CN112226468B - 酶催化的双迈克尔连续加成方法 - Google Patents
酶催化的双迈克尔连续加成方法 Download PDFInfo
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- CN112226468B CN112226468B CN202011479821.XA CN202011479821A CN112226468B CN 112226468 B CN112226468 B CN 112226468B CN 202011479821 A CN202011479821 A CN 202011479821A CN 112226468 B CN112226468 B CN 112226468B
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 2
- WGTASENVNYJZBK-UHFFFAOYSA-N 3,4,5-trimethoxyamphetamine Chemical compound COC1=CC(CC(C)N)=CC(OC)=C1OC WGTASENVNYJZBK-UHFFFAOYSA-N 0.000 description 2
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- 230000002572 peristaltic effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- LYBIZMNPXTXVMV-UHFFFAOYSA-N propan-2-yl prop-2-enoate Chemical compound CC(C)OC(=O)C=C LYBIZMNPXTXVMV-UHFFFAOYSA-N 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
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- 241000589513 Burkholderia cepacia Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000223258 Thermomyces lanuginosus Species 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
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- 239000012230 colorless oil Substances 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
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- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
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- 230000002799 radiopharmaceutical effect Effects 0.000 description 1
- SONJTKJMTWTJCT-UHFFFAOYSA-K rhodium(iii) chloride Chemical compound [Cl-].[Cl-].[Cl-].[Rh+3] SONJTKJMTWTJCT-UHFFFAOYSA-K 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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CN111286497B (zh) * | 2020-02-19 | 2021-08-24 | 江南大学 | 一种催化性能提高的脂肪酶及其应用 |
CN111676255A (zh) * | 2020-05-19 | 2020-09-18 | 浙江农林大学 | 一种脂肪酶催化在线合成3-苯氨基丙羟肟酸的方法 |
CN111690695A (zh) * | 2020-05-19 | 2020-09-22 | 浙江工业大学 | 3-苯氨基丙羟肟酸的酶促微流控在线合成方法 |
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Effective date of registration: 20231207 Address after: 300467 factory building A04, zone 1, binlv Industrial Park, anzheng Road, Binhai Tianjin eco city tourism zone, Binhai New Area, Tianjin Patentee after: Tianjin kailaiying Pharmaceutical Technology Development Co.,Ltd. Address before: No.71, 7th Street, Binhai New Area Economic and Technological Development Zone, Tianjin 300457 Patentee before: ASYMCHEM LIFE SCIENCE (TIANJIN) Co.,Ltd. |
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Effective date of registration: 20231218 Address after: Yimatu Village, Yimatu Town, Fumeng County, Fuxin City, Liaoning Province (Fluorine Chemical Industry Park) Patentee after: LIAONING ASYMCHEM LABORATORIES Co.,Ltd. Address before: 300467 factory building A04, zone 1, binlv Industrial Park, anzheng Road, Binhai Tianjin eco city tourism zone, Binhai New Area, Tianjin Patentee before: Tianjin kailaiying Pharmaceutical Technology Development Co.,Ltd. |
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