CN107823596A - A kind of mouth containing system of mourning product and preparation method for being used for cough and asthma - Google Patents
A kind of mouth containing system of mourning product and preparation method for being used for cough and asthma Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/342—Adenophora
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The present invention relates to traditional Chinese medical science product and its process technology, and in particular to a kind of mouth containing system of mourning product and preparation method for being used for cough and asthma.The product is the aqueous extract and mushroom parent species liquid and northern Cordyceps militaris parent species liquid common fermentation products therefrom of following bulk drug；The weight of bulk drug is：Orange 45 55, almond 37, the tuber of stemona 8 15, pinellia 37, fritillaria thunbergii 37, bulbus fritillariae cirrhosae 37, cordate houttuynia 18 25, raw ternip 45 55, product real 37, product shell 37, solanum lyratum 37, dried orange peel 37, rascal 37, ginger 37, mulberries 37, purslane 37, Cynanchum glaucescens 37, crystobalite 37, BAISHASHEN 37, Asiatic plantain 37, leaflet desmodium 37, loguat leaf 37, red bayberry dry 37.The product can effectively alleviate the disease such as cough, uncomfortable in chest, expiratory dyspnea, expectoration, Small side effects.
Description
Technical field
The present invention relates to traditional Chinese medical science product and its process technology, and in particular to a kind of mouth containing system of mourning product for being used for cough and asthma
With preparation method.
Background technology
Asthma is by the various kinds of cell chronic airway that particularly mast cell, eosinophil and T lymphocytes participate in
Inflammation, it is a kind of disease of the multiple-factor inheritance tendency with complex character, it is characterized in that nonpenetrance, hereditary heterogeneousization is more
Gene genetic and synergy.Clinical manifestation is ictal cough, uncomfortable in chest and expiratory dyspnea.Some patientss expectoration, more than breaking-out
Abundant expectoration when tending to alleviate.The order of severity and duration individual difference during breaking-out is very big, and the lighter only has feeling of chest tightness, continues
Several minutes, severe one is extremely had difficulty in breathing, continued for several weeks or longer time.The characteristics of symptom is invertibity, i.e., can be after treatment
Alleviate in short period, part natural remission, also there is small part not alleviate and be in persistent state.Breaking-out often have certain induction because
Element, many patient episodes have an obvious biological law, break out or aggravate during daily morning 2~6, when being typically apt to occur in spring and summer handing-over
Or winter.
The medicine for the treatment of asthma is more at present, is broadly divided into two classes：(1) bronchodilatation medicine：β 2 receptor agonist, anti-courage
Alkali medicine, theophylline class；(2) anti-inflammatory agent：Glucocorticoid, leukotriene modifer.Long-term anti-inflammatory treatment is the treatment on basis, and first choice is inhaled
Enter hormone；The choice drug of emergent relief of symptoms is suction β2agonists；The undesirable person of Morbidity control after rule powder for inhalation, preferably
Add with the long-acting β2agonists of suction, or slow release theophylline；Severe asthma patient, by above-mentioned treatment still prolonged and repeated breaking-out when, can
Consideration do intensive treatment, i.e., handled according to severe asthma attacks, give heavy dose of hormone etc. treatment, treat symptom control completely, lung
After functional rehabilitation optimum level and PEF (maximum expiratory flow volume) stability bandwidth are normal after 2 to 4 days, hormone dosage is gradually decreased.For a long time
It is larger using these side effects of pharmaceutical drugs, such as β2agonists easily cause palpitaition, hand shaking, muscle twitches, it is long-term use of may
Cause beta 2 receptor function to be lowered with airway reactivity to increase.The therapeutic dose and toxic dose of theophylline class medicine are very close, hold
Easily cause Nausea and vomiting, poor appetite, insomnia, tachycardia, heart-rate-turbulence, convulsions, blood pressure rapid drawdown.Long-term use of hormone is easy
Initiation pharyngeal pain, pharyngeal fungal infection, increased weight, blood glucose increase, the symptom such as osteoporosis.
