CN112105360B - 用于癌症治疗的bcl-2蛋白降解剂 - Google Patents
用于癌症治疗的bcl-2蛋白降解剂 Download PDFInfo
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- CN112105360B CN112105360B CN201980021244.9A CN201980021244A CN112105360B CN 112105360 B CN112105360 B CN 112105360B CN 201980021244 A CN201980021244 A CN 201980021244A CN 112105360 B CN112105360 B CN 112105360B
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- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
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- G06N3/02—Neural networks
- G06N3/06—Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons
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- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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- A—HUMAN NECESSITIES
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862620219P | 2018-01-22 | 2018-01-22 | |
| US62/620219 | 2018-01-22 | ||
| PCT/US2019/014545 WO2019144117A1 (en) | 2018-01-22 | 2019-01-22 | Bcl-2 proteins degraders for cancer treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112105360A CN112105360A (zh) | 2020-12-18 |
| CN112105360B true CN112105360B (zh) | 2024-01-30 |
Family
ID=67301223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980021244.9A Active CN112105360B (zh) | 2018-01-22 | 2019-01-22 | 用于癌症治疗的bcl-2蛋白降解剂 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12118414B2 (https=) |
| EP (1) | EP3743069B1 (https=) |
| JP (1) | JP7385284B2 (https=) |
| CN (1) | CN112105360B (https=) |
| CA (1) | CA3088253A1 (https=) |
| ES (1) | ES3041854T3 (https=) |
| WO (1) | WO2019144117A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP6936498B2 (ja) | 2016-04-21 | 2021-09-15 | バイオベンチャーズ・リミテッド・ライアビリティ・カンパニーBioVentures, LLC | 抗アポトーシス性Bcl−2ファミリータンパク質の分解を誘導する化合物及びその使用 |
| EP3532464A4 (en) | 2016-10-28 | 2020-07-08 | Icahn School of Medicine at Mount Sinai | COMPOSITIONS AND METHODS FOR THE TREATMENT OF EZH2 MEDIATION CANCER |
| EP3743069B1 (en) | 2018-01-22 | 2025-08-06 | BioVentures, LLC | Bcl-2 proteins degraders for cancer treatment |
| CN118908962A (zh) | 2019-05-06 | 2024-11-08 | 西奈山伊坎医学院 | 作为hpk1的降解剂的异双功能化合物 |
| WO2021007307A1 (en) * | 2019-07-10 | 2021-01-14 | Recurium Ip Holdings, Llc | Bcl-2 protein inhibitors |
| WO2021078301A1 (zh) * | 2019-10-24 | 2021-04-29 | 上海科技大学 | 蛋白降解剂及其在疾病治疗中的应用 |
| MX2022010512A (es) * | 2020-04-28 | 2022-11-16 | Recurium Ip Holdings Llc | Inhibidores de proteína bcl-2. |
| CN116490169A (zh) * | 2020-11-10 | 2023-07-25 | 辩证疗法公司 | 小分子制剂 |
| CA3173819A1 (en) * | 2020-12-23 | 2022-06-30 | Dana-Farber Cancer Institute, Inc. | Small molecule degraders of phosphatidylinositol-5-phosphate 4-kinase type 2 and uses thereof |
| CN117794929A (zh) | 2021-02-02 | 2024-03-29 | 法国施维雅药厂 | 选择性bcl-xl protac化合物及使用方法 |
| CN113248415B (zh) * | 2021-05-26 | 2022-08-09 | 苏州正永生物医药有限公司 | 一种abt-737关键中间体的制备方法以及abt-737的制备方法 |
| CN118339566A (zh) | 2021-06-11 | 2024-07-12 | 西克公司 | 针对超导量子电路的通量偏置的系统和方法 |
