CN112999130A

CN112999130A - Scalp care solution based on crocus sativus and preparation method thereof

Info

Publication number: CN112999130A
Application number: CN202110147228.3A
Authority: CN
Inventors: 陈明建; 王平
Original assignee: Shanghai Yaoxin Biotechnology Co ltd
Current assignee: Shanghai Yaoxin Biotechnology Co ltd
Priority date: 2021-02-03
Filing date: 2021-02-03
Publication date: 2021-06-22

Abstract

A scalp care solution based on crocus sativus and a preparation method thereof relate to the technical field of scalp care, and the scalp care solution comprises the following components in percentage by mass: extracting crocus sativus to obtain pure dew: 81.27-91.52%, disodium EDTA: 0.01-0.03%, butanediol: 4-5%, p-hydroxyacetophenone: 0.1-0.3%, 1, 2-pentanediol: 0.1-1%, hydroxyphenylpropionamide benzoic acid: 0.5-2%, tromethamine: 0.01-0.1%, deionized water: 2-5%, caprylyl hydroxamic acid: 0.05-0.4%, glyceryl caprylate: 0.05-0.4%, methyl propylene glycol: 0.05-0.4%, lactobacillus/soy milk fermentation product filtrate: 0.5-1%, the saffron component in the invention is matched with other components for relieving scalp in the nursing liquid, so that the scalp environment is better improved, the problem that the scalp environment balance is damaged is radically solved, and the hair growth is better facilitated.

Description

Scalp care solution based on crocus sativus and preparation method thereof

Technical Field

The invention relates to the technical field of scalp care, in particular to a scalp care solution based on crocus sativus and a preparation method thereof.

Background

The hair conditioner is a cosmetic lotion for protecting hair. It has effects of conditioning hair, keeping hair natural and healthy, preventing alopecia, relieving dandruff, and promoting hair growth. The hair conditioner consists of rubefacient, irritant, nutrient, hair growing agent, anti-inflammatory bactericide, humectant, thickener, etc. The hair conditioner is mainly used for supplementing water and hydrolyzing protein like smoothing toner in cosmetics. When in use, the hair conditioner is shaken up and then sprayed on hair. Has effects in balancing pH, tightening hair flake, resisting ultraviolet, and supplementing nutrition. Can also be used as care solution before scalding.

At present, similar care products in the market are basically used for caring hair, for example, the invention patent with the publication number of CN110934752A discloses a hair care essence composition, which not only presents beautiful double-phase appearance, but also has the obvious effects of quickly moisturizing, smoothing, softening and resisting frizzy hair and improving the glossiness of the hair, and has light and thin texture and no washing. And publication No. CN111759754A discloses a hair care composition, a hair care film and a preparation method thereof, the hair care composition and the hair care film can keep hair moist and smooth, are easy to wash, and can effectively protect the health of hair and scalp. Also, for example, chinese invention with publication No. CN110051608A discloses an anti-hair loss and hair nourishing spray essence containing saffron extract and a preparation method thereof, which can protect hair follicles, inhibit bacteria, relieve itching, prevent hair loss, promote hair growth, protect hair, smoothen hair, improve scalp microcirculation, and also have antagonistic effect on AR receptors. The spray essence for preventing hair loss and nourishing hair adopts a plant bacteriostatic agent of a bright peptide antibacterial liquid for bacteriostasis, is mild and non-irritant, and has the effects of moisturizing and replenishing the scalp. In addition, the product is a spray, so the product is convenient to use and does not need to be cleaned, and can provide nutrition for the scalp for a long time. The three inventions are illustrated by aiming at the hair care, the active ingredients for generating the care effect in the first two prior arts are basically the surfactants, the silicon emulsions, the humectants, the silicone oils and the like, which are all conventional ingredients, while the saffron extract is used in the third prior art, however, the using content of the saffron extract in the anti-hair loss hair-nourishing spray essence is less, and relatively, the using content of distilled water is more, which can dilute the concentration of the saffron extract and influence the effect of the saffron, moreover, the saffron extract is greatly damaged by the extraction mode of the saffron extract, the quality of the concentrated extract is ten times of the initial saffron quality, in fact, the content of the effective ingredients of the picrorin and the like actually contained in the saffron extract is very low, in addition, the ingredients used in the patent are single, and the ingredients actually playing the hair care role are the saffron extract and the Logicos tincture L, the user needs to use the spray essence for a long time to gradually take effect, and the effect is difficult to take quickly, and the user is difficult to insist on using the spray essence for many times.