Asthma is a kind of chronic disease easily recurred, it is therefore necessary to which asthma disease can effectively be alleviated by researching and developing one kind
The good Chinese medicine preparation of shape, long-term use of security.
The content of the invention
In order to make up the big deficiency of existing asthmatic medicament long-term use side effect, the present invention provides a kind of for coughing and roaring
The mouth containing system of mourning product and its preparation technology of asthma, it can effectively alleviate the diseases such as cough, uncomfortable in chest, expiratory dyspnea and expectoration, make for a long time
It is safe with Small side effects.
The claimed technical scheme of the present invention is as follows：
A kind of mouth containing system of mourning product for being used for cough and asthma, it is characterised in that：
It is that the aqueous extract of following bulk drug carries out the production obtained by common fermentation with mushroom parent species liquid and northern Cordyceps militaris parent species liquid
Thing；
The weight of the bulk drug is：
Orange 45-55, almond 3-7, tuber of stemona 8-15, pinellia 3-7, fritillaria thunbergii 3-7, bulbus fritillariae cirrhosae 3-7, cordate houttuynia 18-25,
Raw ternip 45-55, long-pending real 3-7, long-pending shell 3-7, solanum lyratum 3-7, dried orange peel 3-7, rascal 3-7, ginger 3-7, mulberries 3-7, purslane
3-7, Cynanchum glaucescens 3-7, crystobalite 3-7, BAISHASHEN 3-7, Asiatic plantain 3-7, leaflet desmodium 3-7, loguat leaf 3-7, red bayberry do 3-7.
Preferably, the aqueous extract of the bulk drug uses hydrogen rich water as Extraction solvent, and the hydrogen rich water is day Tian Tianling
Water.
Preferably, the bulk drug has following any group of weight：
Orange 50, almond 5, the tuber of stemona 10, pinellia 5, fritillaria thunbergii 5, bulbus fritillariae cirrhosae 5, cordate houttuynia 20, raw ternip 50, product real 5,
Product shell 5, solanum lyratum 5, dried orange peel 5, rascal 5, ginger 5, mulberries 5, purslane 5, Cynanchum glaucescens 5, crystobalite 5, BAISHASHEN 5, Asiatic plantain 5,
Leaflet desmodium 5, loguat leaf 5, red bayberry dry 5；
Orange 45, almond 4, the tuber of stemona 8, pinellia 7, fritillaria thunbergii 3, bulbus fritillariae cirrhosae 7, cordate houttuynia 23, raw ternip 55, product real 3,
Product shell 7, solanum lyratum 3, dried orange peel 3, rascal 7, ginger 3, mulberries 3, purslane 7, Cynanchum glaucescens 3, crystobalite 6, BAISHASHEN 7, Asiatic plantain 3,
Leaflet desmodium 7, loguat leaf 7, red bayberry dry 7；
Orange 55, almond 6, the tuber of stemona 15, pinellia 3, fritillaria thunbergii 7, bulbus fritillariae cirrhosae 3, cordate houttuynia 19, raw ternip 45, product real 7,
Product shell 3, solanum lyratum 7, dried orange peel 7, rascal 3, ginger 7, mulberries 7, purslane 3, Cynanchum glaucescens 7, crystobalite 4, BAISHASHEN 3, Asiatic plantain 7,
Leaflet desmodium 3, loguat leaf 3, red bayberry dry 3；
Orange 48, almond 3, the tuber of stemona 9, pinellia 6, fritillaria thunbergii 4, bulbus fritillariae cirrhosae 6, cordate houttuynia 18, raw ternip 53, product real 4,
Product shell 6, solanum lyratum 4, dried orange peel 4, rascal 6, ginger 4, mulberries 4, purslane 6, Cynanchum glaucescens 4, crystobalite 7, BAISHASHEN 6, Asiatic plantain 4,
Leaflet desmodium 6, loguat leaf 6, red bayberry dry 6；Or
Orange 54, almond 7, the tuber of stemona 13, pinellia 4, fritillaria thunbergii 6, bulbus fritillariae cirrhosae 4, cordate houttuynia 25, raw ternip 47, product real 6,
Product shell 4, solanum lyratum 6, dried orange peel 6, rascal 4, ginger 6, mulberries 6, purslane 4, Cynanchum glaucescens 6, crystobalite 3, BAISHASHEN 4, Asiatic plantain 6,
Leaflet desmodium 4, loguat leaf 4, red bayberry dry 4.
