CN104068379A - Health-care oral solution - Google Patents
Health-care oral solution Download PDFInfo
- Publication number
- CN104068379A CN104068379A CN201410294324.0A CN201410294324A CN104068379A CN 104068379 A CN104068379 A CN 104068379A CN 201410294324 A CN201410294324 A CN 201410294324A CN 104068379 A CN104068379 A CN 104068379A
- Authority
- CN
- China
- Prior art keywords
- tuber
- polygonati officinalis
- dwarf lilyturf
- radix polygonati
- enzymolysis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940100688 oral solution Drugs 0.000 title abstract 3
- 238000000855 fermentation Methods 0.000 claims abstract description 59
- 230000004151 fermentation Effects 0.000 claims abstract description 59
- 238000002360 preparation method Methods 0.000 claims abstract description 43
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 11
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- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 9
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- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
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- 241001633680 Polygonatum odoratum Species 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
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- 229940114124 ferulic acid Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/70—Clarifying or fining of non-alcoholic beverages; Removing unwanted matter
- A23L2/84—Clarifying or fining of non-alcoholic beverages; Removing unwanted matter using microorganisms or biological material, e.g. enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a health-care oral solution and a preparation method thereof, belonging to the field of health-care foods. The oral solution is prepared by mixing the following components in parts by weight: a cordyceps sinensis fermentation solution, a lentinus edodes fermentation solution, a lucid ganoderma fermentation solution, a radix polygonati officinalis and radix ophiopogonis extract, honey, agar and VC sodium, wherein radix polygonati officinalis and radix ophiopogonis enzymatic hydrolysate with the adding mass percent being 10-20% is added into a cordyceps sinensis fermentation solution culture medium; when the lentinus edodes fermentation solution is fermented for 5-8 hours, radix ophiopogonis enzymatic hydrolysate with the adding mass percent being 10-15% is added. The radix polygonati officinalis and radix ophiopogonis enzymatic hydrolysate treated by an enzymolysis method is used as a cordyceps sinensis culture medium so as to effectively improve the decomposition and the releasing of nutritional ingredients in radix polygonati officinalis and radix ophiopogonis; meanwhile, the nutritional ingredients in radix polygonati officinalis and radix ophiopogonis can be effectively absorbed by cordyceps sinensis and are converted. The product has the effects of nourishing lung and kidney, improving the immunity and the like, and is particularly suitable for old people and sub-healthy crowds to eat.
Description
Technical field:
The invention belongs to field of health care products, particularly relate to health care oral liquid taking fungal fermented filtrate as main material production and preparation method thereof.
Background technology:
Oral liquid is a kind of novel form growing up in recent years, and it has absorbed the process characteristic of traditional Chinese medicine, and further refining, concentrated, embedding of decoction, sterilizing are obtained.Oral liquid is to come across market with a kind of form of health products the earliest, as Oral Liquid Radix Panacis Quinquefolii, unit's energy oral liquid, Ferulic acid etc.; There is the advantages such as taking dose is little, absorption is very fast, steady quality, easy to carry and use, easy preservation, applicable suitability for industrialized production due to oral liquid, thereby recently, many curative oral liquids also emerge in multitude in preparation, as chaihu oral liquid, Compound Hydrochloride Phenylpropanolamine, oral liquid of honeysuckle flower and scutellaria, antiviral oral liquor, heat-clearing and detoxicating oral liquid etc.; Some kind can be suitable for tcm emergency medication, as Sini Tang oral liquid, oral liquid of honeysuckle flower and scutellaria, therefore many in recent years, tablet, granule, pill, decoction, herb mixture, injection etc. were changed system into oral liquid, and made it to become and in pharmaceutical preparation, develop one of formulation faster.
The traditional decocting method of the general employing of preparation of oral liquid, first will precipitate after suitable decocting liquid concentrating again, or removes oil-soluble impurities with ethanol extract from water precipitation, then add suitable additives, dissolving mixes, and filters clarification, press injection technological requirement, embedding in ampoule or easy open cover bottle, sterilizing and get final product.For example, publication number is the patent of invention " cordyceps mushroom composition, cordyceps mushroom polyoses oral liquid and preparation method thereof " of CN101502607A, it discloses a kind of cordyceps mushroom polyoses oral liquid, its manufacture craft is exactly to utilize traditional decocting method to be made: first cordyceps mushroom composition slow fire is carried out to extracted many times, after more last whole leaching liquors being mixed, purify, are concentrated, add anticorrisive agent, then be made through packing, sterilizing.Publication number is that the patent of invention " Ganoderma lucidum oral liquid " of CN103610059A discloses another kind of preparation method, and it is directly made the auxiliary materials such as bulk drug glossy ganoderma, Ji Songrong, barrenwort and steviol glycoside with pure water constant volume; Though this preparation method process is simple, glossy ganoderma is all steep in wine or first after extracting, use conventionally, directly with pure water, glossy ganoderma and other material constant volumes is configured, and the medicine and health care value of glossy ganoderma is had a greatly reduced quality.And the decocting method of aforementioned conventional, though extraction effect is better, but its complex manufacturing process, and oral liquid is all higher to the requirement of production equipment and process conditions, and production cost is also more expensive.
