CN1120455A

CN1120455A - Chinese caterpillar fungus-contg. "Chongcaowang" prescription and its prodn. technique

Info

Publication number: CN1120455A
Application number: CN 94116924
Authority: CN
Inventors: 顾霆
Original assignee: Individual
Current assignee: Individual
Priority date: 1994-10-14
Filing date: 1994-10-14
Publication date: 1996-04-17

Abstract

The health-care oral liquid or capsule is made up of cordyceps, champignon and lucid ganoderma through deep ferment with special medium, breaking cells, insulating treatment for a while, and mixing with decoction of Chinese-medicinal materials such as dogwood fruit, and features special effectiveness.

Description

A kind of novel Cordyceps king prescription and production technology

The present invention relates to a kind of new health care product oral liquid or capsular prescription and preparation method.

At present, be that the similar health product kind of base stock preparation is a lot of with Cordyceps etc., but generally all select the sporophore of natural cs and Lentinus Edodes, Ganoderma for use, mix after the pulverizing; Or carry out solid fermentation, together with culture medium dry, pulverize, selection, pelletize, packing; Or carry out liquid submerged fermentation, thalline is filtered out the reconcentration fermentation liquid.Before a kind of because natural resources limit, cause to yield poorly, the cost height is difficult to apply, and meets the need of market.Second kind of more original backwardness of solid fermentation though can reduce certain cost, because of can not large-scale production, and be easily polluted, and causes loss, also is eliminated gradually.The third deep fermentation influences some active ingredient and characteristics that natural material has because thalline is filtered out.

Purpose of the present invention is to adopt modern fermentation technology, carries out deep liquid and cultivates, not only can control production, improve output, reduce cost, but also the activity and the characteristics that can keep natural material to have, and, bring into play its effect more fully being equipped with on the basis of other Chinese medicinal ingredients.

Content of the present invention and main points:

1. prescription is formed

Product formula: with 10, the 000ml meter

(1) Cordyceps (fermentation liquid) 7,000ml

Lentinus Edodes (fermentation liquid) 2,000ml

Ganoderma (fermentation liquid) 1,000ml

(2) Radix Ophiopogonis 30-45g, Rhizoma Polygonati Odorati 30-45g, Fructus Corni 30-50g,

Herba Cistanches 25-45g, JIUBAI 15-25g, Herba Epimedii 15-30g,

Cortex Eucommiae 60-85g, field dobber 10-20g, Spica Prunellae 70-90g, the decocting of 5 times of amounts boil 2 times, filter medicinal liquid, decocted 15-20 minute for the first time, decocted 90-120 minute for the second time.

To add Mel, sweeting agent, antiseptic etc., packaging sterilizing after the mixing of (1) (2).Outer package gets finished product.

Culture medium prescription: (the same medium combination is used in Cordyceps, Lentinus Edodes, three kinds of fermentations of Ganoderma)

Water 1,000ml, yellow Semen setariae 25-28g, monosaccharide (as glucose etc.) 2-5g, disaccharidase (as white sugar etc.) 7.5g, potassium dihydrogen sulfate 0.5-1.8g, sulfate (as magnesium salt, iron salt, calcium salt, zinc salt etc.) 0.1-0.5g, organic nitrogen source is (as peptone, dried silkworm chrysalis meal, yeast powder etc.) 0.15-2.8g, aminoacid (as asparagine etc.) 0.1-0.2g, vitamin (as VB1, VB6 etc.) 0.4g.

2. preparation condition

Seed tank: A ' (Cordyceps fungus) inoculum concentration 5% is planted 20-24 hour age, terminal point: weight in wet base 13-18%, pH 〉=3.

B ' (Lentinus Edodes fungus) inoculum concentration 5% is planted 40-48 hour age, terminal point: weight in wet base 5-8%, pH 〉=4.

C ' (Ganderma lucidum) inoculum concentration 5% is planted 20-24 hour age, terminal point: weight in wet base 6-9%, pH 〉=3.5.

Fermentation tank: A (Cordyceps), 3000 liters of jars, inoculum concentration 10% is planted 15-20 hour age, terminal point: weight in wet base 12-16%, pH 〉=3.

B (Lentinus Edodes fungus), 1000 liters of jars, inoculum concentration 10% is planted 20-24 hour age, terminal point: weight in wet base 4-8%, pH 〉=4.

C (Ganderma lucidum), 500 liters of jars, inoculum concentration 10% is planted 16-20 hour age, terminal point: weight in wet base 5-8%, pH 〉=4.5.

Fermentation parameter: seed tank, fermentation tank is identical.

