CN112930336A - 光学活性的1-环丙基烷基-1-胺的可放大合成 - Google Patents

光学活性的1-环丙基烷基-1-胺的可放大合成 Download PDF

Info

Publication number
CN112930336A
CN112930336A CN201980069158.5A CN201980069158A CN112930336A CN 112930336 A CN112930336 A CN 112930336A CN 201980069158 A CN201980069158 A CN 201980069158A CN 112930336 A CN112930336 A CN 112930336A
Authority
CN
China
Prior art keywords
formula
amine
compound
cyclopropylalkyl
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201980069158.5A
Other languages
English (en)
Chinese (zh)
Inventor
邓达
杜占权
K·格罗尔
S·霍夫迪兹
M·劳贝
M·庞格尔
C·林克
肖青
朱志斌
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of CN112930336A publication Critical patent/CN112930336A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
    • C07C209/28—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds by reduction with other reducing agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/03—Monoamines
    • C07C211/08—Monoamines containing alkyl groups having a different number of carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201980069158.5A 2018-10-18 2019-10-17 光学活性的1-环丙基烷基-1-胺的可放大合成 Pending CN112930336A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2018/110852 2018-10-18
CN2018110852 2018-10-18
PCT/EP2019/078208 WO2020079145A1 (en) 2018-10-18 2019-10-17 Scalable synthesis of optically active 1-cyclopropylalkyl-1-amines

Publications (1)

Publication Number Publication Date
CN112930336A true CN112930336A (zh) 2021-06-08

Family

ID=68290245

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980069158.5A Pending CN112930336A (zh) 2018-10-18 2019-10-17 光学活性的1-环丙基烷基-1-胺的可放大合成

Country Status (5)

Country Link
US (1) US20210395185A1 (https=)
EP (1) EP3867224A1 (https=)
JP (1) JP2022504780A (https=)
CN (1) CN112930336A (https=)
WO (1) WO2020079145A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112552184B (zh) * 2020-12-18 2022-05-10 诚达药业股份有限公司 一种含环丙基手性胺盐酸盐的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1989097A (zh) * 2004-07-22 2007-06-27 帝斯曼知识产权资产管理有限公司 用于制备非对映异构体富集的化合物的方法
CN101180256A (zh) * 2005-05-24 2008-05-14 阿斯利康(瑞典)有限公司 动力学拆分(取代的)(r)-或(s)-扁桃酸的方法
CN102164903A (zh) * 2008-07-23 2011-08-24 帝斯曼知识产权资产管理有限公司 2(s),4(s),5(s),7(s)-2,7-二烷基-4-羟基-5-氨基-8-芳基-辛酰胺的合成路线

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4287703B2 (ja) * 2003-06-11 2009-07-01 セントラル硝子株式会社 光学活性１−アルキル置換−２，２，２−トリフルオロエチルアミンの製造方法
AU2008335761B2 (en) 2007-12-13 2014-04-24 Merck Sharp & Dohme Corp. Inhibitors of janus kinases
WO2011076744A1 (en) * 2009-12-21 2011-06-30 Novartis Ag Disubstituted heteroaryl-fused pyridines
NZ723530A (en) 2014-04-14 2023-05-26 Boehringer Ingelheim Int Compounds as modulators of ror gamma
EP3356366B1 (en) 2015-10-01 2019-08-28 Boehringer Ingelheim International GmbH Pteridine derivatives as modulators of ror gamma
US11358967B2 (en) 2016-01-20 2022-06-14 Boehringer Ingelheim International Gmbh Substituted pyrazino[2,3-b]pyrazines and pyrazino[2,3-c]pyridazines as modulators of ROR gamma

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1989097A (zh) * 2004-07-22 2007-06-27 帝斯曼知识产权资产管理有限公司 用于制备非对映异构体富集的化合物的方法
CN101180256A (zh) * 2005-05-24 2008-05-14 阿斯利康(瑞典)有限公司 动力学拆分(取代的)(r)-或(s)-扁桃酸的方法
CN102164903A (zh) * 2008-07-23 2011-08-24 帝斯曼知识产权资产管理有限公司 2(s),4(s),5(s),7(s)-2,7-二烷基-4-羟基-5-氨基-8-芳基-辛酰胺的合成路线