A kind of raw material drug composition for being used to prepare cough and asthma mouth containing system of mourning product, it is characterised in that：Including A raw materials
Medicine, its weight are：
Orange 45-55, almond 3-7, tuber of stemona 8-15, pinellia 3-7, fritillaria thunbergii 3-7, bulbus fritillariae cirrhosae 3-7, cordate houttuynia 18-25,
Raw ternip 45-55, long-pending real 3-7, long-pending shell 3-7, solanum lyratum 3-7, dried orange peel 3-7, rascal 3-7, ginger 3-7, mulberries 3-7, purslane
3-7, Cynanchum glaucescens 3-7, crystobalite 3-7, BAISHASHEN 3-7, Asiatic plantain 3-7, leaflet desmodium 3-7, loguat leaf 3-7, red bayberry do 3-7.
Preferably, the A bulk drugs have following any group of weight：
Orange 50, almond 5, the tuber of stemona 10, pinellia 5, fritillaria thunbergii 5, bulbus fritillariae cirrhosae 5, cordate houttuynia 20, raw ternip 50, product real 5,
Product shell 5, solanum lyratum 5, dried orange peel 5, rascal 5, ginger 5, mulberries 5, purslane 5, Cynanchum glaucescens 5, crystobalite 5, BAISHASHEN 5, Asiatic plantain 5,
Leaflet desmodium 5, loguat leaf 5, red bayberry dry 5；
Orange 45, almond 4, the tuber of stemona 8, pinellia 7, fritillaria thunbergii 3, bulbus fritillariae cirrhosae 7, cordate houttuynia 23, raw ternip 55, product real 3,
Product shell 7, solanum lyratum 3, dried orange peel 3, rascal 7, ginger 3, mulberries 3, purslane 7, Cynanchum glaucescens 3, crystobalite 6, BAISHASHEN 7, Asiatic plantain 3,
Leaflet desmodium 7, loguat leaf 7, red bayberry dry 7；
Orange 55, almond 6, the tuber of stemona 15, pinellia 3, fritillaria thunbergii 7, bulbus fritillariae cirrhosae 3, cordate houttuynia 19, raw ternip 45, product real 7,
Product shell 3, solanum lyratum 7, dried orange peel 7, rascal 3, ginger 7, mulberries 7, purslane 3, Cynanchum glaucescens 7, crystobalite 4, BAISHASHEN 3, Asiatic plantain 7,
Leaflet desmodium 3, loguat leaf 3, red bayberry dry 3；
Orange 48, almond 3, the tuber of stemona 9, pinellia 6, fritillaria thunbergii 4, bulbus fritillariae cirrhosae 6, cordate houttuynia 18, raw ternip 53, product real 4,
Product shell 6, solanum lyratum 4, dried orange peel 4, rascal 6, ginger 4, mulberries 4, purslane 6, Cynanchum glaucescens 4, crystobalite 7, BAISHASHEN 6, Asiatic plantain 4,
Leaflet desmodium 6, loguat leaf 6, red bayberry dry 6；Or
Orange 54, almond 7, the tuber of stemona 13, pinellia 4, fritillaria thunbergii 6, bulbus fritillariae cirrhosae 4, cordate houttuynia 25, raw ternip 47, product real 6,
Product shell 4, solanum lyratum 6, dried orange peel 6, rascal 4, ginger 6, mulberries 6, purslane 4, Cynanchum glaucescens 6, crystobalite 3, BAISHASHEN 4, Asiatic plantain 6,
Leaflet desmodium 4, loguat leaf 4, red bayberry dry 4.