Mushroom, is famous edible one of medicinal fungi of holding concurrently in the world, has very high nutritive value, and complex chemical composition, pharmacologically active are strong, and clinical application range is wide, its except edible, also with other variety of way by people's extensive use.In the publication number patent of invention " thering is mushroom fermentation oral liquid of antitumor activity and preparation method thereof " that is CN101167760A, a kind of mushroom oral liquid and preparation method thereof is disclosed, it is taking glucose, young beer yeast, sucrose, whole milk powder, peptone, potassium dihydrogen phosphate, vitamin B1 and B2 etc. as culture medium, with the mycelium inoculation of mushroom C91-3, centrifugal through submerged fermentation, 4 DEG C, obtain mushroom ferment mother liquor after filtering, add in proportion again sweetener, can make mushroom fermentation oral liquid.
Radix polygonati officinalis, formal name used at school: Polygonatum odoratum (Mill.) Druce is Liliaceae herbaceos perennial.Rhizome horizontal walk, meat yellow-white, the most fibrous roots of close life.Blade face green, below grey.Flower armpit is raw, and common 1-3 cluster.Originate in In Southwest China, but wild distribution is very wide.Cold-resistant, also resistance to the moon, happiness wet environment, suitable growth is in containing the abundant chesson of humus.Collective Notes to the Canon of Materia medica cloud " stem is tetanic, like bamboo arrow shaft, has joint ".Therefore there is the name of radix polygonati officinalis.The rhizome of plant can hyoscine, and Chinese medicine name is also radix polygonati officinalis, and excavate autumn, cleans, and shines to softness, repeatedly rubs, and airing, to without hard-core, is dried, or after steaming thoroughly, rubs to translucent, dries, and cuts sheet or section is used.Radix polygonati officinalis is extracted flavonoids material and is combined with mulberry-leaf extract DNJ and forms a kind of novel substance---and wash the clear sugar of pancreas plain (cics), there is the effects such as hypoglycemic, blood fat, blood pressure.
The tuber of dwarf lilyturf: have another name called RADIX OPHIOPOGONIS from Hangzhou of China, bamboo water pipe tuber of dwarf lilyturf; Originating in Zhejiang Hangzhou bamboo water pipe bridge one band person, is liliaceous plant, and product are of fine quality, is authentic medicinal herbs.Be spindle the tuber of dwarf lilyturf, two ends are point slightly, long 1.5-3cm, and diameter 0.3-0.6cm, surperficial yellow-white or faint yellow, has thin longitudinal grin, and matter is pliable and tough, section yellow-white, translucent, center pillar is tiny.The tuber of dwarf lilyturf is sweet, and micro-hardship, is slightly cold, can nourishing Yin and promoting production of body fluid, and moistening lung clears away heart-fire.Be usually used in dryness of the lung dry cough, deficiency of Yin consumptive disease is coughed, larynx numbness pharyngalgia, and Tianjin wound is thirsty, and interior heat is quenched one's thirst, vexed insomnia, the dry constipation of intestines.
How in the technology path of existing oral liquid and processing technology, improve processing method, effectively improving that the medicinal of oral liquid Raw medicine and health care be worth has been one of primary problem solving, and significant.
Summary of the invention:
The object of this invention is to provide a kind of health care oral liquid prepared by fungal fermented filtrate and preparation method thereof that utilizes.
Technical scheme of the present invention is summarized as follows:
A kind of health care oral liquid, consists of: cordyceps sinensis fermentation liquor 30-50 part, Lentinus edodes fermented liquid 15-25 part, ganoderma lucidum fermented liquid 18-24 part, radix polygonati officinalis ophiopogon japonicus extract 3-5 part, honey 4-5 part, 0.1 part, agar, VC sodium 0.4-0.5 part by weight;
Described cordyceps sinensis fermentation liquor fermentation medium component comprises: millet 2%, and peptone 1%, beef extract 1%, corn 2.5%, potassium dihydrogen phosphate 0.5%, insufficient section distilled water is supplied, pH7.0-7.2;
In described Chinese caterpillar fungus fermentation culture medium, being added with mass ratio is the radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf of 10-20%;
The preparation method of the described radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf is as follows: the mass ratio of radix polygonati officinalis and the tuber of dwarf lilyturf is 2:1-2, both were pulverized to 100 orders, crushed mixture is added to doubly water-soluble solution of 4-6, add the cellulase of mixture quality 2-3%, control temperature is 45-55 DEG C, pH is 4.5-6, enzymolysis 30-40 minute, adjusting temperature is 80 DEG C again, keeps 10-30 minutes, controls subsequently temperature to 50-60 DEG C, add the amylase of mixture quality 1-3%, pH is 4-6, after enzymolysis 30-60 minute, obtains the radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf.
Described ganoderma lucidum fermented liquid adds in fermentation the enzymolysis liquid tuber of dwarf lilyturf that mass ratio is 10-15% 5-8 hour time;
Described tuber of dwarf lilyturf, the preparation method of enzymolysis liquid was as follows: pulverize 100 orders the tuber of dwarf lilyturf, crushed material is added to doubly water-soluble solution of 4-6, and added the cellulase of mixture quality 2-3%, control temperature is 45-55 DEG C, and pH is 4.5-6, and enzymolysis 30-40 minute obtains the enzymolysis liquid tuber of dwarf lilyturf.
