CN108663303A - A kind of blood analyser - Google Patents
A kind of blood analyser Download PDFInfo
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- CN108663303A CN108663303A CN201810843427.6A CN201810843427A CN108663303A CN 108663303 A CN108663303 A CN 108663303A CN 201810843427 A CN201810843427 A CN 201810843427A CN 108663303 A CN108663303 A CN 108663303A
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- solenoid valve
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- measurement module
- blood
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- 210000004369 blood Anatomy 0.000 title claims abstract description 50
- 239000008280 blood Substances 0.000 title claims abstract description 50
- 238000005259 measurement Methods 0.000 claims abstract description 74
- 238000001514 detection method Methods 0.000 claims abstract description 51
- 239000012530 fluid Substances 0.000 claims abstract description 39
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 32
- 210000001772 blood platelet Anatomy 0.000 claims abstract description 28
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 26
- 238000004140 cleaning Methods 0.000 claims abstract description 20
- 210000000265 leukocyte Anatomy 0.000 claims abstract description 20
- 239000011159 matrix material Substances 0.000 claims abstract description 11
- 238000012545 processing Methods 0.000 claims abstract description 10
- 239000010808 liquid waste Substances 0.000 claims abstract description 8
- 230000004044 response Effects 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims description 28
- 238000006243 chemical reaction Methods 0.000 claims description 23
- 239000002699 waste material Substances 0.000 claims description 20
- 238000010438 heat treatment Methods 0.000 claims description 13
- 238000002955 isolation Methods 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 8
- 238000002835 absorbance Methods 0.000 claims description 7
- 230000008859 change Effects 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- 108010074051 C-Reactive Protein Proteins 0.000 abstract description 11
- 102100032752 C-reactive protein Human genes 0.000 abstract description 11
- 238000012360 testing method Methods 0.000 abstract description 9
- 239000003795 chemical substances by application Substances 0.000 abstract description 5
- 206010061218 Inflammation Diseases 0.000 abstract description 4
- 230000004054 inflammatory process Effects 0.000 abstract description 4
- 210000004027 cell Anatomy 0.000 description 19
- 238000000034 method Methods 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 5
- 230000003287 optical effect Effects 0.000 description 5
- 238000004820 blood count Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
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- 238000002156 mixing Methods 0.000 description 4
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- 238000010790 dilution Methods 0.000 description 3
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- 230000005611 electricity Effects 0.000 description 3
- 238000005286 illumination Methods 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000009385 viral infection Effects 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 230000008033 biological extinction Effects 0.000 description 2
- 238000004159 blood analysis Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000005684 electric field Effects 0.000 description 2
- 238000000684 flow cytometry Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000004493 neutrocyte Anatomy 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/12—Coulter-counters
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N15/1429—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its signal processing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
- G01N21/3151—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths using two sources of radiation of different wavelengths
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- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/33—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3577—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
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- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N2015/1486—Counting the particles
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
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- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N2015/1488—Methods for deciding
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N2021/3129—Determining multicomponents by multiwavelength light
Abstract
The present invention relates to a kind of blood analysers, including inhale sample dispensing module, reagent dispensing module, fluid dynamic and liquid waste processing module, red blood cell and blood platelet measurement module, leukocyte differential count measurement module and Biochemistry measurement module.Biochemistry measurement module is used for the response measurement of biochemical project, including：Colorimetric device, agent bin, cleaning station and colorimetric detection block, wherein colorimetric device includes colorimetric disc and the N cuvette on colorimetric disc, colorimetric detection block includes light emitting diode matrix, light pipe, collimation lens and photodiode, N number of cuvette circumferentially arranges on colorimetric disc, colorimetric disc rotates, and drives cuvette across collimation lens and photodiode.The present invention integrates blood routine and biochemistry detection in one, and once test can detect the inflammation indexes such as blood routine and c reactive protein, SAA simultaneously an one pipe blood of instrument, save Clinical practice cost and human cost.
Description
Technical field
The present invention relates to medical instruments field more particularly to a kind of blood analysers.
Background technology
In clinical application, it is frequently run onto some patients and needs while detecting blood routine and certain Special Proteins to diagnose the trouble
Whether person brings slight illness due to bacterium or virus infection, and Special Proteins detection is due to the use of different in blood routine detection and blood
Methodology, so generally being completed by different instruments.For example, when clinical progress blood routine detection, using based on flow cytometry
Differential hematology analyzer carry out in whole blood sample white blood count and differential, red blood cell and enumeration of thrombocytes and red thin
The colorimetric detection of hemoglobin in born of the same parents；Quantitative detection to Special Proteins in blood measures original using spectrophotometric is based on
The Biochemical Analyzer or Special Protein Analyzer of reason are to the detections such as albumen, antibody in serum sample, this conventional detection hand
Section brings following problem：1, two pipe blood samples complete test：For supermatic blood analyser and Biochemical Analyzer, sample
It cannot be compatible with, blood analyser uses whole blood, Biochemical Analyzer to use serum, clinical examination that two pipe blood sample of patient need to be taken to distinguish
Test increases patient suffering, as a result cannot provide simultaneously, and blood routine detection is faster than biochemistry detection, increases the report stand-by period；2、
One pipe blood sample completes test：One pipe blood of patient is taken, blood routine, semi-automatic special proteins are detected using automatic blood analyzer
Analyzer or test strips etc. carry out Special Proteins and quantitatively or semi-quantitatively detect, and handle by hand, increase cost of labor and manual operations
The uncertainty brought.