The preparation method of any described mouth containing system of mourning product for being used for cough and asthma, it is characterised in that：Including following step
Suddenly：
(1) aqueous extract of preparing raw material medicine；
(2) aqueous extract of bulk drug and mushroom parent species liquid and northern Cordyceps militaris parent species liquid are subjected to common fermentation, fermented
Product；
Characterized in that, the extraction process of the aqueous extract of the bulk drug is as follows：In extraction vessel, water and original are added
Expect medicine；The part by weight of water and the bulk drug is 3-6：1, under 25-35 DEG C, 800mpa environment extract 30-50 minutes obtain
The aqueous extract of the bulk drug.
Preferably, the water is hydrogen rich water, and hydrogen rich water and the part by weight of the bulk drug are 4-5：1,28-32 DEG C,
Extraction 30-40 minutes obtain the aqueous extract of the bulk drug under 800mpa environment.
Preferably, the progress common fermentation refers to
In fermentation tank, by 30-50：30-50：5-10：The aqueous extract of the 5-10 volume ratio addition bulk drug,
Water, mushroom parent species liquid and northern Cordyceps militaris parent species liquid, ferment and put tank when reaching more than 80g/L to effective solid contents.
Preferably, by 35-45：35-45：6-8：6-8 volume ratio adds aqueous extract, water, the mushroom of the bulk drug
Parent species liquid and northern Cordyceps militaris parent species liquid.
Preferably, after fermentation ends put tank, tunning enters alcohol precipitation extractor, the hair described in less than 30 DEG C of floodings
Ferment product 5 hours, is then boiled, and filtering, takes filtrate, and the ethanol that the volume fraction for adding 4 times of filtrate volumes is 75% is soaked
Profit, 50 DEG C of recovery ethanol are warming up to after stirring, finally precipitation is dried at a temperature of≤55 DEG C, is milled, crosses 60 mesh sieves
Finished product is obtained, or is spray-dried to obtain finished product.
Inventor passes on definition, the compatibility thought of Chinese medicine medication, in compatibility according to the traditional Chinese medical science by research to the ancient times of asthma
On the basis of the Chinese medicine material medicine gone out, edible mushroom creatively is used in combination with the method for co-fermentation, is eaten by fermenting
Greatly improved with the ratio of the polysaccharide in bacterium, the plant polyose in Chinese medicine, while make other active ingredient separation in Chinese medicine
Out.Plant polyose and edible fungi polysaccharide collaboration leniently act on patients immune system, patients immune system is gradually recovered
To normal level, strengthen the recognition capability to foreign substance, improve Abwehrkraft des Koepers, gradually reduce asthma attack frequency；Meanwhile
Active ingredient in Chinese medicine material medicine can relieving cough and asthma, qi-regulating and phlegm-dissipating, clearing heat and promoting fluid, abundant expectoration when can effectively alleviate asthma attack
The symptoms such as cough, shortness of breath uncomfortable in chest.Both combine, and can play a part for the treatment of both principal and secondary aspect of disease for cough and asthma.
The product of present invention water used in preparation process is preferably hydrogen rich water, and hydrogen rich water is best polyphenoils,
Integrate high hydrogen amount, alkalescent, negative potential, micromolecular water, easily being shuttled in cell membrane participates in metabolism, thin so as to promote
Born of the same parents' toxin expelling, add the aquation of cell.
Another main contribution of the present invention is, additionally provides the preparation of the mouth containing system of mourning product specifically for the present invention
Method, preferably hydrogen rich water extract traditional Chinese medicine ingredients as solvent under normal temperature, super-pressure (30 DEG C, 800mpa), can be to greatest extent
Ground extracts Chinese medicine plant cell wall content, and keeps original composition, its molecular structure simply from diminishing greatly so that
Retain drug effect and bulk drug is basically identical.
Multiple components have relieving cough and asthma, qi-regulating and phlegm-dissipating work in the Chinese medicine used in the mouth containing system of mourning product of the present invention
With the bulk drug pharmacology of use is as follows：
It is orange：For rutaceae orange Citrus reticulata Blanco and its drying outer layer fruit of variety
Skin, nickname Exocarpium Citri Rubrum, rue skin, rue are red.Acrid flavour, hardship, warm-natured, return lung, the spleen channel.With regulating the flow of QI to ease the stomach, it is eliminating dampness and eliminating phlegm the effect of, be used for
Coughing with a lot of sputum, dyspepsia are got sick from drinking too much wine, and evil of vomitting ruffian is vexed.
