CN112585118A - 乙型肝炎衣壳装配调节剂 - Google Patents

乙型肝炎衣壳装配调节剂 Download PDF

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Publication number
CN112585118A
CN112585118A CN201980054009.1A CN201980054009A CN112585118A CN 112585118 A CN112585118 A CN 112585118A CN 201980054009 A CN201980054009 A CN 201980054009A CN 112585118 A CN112585118 A CN 112585118A
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alkyl
heterocycloalkyl
cycloalkyl
heteroaryl
aryl
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Chinese (zh)
Inventor
克里斯多佛·J·伯恩斯
格伦·科伯恩
斌·刘
姚江超
克里斯多佛·贝内塔托斯
史蒂文·A·博伊德
斯蒂芬·M·康登
托马斯·海莫威茨
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VenatoRx Pharmaceuticals Inc
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VenatoRx Pharmaceuticals Inc
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
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  • Organic Chemistry (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201980054009.1A 2018-06-11 2019-06-11 乙型肝炎衣壳装配调节剂 Pending CN112585118A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862683557P 2018-06-11 2018-06-11
US62/683,557 2018-06-11
US201962832734P 2019-04-11 2019-04-11
US62/832,734 2019-04-11
PCT/US2019/036611 WO2019241292A1 (en) 2018-06-11 2019-06-11 Hepatitis b capsid assembly modulators

Publications (1)

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CN112585118A true CN112585118A (zh) 2021-03-30

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US (4) US10590076B2 (https=)
EP (1) EP3807246A4 (https=)
JP (1) JP2021527638A (https=)
KR (1) KR20210019489A (https=)
CN (1) CN112585118A (https=)
AU (1) AU2019284617A1 (https=)
BR (1) BR112020025073A2 (https=)
CA (1) CA3102972A1 (https=)
DE (1) DE202019005471U1 (https=)
GB (1) GB2583614B (https=)
IL (1) IL279242A (https=)
PH (1) PH12020552127A1 (https=)
SG (1) SG11202012346YA (https=)
TW (1) TW202016073A (https=)
WO (1) WO2019241292A1 (https=)

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CN111868026A (zh) * 2018-03-30 2020-10-30 正大天晴药业集团股份有限公司 含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途
CN113365999A (zh) * 2019-01-31 2021-09-07 正大天晴药业集团股份有限公司 含有吡咯并杂环的衣壳蛋白装配抑制剂
WO2024149314A1 (zh) * 2023-01-12 2024-07-18 成都微芯药业有限公司 氨基噻吩类化合物、其制备方法及用途

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WO2015191907A1 (en) 2014-06-11 2015-12-17 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
WO2019118358A1 (en) 2017-12-11 2019-06-20 VenatoRx Pharmaceuticals, Inc. Hepatitis b capsid assembly modulators
KR102752886B1 (ko) * 2018-05-25 2025-01-09 치아타이 티안큉 파마수티컬 그룹 주식회사 2,3-디히드로-1h-피롤리진-7-포름아미드 유도체 및 그 사용
DE202019005471U1 (de) 2018-06-11 2020-09-17 VenatoRx Pharmaceuticals, Inc. Hepatitis B Kapsid-Assemblierungsmodulatoren
BR112021006403A2 (pt) * 2018-10-05 2021-07-06 Univ Emory agentes monômeros e multiméricos anti-hbv
EA202092159A1 (ru) * 2019-01-25 2020-12-15 Чиа Тай Тянцин Фармасьютикал Груп Ко., Лтд. Содержащий n-гетероциклическое пятичленное кольцо ингибитор сборки капсидного белка, его фармацевтическая композиция и их применение
ES3064043T3 (en) 2019-09-29 2026-04-22 Chia Tai Tianqing Pharmaceutical Group Co Ltd Crystalline forms of a capsid protein assembly inhibitor containing a pyrrole ring, and application thereof
WO2021058001A1 (zh) 2019-09-29 2021-04-01 正大天晴药业集团股份有限公司 N杂五元环化合物的晶型及其应用
AU2020385034B2 (en) * 2019-11-13 2024-11-14 Xi'an Xintong Pharmaceutical Research Co., Ltd. HBV inhibitor and use thereof
WO2021119081A1 (en) * 2019-12-10 2021-06-17 VenatoRx Pharmaceuticals, Inc. Hepatitis b capsid assembly modulators
WO2021178362A1 (en) * 2020-03-03 2021-09-10 VenatoRx Pharmaceuticals, Inc. Hepatitis b capsid assembly modulators
WO2021197486A1 (zh) * 2020-04-03 2021-10-07 东莞市东阳光新药研发有限公司 新型螺环类化合物及其在药物中的应用
JP2024537830A (ja) 2021-10-08 2024-10-16 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド カプシドタンパク質阻害剤と逆転写酵素阻害剤とを含む医薬組合せ

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