The preparation method of described radix polygonati officinalis ophiopogon japonicus extract is as follows:
The mass ratio of radix polygonati officinalis and the tuber of dwarf lilyturf is 3:1-2, pulverize radix polygonati officinalis and the tuber of dwarf lilyturf as particulate, add in jacketed pan, add 5-8 times of water, boil, keeping micro-boils 90 minutes, to the cellulase and the hemicellulase that add mixed liquor quality 1-2% in mixed liquor, control temperature 45-55 DEG C, pH is 4.5-6, enzymolysis 30-50 minute, the ratio of cellulase and hemicellulase is 1:2, enzymolysis liquid is crossed 200 mesh sieves, enter vacuum concentrator, filter residue adds 240L water and again boils, micro-boiling 60 minutes, cross 200 mesh sieves, filter residue discards, filtrate and filtrate merging for the first time, Vacuum Concentration is to the long-pending 20-40% of original mixed liquid, obtain radix polygonati officinalis ophiopogon japonicus extract.
The preparation method of described health care oral liquid, comprises the steps:
The allotment of zymotic fluid: by ratio of weight and the number of copies, cordyceps sinensis fermentation liquor, Lentinus edodes fermented liquid and ganoderma lucidum fermented liquid are mixed, add radix polygonati officinalis ophiopogon japonicus extract, honey, agar and VC sodium in the fungal fermented filtrate mixing;
Zymotic fluid homogeneous processing: zymotic fluid temperature is adjusted to 70-90 DEG C and flow to colloid mill, the gap of adjusting colloid mill stator and rotor is 10-50 microns, and mycelium in zymotic fluid is carried out to fragmentation, and colloid mill flow is 1-5 tons/hours; Through high pressure homogenizer processing, adjusting high pressure homogenizer pressure is 20-60Mpa again, and high-pressure homogeneous flow is 0.5-3 tons/hours, and sediments microscope inspection mycelium sporoderm-broken rate is 100%;
Filling sterilizing: zymotic fluid after treatment is first carried out filling, filling after at the temperature of 95 DEG C-135 DEG C, sterilizing 20-50 seconds, obtains oral liquid.
Beneficial effect:
The present invention adopts the enzyme solution radix polygonati officinalis after treatment enzymolysis liquid tuber of dwarf lilyturf as culture medium of Cordyceps militaris, effectively raises decomposition and the release of nutritional labeling in radix polygonati officinalis tuber of dwarf lilyturf; Also be conducive to Chinese caterpillar fungus simultaneously and effectively absorb the nutritional labeling in radix polygonati officinalis tuber of dwarf lilyturf and effectively transform, improve the nutritive value of Chinese caterpillar fungus, the polyoses content of Chinese caterpillar fungus is processed the raising 3-5% than non-processing by the method.
Ganoderma lucidum product is because the interpolation of the enzymolysis liquid tuber of dwarf lilyturf makes the content of polysaccharide improve 3-6% (determination of polysaccharide adopts phenol sulfuric acid process) than general ganoderma lucidum fermented liquid, dietary fiber content is brought up to more than 3.5% (dietary fiber is measured and adopted Southgate improved method) by 2-3%, this product integrates all multi-nutrients of multiple eating bacterium, is a kind of good tonic nutritious food that has nourishing, improves efficacy of immunity.This product has nourishing lung and kidney, improves the effects such as immunity.Be particularly suitable for the elderly and sub-health population edible.Show that through the edible test of the elderly this product can effectively eliminate fatigue, improve immunity.This product instant, direct-edible also can be edible after heating, can be used as dining table convenient dish, also can be used as chafing dish reinforced, be to meet the allegro a kind of convenient and instant food of the modern life, be a kind of nourishing health-care food with Chinese traditional characteristic.
Detailed description of the invention:
Embodiment 1
A kind of health care oral liquid, consists of: 40 parts of cordyceps sinensis fermentation liquors, 20 parts of Lentinus edodes fermented liquids, 20 parts of ganoderma lucidum fermented liquids, 4 parts of radix polygonati officinalis ophiopogon japonicus extracts, 4 parts of honey, 0.1 part, agar, 0.4 part, VC sodium by weight.
Embodiment 2
The preparation method of described oral liquid, comprises the steps:
The allotment of zymotic fluid: by ratio of weight and the number of copies, cordyceps sinensis fermentation liquor, Lentinus edodes fermented liquid and ganoderma lucidum fermented liquid are mixed, add radix polygonati officinalis ophiopogon japonicus extract, honey, agar and VC sodium in the fungal fermented filtrate mixing;
Zymotic fluid homogeneous processing: zymotic fluid is maintained the temperature to 80 DEG C and flow to colloid mill, the gap of adjusting colloid mill stator and rotor is 35 microns, and mycelium in zymotic fluid is carried out to fragmentation, and colloid mill flow is 3.5 tons/hour; Through high pressure homogenizer processing, adjusting high pressure homogenizer pressure is 40Mpa again, and high-pressure homogeneous flow is 2 tons/hour, and sediments microscope inspection mycelium sporoderm-broken rate is 100%;
Filling sterilizing: zymotic fluid after treatment is first carried out filling, filling after at 120 DEG C, sterilizing 35 seconds, obtains oral liquid;
(1) preparation of described cordyceps sinensis fermentation liquor: adopt slant strains to spread cultivation step by step and obtain aweto fungus zymotic fluid;
(1) first order seed is cultivated: Chinese caterpillar fungus slant strains is accessed in 500 ml shake flasks to 100 milliliters of fermentation medium loading amounts, 180 revs/min of rotary shaking tables, 24 DEG C of cultivation temperature, incubation time 50 hours;
(2) secondary seed is cultivated: by first order seed, according in 500 milliliters of secondary seed shaking flasks of inoculum concentration access of 10%, condition of culture is identical with first order seed;
(3) three grades of seed culture: secondary seed is accessed in 5000 milliliters of three grades of seed shaking flasks to 1000 milliliters of fermentation medium loading amounts, 100 revs/min of rotary shaking tables, 24 DEG C of cultivation temperature, incubation time 50 hours with 10% inoculum concentration;
(4) first class seed pot is cultivated: the first class seed pot by three grades of seeds taking 10% inoculum concentration access total measurement (volume) as 150L, fermentation medium loading amount 100L, 24 DEG C of cultivation temperature, 150 revs/min of mixing speeds, ventilation (V/V) 1:0.5, tank pressure 0.05Mpa, incubation time 48 hours;
(5) secondary seed tank is cultivated: first class seed pot bacterial classification is accessed to total measurement (volume) as 1.5 tons of secondary seed tanks taking 10% inoculum concentration, and 1 ton of fermentation medium loading amount, condition of culture is identical with first class seed pot;
(6) fermentation tank culture: the fermentation tank by the bacterial classification in secondary seed tank taking 10% inoculum concentration access total measurement (volume) as 13 tons, 10 tons of fermentation medium loading amounts, 24 DEG C of cultivation temperature, 100 revs/min of mixing speeds, ventilation (V/V) 1:0.4, tank pressure 0.05Mpa, incubation time 72 hours.
