprises:
and after the first diluent is used for washing and soaking the detection pool for a third preset time, emptying the detection pool.
8. The method for cleaning a detection cell according to claim 6, wherein the step of pushing a first diluent to the detection cell, and after the step of rinsing and soaking the detection cell with the first diluent for a third preset time and then discharging the diluent, the step of performing the early-stage cleaning on the detection cell further comprises:
and pushing a second diluent to the detection pool, and discharging the second diluent after the second diluent washes and soaks the detection pool for a fourth preset time.
9. The method for washing a test cell according to claim 8, wherein said draining the second diluent after washing and soaking the test cell with the second diluent for a fourth predetermined time comprises: and after the second diluent is used for washing and soaking the detection pool for a fourth preset time, emptying the detection pool.
10. The method of washing a test cell of claim 8, wherein the first diluent and the second diluent are the same.
11. The method of washing a test cell of claim 8, wherein the fourth predetermined time is greater than the third predetermined time.
12. The method of washing a measuring cell according to claim 1, wherein the measuring reagent is immersed in the measuring cell at a level higher than a level of the reagent used in the preliminary washing.
13. The method of cleaning a detection cell according to any one of claims 4 to 12, wherein the cleaning liquid is an alkaline or acidic cleaning liquid.
14. The method for washing a measuring cell according to any one of claims 1 to 12, wherein the measuring reagent is a hemolytic agent for measuring a specific protein.
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