Almond：It is the seed of rose family apricot, is divided into dessert almond and semen armeniacae amarae.Semen armeniacae amarae bitter, slightly warm in nature is slightly poisonous, tool
There is the effect of relieving cough and asthma, to relax bowel.Dessert almond is sweet, mild-natured, has the effect of moistening the lung and relieve the cough, is mainly used in consumptive disease cough
Cough.
The tuber of stemona：It is the plant Stemona japonica of Stemonaceae, also known as mother-in-law woman is careless, belongs to perennial herb.The nickname tuber of stemona
Grass, hundred roots, noisy lice, beautiful vertical bamboo flute, arrow shaft, medicine lice medicine.It is sweet, bitter, slightly warm in nature, return lung warp.With relieving cough and reducing sputum, gentle lung qi,
The effect of radiating inducing diaphoresis, coughed for new chronic cough, pulmonary tuberculosis cough, pertussis.
Pinellia：Since ancient times, the tuber of pinellia is listed in drugs class Chinese medicine, and the pinellia toxicity obtained after processing reduces.Ginger
Tuber of pinellia acrid flavour, warm-natured, returns spleen, stomach, lung channel.There is eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, for many coughs of phlegm, vomiting gastric disorder causing nausea,
Chest gastral cavity ruffian, globus hysteriocus.
Fritillaria thunbergii：Fritillaria thunbergii, also known as bulb of thunberg fritillary, it is perennial Liliaceae herbaceous plant fritillaria thunbergii
Bulb.Bitter, cold in nature, return lung, the heart channel of Hang-Shaoyin.The effect of with clearing heat and eliminating phlegm, powder detoxifcation, cure mainly wind-heat or phlegm-heat cough, lung carbuncle
Larynx numbness, scrofula, sore swollen toxin.
Bulbus fritillariae cirrhosae：Fritillaria praewalskii maxim ex Batal, liliaceous plant, are grown in temperate zone height
It is the rare traditional Chinese medicine to moisten the lung and relieve the cough in mountain, the mixed coniferous broad leaved forest of plateau band, coniferous forest, alpine scrub.Bitter, sweet, property
It is slightly cold, return lung, the heart channel of Hang-Shaoyin.With clearing heat and eliminating phlegm, moisten the lung and relieve the cough, the effect of mass dissipating and swelling eliminating, cure mainly consumptive disease chronic cough, lung-heat type cough, lung
Carbuncle pyemesis, scrofula tuberculosis, acute mastitis, sore swells.
Cordate houttuynia：For saururaceae plant houttuynia cordata (Houttuynia cordata Thunb.) dry aerial parts.Taste
It is pungent, cold, return lung warp.The effect for the treatment of sore, promoting urination and removing dampness, clearing away heat to cure dysentery, stomach strengthening and digestion promoting with clearing heat and detoxicating, detumescence, is used for
It is the lung carbuncle of trouble, sore swollen toxin, retention of heat in the spleen and stomach etc. to treat real heat, heat toxin, damp evil, disease heat.
Raw ternip：Rhizome vegetable, Cruciferae radish platymiscium.It is sweet, pungent, cool in nature, enter liver, stomach, lung, large intestine channel.
With clearing heat and promoting fluid, cooling blood and hemostasis, lower gas it is wide in, relieving dyspepsia, Appetizing spleen-tonifying, qi-regulating and phlegm-dissipating the effect of, can treat hypertension,
Asthma, influenza and infantile pneumonia.
Product is real：Also known as the dried immature fruit of citron orange, it is rutaceae bitter orange and its drying young fruit of variety or sweet orange.Bitter, pungent, property
It is slightly cold, returns spleen, stomach, large intestine channel.With the effect of relieving stagnant Qi disperse accumulations, resolving sputum removes ruffian, for coughing, dyspepsia is stagnated, constipation of suffering from abdominal pain, water
It is swollen to wait disease.