In addition, the active ingredients in the existing individual products for scalp care are not saffron extract, the addition amount is small, the scalp problems can be treated only by temporary solution but not by permanent solution, and the products with a certain efficacy have great irritation. Thus, there is room for improvement.

Disclosure of Invention

Aiming at the defects in the prior art, one of the purposes of the invention is to provide a scalp care solution based on crocus sativus, and the specific scheme is as follows:

a scalp care solution based on crocus sativus comprises the following components in parts by mass:

extracting crocus sativus to obtain pure dew: 81.27-91.52%

Disodium EDTA: 0.01 to 0.03 percent

Butanediol: 4 to 5 percent

P-hydroxyacetophenone: 0.1 to 0.3 percent

1, 2-pentanediol: 0.1 to 1 percent

Hydroxyphenylpropionamide benzoic acid: 0.5 to 2 percent

Tromethamine: 0.01 to 0.1 percent

Deionized water: 2 to 5 percent

Caprylyl hydroximic acid: 0.05-0.4%

Glyceryl caprylate: 0.05-0.4%

Methyl propylene glycol: 0.05-0.4%

Lactobacillus/soy milk fermentation product filtrate: 0.5 to 1 percent.

Further, the care solution also comprises 1-2% of polysorbate-20 and 0.01-0.1% of saffron oil.

Furthermore, the care solution also comprises 0.1-1% of hydrolyzed olive leaf extract.

The invention also aims to provide a preparation method of the scalp care solution, which comprises the following specific scheme:

a preparation method of a scalp care solution comprises the following steps:

s1: stirring and dissolving tromethamine with deionized water in advance for later use;

s2: heating crocus sativus oil with polysorbate-20 in a container to 48-52 deg.C, stirring and pre-dissolving;

s3: sequentially adding crocus sativus extract hydrosol, EDTA disodium, butanediol and p-hydroxyacetophenone into a reaction pot, stirring at the stirring speed of 110-;

s4: after the materials are completely dissolved in a reaction pot in S3, cooling to 45 ℃, sequentially adding 1, 2-pentanediol, hydroxyphenylpropionamide benzoic acid, pre-dissolved tromethamine in S1, caprylyl hydroxamic acid, glyceryl caprylate, methyl propanediol, lactobacillus/soybean milk fermentation product filtrate, pre-dissolved polysorbate-20 in S2, saffron oil and hydrolyzed olive leaf extract, and stirring at the speed of 180 revolutions per minute until the materials are completely dissolved;

s5: discharging after the inspection is qualified for later use.

Further, the extraction process of the crocus sativus extract hydrosol is as follows:

the crocus sativus and water are respectively placed in a first heating container and a second heating container, water vapor generated after the water is boiled enters from the lower part of the second heating container and goes out from the upper part of the second heating container, the crocus sativus is heated for 4-5 hours, the water vapor carrying crocus sativus components passes through a condenser and then enters a layered extractor to be gradually separated into an upper layer and a lower layer, and the lower layer of the layered extractor can release crocus sativus extract hydrosol.

Furthermore, the ratio of the crocus sativus to the water is 1 (1-1.5).

Compared with the prior art, the invention has the following beneficial effects:

the scalp care solution disclosed by the invention is used for the scalp, saffron-extracted hydrolat is used as a main base material, the content is high, water is not added basically, deionized water is only used as a solvent of tromethamine, the concentration of saffron components is hardly influenced by the deionized water, the effect of the saffron is fully exerted, the scalp blood circulation is promoted, the antioxidant capacity and the antifungal capacity of the scalp care solution are exerted, other scalp-soothing components in the care solution are combined, the scalp environment is better improved, the problem that the scalp environment balance is damaged is solved fundamentally, and the growth of the hair is facilitated.

