CN112513032B - 作为trk受体的调节剂的4-取代的苯基-1,3,5-三嗪衍生物 - Google Patents

作为trk受体的调节剂的4-取代的苯基-1,3,5-三嗪衍生物 Download PDF

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CN112513032B
CN112513032B CN201980045116.8A CN201980045116A CN112513032B CN 112513032 B CN112513032 B CN 112513032B CN 201980045116 A CN201980045116 A CN 201980045116A CN 112513032 B CN112513032 B CN 112513032B
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disease
methyl
dementia
trione
groups
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CN112513032A (zh
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贡纳尔·努德瓦尔
蓬图斯·福塞尔
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Aztec Pharmaceuticals
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Aztec Pharmaceuticals
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201980045116.8A 2018-06-28 2019-06-28 作为trk受体的调节剂的4-取代的苯基-1,3,5-三嗪衍生物 Active CN112513032B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1810668.2A GB201810668D0 (en) 2018-06-28 2018-06-28 New compounds
GB1810668.2 2018-06-28
PCT/GB2019/051853 WO2020002950A1 (en) 2018-06-28 2019-06-28 4-substituted phenyl-1,3,5-triazine derivatives as modulators of trk receptors

Publications (2)

Publication Number Publication Date
CN112513032A CN112513032A (zh) 2021-03-16
CN112513032B true CN112513032B (zh) 2024-07-02

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CN201980045116.8A Active CN112513032B (zh) 2018-06-28 2019-06-28 作为trk受体的调节剂的4-取代的苯基-1,3,5-三嗪衍生物

Country Status (10)

Country Link
US (1) US11840524B2 (https=)
EP (1) EP3814335B1 (https=)
JP (1) JP7510358B2 (https=)
KR (1) KR20210024531A (https=)
CN (1) CN112513032B (https=)
BR (1) BR112020026619A2 (https=)
CA (1) CA3104237A1 (https=)
ES (1) ES2935183T3 (https=)
GB (1) GB201810668D0 (https=)
WO (1) WO2020002950A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA52415A (fr) 2018-02-26 2021-01-06 AlzeCure Pharma AB Dérivés de triazine pour le traitement de maladies associées à des neurotrophines
GB201912404D0 (en) * 2019-08-29 2019-10-16 AlzeCure Pharma AB New compounds
AU2021283892A1 (en) * 2020-06-03 2023-02-02 Dana-Farber Cancer Institute, Inc. Inhibitors of transcriptional enhanced associate domain (TEAD) and uses thereof
WO2025232990A1 (en) 2024-05-09 2025-11-13 AlzeCure Pharma AB Triazinone derivatives for use in the treatment of inflammation

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CN105209427A (zh) * 2013-03-15 2015-12-30 特罗菲克斯制药股份有限公司 非肽bdnf神经营养蛋白模拟物

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Publication number Publication date
US20210371402A1 (en) 2021-12-02
CN112513032A (zh) 2021-03-16
CA3104237A1 (en) 2020-01-02
US11840524B2 (en) 2023-12-12
WO2020002950A1 (en) 2020-01-02
EP3814335A1 (en) 2021-05-05
GB201810668D0 (en) 2018-08-15
KR20210024531A (ko) 2021-03-05
JP7510358B2 (ja) 2024-07-03
BR112020026619A2 (pt) 2021-03-30
EP3814335B1 (en) 2022-11-09
JP2021529168A (ja) 2021-10-28
ES2935183T3 (es) 2023-03-02

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