In recent years, the needs of of detection, individual cellanalyzer producers are diagnosed for patient's inflammation infection to meet clinic
It is proposed differential hematology analyzer and c reactive protein all-in-one machine, for the clinical blood examination for bacterium infection, Yi Shengke
To use a pipe blood, an instrument, one-shot measurement to obtain blood routine detection and c reactive protein testing result, pass through leucocyte meter
Number, neutrophil leucocyte ratio and c reactive protein concentration value carry out bacterium infection diagnosis, and this new blood analysis instrument is facing
Popular welcome is received in bed application, but far can not also meet demand；Main problem is that patient's infection may be bacterium
Or virus infection, and leucocyte, neutrophil leucocyte and c reactive protein have good specificity for bacterium infection, for virus
Infection, then without apparent specificity, it is therefore desirable to which the range for widening blood routine and Special Proteins detection provides more detections and refers to
Mark.
Invention content
It is an object of the present invention to solve above-mentioned shortcoming existing in the prior art.
To achieve the above object, the present invention provides a kind of blood analyser, including inhales sample dispensing module, reagent dispensing mould
Block, fluid dynamic and liquid waste processing module, red blood cell and blood platelet measurement module, leukocyte differential count measurement module and Biochemistry measurement
Module；The outer blood sample of sample dispensing module suction machine is inhaled, and blood sample is distributed to leukocyte differential count measurement module and Biochemistry measurement module；
Reagent dispensing module is temporally required red blood cell and blood platelet measurement module, leukocyte differential count measurement module and Biochemistry measurement mould
Quantitative detecting reagent needed for block is distributed to red blood cell and blood platelet measurement module, leukocyte differential count measurement module and Biochemistry measurement mould
Block；Fluid dynamic and liquid waste processing module will inhale sample dispensing module, red blood cell and blood platelet measurement module, leukocyte differential count and measure
Outside the waste liquid discharge machine that module and Biochemistry measurement module generate, while required sheath is provided for red blood cell and blood platelet measurement module
Liquid；The quantity and size and platelet counts and size of red blood cell and blood platelet measurement module for detecting red blood cell；It is white thin
Born of the same parents' category measurement module is used for leukocyte differential count；Biochemistry measurement module is used for the response measurement of biochemical project, Biochemistry measurement module
Including：Colorimetric device, agent bin, cleaning station and colorimetric detection block, wherein colorimetric device include colorimetric disc and are located on colorimetric disc
N cuvette, detect cuvette in each sample reaction solution absorbance, wherein N is positive integer, and, N be greater than or equal to 2；
Colorimetric detection block includes light emitting diode matrix, light pipe, collimation lens and photodiode, and N number of cuvette is on colorimetric disc
It circumferentially arranges, colorimetric disc rotation drives cuvette across collimation lens and photodiode.
Preferably, it includes suction needle, cleaning swab, the first solenoid valve and second solenoid valve to inhale sample dispensing module.
Preferably, reagent dispensing module includes；Reagent injector pump, third solenoid valve, the 4th solenoid valve, the 5th solenoid valve and
6th solenoid valve.
Preferably, fluid dynamic and liquid waste processing module include：First diaphragm pump, the second diaphragm pump, third diaphragm pump, just
Press pond, sheath liquid pool, the 7th solenoid valve, the 8th solenoid valve, the 9th solenoid valve, the tenth solenoid valve, the 11st solenoid valve, the 12nd electricity
Magnet valve, the 13rd solenoid valve, the 14th solenoid valve, the 15th solenoid valve.
Preferably, red blood cell and blood platelet measurement module include counting chamber, sheath fluid isolation tank, waste liquid isolation tank, impedance sample
This syringe pump, the 16th solenoid valve, the 17th solenoid valve, the 18th solenoid valve, the 19th solenoid valve, the 20th solenoid valve,
21 solenoid valves.
It is further preferred that counting chamber includes counting chamber after-bay, counting chamber forebay, gem hole gasket, gem hole, sample
Needle stand, specimen needle, forebay electrode tube, after-bay leakage fluid dram and after-bay electrode；Wherein, counting chamber after-bay is accessed by forebay electrode tube
Anode is accessed in cathode, counting chamber forebay by after-bay electrode.
Preferably, leukocyte differential count measurement module includes：Reaction tank, flow chamber, sample injections pump, sheath fluid syringe pump give up
Liquid pool, the 22nd solenoid valve, the 23rd solenoid valve, the 24th solenoid valve, the 25th solenoid valve, the 26th electromagnetism
Valve, the 27th solenoid valve.