Specifically, the crocus sativus extract hydrosol, the crocus sativus oil are used as main skin conditioners, the hydroxyphenyl propionamide benzoic acid and lactobacillus/soybean milk fermentation product filtrate are used as auxiliary skin conditioners, the p-hydroxyacetophenone is used as an antioxidant, the butanediol and the 1, 2-pentanediol are combined to be used as a humectant, the glyceryl caprylate is used as a softener, when the scalp care solution acts on the scalp, the scalp care solution is mild and has small stimulation, the scalp blood circulation is promoted, the scalp can be relieved by combining a massage method, and the scalp can be sterilized, so that the possibility of scalp itching is relieved. For review, the present invention uses saffron as the main ingredient, and combines with a plurality of other soothing ingredients to jointly exert the efficacy in scalp care.

According to the invention, the crocus sativus component is mainly crocus sativus extract hydrosol, the crocus sativus extract hydrosol is not required to be directly soaked in water in the extracting mode, the defects that aromatic components are damaged and aromatic substances are wasted by a water body when water and crocus sativus are integrally mixed for distillation are avoided in the extracting mode, the ratio of the crocus sativus to the water is close, the prepared crocus sativus extract hydrosol is high in purity, the efficacy of the finally obtained scalp care solution is enhanced, and the effect is quick.

Detailed Description

The present invention will be described in further detail with reference to examples, but the present invention is not limited to these examples.

Comparative example 1

See the hair loss prevention and hair care spray essence in the Chinese invention with the publication number of CN 110051608A.

Example 1

extracting crocus sativus to obtain pure dew: 81.27 percent

Disodium EDTA: 0.03 percent

Butanediol: 5 percent of

P-hydroxyacetophenone: 0.3 percent of

1, 2-pentanediol: 1 percent of

Hydroxyphenylpropionamide benzoic acid: 2 percent of

Tromethamine: 0.1 percent of

Deionized water: 5 percent of

Caprylyl hydroximic acid: 0.4 percent

Glyceryl caprylate: 0.4 percent

Methyl propylene glycol: 0.4 percent

Lactobacillus/soy milk fermentation product filtrate: 1 percent.

Polysorbate-20: 2 percent of

Saffron oil: 0.1 percent.

Hydrolyzed olive leaf extract: 1 percent.

Example 2

extracting crocus sativus to obtain pure dew: 91.52 percent

Disodium EDTA: 0.01 percent

Butanediol: 4 percent of

P-hydroxyacetophenone: 0.1 percent of

1, 2-pentanediol: 0.1 percent of

Hydroxyphenylpropionamide benzoic acid: 0.5 percent

Tromethamine: 0.01 percent

Deionized water: 2 percent of

Caprylyl hydroximic acid: 0.05 percent

Glyceryl caprylate: 0.05 percent

Methyl propylene glycol: 0.05 percent

Lactobacillus/soy milk fermentation product filtrate: 0.5 percent.

Polysorbate-20: 1 percent of

Saffron oil: 0.01 percent.

Hydrolyzed olive leaf extract: 0.1 percent.

Example 3

extracting crocus sativus to obtain pure dew: 87.83 percent

Disodium EDTA: 0.02 percent

Butanediol: 4 percent of

P-hydroxyacetophenone: 0.2 percent of

1, 2-pentanediol: 0.5 percent

Hydroxyphenylpropionamide benzoic acid: 1 percent of

Tromethamine: 0.05 percent

Deionized water: 3 percent of

Caprylyl hydroximic acid: 0.2 percent of

Glyceryl caprylate: 0.2 percent of

Methyl propylene glycol: 0.2 percent of

Lactobacillus/soy milk fermentation product filtrate: 0.75 percent.

Polysorbate-20: 1.5 percent

Saffron oil: 0.05 percent.

Hydrolyzed olive leaf extract: 0.5 percent.

