CN112105369A - 源自基因敲除猪的血液产品及其用途 - Google Patents
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Abstract
提供了一种源自基因敲除猪的血液产品,以及该血液产品的应用。该血液产品与人血清中免疫球蛋白结合降低,对克服超急性免疫排斥反应有作用。
Description
PCT国内申请,说明书已公开。
Claims (21)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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CN201810426018.6A CN108588123A (zh) | 2018-05-07 | 2018-05-07 | CRISPR/Cas9载体组合在制备基因敲除猪的血液制品中的应用 |
CN2018104260186 | 2018-05-07 | ||
PCT/CN2019/085773 WO2019214591A1 (zh) | 2018-05-07 | 2019-05-07 | 源自基因敲除猪的血液产品及其用途 |
Publications (2)
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CN112105369A true CN112105369A (zh) | 2020-12-18 |
CN112105369B CN112105369B (zh) | 2024-05-14 |
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CN201810426018.6A Pending CN108588123A (zh) | 2018-05-07 | 2018-05-07 | CRISPR/Cas9载体组合在制备基因敲除猪的血液制品中的应用 |
CN201980030378.7A Active CN112105369B (zh) | 2018-05-07 | 2019-05-07 | 源自基因敲除猪的血液产品及其用途 |
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CN201810426018.6A Pending CN108588123A (zh) | 2018-05-07 | 2018-05-07 | CRISPR/Cas9载体组合在制备基因敲除猪的血液制品中的应用 |
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US (1) | US20210254004A1 (zh) |
EP (1) | EP3791887A4 (zh) |
JP (1) | JP7285578B2 (zh) |
CN (2) | CN108588123A (zh) |
WO (1) | WO2019214591A1 (zh) |
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CA2853829C (en) | 2011-07-22 | 2023-09-26 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
US20150166982A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting pi3k point mutations |
US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
EP4269577A3 (en) | 2015-10-23 | 2024-01-17 | President and Fellows of Harvard College | Nucleobase editors and uses thereof |
SG11201900907YA (en) | 2016-08-03 | 2019-02-27 | Harvard College | Adenosine nucleobase editors and uses thereof |
WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
CN110214180A (zh) | 2016-10-14 | 2019-09-06 | 哈佛大学的校长及成员们 | 核碱基编辑器的aav递送 |
US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
EP3592777A1 (en) | 2017-03-10 | 2020-01-15 | President and Fellows of Harvard College | Cytosine to guanine base editor |
CN110914426A (zh) | 2017-03-23 | 2020-03-24 | 哈佛大学的校长及成员们 | 包含核酸可编程dna结合蛋白的核碱基编辑器 |
WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
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