Described above-mentioned cordyceps sinensis fermentation liquor fermentation medium consists of: millet 2%, peptone 1%, beef extract 1%, corn 2.5%, the radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf of potassium dihydrogen phosphate 0.5%, 15%; Insufficient section distilled water is supplied, pH7.0-7.2,121 DEG C of high pressure steam sterilization 20min.
The preparation method of the described radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf is as follows: the mass ratio of radix polygonati officinalis and the tuber of dwarf lilyturf is 2:1, and both were pulverized to 100 orders, and crushed mixture is added to 5 times of water-soluble solutions, add the cellulase of mixture quality 2.5%, controlling temperature is 50 DEG C, and pH is 5, enzymolysis 35 minutes, adjusting temperature is 80 DEG C again, keeps 20 minutes, controls subsequently temperature to 55 DEG C, add the amylase of mixture quality 2%, pH is 5, and enzymolysis, after 45 minutes, obtains the radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf.
(2) preparation of described ganoderma lucidum fermented liquid: adopt slant strains to spread cultivation step by step and obtain ganoderma lucidum liquid submerged fermentation liquid:
(1) first order seed is cultivated: glossy ganoderma slant strains is accessed in 500 ml shake flasks that 100 milliliters of culture mediums are housed and cultivated, condition of culture: 150 revs/min of rotary shaking tables, cultivate 50 hours for 28 DEG C.
(2) secondary seed is cultivated: one-level shake-flask seed is accessed in 500 milliliters of secondary seed blake bottles that 100 milliliters of culture mediums are housed and cultivated with 10% inoculum concentration, and, condition of culture is identical with first order seed.
(3) three grades of seed culture: secondary seed is transferred to be equipped with in 5000 milliliters of three grades of seed culture bottles of 1000 milliliters of culture mediums with 10% inoculum concentration and cultivate, condition of culture: 180 revs/min of rotary shaking tables, cultivate 50 hours for 28 DEG C.
(4) first class seed pot is cultivated: the total measurement (volume) that 0.1 ton of fermentation medium is equipped with in the inoculum concentration access by three grades of seeds taking 10% is cultivated as the first class seed pot of 0.15 ton, condition of culture is: 28 DEG C of cultivation temperature, 150 revs/min of mixing speeds, ventilation (V/V) 1:0.5, tank pressure 0.05Mpa, cultivates 48 hours.
(5) secondary seed tank is cultivated: the bacterium liquid of first class seed pot is cultivated in 1.5 tons of secondary seed tanks taking 10% the inoculum concentration total measurement (volume) that 1 ton of fermentation medium is housed of transferring, and condition of culture is identical with first class seed pot.
(6) fermentation tank culture: finally the seed in secondary seed tank is accessed to the total measurement (volume) that 10 tons of fermentation mediums are housed in the fermentation tank of 15 tons taking 10% inoculum concentration.28 DEG C of fermentation tank culture temperature, 100 revs/min of mixing speeds, ventilation (V/V) 1:0.5, tank pressure 0.05Mpa, cultivates 120 hours.
It is 12% the enzymolysis liquid tuber of dwarf lilyturf that described ganoderma lucidum fermented liquid adds mass ratio 7 hours time in fermentation;
Described tuber of dwarf lilyturf, the preparation method of enzymolysis liquid was as follows: pulverize 100 orders the tuber of dwarf lilyturf, crushed mixture is added to 5 times of water-soluble solutions, and added the cellulase of mixture quality 2%, controlling temperature is 50 DEG C, and pH is 5.2, and enzymolysis 35 minutes, obtains the enzymolysis liquid tuber of dwarf lilyturf.
Described above-mentioned ganoderma lucidum fermented liquid fermentation medium consists of: millet 2%, and peptone 1%, beef extract 1%, corn 2.5%, potassium dihydrogen phosphate 0.5%, insufficient section distilled water is supplied, pH7.0-7.2,121 DEG C of high pressure steam sterilization 20min.