In examples 1-3, saffron extract hydrosol was used as a skin conditioner, disodium EDTA was used as a chelating agent, butylene glycol was used as a humectant, p-hydroxyacetophenone was used as an antioxidant, 1, 2-pentanediol was used as a humectant, hydroxyphenylpropionamide benzoic acid was used as a skin conditioner, tromethamine was used as a pH adjuster, deionized water was used as a solvent, caprylyl hydroxamic acid was used as a chelating agent, glyceryl caprylate was used as a softener, methyl propylene glycol was used as a solvent, lactobacillus/soybean milk fermentation product filtrate was used as a skin conditioner, polysorbate-20 was used as an emulsifier, saffron oil was used as a skin conditioner, and hydrolyzed olive leaf extract was used as a skin conditioner.

The crocus sativus extract hydrosol and crocus sativus oil can promote scalp blood circulation, and also have antioxidant and antifungal effects, and hydroxyphenyl propionamide benzoic acid can resist histamine, irritation and itching. Can effectively inhibit skin erythema, edema and pruritus caused by histamine. Can buffer the sensitizing substances. The hydrolyzed olive leaf extract has the effects of diminishing inflammation, relieving and resisting allergy, whitening and removing freckles, and is suitable for 8 types of skin, namely oily skin, tolerant skin, non-pigmented skin, dry skin, wrinkled skin, sensitive skin, pigmented skin and compact skin. The combined action improves the scalp environment, and radically solves the problem that the scalp environment is damaged in a balanced way.

Aiming at the embodiments 1-3, the invention is also provided with a preparation method of the scalp care solution, and the preparation method comprises the following steps:

s2: heating crocus sativus oil with polysorbate-20 in a container to 50 deg.C, stirring and pre-dissolving;

s4: after the materials are completely dissolved in a reaction pot in S3, cooling to 45 ℃, sequentially adding 1, 2-pentanediol, hydroxyphenylpropionamide benzoic acid, pre-dissolved tromethamine in S1, caprylyl hydroxamic acid, glyceryl caprylate, methyl propanediol, lactobacillus/soybean milk fermentation product filtrate, pre-dissolved polysorbate-20 in S2, saffron oil and a hydrolyzed olive leaf extract, and stirring at the speed of 200 r/min until the materials are completely dissolved;

s5: discharging after the inspection is qualified for later use.

In detail, the extraction process of the crocus sativus extract hydrosol is as follows:

the crocus sativus and water are respectively placed in a first heating container and a second heating container, the ratio of the crocus sativus to the water is 1 (1-1.5), the specific ratio is determined according to actual operation, water vapor generated after the water is boiled enters and exits from the second heating container, the crocus sativus is heated for 4-5 hours, the water vapor carrying crocus sativus components passes through a condenser and then enters a layered extractor to be gradually separated into an upper layer and a lower layer, and the lower layer of the layered extractor can release crocus sativus extract hydrolat.

First heating container can adopt the round flask, is convenient for be heated evenly, and the second heating container can adopt cylindrical storage tank, and the intercommunication is provided with the glass pipe between the top of first heating container and second heating container's the bottom, and the lateral wall and the condenser intercommunication of second heating container, the export of condenser are directly over the import funnel of layering extractor, and the intercommunication is provided with the outlet pipe on the lateral wall that layering extractor is close to the bottom.

In the Chinese invention with the publication number of CN110051608A, the saffron extract is prepared by physical crushing treatment and then is treated according to the proportion of 1: 45, the effective saffron ingredients in the finally obtained saffron extract are mixed with each other, compared with the Chinese invention with the publication number of CN110051608A, the method for extracting the saffron hydrolat is less difficult to operate, the ratio of the saffron to water is close to that of the saffron in the method for extracting the hydrosol, the saffron does not need to be soaked in the solution, the physical damage to the saffron is not needed, the possibility of damaging the aromatic ingredients and wasting the aromatic substances is greatly reduced compared with the traditional distillation method, and the purity of the prepared saffron extract hydrolat is higher.

