CN1132629C - 酪氨酸和聚合过敏素的组合物 - Google Patents
酪氨酸和聚合过敏素的组合物 Download PDFInfo
- Publication number
- CN1132629C CN1132629C CN96193592A CN96193592A CN1132629C CN 1132629 C CN1132629 C CN 1132629C CN 96193592 A CN96193592 A CN 96193592A CN 96193592 A CN96193592 A CN 96193592A CN 1132629 C CN1132629 C CN 1132629C
- Authority
- CN
- China
- Prior art keywords
- tyrosine
- anaphylactin
- solution
- allergen
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 title claims abstract description 23
- 239000000203 mixture Substances 0.000 title claims abstract description 21
- 239000013566 allergen Substances 0.000 title claims abstract description 14
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 title description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims abstract description 25
- 239000000243 solution Substances 0.000 claims abstract description 25
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 5
- 239000007864 aqueous solution Substances 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 6
- 238000006386 neutralization reaction Methods 0.000 claims description 6
- 241000238740 Dermatophagoides pteronyssinus Species 0.000 claims description 5
- 238000006116 polymerization reaction Methods 0.000 claims description 5
- 238000000975 co-precipitation Methods 0.000 claims description 4
- 230000035479 physiological effects, processes and functions Effects 0.000 claims description 4
- 206010002198 Anaphylactic reaction Diseases 0.000 claims description 3
- 230000036783 anaphylactic response Effects 0.000 claims description 3
- 208000003455 anaphylaxis Diseases 0.000 claims description 3
- 238000000586 desensitisation Methods 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 abstract description 2
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 229960004441 tyrosine Drugs 0.000 description 16
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 238000000502 dialysis Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 235000003932 Betula Nutrition 0.000 description 1
- 241000219429 Betula Species 0.000 description 1
- 235000000509 Chenopodium ambrosioides Nutrition 0.000 description 1
- 244000098897 Chenopodium botrys Species 0.000 description 1
- 235000005490 Chenopodium botrys Nutrition 0.000 description 1
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000004508 fractional distillation Methods 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 230000000774 hypoallergenic effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 238000000247 postprecipitation Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000007614 solvation Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9508785.4A GB9508785D0 (en) | 1995-04-29 | 1995-04-29 | Novel compositions |
| GB9508785.4 | 1995-04-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1183046A CN1183046A (zh) | 1998-05-27 |
| CN1132629C true CN1132629C (zh) | 2003-12-31 |
Family
ID=10773769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96193592A Expired - Lifetime CN1132629C (zh) | 1995-04-29 | 1996-04-25 | 酪氨酸和聚合过敏素的组合物 |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0825874A1 (ru) |
| JP (1) | JPH11504338A (ru) |
| KR (1) | KR19990008120A (ru) |
| CN (1) | CN1132629C (ru) |
| AU (1) | AU705873B2 (ru) |
| BG (1) | BG63990B1 (ru) |
| BR (1) | BR9608123A (ru) |
| CA (1) | CA2217388A1 (ru) |
| CZ (1) | CZ288401B6 (ru) |
| EA (1) | EA199700271A1 (ru) |
| GB (1) | GB9508785D0 (ru) |
| HK (1) | HK1010834A1 (ru) |
| HU (1) | HUP9802237A3 (ru) |
| NO (1) | NO974893D0 (ru) |
| NZ (1) | NZ308080A (ru) |
| PL (1) | PL183484B1 (ru) |
| SK (1) | SK281877B6 (ru) |
| TR (1) | TR199701265T1 (ru) |
| WO (1) | WO1996034626A1 (ru) |
| ZA (1) | ZA963340B (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9706957D0 (en) | 1997-04-05 | 1997-05-21 | Smithkline Beecham Plc | Formulation |
| GB9820525D0 (en) * | 1998-09-21 | 1998-11-11 | Allergy Therapeutics Ltd | Formulation |