(3) preparation method of radix polygonati officinalis ophiopogon japonicus extract is as follows:
The mass ratio of radix polygonati officinalis and the tuber of dwarf lilyturf is 3:2; Pulverize radix polygonati officinalis and the tuber of dwarf lilyturf as particulate, add in jacketed pan, add 7 times of water, boil, keep micro-and boil 90 minutes, to the cellulase and the hemicellulase that add mixed liquor quality 2% in mixed liquor, control temperature 50 C, pH is 5, enzymolysis 40 minutes, the ratio of cellulase and hemicellulase is 1:2, enzymolysis liquid is crossed 200 mesh sieves, enters vacuum concentrator, and filter residue adds 240L water and again boils, micro-boiling 60 minutes, cross 200 mesh sieves, filter residue discards, filtrate and filtrate merging for the first time, Vacuum Concentration to original mixed liquid amasss 30%, obtains radix polygonati officinalis ophiopogon japonicus extract.
In the present invention, cordyceps species is bought in Chinese industrial microorganism fungus kind preservation administrative center, and deposit number is CICC14015, and lucidum strain is bought in Chinese industrial microorganism fungus kind preservation administrative center, and deposit number is CICC14027.
The preparation method of Lentinus edodes fermented liquid is as follows: the patent of invention that is CN101167760A with reference to publication number " having mushroom fermentation oral liquid of antitumor activity and preparation method thereof " is prepared.
Embodiment 3
A kind of health care oral liquid, consists of: 50 parts of cordyceps sinensis fermentation liquors, 15 parts of Lentinus edodes fermented liquids, 18 parts of ganoderma lucidum fermented liquids, 5 parts of radix polygonati officinalis ophiopogon japonicus extracts, 5 parts of honey, 0.1 part, agar, 0.5 part, VC sodium by weight;
Described cordyceps sinensis fermentation liquor fermentation medium component comprises: millet 2%, and peptone 1%, beef extract 1%, corn 2.5%, potassium dihydrogen phosphate 0.5%, insufficient section distilled water is supplied, pH7.0-7.2;
In described Chinese caterpillar fungus fermentation culture medium, be added with mass ratio and be 20% the radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf;
The preparation method of the described radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf is as follows: the mass ratio of radix polygonati officinalis and the tuber of dwarf lilyturf is 2:2, and both were pulverized to 100 orders, and crushed mixture is added to 6 times of water-soluble solutions, add the cellulase of mixture quality 3%, controlling temperature is 55 DEG C, and pH is 6, enzymolysis 40 minutes, adjusting temperature is 80 DEG C again, keeps 30 minutes, controls subsequently temperature to 50 DEG C, add the amylase of mixture quality 3%, pH is 6, and enzymolysis, after 30 minutes, obtains the radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf.
It is 15% the enzymolysis liquid tuber of dwarf lilyturf that described ganoderma lucidum fermented liquid adds mass ratio 8 hours time in fermentation;
Described tuber of dwarf lilyturf, the preparation method of enzymolysis liquid was as follows: pulverize 100 orders the tuber of dwarf lilyturf, crushed material is added to 6 times of water-soluble solutions, and added the cellulase of mixture quality 3%, controlling temperature is 55 DEG C, and pH is 4.5, and enzymolysis 40 minutes, obtains the enzymolysis liquid tuber of dwarf lilyturf.
The preparation method of described radix polygonati officinalis ophiopogon japonicus extract is as follows:
The mass ratio of radix polygonati officinalis and the tuber of dwarf lilyturf is 3:1; Pulverize radix polygonati officinalis and the tuber of dwarf lilyturf as particulate, add in jacketed pan, add 8 times of water, boil, keep micro-and boil 90 minutes, to the cellulase and the hemicellulase that add mixed liquor quality 1% in mixed liquor, control temperature 45 C, pH is 6, enzymolysis 50 minutes, the ratio of cellulase and hemicellulase is 1:2, enzymolysis liquid is crossed 200 mesh sieves, enters vacuum concentrator, and filter residue adds 240L water and again boils, micro-boiling 60 minutes, cross 200 mesh sieves, filter residue discards, filtrate and filtrate merging for the first time, Vacuum Concentration to original mixed liquid amasss 40%, obtains radix polygonati officinalis ophiopogon japonicus extract.
Embodiment 4
A kind of health care oral liquid, consists of: 30 parts of cordyceps sinensis fermentation liquors, 25 parts of Lentinus edodes fermented liquids, 24 parts of ganoderma lucidum fermented liquids, 3 parts of radix polygonati officinalis ophiopogon japonicus extracts, 4.5 parts of honey, 0.1 part, agar, 0.45 part, VC sodium by weight;
Described cordyceps sinensis fermentation liquor fermentation medium component comprises: millet 2%, and peptone 1%, beef extract 1%, corn 2.5%, potassium dihydrogen phosphate 0.5%, insufficient section distilled water is supplied, pH7.0-7.2;
In described Chinese caterpillar fungus fermentation culture medium, be added with mass ratio and be 10% the radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf;
The preparation method of the described radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf is as follows: the mass ratio of radix polygonati officinalis and the tuber of dwarf lilyturf is 2:1.5, and both were pulverized to 100 orders, and crushed mixture is added to 4 times of water-soluble solutions, add the cellulase of mixture quality 2%, controlling temperature is 45 DEG C, and pH is 4.5, enzymolysis 30 minutes, adjusting temperature is 80 DEG C again, keeps 10 minutes, controls subsequently temperature to 60 DEG C, add the amylase of mixture quality 1%, pH is 4, and enzymolysis, after 60 minutes, obtains the radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf.