Preferably, colorimetric disc includes colorimetric disc heat block, colorimetric disc carrier, colorimetric disc shaft, colorimetric coil motor, colorimetric disc
Heating film forms, wherein is fixed in the middle part of colorimetric disc carrier in colorimetric disc shaft, colorimetric disc branch is hung at the top of cuvette
The edge of frame, colorimetric disc heat block include a bottom parts and two contour concentric hollow cylindrical parts, two open circles
Post part and bottom parts are integrally formed, and two hollow cylindrical parts and bottom parts constitute a toroidal cavity, cuvette
Cup body be located in toroidal cavity, colorimetric disc heating film is heated for heating colorimetric disc heat block in toroidal cavity
Air.
The present invention has advantageous effect：(1) five classification blood routines and biochemistry detection are integrated in one, an instrument one
Pipe blood once test the inflammation indexes such as blood routine and c reactive protein, SAA can be detected simultaneously, save Clinical practice cost with
Human cost.(2) system structure is simple, safeguards, reliability height low with manufacturing cost：Compared with Conventional blood analyzer, only increase
Colorimetric disc, agent bin and Photoelectric Detection module, wherein Photoelectric Detection module is added to use the compound timesharing detection side of multichannel monochromatic source
Formula forms array by multiple single color LEDs and realizes that colorimetric detection (3) system of different wave length extends flexibly and easily, removes
Outside blood routine, multiple biochemistry detecting items can be supported, cover clinical common inflammation index.
Description of the drawings
Fig. 1 is a kind of structural schematic diagram of blood analyser provided by the invention；
Fig. 2 is a kind of structural schematic diagram of counting chamber provided in an embodiment of the present invention；
Fig. 3 is a kind of Coulter principle figure provided in an embodiment of the present invention；
Fig. 4 is a kind of sheath stream impedance samples pulse diagram provided in an embodiment of the present invention；
Fig. 5 is a kind of Biochemistry measurement principle schematic provided in an embodiment of the present invention；
Fig. 6 is a kind of colorimetric disc structural schematic diagram provided in an embodiment of the present invention.
Specific implementation mode
With reference to the accompanying drawings and examples, technical scheme of the present invention will be described in further detail.
Such as Fig. 1-6, blood analyser provided in an embodiment of the present invention, including inhale sample dispensing module 1, reagent dispensing module 2,
Fluid dynamic and liquid waste processing module 3, red blood cell and blood platelet measurement module 4, leukocyte differential count measurement module 5 and Biochemistry measurement
Module 6.
Such as Fig. 1, inhales sample and dispense module 1：The outer blood sample of realization machine is drawn, and is distributed into leukocyte differential count measurement module and reacted
Each colorimetric pool in pond and Biochemistry measurement module；It completes after inhaling sample dispensing, clean and measures standby mode into next time；Its main device
Component includes：Suction needle 101 cleans swab 102, the first solenoid valve 103 and second solenoid valve 104.
Reagent dispenses module 2：It temporally requires to distribute quantitative detecting reagent needed for each measurement module to red blood cell and blood
Platelet measurement module, leukocyte differential count measurement module and Biochemistry measurement module；Its main device component includes：Reagent injector pump 201,
Third solenoid valve 202, the 4th solenoid valve 203, the 5th solenoid valve 204, the 6th solenoid valve 205.
Fluid dynamic and liquid waste processing module 3：Outside the waste liquid discharge machine that other resume module samples are generated, while being red
Cell and blood platelet measurement module provide required sheath fluid；Its main device component includes the first diaphragm pump 301, the second diaphragm pump
302, third diaphragm pump 303, positive pressure pond 304, sheath liquid pool 305, the 7th solenoid valve 306, the 8th solenoid valve 307, the 9th solenoid valve
308, the tenth solenoid valve 309, the 11st solenoid valve 310, the 12nd solenoid valve 311, the 13rd solenoid valve 312, the 14th electromagnetism
Valve 313, the 15th solenoid valve 314.
Red blood cell and blood platelet measurement module 4：Red blood cell and platelet counts, size are detected with sheath-flow impedance method, every
Cell measurement and sensor cleaning are completed in a measurement procedure；Its main device component includes：Counting chamber 401, sheath fluid isolation tank
402, waste liquid isolation tank 403, the 404, the 16th solenoid valve 405 of impedance samples syringe pump, the 406, the 18th electricity of the 17th solenoid valve
Magnet valve 407, the 19th solenoid valve 408, the 20th solenoid valve 409, the 21st solenoid valve 410.
Leukocyte differential count measurement module 5：Quantity of leucocyte is detected with optical scattering method and is carried out according to scattered light signal white
Cell classification, wherein white blood count and differential is respectively two measurement procedures, passes through quilt in reaction tank in timesharing detection module
The sample of different reagent processing reaches counting sort purpose；Its main device component includes：Reaction tank 501, flow chamber 502, sample
Syringe pump 503, sheath fluid syringe pump 504, the 505, the 22nd solenoid valve 506 of waste liquid pool, the 23rd solenoid valve the 507, the 20th
Four solenoid valves 508, the 25th solenoid valve 509, the 26th solenoid valve 510, the 511, the 28th electricity of the 27th solenoid valve
Magnet valve 512.