Ventilating ratio: 1: 0.2-0.3 (later stage increasing)

Rotating speed: 180-220 rev/min

Temperature: 23-25 ℃

Fermentation tank blade diameter length ratio: 1: 1.5-1.8

Adopt described preparation method,, the intracellular matter after the fragmentation is fully oozed out at canned preincubation.During termination, carry out high-temperature inactivation or quenching inactivation and handle, can get the product of different requirements, handle, can increase spore content, reach different efficacies as adopting the quenching inactivation.Described preparation method to Cordyceps, Lentinus Edodes, three kinds of strains of Ganoderma, has been used identical culture medium, has reduced workload and difficulty thereof.In addition, resulting product is half a suspendible liquid after whole beer and the processing of interpolation Chinese medicine, and all thalline all remain, thereby have kept some water-insoluble active ingredient.

Using the method for preparing capsule formulation, is with after the above-mentioned finished product liquid concentration, adds filler (as starch), dries, and incapsulates to get final product.

Prepared oral liquid or the capsule according to the present invention, the enhancing human body immunity function promotes the differentiation of T cell, NK cell effectively, activating macrophage is resisted heterologous protein, effectively as virus, tumor cells etc. all have obvious health care effect to taking good care of after weak, rehabilitation after being ill, the chemotherapy.

Advantage of the present invention and good effect are, adopt modern submerged fermentation technology, obtain the whole beer that the thalline glue is lumped together, carry out cell breakage again, concentrate and be equipped with some kinds of Chinese medicines and modulate, both can keep the active ingredient of natural cordyceps, Lentinus Edodes and Ganoderma, play the special medical health-care effect, may command production again, improve output, reduce cost, widely popularize, produce obvious social and economic benefit.Technological process: see Figure of description.

Claims

1. a new health care product oral liquid or capsular prescription and preparation method is characterized in that:

A. Cordyceps, Lentinus Edodes, deep glossy ganoderma fermenting have been used identical culture medium respectively

Combination;

B. control fermentation parameter and terminal point weight in wet base and pH value;

C. adopt somatic cells fragmentation, canned preincubation to handle a period of time etc. in the production procedure

Step;

D. product formula is that fermentation liquids such as Cordyceps are mixed with herb liquids such as frying in shallow oil well-done Fructus Corni

Handle.

2. according to described prescription of claim 1 and preparation method, it is characterized in that culture medium prescription is moisture 1,000ml, yellow Semen setariae 25-28g, monosaccharide (as glucose etc.) 2-5g, disaccharidase (as white sugar etc.) 7.5g, potassium dihydrogen sulfate 0.5-1.8g, sulfate (as magnesium salt, iron salt, calcium salt, zinc salt etc.) 0.1-0.5g, organic nitrogen source (as peptone, dried silkworm chrysalis meal, yeast powder etc.) 0.15-2.8g, aminoacid (as asparagine etc.) 0.1-0.2g, vitamin (as VB1, VB6 etc.) 0.4g.

3. according to described prescription of claim 1 and preparation method, it is characterized in that fermentation parameter is controlled to be: ventilating ratio 1: 0.2-0.3 (later stage increasing)

Rotating speed 180-220 rev/min

23 ℃-25 ℃ of temperature

Fermentation tank blade diameter length ratio 1: 1.5-1.8 terminal point weight in wet base and pH value are controlled to be:

Weight in wet base pH value weight in wet base pH value Cordyceps kind 13-18%＞3 12-16%＞sub-5-8% of 3 Lentinus Edodess＞4 ferment 4-8%＞4 Ganoderma jar 6-9%＞3.5 jars of 5-8%＞4.5

4. according to described prescription of claim 1 and preparation method, it is characterized in that adopting in the production procedure colloid mill, form half suspendible glue, be incubated down at 40-45 ℃ and dispose 10-15 hour, intracellular matter is fully oozed out the fragmentation of somatic cells wall.

5. according to described prescription of claim 1 and preparation method, it is characterized in that the finished product preparation in 10.000ml, gets (1) Cordyceps (fermentation liquid) 7,000ml

Lentinus Edodes (fermentation liquid) 2,000ml

Ganoderma (fermentation liquid) 1,000ml

(2) Radix Ophiopogonis 30-45g, Rhizoma Polygonati Odorati 30-45g, Fructus Corni 30-50g, Herba Cistanches 25-45g, JIUBAI 15-25g, Herba Epimedii 15-30g, Cortex Eucommiae 60-85g, field dobber 10-20g, Spica Prunellae 70-90g

Chinese medicine is boiled secondary with the decocting of 5 times of amounts, filter medicinal liquid, decocted 15-20 minute for the first time, decocted 90-120 minute for the second time.

To add Mel, sweeting agent, antiseptic etc. after the mixing of (1) (2), packaging sterilizing, outer package gets finished product.