CN112384527B - Wnt信号传递激动剂分子 - Google Patents

Wnt信号传递激动剂分子 Download PDF

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CN112384527B
CN112384527B CN201980021129.1A CN201980021129A CN112384527B CN 112384527 B CN112384527 B CN 112384527B CN 201980021129 A CN201980021129 A CN 201980021129A CN 112384527 B CN112384527 B CN 112384527B
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residue
seq
alanine
reck
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CN112384527A (zh
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B·范霍莱贝克
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Universite Libre de Bruxelles ULB
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    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

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CN201980021129.1A 2018-03-23 2019-03-22 Wnt信号传递激动剂分子 Active CN112384527B (zh)

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EP18163777 2018-03-23
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PCT/EP2019/057243 WO2019180204A1 (en) 2018-03-23 2019-03-22 Wnt signaling agonist molecules

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US11773171B2 (en) 2017-12-19 2023-10-03 Surrozen Operating, Inc. WNT surrogate molecules and uses thereof
CA3206769A1 (en) * 2021-01-28 2022-08-04 Kyung Won Park Gene therapy for treating neurodegenerative diseases
WO2022164259A1 (ko) * 2021-01-28 2022-08-04 주식회사 에이브레인 신경 퇴행성 질환의 치료를 위한 유전자 요법
WO2023094581A1 (en) 2021-11-29 2023-06-01 Université Libre de Bruxelles Compositions for the treatment of glioblastoma
WO2024040118A2 (en) * 2022-08-16 2024-02-22 Surrozen Operating, Inc. Cell targeting multicomponent polypeptide
WO2024200352A1 (en) 2023-03-24 2024-10-03 Université Libre de Bruxelles Compositions for preventing and/or treating neurocovid
CN121358757A (zh) 2023-05-30 2026-01-16 纽瓦斯克生物技术公司 具有氨基酸添加物的wnt7分子
EP4720099A1 (en) 2023-05-30 2026-04-08 NeuVasQ Biotechnologies SA Mutant wnt7 proteins with c-terminal amino acid addition
WO2025093683A1 (en) * 2023-11-03 2025-05-08 Neuvasq Biotechnologies Sa Wnt7 signaling agonists
WO2026068859A1 (en) 2024-09-30 2026-04-02 Université Libre de Bruxelles Wnt signaling agonist molecules in the treatment of a bone-related disease or disorder

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CA3088676A1 (en) 2019-09-26
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EP3768701B1 (en) 2023-08-02
JP7390729B2 (ja) 2023-12-04
KR20210005597A (ko) 2021-01-14
ES2960925T3 (es) 2024-03-07
IL277307B2 (en) 2025-03-01
US20240092848A1 (en) 2024-03-21
BR112020018908A2 (pt) 2021-01-26
US20230212240A1 (en) 2023-07-06
KR102879500B1 (ko) 2025-10-31
WO2019180204A1 (en) 2019-09-26
CN112384527A (zh) 2021-02-19
CN116942851A (zh) 2023-10-27
US20230399369A1 (en) 2023-12-14
EP4163295A1 (en) 2023-04-12
JP2021518151A (ja) 2021-08-02
IL277307B1 (en) 2024-11-01
AU2019237215A1 (en) 2020-07-23
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US11840557B2 (en) 2023-12-12
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