Biochemistry measurement module 6：The absorbance that each sample reaction solution in cuvette is detected with optical colorimetric method, is become by absorbance
Change and calculate concentration of specimens, wherein the module includes reagent refrigerating structure and colorimetric dish structure, colorimetric disc be arranged multiple cuvettes with
And the LED and receipts photodetection assembly of specific wavelength, colorimetric disc rotate cuvette and pass through LED and receive photodetection assembly, obtain extinction
Degree variation；Its main device component includes：Colorimetric device 601 on bottom plate, agent bin 602, cleaning station 603, colorimetric inspection
Block 604 is surveyed, 4 lifes can be carried out at the same time here by taking 4 cuvettes as an example comprising no less than 2 cuvettes wherein in colorimetric device
The response measurement of change project.
The implementation method of the blood analyser is illustrated below.
Blood analyser system specific workflow includes to inhale sample dispensing and reagent dispensing, incubation reaction, pattern detection.
It inhales sample dispensing and reagent dispensing specifically includes：Sample injections pump 503 will be determined by second solenoid valve 104 and pipeline
The sample of amount sucks specimen needle 101, such as the blood sample of 20ul, is cleaned by the first solenoid valve 103 by sheath fluid syringe pump 504
The outer wall of specimen needle 101, meanwhile, the first diaphragm pump 301 and 11 solenoid valves 310 extract cleaning outer wall waste liquid；Foundation after the completion
The sample of absorption is quantitatively adding the colorimetric of reaction tank 501 and colorimetric device 601 by specimen needle 101 by test event respectively
In cup, while will be each logical by the 4th solenoid valve 203, the 5th solenoid valve 204 and the 6th solenoid valve 205 by reagent injector pump 201
Reagent quantitative needed for road is added in the cuvette of reaction tank 501 and colorimetric device 601；Reagent injector pump 201 in reagent by machine outside
Reagent provides；Dilution needed for reaction tank 501 passes through the 22nd solenoid valve 506, the 23rd electromagnetism by sheath fluid syringe pump 504
Valve 507 and the 24th solenoid valve 508 are quantitatively adding, and required dilution is noted by reagent in cuvette 6012 in colorimetric device 601
Pump 201 is penetrated to be quantitatively adding by third solenoid valve 202；After the completion, it is the sample reagent mixing of determining thinner ratio in each reaction tank
Liquid；After the completion of specimen needle 101 is loaded, cleaned by second solenoid valve 104, the 25th solenoid valve 509 by sheath fluid syringe pump 504
101 inner wall of specimen needle, mechanism driving cleaning swab 102 are moved along 101 outer wall of specimen needle, while by the first diaphragm pump 301 and the
11 solenoid valves 310 generate negative pressure extracting and clean waste liquid.
Incubation reaction specifically includes：In reaction tank 501, sample is with two kinds of reagents to react a timing in certain temperature
Between, certain positive pressure, the production of the tenth solenoid valve 309 of of short duration opening are generated in positive pressure pond 304 by third diaphragm pump 303 in reaction process
Sample and reagent in anger bubble mixing reaction tank 501；Meanwhile sample and reagent in each cuvette 6012 in colorimetric device 601
Hybrid reaction, colorimetric device 601 provide 35 DEG C of temperature environments, and the top of colorimetric device 601 is arranged cleaning station 603, on cleaning station 603
Cleaning needle and bubble needle are installed, certain positive pressure, the 9th electromagnetism of of short duration opening are generated in positive pressure pond 304 by third diaphragm pump 303
Valve 308 generates bubble, while bubble needle is inserted into corresponding cuvette and blows out bubble by cleaning station 603, and mixing colorimetric device 601 respectively compares
Sample mixed liquor in color cup；Reaction tank 501 with stood after sample mixing in each cuvette in colorimetric device 601 it is to be measured；
In one example, the temperature of reaction tank 501 is 35 DEG C.
Pattern detection and cleaning specifically include：Pattern detection is completed by red blood cell and blood platelet measurement module 4 red thin respectively
The measurement of born of the same parents and platelet counts, size is completed white blood count and differential by leukocyte differential count measurement module 5 and is measured, biochemical
Measurement module 6 is completed the biochemical projects such as c reactive protein and is measured.
Red blood cell and blood platelet measuring process are：Sheath fluid syringe pump 504 passes through the 16th solenoid valve 405, the 17th electromagnetism
Valve 406 and the 22nd solenoid valve 506 are drawn in the pipeline that a certain amount of sample is connected to counting chamber 401, meanwhile, positive pressure pond
304 generate certain positive pressure, such as 40KPa, are loaded onto on the sheath fluid in sheath liquid pool 305 by opening the 8th solenoid valve 307, impedance
Sample enters counting chamber 401 in 404 promotion pipeline of sample injections pump, while the 19th solenoid valve 408 is opened push-in sheath fluid and entered
Counting chamber 401 forms sheath stream and passes through 401 detection zone of counting chamber, starts to detect red blood cell and blood platelet, detection zone is added with Constant Electric Current
, each red blood cell and blood platelet can generate and the relevant electric pulse of own vol, collection electric impulse signal by detection zone
Form the quantity and size information of tested sample；To prevent the cell reflux detected to detection zone, while opening the 21st
Solenoid valve 410 accesses sheath fluid to 401 after-bay of counting chamber by sheath fluid isolation tank 402；After a certain period of time, impedance samples are injected for detection
Pump 404 is completed to push away sample, opens the 18th solenoid valve 407 cleaning sample pipeline and counting chamber 401, the waste liquid that detection and cleaning generate
Waste liquid pool 505 is discharged by waste liquid isolation tank；To prevent from retaining bubble in counting chamber 401, the 20th electromagnetism is opened in cleaning process
Bubble in counting chamber 401 is discharged into waste liquid pool 505 by valve 409.