In addition, the extraction process of the crocus sativus extract hydrosol can also be as follows:

loading the selected high-quality saffron into a tray, placing the tray into a freeze-drying bin in a freeze dryer, carrying out freeze-drying dehydration, wherein the temperature of the freeze-drying bin is lower than 60 ℃, carrying out condensation crystallization on steam containing saffron liquid generated by evaporation in the drying process, continuously washing ice crystals formed by steam crystallization by using the saffron liquid with the temperature of 50-60 ℃, mixing the melted ice crystals into the saffron liquid, collecting, storing and circularly washing the ice crystals to finally obtain the crocus sativus extract hydrolat. Compared with the Chinese invention with the publication number of CN110051608A, the extraction method does not need to use extra solvent to react with the saffron and does not need to physically damage the saffron, and the saffron extract in the saffron extract can be collected and extracted without a high-temperature environment, thereby protecting the nutrient components in the saffron extract.

And (3) effect testing: the scalp care solutions finally obtained by the preparation methods of examples 1 to 3 and comparative example 1 were used clinically.

Selecting 120 experimenters, the age is 25-45 years, wherein 60 male patients and 60 female patients are averagely divided into 4 groups, each group comprises 30 male patients and 15 female patients, wherein each group of experimenters respectively uses the scalp care solution in the embodiments 1-3 and the anti-hair loss hair-nourishing spray essence in the comparative example 1, the scalp care solution and the anti-hair loss hair-nourishing spray essence are respectively arranged in a bottle body with an atomizing nozzle, the scalp care solution and the anti-hair loss hair-nourishing spray essence are directly sprayed on the scalp and the hair, the scalp and the hair are gently massaged for 5-10 minutes, the application is continuously carried out for 1 time every day, the days are recorded, after one week, the experimenters are subjected to scalp and hair follicle detection every other week, the total record is 2 weeks, and the dandruff degree, the head itching interval days and the oil. The test results are shown in the following tables.

Dandruff Rate test

Table one: test results of degree of dandruff at week 1

Degree	Example 1	Example 2	Example 3	Comparative example 1
					Is free of	6/7 of male	7/7 Male/female	8/9 male/female	5/7 male/female
Is less	Male 4/female 4	Male 4/female 4	Male 4/female 3	Male 2/female 1
					Much more	Male 2/female 2	Male 2/female 2	Male 1/female 2	Male 3/female 3
Multiple purpose	Male 3/female 2	Male 2/female 2	Male 2/female 1	5/4 for male

Table two: test results of degree of dandruff at week 2

Degree	Example 1	Example 2	Example 3	Comparative example 1
					Is free of	7/7 Male/female	8/7 male	9/10 Male/female	5/7 male/female
Is less	Male 4/female 5	Male 4/female 5	Male 4/female 2	Male 2/female 2
					Much more	Male 2/female 1	Male 1/female 2	Male 1/female 2	Male 3/female 2
Multiple purpose	Male 2/female 2	Male 2/female 1	Male 1/female 1	5/4 for male

According to the dandruff degree test, after one week, the experimenters comparing the use examples 1-3 with the comparative example 1 all have higher effect than the comparative example 1, and the dandruff removing effect of the examples 1-3 is sequentially enhanced, and the number of people without dandruff in the example 3 is more than half. After two weeks, the anti-dandruff effect of comparative example 1 was not improved, while the anti-dandruff effects of examples 1 to 3 were all improved with the passage of time, confirming that the scalp care solution of the present invention has strong efficacy and fast-acting function.