| GB0000891D0 (en) | 2000-01-14 | 2000-03-08 | Allergy Therapeutics Ltd | Formulation |
| GB201106802D0 (en) | 2011-04-21 | 2011-06-01 | Allergy Therapeutics Ltd | Process for preparing vaccine composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4070455A (en) * | 1974-02-16 | 1978-01-24 | Beecham Group Limited | Process for preparing injectable desensitizing compositions and products thereof in microparticle form |
| EP0058021A2 (en) * | 1981-02-06 | 1982-08-18 | Beecham Group Plc | Pharmaceutical compositions |
| EP0367306A2 (en) * | 1988-11-04 | 1990-05-09 | Corporacion Biologica Farmaceutica, Sa (C.B.F. , S.A.) | Procedure for polymerized allergenis production |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1377074A (en) * | 1971-07-13 | 1974-12-11 | Beecham Group Ltd | Process for preparing injectable compositions |
-
1995
- 1995-04-29 GB GBGB9508785.4A patent/GB9508785D0/en active Pending
-
1996
- 1996-04-25 JP JP8532981A patent/JPH11504338A/ja active Pending
- 1996-04-25 CA CA002217388A patent/CA2217388A1/en not_active Abandoned
- 1996-04-25 CZ CZ19973429A patent/CZ288401B6/cs not_active IP Right Cessation
- 1996-04-25 TR TR97/01265T patent/TR199701265T1/xx unknown
- 1996-04-25 EP EP96914124A patent/EP0825874A1/en not_active Withdrawn
- 1996-04-25 AU AU57616/96A patent/AU705873B2/en not_active Expired
- 1996-04-25 BR BR9608123A patent/BR9608123A/pt not_active Application Discontinuation
- 1996-04-25 HU HU9802237A patent/HUP9802237A3/hu unknown
- 1996-04-25 EA EA199700271A patent/EA199700271A1/ru unknown
- 1996-04-25 NZ NZ308080A patent/NZ308080A/xx not_active IP Right Cessation
- 1996-04-25 SK SK1461-97A patent/SK281877B6/sk not_active IP Right Cessation
- 1996-04-25 WO PCT/EP1996/001733 patent/WO1996034626A1/en not_active Application Discontinuation
- 1996-04-25 KR KR1019970707645A patent/KR19990008120A/ko not_active Application Discontinuation
- 1996-04-25 PL PL96323104A patent/PL183484B1/pl unknown
- 1996-04-25 CN CN96193592A patent/CN1132629C/zh not_active Expired - Lifetime
- 1996-04-26 ZA ZA963340A patent/ZA963340B/xx unknown
-
1997
- 1997-10-23 NO NO974893A patent/NO974893D0/no not_active Application Discontinuation
- 1997-10-29 BG BG102004A patent/BG63990B1/bg unknown
-
1998
- 1998-11-20 HK HK98112143A patent/HK1010834A1/xx not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4070455A (en) * | 1974-02-16 | 1978-01-24 | Beecham Group Limited | Process for preparing injectable desensitizing compositions and products thereof in microparticle form |
| EP0058021A2 (en) * | 1981-02-06 | 1982-08-18 | Beecham Group Plc | Pharmaceutical compositions |
| EP0367306A2 (en) * | 1988-11-04 | 1990-05-09 | Corporacion Biologica Farmaceutica, Sa (C.B.F. , S.A.) | Procedure for polymerized allergenis production |
Also Published As
| Publication number | Publication date |
|---|---|
| SK281877B6 (sk) | 2001-08-06 |
| NO974893L (no) | 1997-10-23 |
| AU705873B2 (en) | 1999-06-03 |
| NZ308080A (en) | 1999-05-28 |
| HK1010834A1 (en) | 1999-07-02 |
| BG63990B1 (bg) | 2003-09-30 |
| SK146197A3 (en) | 1998-05-06 |
| NO974893D0 (no) | 1997-10-23 |
| CA2217388A1 (en) | 1996-11-07 |
| PL183484B1 (pl) | 2002-06-28 |
| GB9508785D0 (en) | 1995-06-21 |
| EP0825874A1 (en) | 1998-03-04 |
| HUP9802237A3 (en) | 2000-06-28 |
| HUP9802237A2 (hu) | 1999-02-01 |
| BG102004A (en) | 1998-11-30 |
| BR9608123A (pt) | 1999-02-09 |
| CZ288401B6 (en) | 2001-06-13 |
| KR19990008120A (ko) | 1999-01-25 |
| EA199700271A1 (ru) | 1998-04-30 |
| TR199701265T1 (xx) | 1998-02-21 |
| WO1996034626A1 (en) | 1996-11-07 |
| JPH11504338A (ja) | 1999-04-20 |
| AU5761696A (en) | 1996-11-21 |
| CN1183046A (zh) | 1998-05-27 |
| CZ342997A3 (cs) | 1998-03-18 |
| PL323104A1 (en) | 1998-03-16 |
| ZA963340B (en) | 1997-03-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20031231 |
|
| EXPY | Termination of patent right or utility model |