JP2022504780A - 光学活性１－シクロプロピルアルキル－１－アミンのスケーラブルな合成 - Google Patents

光学活性１－シクロプロピルアルキル－１－アミンのスケーラブルな合成 Download PDF

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Publication number
JP2022504780A
JP2022504780A JP2021520147A JP2021520147A JP2022504780A JP 2022504780 A JP2022504780 A JP 2022504780A JP 2021520147 A JP2021520147 A JP 2021520147A JP 2021520147 A JP2021520147 A JP 2021520147A JP 2022504780 A JP2022504780 A JP 2022504780A
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JP
Japan
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formula
amine
compound
iii
cyclopropylalkyl
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JP2021520147A
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Japanese (ja)
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JP2022504780A5 (https=
Inventor
ダ デン
ザンクアン デュ
クラウス グロル
サブリーナ ホーフェディッツ
マリオン ラウベ
ミヒャエル パンゲアル
クリスティアン リンク
チン シャオ
ジビン ズー
Original Assignee
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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Publication of JP2022504780A publication Critical patent/JP2022504780A/ja
Publication of JP2022504780A5 publication Critical patent/JP2022504780A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
    • C07C209/28—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds by reduction with other reducing agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/03—Monoamines
    • C07C211/08—Monoamines containing alkyl groups having a different number of carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2021520147A 2018-10-18 2019-10-17 光学活性１－シクロプロピルアルキル－１－アミンのスケーラブルな合成 Pending JP2022504780A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2018/110852 2018-10-18
CN2018110852 2018-10-18
PCT/EP2019/078208 WO2020079145A1 (en) 2018-10-18 2019-10-17 Scalable synthesis of optically active 1-cyclopropylalkyl-1-amines

Publications (2)

Publication Number Publication Date
JP2022504780A true JP2022504780A (ja) 2022-01-13
JP2022504780A5 JP2022504780A5 (https=) 2022-10-20

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JP2021520147A Pending JP2022504780A (ja) 2018-10-18 2019-10-17 光学活性１－シクロプロピルアルキル－１－アミンのスケーラブルな合成

Country Status (5)

Country Link
US (1) US20210395185A1 (https=)
EP (1) EP3867224A1 (https=)
JP (1) JP2022504780A (https=)
CN (1) CN112930336A (https=)
WO (1) WO2020079145A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112552184B (zh) * 2020-12-18 2022-05-10 诚达药业股份有限公司 一种含环丙基手性胺盐酸盐的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005002036A (ja) * 2003-06-11 2005-01-06 Central Glass Co Ltd 光学活性１−アルキル置換−２，２，２−トリフルオロエチルアミンの製造方法
JP2008506746A (ja) * 2004-07-22 2008-03-06 ディーエスエム アイピー アセッツ ビー．ブイ． ジアステレオマーに富んだ化合物の調製方法
JP2013515032A (ja) * 2009-12-21 2013-05-02 ノバルティス アーゲー 二置換ヘテロアリール縮合ピリジン類

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0510546D0 (en) * 2005-05-24 2005-06-29 Astrazeneca Ab New process
AU2008335761B2 (en) 2007-12-13 2014-04-24 Merck Sharp & Dohme Corp. Inhibitors of janus kinases
BRPI0916544A2 (pt) * 2008-07-23 2015-08-04 Dsm Ip Assets Bv Rotas de síntese para 2(s), 4(s), 5(s), 7(s) - 2, 7 dialquil-4-hidroxi-2-amino-8-aril-octanoil amida
NZ723530A (en) 2014-04-14 2023-05-26 Boehringer Ingelheim Int Compounds as modulators of ror gamma
EP3356366B1 (en) 2015-10-01 2019-08-28 Boehringer Ingelheim International GmbH Pteridine derivatives as modulators of ror gamma
US11358967B2 (en) 2016-01-20 2022-06-14 Boehringer Ingelheim International Gmbh Substituted pyrazino[2,3-b]pyrazines and pyrazino[2,3-c]pyridazines as modulators of ROR gamma

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005002036A (ja) * 2003-06-11 2005-01-06 Central Glass Co Ltd 光学活性１−アルキル置換−２，２，２−トリフルオロエチルアミンの製造方法
JP2008506746A (ja) * 2004-07-22 2008-03-06 ディーエスエム アイピー アセッツ ビー．ブイ． ジアステレオマーに富んだ化合物の調製方法
JP2013515032A (ja) * 2009-12-21 2013-05-02 ノバルティス アーゲー 二置換ヘテロアリール縮合ピリジン類

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Publication number Publication date
WO2020079145A1 (en) 2020-04-23
EP3867224A1 (en) 2021-08-25
CN112930336A (zh) 2021-06-08
US20210395185A1 (en) 2021-12-23

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