Interval days of itch

Table three: test results of days between first itching on week 1

Number of days	Example 1	Example 2	Example 3	Comparative example 1
					3	8/7 male	8/9 male/female	9/10 Male/female	8/8 Male/female
2	5/6 male/female	Male 4/female 5	Male 4/female 3	Male 3/female 4
					1	Male 2/female 2	Male 3/female 2	Male 2/female 2	Male 4/female 3

Table four: test results of days between first itch on week 2

Number of days	Example 1	Example 2	Example 3	Comparative example 1
					3	8/8 Male/female	Male 10/female 9	Male 11 and female 11	8/8 Male/female
2	5/5 of male/female	Male 3/female 5	Male 3/female 3	Male 3/female 4
					1	Male 2/female 2	Male 2/female 2	Male 1/female 1	Male 4/female 3

According to the test of the number of days between the head itching, after one week, the experimenters comparing the use examples 1-3 with the comparative example 1 all have higher effects of the use examples 1-3 than the comparative example 1, and the effects of relieving the head itching of the examples 1-3 are sequentially enhanced. After two weeks, the anti-dandruff effect of comparative example 1 is not improved, the effect of relieving the head itch of examples 1 to 3 is improved with the passage of time, and the ratio of the number of the people with the longest head itch days in examples 2 and 3 is more than or equal to two thirds, thereby verifying that the scalp care solution of the present invention has strong efficacy and quick effect.

Head oil level test

The classification is carried out according to the oil data in the hair follicle detection, the classification comprises 1 level, 2 level and 3 level, and the higher the oil is, the higher the oil outlet degree is. The experimenter performed hair follicle examination two days without washing hair.

Table one: test results for oil level in week 1

Grade	Example 1	Example 2	Example 3	Comparative example 1
					Level 1	6/7 of male	7/7 Male/female	8/9 male/female	8/7 male
Stage 2	5/6 male/female	5/5 of male/female	Male 4/female 4	Male 2/female 3
					Grade 3	Male 4/female 2	Male 3/female 3	Male 3/female 2	5/5 of male/female

Table two: test results for cycle 2 oil level

Degree	Example 1	Example 2	Example 3	Comparative example 1
					Level 1	7/8 Male	8/8 Male/female	9/10 Male/female	8/8 Male/female
Stage 2	6/4 for male	5/5 of male/female	5/4 for male	Male 2/female 3
					Grade 3	Male 3/female 3	Male 2/female 2	Male 2/female 1	5/4 for male

According to the test of the degree of head oil, after one week, the experimenters using the examples 1-3 and the comparative example 1 are compared, the effect of the use examples 1-3 is higher than that of the comparative example 1, the oil removing effect of the examples 1-3 is sequentially enhanced, and the number of the experimenters in the examples 2 and 3 accounts for more than half of the experimenters. After two weeks, the degreasing effect of comparative example 1 was not improved, while the degreasing effects of examples 1 to 3 were improved with the passage of time, verifying that the scalp care solution of the present invention has strong efficacy and fast efficacy.

The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.

Claims

1. A scalp care solution based on crocus sativus is characterized in that the components of the care solution are as follows by mass:

extracting crocus sativus to obtain pure dew: 81.27-91.52%

Disodium EDTA: 0.01 to 0.03 percent

Butanediol: 4 to 5 percent

P-hydroxyacetophenone: 0.1 to 0.3 percent

1, 2-pentanediol: 0.1 to 1 percent

Hydroxyphenylpropionamide benzoic acid: 0.5 to 2 percent

Tromethamine: 0.01 to 0.1 percent

Deionized water: 2 to 5 percent

Caprylyl hydroximic acid: 0.05-0.4%

Glyceryl caprylate: 0.05-0.4%

Methyl propylene glycol: 0.05-0.4%

Lactobacillus/soy milk fermentation product filtrate: 0.5 to 1 percent.

2. The saffron-based scalp care solution according to claim 1, further comprising 1-2% polysorbate-20, 0.01-0.1% saffron oil.

3. A crocus sativus-based scalp care solution according to claim 2, characterized in that it further comprises 0.1-1% of hydrolyzed olive leaf extract.

4. A method for preparing a scalp care solution according to claim 3, comprising the steps of:

s5: discharging after the inspection is qualified for later use.

5. The method for preparing a scalp care solution according to claim 4, wherein the extraction process of the crocus sativus extract hydrolat is as follows:

6. A method for preparing a scalp care solution according to claim 5, wherein the ratio of crocus sativus to water is 1 (1 to 1.5).