It is 10% the enzymolysis liquid tuber of dwarf lilyturf that described ganoderma lucidum fermented liquid adds mass ratio 5 hours time in fermentation;
Described tuber of dwarf lilyturf, the preparation method of enzymolysis liquid was as follows: pulverize 100 orders the tuber of dwarf lilyturf, crushed material is added to 4 times of water-soluble solutions, and added the cellulase of mixture quality 2.5%, controlling temperature is 45 DEG C, and pH is 6, and enzymolysis 30 minutes, obtains the enzymolysis liquid tuber of dwarf lilyturf.
The preparation method of described radix polygonati officinalis ophiopogon japonicus extract is as follows:
The mass ratio of radix polygonati officinalis and the tuber of dwarf lilyturf is 3:1.5; Pulverize radix polygonati officinalis and the tuber of dwarf lilyturf as particulate, add in jacketed pan, add 5 times of water, boil, keep micro-and boil 90 minutes, to the cellulase and the hemicellulase that add mixed liquor quality 1.5% in mixed liquor, control 55 DEG C of temperature, pH is 4.5, enzymolysis 30 minutes, the ratio of cellulase and hemicellulase is 1:2, enzymolysis liquid is crossed 200 mesh sieves, enters vacuum concentrator, and filter residue adds 240L water and again boils, micro-boiling 60 minutes, cross 200 mesh sieves, filter residue discards, filtrate and filtrate merging for the first time, Vacuum Concentration to original mixed liquid amasss 20%, obtains radix polygonati officinalis ophiopogon japonicus extract.
Embodiment 5
The preparation method of described oral liquid, comprises the steps:
The allotment of zymotic fluid: by ratio of weight and the number of copies, cordyceps sinensis fermentation liquor, Lentinus edodes fermented liquid and ganoderma lucidum fermented liquid are mixed, add radix polygonati officinalis ophiopogon japonicus extract, honey, agar and VC sodium in the fungal fermented filtrate mixing;
Zymotic fluid homogeneous processing: zymotic fluid is maintained the temperature to 90 DEG C and flow to colloid mill, the gap of adjusting colloid mill stator and rotor is 25 microns, and mycelium in zymotic fluid is carried out to fragmentation, and colloid mill flow is 1 ton/hour; Through high pressure homogenizer processing, adjusting high pressure homogenizer pressure is 60Mpa again, and high-pressure homogeneous flow is 3 tons/hour, and sediments microscope inspection mycelium sporoderm-broken rate is 100%;
Filling sterilizing: zymotic fluid after treatment is first carried out filling, filling after at 135 DEG C, sterilizing 20 seconds, obtains oral liquid.
Eating effect narration:
This product selects 100 ages of Beijing area to eat continuously January the elderly of 60-75 years old weak easy catching a cold in the winter time, edible 100 grams of every day, to eat front and edible rear effect comparison, the results are shown in Table 1, result shows that this product has positive effect to raising the elderly resistance, enhancing body immunity, and product has good edible and nutritious tonifying effect.Many continuously edible this product old men reflect that to take for a long time effect better, and have no interest the whole year, and health is better.
The table 1 edible fungi nutrition nourishing soup eating effect table of comparisons
| Number | Edible first 30 days times of common cold (total) | Times of common cold (total) in 30 days after edible January |
| 100 | 31 | 8 |
Claims (10)
1. a health care oral liquid, is characterized in that, consists of by weight: cordyceps sinensis fermentation liquor 30-50 part, Lentinus edodes fermented liquid 15-25 part, ganoderma lucidum fermented liquid 18-24 part, radix polygonati officinalis ophiopogon japonicus extract 3-5 part, honey 4-5 part, 0.1 part, agar, VC sodium 0.4-0.5 part.
2. health care oral liquid according to claim 1, is characterized in that, described cordyceps sinensis fermentation liquor fermentation medium component comprises: millet 2%, peptone 1%, beef extract 1%, corn 2.5%, potassium dihydrogen phosphate 0.5%, insufficient section distilled water is supplied, pH7.0-7.2.
3. health care oral liquid according to claim 2, is characterized in that, in described Chinese caterpillar fungus fermentation culture medium, being added with mass ratio is the radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf of 10-20%;
The preparation method of the described radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf is as follows:
The mass ratio of radix polygonati officinalis and the tuber of dwarf lilyturf is 2:1-2, and both were pulverized to 100 orders, and crushed mixture is added to doubly water-soluble solution of 4-6, add the cellulase of mixture quality 2-3%, control temperature is 45-55 DEG C, and pH is 4.5-6, enzymolysis 30-40 minute, adjusting temperature is 80 DEG C again, keep 10-30 minutes, control subsequently temperature to 50-60 DEG C, add the amylase of mixture quality 1-3%, pH is 4-6, obtains the radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf after enzymolysis 30-60 minute.
4. according to the arbitrary described health care oral liquid of claim 1-3, it is characterized in that, described ganoderma lucidum fermented liquid adds the enzymolysis liquid tuber of dwarf lilyturf that mass ratio is 10-15% in the time fermenting to 5-8 hour;
Described tuber of dwarf lilyturf, the preparation method of enzymolysis liquid was as follows:
Pulverize 100 orders the tuber of dwarf lilyturf, crushed material is added to doubly water-soluble solution of 4-6, and added the cellulase of mixture quality 2-3%, control temperature is 45-55 DEG C, and pH is 4.5-6, and enzymolysis 30-40 minute obtains the enzymolysis liquid tuber of dwarf lilyturf.