White blood count and differential measuring process is：Sheath fluid syringe pump 504 passes through the 22nd solenoid valve the 506, the 20th
Four solenoid valves 508 close the 20th by the pipeline of leucocyte prepare liquid inhalation flow room 502 completely reacted in reaction tank 501
Two solenoid valves 506, the 24th solenoid valve 508 open the 23rd solenoid valve 507 and the 27th solenoid valve 511, by sample
This syringe pump 503 by pipeline sample be pushed into flow chamber 502, while sheath fluid syringe pump 504 by the 26th solenoid valve 510,
Sheath fluid is pushed into flow chamber 502 by the 27th solenoid valve 511, and sample forms sheath stream with sheath fluid in flow chamber 502 and passes through detection
Area, the detection zone and laser coupled of flow chamber 502, cell enter detection zone and generate scattered light signal by laser irradiation, collect and dissipate
Penetrate quantity, size and classification information that optical signal forms tested sample；The sample measured is flowed by the 28th solenoid valve 512
Enter waste liquid pool 505, when waste liquid is more in waste liquid pool 505, is arranged waste liquid by the 13rd solenoid valve 312 by the second diaphragm pump 302
Go out outside machine.
Biochemical project measuring process is：Colorimetric disc 6011 drives each cuvette to rotate, and passes through colorimetric detection block 604 successively,
Multiple and different wavelength light sources and a light receiving device are set on colorimetric detection block 604, and each cuvette passes through colorimetric detection block 604
When, it stops and is no less than 1 second time, according to detected project, specified wavelength light source igniting in colorimetric detection block 604, time-division illumination
Reaction solution in cuvette, for example, when being c reactive protein project in cuvette, the light source lighted is 375nm and 850nm wavelength, is led to
The absorbance for collecting this two wavelength is crossed, the project of being tested concentration of specimens is calculated；After being measured, is driven and cleaned by cleaning station 603
Needle enters cuvette 6012, and the second diaphragm pump 302 and the 14th solenoid valve 313 are opened, and draw reaction solution in cuvette 6012, so
Dilution cuvette 6012 is injected by cleaning station cleaning needle by third solenoid valve 202 by reagent injector pump 201 afterwards to clean,
Cuvette 6012 is cleaned multiple times until no specimen remains.
In one example, such as Fig. 2, counting chamber 401, the sheath flow impedance combined with " Kurt " principle for flow cytometry
Counting chamber, structure include mainly counting chamber after-bay 4011, counting chamber forebay 4012, gem hole gasket 4013, gem hole
4014, sample needle stand 4015, specimen needle 4016, forebay electrode tube 4017, after-bay leakage fluid dram 4018, after-bay electrode 4019；Wherein,
Counting chamber after-bay 4011 accesses cathode by forebay electrode tube 4017, and counting chamber forebay 4012 is accessed just by after-bay electrode 4019
Pole forms constant current electric field in gem hole as a result,；To prevent positive electrode ionization oxidation, after-bay electrode 4019 from using platinum material
It makes.When sample is injected from specimen needle 4016, sheath fluid is injected from forebay sheath fluid entrance, and sample cell is wrapped up by sheath fluid, by treasured
When stone hole 4014, displacement wherein sheath fluid causes resistance in gem hole 4014 to rise, and generates electric pulse, and cell size determines pulse
Amplitude, cell quantity determine number of pulses；After cell flows out gem hole 4014, to prevent cell reflux from entering electric field, lead to letter
Number interference, injects sheath fluid simultaneously in counting chamber after-bay 4011, double sheath streams are consequently formed escort tested cell and flow directly into after-bay
Leakage fluid dram 4018 flows into waste liquid；Since sample cell is wrapped up by sheath fluid, cell easily passes through gem hole 4014 at arrangement one by one, keeps away
Exempt from, since concentration of specimens is excessively high, cell overlap to be caused to pass through, and generates error of omission cell situation.
Such as Fig. 3 and Fig. 4, wherein Fig. 3 is that overlapping cell causes when traditional " Kurt " principle detects high concentration cell sample
" M " shape pulse situation, Fig. 4 are cell pulse situation when the present embodiment mesotheca flow impedance counting chamber detects high concentration cell sample,
" M " shape pulse probabilities substantially reduce.
