CN112823152A - 用于制备布罗莫结构域抑制剂的方法 - Google Patents

用于制备布罗莫结构域抑制剂的方法 Download PDF

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CN112823152A
CN112823152A CN201980060552.2A CN201980060552A CN112823152A CN 112823152 A CN112823152 A CN 112823152A CN 201980060552 A CN201980060552 A CN 201980060552A CN 112823152 A CN112823152 A CN 112823152A
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substituted
compound
optionally substituted
formula
group
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Chinese (zh)
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J·F·特拉弗斯
K·H-Y·杨
A·C·费雷蒂
H·阿利特
J·莫塞利
A·M·鲁达
D·普里默
S·菲利普
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Celgene Quanticel Research Inc
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    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
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    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/20—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/21—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C205/22—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring having one nitro groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C215/74—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C215/76—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton of the same non-condensed six-membered aromatic ring
    • C07C215/78—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton of the same non-condensed six-membered aromatic ring containing at least two hydroxy groups bound to the carbon skeleton
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/30—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same unsaturated acyclic carbon skeleton
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    • C07C255/00—Carboxylic acid nitriles
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    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
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    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/41—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
    • C07C309/42—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
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    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
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    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
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    • C07C43/00—Ethers; Compounds having groups, groups or groups
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    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
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    • C07—ORGANIC CHEMISTRY
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    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
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    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
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    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
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    • C07C67/00—Preparation of carboxylic acid esters
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
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    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
CN201980060552.2A 2018-07-23 2019-07-23 用于制备布罗莫结构域抑制剂的方法 Pending CN112823152A (zh)

Applications Claiming Priority (3)

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US201862702085P 2018-07-23 2018-07-23
US62/702,085 2018-07-23
PCT/US2019/042914 WO2020023438A2 (en) 2018-07-23 2019-07-23 Process for the preparation of bromodomain inhibitor

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US (2) US11566004B2 (ru)
EP (1) EP3826992A2 (ru)
JP (1) JP7434274B2 (ru)
KR (1) KR20210058817A (ru)
CN (1) CN112823152A (ru)
AU (1) AU2019309693B2 (ru)
BR (1) BR112021001019A2 (ru)
CA (1) CA3107050A1 (ru)
EA (1) EA202190170A1 (ru)
IL (1) IL280312B2 (ru)
MX (1) MX2021000657A (ru)
SG (1) SG11202100346PA (ru)
WO (1) WO2020023438A2 (ru)

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TW202327588A (zh) * 2021-11-10 2023-07-16 美商賽基昆堤塞爾研發公司 治療神經膠質母細胞瘤之方法

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CN105073720A (zh) * 2013-03-28 2015-11-18 赛诺菲 联芳基-丙酸衍生物及其作为药物的用途
CN105828820A (zh) * 2013-10-18 2016-08-03 赛尔基因昆蒂赛尔研究公司 布罗莫结构域抑制剂
CN107613981A (zh) * 2015-04-22 2018-01-19 赛尔基因昆蒂赛尔研究公司 布罗莫结构域抑制剂
CN107635558A (zh) * 2015-04-15 2018-01-26 赛尔基因昆蒂赛尔研究公司 布罗莫结构域抑制剂
WO2018075796A1 (en) * 2016-10-20 2018-04-26 Celgene Quanticel Research, Inc Bromodomain inhibitor

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DE10040051A1 (de) * 2000-08-11 2002-02-21 Basf Ag Derivate des 4-(Trifluormethyl)-phenols sowie Derivate des 4-(Trifluormethylphenyl)-2-(tetrahydropyranyl)ethers und Verfahren zu ihre Herstellung
EP1652842B1 (en) * 2003-07-30 2012-04-11 Kyowa Hakko Kirin Co., Ltd. Indazole derivatives
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BR112018003181A2 (pt) 2015-08-20 2018-09-25 Viiv Healthcare Uk No 5 Ltd composto, composição, e, método para tratar infecção por hiv
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CN105073720A (zh) * 2013-03-28 2015-11-18 赛诺菲 联芳基-丙酸衍生物及其作为药物的用途
CN105828820A (zh) * 2013-10-18 2016-08-03 赛尔基因昆蒂赛尔研究公司 布罗莫结构域抑制剂
CN107635558A (zh) * 2015-04-15 2018-01-26 赛尔基因昆蒂赛尔研究公司 布罗莫结构域抑制剂
CN107613981A (zh) * 2015-04-22 2018-01-19 赛尔基因昆蒂赛尔研究公司 布罗莫结构域抑制剂
WO2018075796A1 (en) * 2016-10-20 2018-04-26 Celgene Quanticel Research, Inc Bromodomain inhibitor

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KR20210058817A (ko) 2021-05-24
EP3826992A2 (en) 2021-06-02
IL280312B1 (en) 2023-12-01
US11566004B2 (en) 2023-01-31
AU2019309693A1 (en) 2021-03-04
JP7434274B2 (ja) 2024-02-20
US20220064121A1 (en) 2022-03-03
EA202190170A1 (ru) 2021-08-13
CA3107050A1 (en) 2020-01-30
WO2020023438A3 (en) 2020-05-22
IL280312B2 (en) 2024-04-01
SG11202100346PA (en) 2021-02-25
US20230128975A1 (en) 2023-04-27
IL280312A (en) 2021-03-25
WO2020023438A2 (en) 2020-01-30
BR112021001019A2 (pt) 2021-04-13
JP2021530550A (ja) 2021-11-11
MX2021000657A (es) 2021-05-12

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