5. health care oral liquid according to claim 1, is characterized in that, the preparation method of described radix polygonati officinalis ophiopogon japonicus extract is as follows:
The mass ratio of radix polygonati officinalis and the tuber of dwarf lilyturf is 3:1-2, pulverize radix polygonati officinalis and the tuber of dwarf lilyturf as particulate, add in jacketed pan, add 5-8 times of water, boil, keeping micro-boils 90 minutes, to the cellulase and the hemicellulase that add mixed liquor quality 1-2% in mixed liquor, control temperature 45-55 DEG C, pH is 4.5-6, enzymolysis 30-50 minute, the ratio of cellulase and hemicellulase is 1:2, enzymolysis liquid is crossed 200 mesh sieves, enter vacuum concentrator, filter residue adds 240L water and again boils, micro-boiling 60 minutes, cross 200 mesh sieves, filter residue discards, filtrate and filtrate merging for the first time, Vacuum Concentration is to the long-pending 20-40% of original mixed liquid, obtain radix polygonati officinalis ophiopogon japonicus extract.
6. a preparation method for health care oral liquid as described in claim 1-5, comprises the steps:
The allotment of zymotic fluid: by ratio of weight and the number of copies, cordyceps sinensis fermentation liquor, Lentinus edodes fermented liquid and ganoderma lucidum fermented liquid are mixed, add radix polygonati officinalis ophiopogon japonicus extract, honey, agar and VC sodium in the fungal fermented filtrate mixing;
Zymotic fluid homogeneous processing: zymotic fluid temperature is adjusted to 70-90 DEG C and flow to colloid mill, the gap of adjusting colloid mill stator and rotor is 10-50 microns, and mycelium in zymotic fluid is carried out to fragmentation, and colloid mill flow is 1-5 tons/hours; Through high pressure homogenizer processing, adjusting high pressure homogenizer pressure is 20-60Mpa again, and high-pressure homogeneous flow is 0.5-3 tons/hours, and sediments microscope inspection mycelium sporoderm-broken rate is 100%;
Filling sterilizing: zymotic fluid after treatment is first carried out filling, filling after at the temperature of 95 DEG C-135 DEG C, sterilizing 20-50 seconds, obtains oral liquid.
7. the preparation method of health care oral liquid according to claim 6, is characterized in that, described cordyceps sinensis fermentation liquor fermentation medium component comprises: millet 2%, peptone 1%, beef extract 1%, corn 2.5%, potassium dihydrogen phosphate 0.5%, insufficient section distilled water is supplied, pH7.0-7.2;
In described Chinese caterpillar fungus fermentation culture medium, being added with mass ratio is the radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf of 10-20%;
The preparation method of the described radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf is as follows: the mass ratio of radix polygonati officinalis and the tuber of dwarf lilyturf is 2:1-2, both were pulverized to 100 orders, crushed mixture is added to doubly water-soluble solution of 4-6, add the cellulase of mixture quality 2-3%, control temperature is 45-55 DEG C, pH is 4.5-6, enzymolysis 30-40 minute, adjusting temperature is 80 DEG C again, keeps 10-30 minutes, controls subsequently temperature to 50-60 DEG C, add the amylase of mixture quality 1-3%, pH is 4-6, after enzymolysis 30-60 minute, obtains the radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf.
8. the preparation method of health care oral liquid according to claim 6, is characterized in that, described ganoderma lucidum fermented liquid adds the enzymolysis liquid tuber of dwarf lilyturf that mass ratio is 10-15% in the time fermenting to 5-8 hour;
Described tuber of dwarf lilyturf, the preparation method of enzymolysis liquid was as follows:
Pulverize 100 orders the tuber of dwarf lilyturf, crushed material is added to doubly water-soluble solution of 4-6, and added the cellulase of mixture quality 2-3%, control temperature is 45-55 DEG C, and pH is 4.5-6, and enzymolysis 30-40 minute obtains the enzymolysis liquid tuber of dwarf lilyturf.
9. the preparation method of health care oral liquid according to claim 6, is characterized in that, the preparation method of described radix polygonati officinalis ophiopogon japonicus extract is as follows:
The mass ratio of radix polygonati officinalis and the tuber of dwarf lilyturf is 3:1-2, pulverize radix polygonati officinalis and the tuber of dwarf lilyturf as particulate, add in jacketed pan, add 5-8 times of water, boil, keeping micro-boils 90 minutes, to the cellulase and the hemicellulase that add mixed liquor quality 1-2% in mixed liquor, control temperature 45-55 DEG C, pH is 4.5-6, enzymolysis 30-50 minute, the ratio of cellulase and hemicellulase is 1:2, enzymolysis liquid is crossed 200 mesh sieves, enter vacuum concentrator, filter residue adds 240L water and again boils, micro-boiling 60 minutes, cross 200 mesh sieves, filter residue discards, filtrate and filtrate merging for the first time, Vacuum Concentration is to the long-pending 20-40% of original mixed liquid, obtain radix polygonati officinalis ophiopogon japonicus extract.