In one example, Biochemistry measurement module includes：Colorimetric device, agent bin, cleaning station and colorimetric detection block, wherein
Colorimetric device includes colorimetric disc and the N cuvette on colorimetric disc, detects the absorbance of each sample reaction solution in cuvette,
Wherein, N is positive integer, and, N is greater than or equal to 2；Colorimetric detection block include light emitting diode matrix, light pipe, collimation lens and
Photodiode, N number of cuvette circumferentially arrange on colorimetric disc, colorimetric disc rotation, drive cuvette pass through collimation lens and
Between photodiode.
In a more specific example, colorimetric disc includes colorimetric disc heat block, colorimetric disc carrier, colorimetric disc shaft, ratio
Colour disk motor, colorimetric disc heating film composition, wherein be fixed in the middle part of colorimetric disc carrier in colorimetric disc shaft, the top of cuvette
Portion hangs on the edge of colorimetric disc carrier, and colorimetric disc heat block includes a bottom parts and two contour concentric hollow cylinders
Part, two hollow cylindrical parts and bottom parts are integrally formed, and two hollow cylindrical parts and bottom parts constitute a circle
The cup body of annular groove, cuvette is located in toroidal cavity, and colorimetric disc heating film is for heating colorimetric disc heat block, Jin Erjia
Air in hot toroidal cavity.
In one example, such as Fig. 5, Biochemistry measurement module is detected based on extinction colorimetric principle, it is characterized in that multichannel
Monochromatic source compound timesharing detection, structure include mainly colorimetric disc 6011, cuvette 6012, light emitting diode matrix 6041,
Light pipe 6042, collimation lens 6043, photodiode 6044；Wherein, at least N number of cuvette is set on colorimetric disc 6011
6012, N here is not less than 2, and 4 cuvettes 6012 are set as in the present embodiment, and colorimetric disc 6011 drives cuvette 6012 to revolve
Turn, passes through successively by light emitting diode matrix 6041, light pipe 6042, collimation lens 6043 and photodiode 6044 form
Light path detection zone, each cuvette 6012 by light path detection zone when stop at least 1 second, with item to be measured in cuvette 6012
Mesh is foundation, and Systematic selection specifies 6041 time-division illumination of light emitting diode matrix cuvette 6012 to be measured, in addition, being waited for for each
Survey project, system chooses at least two wavelength and carries out time-division illumination colorimetric by light emitting diode matrix 6041, for example, cuvette
Project to be measured is c reactive protein (CRP) in 6012, internal system setting measurement c reactive protein wavelength of light be 340nm and
850nm, when cuvette 6012 rests on light path detection zone, the 340nm light sources on light emitting diode matrix 6041 first irradiate 0.5
Second, then the light source of 850nm irradiates 0.5s, remaining light source does not irradiate on light emitting diode matrix 6041, photodiode 6044
Timesharing receives the optical signal of two wavelength, calculates the absorbance value of test event according to acquisition signal by system.
In one example, the combination of light sources of at least four different wave length is set in the present invention into light emitting diode matrix
6041, using the light pipe 6042 that multiple light sources are emitted to optical coupling, multiple monochromatic sources are combined into a diameter and are not more than
The detection hot spot of 5mm, detection hot spot are radiated at after being collimated by collimation lens 6043 on cuvette 6012.
In one example, 6012 inside of cuvette is 5 × 5mm in the present invention, and light path 5mm, each detection project theory is most
Small volume of surveying is 125ul, therefore the biochemistry detecting item that the present invention is targeted, has and detects small, sample and reagent use
Measure small, at low cost advantage.
In one example, such as Fig. 6, colorimetric disc 6011 in Biochemistry measurement module includes mainly colorimetric disc heat block
60111, colorimetric disc carrier 60112, colorimetric disc shaft 60113, colorimetric coil motor 60114, the composition of colorimetric disc heating film 60115,
Wherein, colorimetric disc heat block 60111 is aluminum, and colorimetric disc heating film 60115 is made of polyimide material, such as Fig. 5, than
Colour disk 6011 is whole to use solid directly-heated mode, heats colorimetric disc heat block 60111 by colorimetric disc heating film 60115, in turn
Air in colorimetric disc heat block 60111 is heated, cuvette 6012 is immersed in 35 DEG C of hot-air, forms air bath effect, right
Reaction solution carries out incubation heating in cuvette；Wherein colorimetric disc heat block 60111 is metal material, and aluminium is closed in the present embodiment
Golden material has thermal capacitance big, and heat insulation effect is good, feature at low cost.
Above specific implementation mode has carried out further in detail the purpose of the present invention, technical solution and advantageous effect
Illustrate, it should be understood that these are only the specific implementation mode of the present invention, the protection model being not intended to limit the present invention
It encloses, all within the spirits and principles of the present invention, any modification, equivalent substitution, improvement and etc. done should be included in the present invention
Protection domain within.