| CA3231175A1 (en) * | 2021-09-01 | 2023-03-09 | Xizang Haisco Pharmaceutical Co., Ltd. | Compound for degradation of bcl-2 family proteins and medical application thereof |
| EP4401729A4 (en) * | 2021-09-17 | 2025-10-01 | Kymera Therapeutics Inc | BCL-XL DEGRADING AGENTS AND THEIR USES |
| WO2023088245A1 (zh) * | 2021-11-17 | 2023-05-25 | 成都先导药物开发股份有限公司 | 一种降解剂及其用途 |
| EP4461730A4 (en) * | 2022-01-04 | 2025-12-24 | Univ Shanghai Technology | PROTEIN DEGRADING AGENTS DEVELOPED BASED ON BCL-2 FAMILY PROTEIN LIGAND COMPOUNDS AND THEIR USE |
| US20250282771A1 (en) | 2022-05-06 | 2025-09-11 | Treeline Biosciences, Inc. | Tetrahydroisoquinoline heterobifunctional bcl-xl degraders |
| JP2025516359A (ja) | 2022-05-06 | 2025-05-27 | ツリーライン バイオサイエンシズ インコーポレイテッド | テトラヒドロイソキノリンヘテロ二官能性bcl-xl分解剤 |
| PE20250007A1 (es) | 2022-05-06 | 2025-01-07 | Treeline Biosciences Inc | Degradadores bcl-xl-heterobifuncionales de tetrahidroisoquinolina |
| EP4522154A1 (en) * | 2022-05-12 | 2025-03-19 | Kymera Therapeutics, Inc. | Bcl-xl/bcl-2 degraders and uses thereof |
| CN117247374B (zh) * | 2022-06-10 | 2026-03-17 | 四川科伦博泰生物医药股份有限公司 | 一种bcl-xl抑制剂及其制药用途 |
| WO2024012449A1 (zh) * | 2022-07-12 | 2024-01-18 | 正大天晴药业集团股份有限公司 | 含有三氟甲基基团的化合物 |
| WO2024067818A1 (zh) * | 2022-09-30 | 2024-04-04 | 江苏恒瑞医药股份有限公司 | 一种用于bcl-2蛋白靶向降解的嵌合体化合物、其制备方法及其在医药上的应用 |
| JP2025533820A (ja) * | 2022-10-03 | 2025-10-09 | ユニバーシティ オブ フロリダ リサーチ ファウンデーション,インコーポレイティド | セレブロン動員性Bcl-xL/Bcl-2二重分解剤 |
| WO2024078581A1 (en) * | 2022-10-12 | 2024-04-18 | Appicine Therapeutics (Hk) Limited | Selective bcl-xl protac compounds and uses thereof |
| WO2024153185A1 (zh) * | 2023-01-18 | 2024-07-25 | 苏州宜联生物医药有限公司 | 包含bcl-2家族蛋白降解剂的抗体药物偶联物及其制备方法和用途 |
| JP2026507476A (ja) * | 2023-02-17 | 2026-03-04 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | トリフルオロメタンスルホニル基を含む化合物 |
| WO2024179577A1 (zh) * | 2023-03-01 | 2024-09-06 | 西藏海思科制药有限公司 | 一种Bcl-2家族蛋白降解剂的药物组合物 |
| WO2025101575A1 (en) | 2023-11-07 | 2025-05-15 | Treeline Biosciences, Inc. | Tetrahydroisoquinoline heterobifunctional bcl-x l degraders |
| WO2025101571A1 (en) | 2023-11-07 | 2025-05-15 | Treeline Biosciences, Inc. | Tetrahydroisoquinoline heterobifunctional bcl-x l degraders |
| TW202527930A (zh) | 2023-11-07 | 2025-07-16 | 美商樹線生物科學公司 | 四氫異喹啉異雙功能bcl-xl降解劑 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017184995A1 (en) * | 2016-04-21 | 2017-10-26 | Bioventures, Llc | Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof |
| CN107614020A (zh) * | 2015-03-18 | 2018-01-19 | 免疫生化公司 | 靶向细胞内肿瘤相关抗原的用于治疗癌症的缀合物 |
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| EP3743069A4 (en) | 2021-06-09 |
| CA3088253A1 (en) | 2019-07-25 |
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| US20210085675A1 (en) | 2021-03-25 |
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| ES3041854T3 (en) | 2025-11-17 |
| US12118414B2 (en) | 2024-10-15 |
| CN112105360A (zh) | 2020-12-18 |
| EP3743069C0 (en) | 2025-08-06 |
| EP3743069A1 (en) | 2020-12-02 |
| JP2021511342A (ja) | 2021-05-06 |
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