Also Published As

Publication number Publication date
WO2020079145A1 (en) 2020-04-23
EP3867224A1 (en) 2021-08-25
US20210395185A1 (en) 2021-12-23
JP2022504780A (ja) 2022-01-13

Similar Documents

Publication Publication Date Title
JP7085641B2 (ja) アルコラート塩基の存在下でのニコチン酸エチルとｎ－ビニルピロリドンとの反応によるラセミ体ニコチンの調製方法
CN107033042A (zh) 用于制备(s)‑1‑(3‑乙氧基‑4‑甲氧基苯基)‑2‑甲烷磺酰基乙胺的工艺
TW200817414A (en) Process for the preparation of asenapine and intermediate products used in said process
CA3150642A1 (en) CANNABINOID DERIVATIVES, PRECURSORS AND USES
KR20230137282A (ko) 프로테인 카이네이즈에 대한 선택적 억제제의 합성에 유용한 중간체 및 이의 제조방법
EP2931708A2 (fr) Composes cyclopropylboroniques, leur procede de preparation et leur utilisation
Zolfigol et al. A simple and efficient route for the synthesis of di and tri (bis (indolyl) methanes) as new triarylmethanes
CN112930336A (zh) 光学活性的1-环丙基烷基-1-胺的可放大合成
Sasikumar et al. Simple and efficient synthesis of (S)-dapoxetine
JP2022537380A (ja) ２－（２，６－ジクロロフェニル）－１－［（１ｓ，３ｒ）－３－（ヒドロキシメチル）－５－（３－ヒドロキシ－３－メチルブチル）－１－メチル－３，４－ジヒドロイソキノリン－２（１ｈ）－イル］エテノンの調製のための方法および中間体
JP7515510B2 (ja) （３ｒ，４ｒ）－１－ベンジル－ｎ，４－ジメチルピペリジン－３－アミンまたはその塩の製造方法、およびそれを使用したトファシチニブの製造方法
Disadee et al. Oxazaborolidine-catalyzed reductive parallel kinetic resolution of ketones from β-nitro-azabicycles for the synthesis of chiral hypoestestatins 1, 2
CN111099986A (zh) 氢化反应方法
Chen et al. Synthetic studies on (+)-biotin, part 15: A chiral squaramide-mediated enantioselective alcoholysis approach toward the total synthesis of (+)-biotin
KR101178108B1 (ko) 신규 이작용성 유기 키랄 촉매 및 이작용성 유기 키랄 촉매를 사용하여 메소-고리형 산무수물로부터 입체선택적 헤미에스터의 제조 방법
CN109651437B (zh) 一种手性氮磷配体及其制备方法，及一种拆分消旋薄荷醇的方法
CN107266317A (zh) 一种手性芳基烯丙基醚类化合物及其合成方法
WO2008065177A1 (fr) Procedes de preparation de la desmethylsertraline ou d'un de ses sels pharmaceutiquement acceptables
JP2018535240A (ja) ベンゾピラン誘導体の精製方法、ベンゾピラン誘導体の結晶形およびベンゾピラン誘導体の結晶形の製造方法
JP2022075375A (ja) 光学活性アミン化合物の製造方法
KR102928097B1 (ko) 입체중심을 갖는 치환기가 도입된 카이랄 카르보레인 및 이의 제조방법
CN114988976B (zh) 一种有机催化Nazarov环化合成手性环戊烯酮类化合物的方法
JP2016536358A (ja) アミドアセタール、ケテン−ｎ，ｏ−アセタール、又はエステルイミドからアミンを製造するための接触水素化
CN108250206A (zh) 一种联芳木脂素类化合物及其中间体的合成方法
Li et al. Desymmetrization of meso-Anhydride Enabled Enantioselective Synthesis of (−)-7-(Bromomethylene)-3-amidobicyclo [2.2. 1] heptane-2-carboxamide, a Scaffold for Divergent Drug Discovery Synthesis

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20210608