10. the preparation method of health care oral liquid according to claim 6, is characterized in that, comprises the steps:
The allotment of zymotic fluid: by ratio of weight and the number of copies, cordyceps sinensis fermentation liquor, Lentinus edodes fermented liquid and ganoderma lucidum fermented liquid are mixed, add radix polygonati officinalis ophiopogon japonicus extract, honey, agar and VC sodium in the fungal fermented filtrate mixing;
Zymotic fluid homogeneous processing: zymotic fluid is maintained the temperature to 80 DEG C and flow to colloid mill, the gap of adjusting colloid mill stator and rotor is 35 microns, and mycelium in zymotic fluid is carried out to fragmentation, and colloid mill flow is 3.5 tons/hour; Through high pressure homogenizer processing, adjusting high pressure homogenizer pressure is 40Mpa again, and high-pressure homogeneous flow is 2 tons/hour, and sediments microscope inspection mycelium sporoderm-broken rate is 100%;
Filling sterilizing: zymotic fluid after treatment is first carried out filling, filling after at 120 DEG C, sterilizing 35 seconds, obtains oral liquid;
Described above-mentioned cordyceps sinensis fermentation liquor fermentation medium consists of: millet 2%, peptone 1%, beef extract 1%, corn 2.5%, the radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf of potassium dihydrogen phosphate 0.5%, 15%; Insufficient section distilled water is supplied, pH7.0-7.2;
The preparation method of the described radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf is as follows: the mass ratio of radix polygonati officinalis and the tuber of dwarf lilyturf is 2:1, and both were pulverized to 100 orders, and crushed mixture is added to 5 times of water-soluble solutions, add the cellulase of mixture quality 2.5%, controlling temperature is 50 DEG C, and pH is 5, enzymolysis 35 minutes, adjusting temperature is 80 DEG C again, keeps 20 minutes, controls subsequently temperature to 55 DEG C, add the amylase of mixture quality 2%, pH is 5, and enzymolysis, after 45 minutes, obtains the radix polygonati officinalis enzymolysis liquid tuber of dwarf lilyturf;
It is 12% the enzymolysis liquid tuber of dwarf lilyturf that described ganoderma lucidum fermented liquid adds mass ratio 7 hours time in fermentation;
Described tuber of dwarf lilyturf, the preparation method of enzymolysis liquid was as follows: pulverize 100 orders the tuber of dwarf lilyturf, crushed mixture is added to 5 times of water-soluble solutions, and added the cellulase of mixture quality 2%, controlling temperature is 50 DEG C, and pH is 5.2, and enzymolysis 35 minutes, obtains the enzymolysis liquid tuber of dwarf lilyturf;
The preparation method of described radix polygonati officinalis ophiopogon japonicus extract is as follows:
The mass ratio of radix polygonati officinalis and the tuber of dwarf lilyturf is 3:2; Pulverize radix polygonati officinalis and the tuber of dwarf lilyturf as particulate, add in jacketed pan, add 7 times of water, boil, keep micro-and boil 90 minutes, to the cellulase and the hemicellulase that add mixed liquor quality 2% in mixed liquor, control temperature 50 C, pH is 5, enzymolysis 40 minutes, the ratio of cellulase and hemicellulase is 1:2, enzymolysis liquid is crossed 200 mesh sieves, enters vacuum concentrator, and filter residue adds 240L water and again boils, micro-boiling 60 minutes, cross 200 mesh sieves, filter residue discards, filtrate and filtrate merging for the first time, Vacuum Concentration to original mixed liquid amasss 30%, obtains radix polygonati officinalis ophiopogon japonicus extract.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104547546A (en) * | 2014-12-26 | 2015-04-29 | 扬子江药业集团四川海蓉药业有限公司 | Traditional Chinese medicinal composition for reinforcing kidney and moistening lung and preparation method of traditional Chinese medicinal composition in different dosage forms |
| CN106038705A (en) * | 2016-08-10 | 2016-10-26 | 翔天农业开发集团股份有限公司 | Antihypertensive health-care capsule and preparation method thereof |
| CN106074713A (en) * | 2016-08-10 | 2016-11-09 | 翔天农业开发集团股份有限公司 | A kind of antihypertensive health care oral liquid and preparation method thereof |
| CN106265936A (en) * | 2016-08-10 | 2017-01-04 | 翔天农业开发集团股份有限公司 | A kind of antihypertensive health care electuary and preparation method thereof |
| CN107823596A (en) * | 2017-11-22 | 2018-03-23 | 中山市择朋生物科技有限公司 | A kind of mouth containing system of mourning product and preparation method for being used for cough and asthma |
| CN107913292A (en) * | 2017-11-16 | 2018-04-17 | 徐州市卡农生物科技有限公司 | A kind of Ganoderma Sinense oral liquid |
| CN109200205A (en) * | 2017-06-30 | 2019-01-15 | 湖北悟芝堂生物科技有限公司 | Ganoderma lucidum traditional Chinese medicine oral liquid |
| CN115644335A (en) * | 2022-10-28 | 2023-01-31 | 江西水圣实业有限公司 | Ginseng and polygonatum odoratum fermented beverage |
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| CN109200205A (en) * | 2017-06-30 | 2019-01-15 | 湖北悟芝堂生物科技有限公司 | Ganoderma lucidum traditional Chinese medicine oral liquid |
| CN107913292A (en) * | 2017-11-16 | 2018-04-17 | 徐州市卡农生物科技有限公司 | A kind of Ganoderma Sinense oral liquid |
| CN107823596A (en) * | 2017-11-22 | 2018-03-23 | 中山市择朋生物科技有限公司 | A kind of mouth containing system of mourning product and preparation method for being used for cough and asthma |
| CN115644335A (en) * | 2022-10-28 | 2023-01-31 | 江西水圣实业有限公司 | Ginseng and polygonatum odoratum fermented beverage |
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