CN112384519A - 一种肽硼酸酯类化合物的合成与用途 - Google Patents
一种肽硼酸酯类化合物的合成与用途 Download PDFInfo
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- CN112384519A CN112384519A CN201980036098.7A CN201980036098A CN112384519A CN 112384519 A CN112384519 A CN 112384519A CN 201980036098 A CN201980036098 A CN 201980036098A CN 112384519 A CN112384519 A CN 112384519A
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- borate
- boronic acid
- cancer
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- 229910052736 halogen Inorganic materials 0.000 claims description 11
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 9
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 125000001624 naphthyl group Chemical group 0.000 claims description 6
- 238000006467 substitution reaction Methods 0.000 claims description 6
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 5
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 5
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Abstract
一种肽硼酸酯类化合物或其药用盐，及其制备方法及在药学上的应用。所述肽硼酸酯类化合物或其药用盐结构如式(I)所示，所述化合物可以用于制备蛋白酶体抑制剂，可以应用于治疗实体瘤和血液瘤
Description
PCT国内申请，说明书已公开。
Claims (10)
- PCT国内申请，权利要求书已公开。
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| CN201810524104.0A CN110540547A (zh) | 2018-05-28 | 2018-05-28 | 一种肽硼酸酯类化合物的合成与用途 |
| CN2018105241040 | 2018-05-28 | ||
| PCT/CN2019/088506 WO2019228299A1 (zh) | 2018-05-28 | 2019-05-27 | 一种肽硼酸酯类化合物的合成与用途 |
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| CN202211551468.0A Pending CN115785137A (zh) | 2018-05-28 | 2019-05-27 | 一种肽硼酸酯类化合物的合成与用途 |
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| US (1) | US11542283B2 (zh) |
| EP (1) | EP3805237A4 (zh) |
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| CN (3) | CN110540547A (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2023078437A1 (zh) | 2021-11-08 | 2023-05-11 | 江苏正大丰海制药有限公司 | 一种肽硼酸类化合物新晶型及其制备方法 |
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| CN110540547A (zh) | 2018-05-28 | 2019-12-06 | 秦艳茹 | 一种肽硼酸酯类化合物的合成与用途 |
| DK3826723T3 (da) * | 2018-07-26 | 2024-01-15 | Merck Patent Gmbh | Boronsyrederivater |
| CN112007160A (zh) * | 2020-08-17 | 2020-12-01 | 暨南大学 | 蛋白酶体抑制剂在抗癌药物中的应用 |
| CN113105486B (zh) * | 2021-02-24 | 2023-08-15 | 南京师范大学 | 一种硼酸酯类化合物及其药学上可接受的盐、其制备方法及其用途 |
| WO2023107470A1 (en) * | 2021-12-06 | 2023-06-15 | Pretzel Therapeutics, Inc. | Lonp1 inhibitors, uses and methods |
| CN114671900A (zh) * | 2022-04-26 | 2022-06-28 | 广州医科大学 | 硼酸类化合物及其应用 |
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- 2019-05-27 CA CA3101824A patent/CA3101824C/en active Active
- 2019-05-27 AU AU2019277933A patent/AU2019277933B2/en active Active
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| US20210214377A1 (en) | 2021-07-15 |
| CN112384519B (zh) | 2022-11-25 |
| EP3805237A4 (en) | 2021-08-18 |
| JP2021526159A (ja) | 2021-09-30 |
| AU2019277933B2 (en) | 2021-12-16 |
| CN115785137A (zh) | 2023-03-14 |
| KR20210010579A (ko) | 2021-01-27 |
| CA3101824C (en) | 2023-08-15 |
| JP7314259B2 (ja) | 2023-07-25 |
| US11542283B2 (en) | 2023-01-03 |
| EP3805237A1 (en) | 2021-04-14 |
| CN110540547A (zh) | 2019-12-06 |
| AU2019277933A1 (en) | 2021-01-07 |
| KR102558265B1 (ko) | 2023-07-20 |
| WO2019228299A1 (zh) | 2019-12-05 |
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