Claims (8)
1. a kind of blood analyser, which is characterized in that including inhaling sample dispensing module, reagent dispensing module, fluid dynamic and waste liquid
Processing module, red blood cell and blood platelet measurement module, leukocyte differential count measurement module and Biochemistry measurement module；
The outer blood sample of suction sample dispensing module suction machine, and blood sample is distributed to leukocyte differential count measurement module and Biochemistry measurement mould
Block；
The reagent dispensing module is temporally required red blood cell and blood platelet measurement module, leukocyte differential count measurement module and life
Change quantitative detecting reagent needed for measurement module to distribute to red blood cell and blood platelet measurement module, leukocyte differential count measurement module and life
Change measurement module；
The fluid dynamic and liquid waste processing module will inhale sample dispensing module, red blood cell and blood platelet measurement module, leucocyte point
Outside the waste liquid discharge machine that class measurement module and Biochemistry measurement module generate, while institute is provided for red blood cell and blood platelet measurement module
The sheath fluid needed；
The red blood cell and blood platelet measurement module are used to detect the quantity and size and platelet counts and big of red blood cell
It is small；
The leukocyte differential count measurement module is used for leukocyte differential count；
The Biochemistry measurement module is used for the response measurement of biochemical project, and the Biochemistry measurement module includes：Colorimetric device, reagent
Storehouse, cleaning station and colorimetric detection block, wherein colorimetric device include colorimetric disc and the N cuvette on colorimetric disc, detect ratio
The absorbance of each sample reaction solution in color cup, wherein N is positive integer, and, N is greater than or equal to 2；
The colorimetric detection block includes light emitting diode matrix, light pipe, collimation lens and photodiode, N number of colorimetric
Cup circumferentially arranges on the colorimetric disc, and colorimetric disc rotation drives cuvette across collimation lens and photodiode.
2. blood analyser according to claim 1, which is characterized in that suction sample dispensing module includes suction needle, clear
Wash swab, the first solenoid valve and second solenoid valve.
3. blood analyser according to claim 1, which is characterized in that the reagent dispenses module and includes；Reagent injector
Pump, third solenoid valve, the 4th solenoid valve, the 5th solenoid valve and the 6th solenoid valve.
4. blood analyser according to claim 1, which is characterized in that the fluid dynamic and liquid waste processing module packet
It includes：First diaphragm pump, the second diaphragm pump, third diaphragm pump, positive pressure pond, sheath liquid pool, the 7th solenoid valve, the 8th solenoid valve, the 9th
Solenoid valve, the tenth solenoid valve, the 11st solenoid valve, the 12nd solenoid valve, the 13rd solenoid valve, the 14th solenoid valve, the 15th
Solenoid valve.
5. blood analyser according to claim 1, which is characterized in that the red blood cell and blood platelet measurement module include
Counting chamber, sheath fluid isolation tank, waste liquid isolation tank, impedance samples syringe pump, the 16th solenoid valve, the 17th solenoid valve, the 18th
Solenoid valve, the 19th solenoid valve, the 20th solenoid valve, the 21st solenoid valve.
6. blood analyser according to claim 1, which is characterized in that the leukocyte differential count measurement module includes：Instead
Ying Chi, flow chamber, sample injections pump, sheath fluid syringe pump, waste liquid pool, the 22nd solenoid valve, the 23rd solenoid valve, the 20th
Four solenoid valves, the 25th solenoid valve, the 26th solenoid valve, the 27th solenoid valve.
7. blood analyser according to claim 5, which is characterized in that the counting chamber includes counting chamber after-bay, counts
Pond forebay, gem hole gasket, gem hole, sample needle stand, specimen needle, forebay electrode tube, after-bay leakage fluid dram and after-bay electrode；Its
In, counting chamber after-bay accesses cathode by forebay electrode tube, and anode is accessed in counting chamber forebay by after-bay electrode.
8. blood analyser according to claim 1, which is characterized in that colorimetric disc includes colorimetric disc heat block, colorimetric disc
Holder, colorimetric disc shaft, colorimetric coil motor, colorimetric disc heating film composition, wherein be fixed on institute in the middle part of the colorimetric disc carrier
It states in colorimetric disc shaft, the edge of colorimetric disc carrier is hung at the top of cuvette, colorimetric disc heat block includes a base plate
It is divided to and two contour concentric hollow cylindrical parts, two hollow cylindrical parts and bottom parts is integrally formed, two open circles
Post part and bottom parts constitute a toroidal cavity, and the cup body of cuvette is located in toroidal cavity, colorimetric disc heating film
For heating colorimetric disc heat block, and then heat the air in toroidal cavity.
