CN1127510C - 凝血酶抑制剂的药物前体 - Google Patents

凝血酶抑制剂的药物前体 Download PDF

Info

Publication number
CN1127510C
CN1127510C CN96180024A CN96180024A CN1127510C CN 1127510 C CN1127510 C CN 1127510C CN 96180024 A CN96180024 A CN 96180024A CN 96180024 A CN96180024 A CN 96180024A CN 1127510 C CN1127510 C CN 1127510C
Authority
CN
China
Prior art keywords
pab
aze
cgl
expression
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN96180024A
Other languages
English (en)
Chinese (zh)
Other versions
CN1209139A (zh
Inventor
T·安顿松
D·古斯塔夫松
K·-J·霍夫曼
J·－E·奈斯特伦
H·泽伦森
M·瑟伦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1209139A publication Critical patent/CN1209139A/zh
Application granted granted Critical
Publication of CN1127510C publication Critical patent/CN1127510C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN96180024A 1995-12-21 1996-12-17 凝血酶抑制剂的药物前体 Expired - Fee Related CN1127510C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9526273A GB9526273D0 (en) 1995-12-21 1995-12-21 New prodrugs
GB9526273.9 1995-12-21

Publications (2)

Publication Number Publication Date
CN1209139A CN1209139A (zh) 1999-02-24
CN1127510C true CN1127510C (zh) 2003-11-12

Family

ID=10785890

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96180024A Expired - Fee Related CN1127510C (zh) 1995-12-21 1996-12-17 凝血酶抑制剂的药物前体

Country Status (8)

Country Link
JP (2) JP3282821B2 (de)
CN (1) CN1127510C (de)
CZ (1) CZ298709B6 (de)
DE (1) DE869966T1 (de)
GB (1) GB9526273D0 (de)
PT (1) PT869966E (de)
UA (1) UA70280C2 (de)
ZA (1) ZA9610353B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR023510A1 (es) * 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994029336A1 (en) * 1993-06-03 1994-12-22 Astra Aktiebolag New peptide derivatives
WO1995035309A1 (de) * 1994-06-17 1995-12-28 Basf Aktiengesellschaft Neue thrombininhibitoren, ihre herstellung und verwendung
WO1996016671A1 (en) * 1994-12-02 1996-06-06 Astra Aktiebolag New antithrombotic formulation, process for its manufacturing, and use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994029336A1 (en) * 1993-06-03 1994-12-22 Astra Aktiebolag New peptide derivatives
WO1995035309A1 (de) * 1994-06-17 1995-12-28 Basf Aktiengesellschaft Neue thrombininhibitoren, ihre herstellung und verwendung
WO1996016671A1 (en) * 1994-12-02 1996-06-06 Astra Aktiebolag New antithrombotic formulation, process for its manufacturing, and use thereof

Also Published As

Publication number Publication date
JP3580535B2 (ja) 2004-10-27
JP3282821B2 (ja) 2002-05-20
JP2001089498A (ja) 2001-04-03
ZA9610353B (en) 1997-06-23
PT869966E (pt) 2005-07-29
GB9526273D0 (en) 1996-02-21
DE869966T1 (de) 1999-06-10
CZ298709B6 (cs) 2007-12-27
CN1209139A (zh) 1999-02-24
CZ177098A3 (cs) 1999-01-13
UA70280C2 (en) 2004-10-15

Similar Documents

Publication Publication Date Title
EP0995755B1 (de) Medikamenten-Vorstufen für Thrombin-Inhibitoren
CN1205187C (zh) 新的脒基衍生物及其作为凝血酶抑制剂的用途
CN1069736A (zh) 新的同配多肽
CN1129604C (zh) 新的氨基酸衍生物及其作为凝血酶抑制剂的用途
CN1175259A (zh) 低分子量双环凝血酶抑制剂
CN1147504C (zh) 新的凝血酶抑制剂,它们的制备和应用
CN1844118A (zh) 可抑制细胞释放肿瘤坏死因子的哌啶－2，6－二酮衍生物
CN1278530A (zh) 新的肽衍生物
CN1098409A (zh) α-哌嗪酮及其应用
CN1202902A (zh) 凝血酶抑制剂
CN1212704A (zh) 丝氨酸蛋白酶抑制剂
CN1429121A (zh) 聚谷氨酸－喜树碱结合物及其制备方法
CN1193978A (zh) 肽基化合物和它们作为金属蛋白酶抑制剂的医疗用途
CN1067249A (zh) 脒基苯丙氨酸衍生物和其制备方法及用途
CN1332737A (zh) 凝血酶抑制剂
CN1058019C (zh) 环状氨基酸衍生物
CN1212705A (zh) 丝氨酸蛋白酶抑制剂
CN1080923A (zh) 磺酰基苄基取代的苯并吡啶酮和吡啶并吡啶酮
CN1209368C (zh) 新的乙酰胺衍生物及其用途
CN1343217A (zh) 新的脒基苄基胺衍生物及其作为凝血酶抑制剂的用途
CN1076443A (zh) 取代的苯乙酰胺
CN1289341A (zh) 凝血酶抑制剂
CN1234039A (zh) 用作基质金属蛋白酶抑制剂的3－巯基乙酰氨基－1.5－二取代的－2－氧代－氮杂环庚烷衍生物
CN1110679A (zh) 脒基酚衍生物
CN1127510C (zh) 凝血酶抑制剂的药物前体

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20031112

Termination date: 20111217