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| CN201810843427.6A CN108663303A (en) | 2018-07-27 | 2018-07-27 | A kind of blood analyser |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109932519A (en) * | 2019-04-19 | 2019-06-25 | 深圳市理邦精密仪器股份有限公司 | Blood test device |
| CN109932520A (en) * | 2019-04-19 | 2019-06-25 | 深圳市理邦精密仪器股份有限公司 | Blood test device |
| WO2020211835A1 (en) * | 2019-04-18 | 2020-10-22 | 山东鑫科生物科技股份有限公司 | Method for measuring bacterial inhibition of antibacterial drug, and bacterial counting device and method thereof |
| CN112444619A (en) * | 2019-08-30 | 2021-03-05 | 深圳迈瑞生物医疗电子股份有限公司 | Impedance method counting device and blood cell analyzer |
| CN112881089A (en) * | 2019-11-29 | 2021-06-01 | 深圳市帝迈生物技术有限公司 | Sampling device, liquid path system and method thereof and sample analyzer |
| CN113311163A (en) * | 2020-02-26 | 2021-08-27 | 深圳迈瑞生物医疗电子股份有限公司 | Cleaning method of detection pool |
| CN113495087A (en) * | 2020-04-03 | 2021-10-12 | 深圳市帝迈生物技术有限公司 | POCT blood cell analyzer and detection method thereof |
| CN114062228A (en) * | 2020-08-07 | 2022-02-18 | 北京鑫骥金诺医疗器械有限公司 | Bacteria counting device with sheath flow impedance sensor and method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1710558A2 (en) * | 2005-04-07 | 2006-10-11 | Sysmex Corporation | Blood analyzer, sample analyzer, and flow cytometer |
| CN102147405A (en) * | 2011-01-12 | 2011-08-10 | 深圳市亚辉龙生物科技有限公司 | Fully automatic biochemical immune analyzer |
| CN202008485U (en) * | 2011-04-14 | 2011-10-12 | 山东博科生物产业有限公司 | Dry and wet biochemical integrated instrument |
| CN203053986U (en) * | 2013-01-17 | 2013-07-10 | 深圳凯为生物科技有限公司 | Cuvette loading structure and full-automatic analyzer |
| CN104280328A (en) * | 2014-06-20 | 2015-01-14 | 博奥生物集团有限公司 | Flow cytometry analysis device and method |
| CN104897557A (en) * | 2015-05-30 | 2015-09-09 | 广州埃克森生物科技有限公司 | Flow cytometry detection fluid circuit system and flow cytometry detection method |
| CN208420635U (en) * | 2018-07-27 | 2019-01-22 | 北京指真生物科技有限公司 | A kind of blood analyser |
-
2018
- 2018-07-27 CN CN201810843427.6A patent/CN108663303A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1710558A2 (en) * | 2005-04-07 | 2006-10-11 | Sysmex Corporation | Blood analyzer, sample analyzer, and flow cytometer |
| CN102147405A (en) * | 2011-01-12 | 2011-08-10 | 深圳市亚辉龙生物科技有限公司 | Fully automatic biochemical immune analyzer |
| CN202008485U (en) * | 2011-04-14 | 2011-10-12 | 山东博科生物产业有限公司 | Dry and wet biochemical integrated instrument |
| CN203053986U (en) * | 2013-01-17 | 2013-07-10 | 深圳凯为生物科技有限公司 | Cuvette loading structure and full-automatic analyzer |
| CN104280328A (en) * | 2014-06-20 | 2015-01-14 | 博奥生物集团有限公司 | Flow cytometry analysis device and method |
| CN104897557A (en) * | 2015-05-30 | 2015-09-09 | 广州埃克森生物科技有限公司 | Flow cytometry detection fluid circuit system and flow cytometry detection method |
| CN208420635U (en) * | 2018-07-27 | 2019-01-22 | 北京指真生物科技有限公司 | A kind of blood analyser |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020211835A1 (en) * | 2019-04-18 | 2020-10-22 | 山东鑫科生物科技股份有限公司 | Method for measuring bacterial inhibition of antibacterial drug, and bacterial counting device and method thereof |
| CN109932519A (en) * | 2019-04-19 | 2019-06-25 | 深圳市理邦精密仪器股份有限公司 | Blood test device |
| CN109932520A (en) * | 2019-04-19 | 2019-06-25 | 深圳市理邦精密仪器股份有限公司 | Blood test device |
| CN112444619A (en) * | 2019-08-30 | 2021-03-05 | 深圳迈瑞生物医疗电子股份有限公司 | Impedance method counting device and blood cell analyzer |
| CN112444619B (en) * | 2019-08-30 | 2023-12-19 | 深圳迈瑞动物医疗科技股份有限公司 | Impedance method counting device and blood cell analyzer |
| CN112881089A (en) * | 2019-11-29 | 2021-06-01 | 深圳市帝迈生物技术有限公司 | Sampling device, liquid path system and method thereof and sample analyzer |
| CN113311163A (en) * | 2020-02-26 | 2021-08-27 | 深圳迈瑞生物医疗电子股份有限公司 | Cleaning method of detection pool |
| CN113311163B (en) * | 2020-02-26 | 2024-04-12 | 深圳迈瑞生物医疗电子股份有限公司 | Cleaning method of detection pool |
| CN113495087A (en) * | 2020-04-03 | 2021-10-12 | 深圳市帝迈生物技术有限公司 | POCT blood cell analyzer and detection method thereof |
| CN113495087B (en) * | 2020-04-03 | 2023-04-07 | 深圳市帝迈生物技术有限公司 | POCT blood cell analyzer and detection method thereof |
| CN114062228A (en) * | 2020-08-07 | 2022-02-18 | 北京鑫骥金诺医疗器械有限公司 | Bacteria counting device with sheath flow impedance sensor and method thereof |
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