Product shell：Also known as Fructus Aurantii, it is the nearly mellow fruit such as rutaceae trifoliate orange, bitter orange, citrus medic L., bitter citrus immature flower.It is cool in nature,
It is bitterly, enter lung, spleen, large intestine channel, there is the effect of relieving stagnant Qi, row phlegm, disperse accumulations, for treating stagnant chest diaphragm phlegm, the feeling of stuffiness in chest, the side of body is swollen, food
Product, gas, the disease such as inverse of vomitting.
Solanum lyratum：Latin name Solanum lyratum Thunb., are Aristolochiaceae, birthwort, alias another name for Sichuan Province sheep
Spring, paddy dish, Herba Bryophylli Pinnati, air draft, Hu Maoteng.It is sweet, bitter, it is cold in nature, enter Liver Channel.The effect of with heat-clearing, dampness removing, wind-dispelling, removing toxic substances,
The diseases such as malaria, jaundice, oedema, gonorrhoea, rheumatic arthritis, erysipelas, furunculosis can be treated.
Dried orange peel：Nickname orange peel, it is the dry of rutaceae orange Citrus reticulata Blanco and its variety
Dry ripe pericarp.Bitter, pungent, warm-natured, return lung, the spleen channel.With regulating qi-flowing for strengthening spleen, it is eliminating dampness and eliminating phlegm the effect of, for abdominal fullness and distention, food
It is few to vomit and diarrhoea, coughing with a lot of sputum.
Rascal：Drying young fruit for rutaceae orange Citrus reticulata Blanco and its variety or not
The pericarp of ripening fruits.Bitter, pungent, warm-natured, Return liver, courage, stomach.With soothing the liver relieving stagnant Qi, disperse accumulationsization is stagnant the effect of, for chest side of body
Distending pain, hernia pain, stagnation of QI due to dyspepsia, abdominal distention.
Ginger：It is Zingiber herbaceos perennial ginger (Zingiber officinale Roscoe) new fresh quench stem, not
Name, which has race, hundred peppery clouds, hooks dress refers to, because ground is pungent, hot and cold boy, fresh ginger, honey process ginger.Acrid flavour, slightly warm in nature, return lung, spleen, stomach
Through.With relieving exterior syndrome and dispelling cold, warming middle energizer to arrest vomiting, the effect of preventing phlegm from forming and stopping coughing, for anemofrigid cold, gastrofrigid vomiting, cold productive cough is coughed.
Mulberries：For the mature fruit cluster of Moraceae deciduous tree mulberry tree.It is sweet, cold in nature, the thoughts of returning home, liver and kidney channel.Mended with enriching yin
Blood, ease constipation, the effect of promoting the production of body fluid, for the yin deficiency deficiency of blood, the deficiency of Yin is quenched one's thirst, and body fluid deficiency is thirsty, dizziness and tinnitus, dry constipation of intestines.
Purslane：For the young young stem and leaf of amaranthaceous plant purslane, alias horse amaranth, Wu Hangcao, five sides grass, long life dish, nine
Lion grass, Ma Shengcai.It is sour, cold in nature, the thoughts of returning home, liver, spleen, large intestine channel.With clearing heat and detoxicating, Li Shui dries, and dissipates the work(of blood detumescence
Effect, for heat toxin rush down dysentery, carbuncle swells boil, erysipelas, scrofula, mesh screen, uterine bleeding, has blood in stool, hemorrhoid blood, leukorrhea with reddish discharge, heat gonorrhea, and swelling of vulva is wet
Tinea, it is white bald.
Cynanchum glaucescens：For Luo Mo sections plant rhizoma et radix cynanchi stauntoni or the dry rhizome and root of leaves of Daphne genkwa Cynanchum glaucescens.Acrid flavour, hardship, slightly warm in nature, return
Lung channel.With sending down abnormally ascending, dissolving phlegm, the effect of cough-relieving, stop up real, coughing with a lot of sputum for lung qi, fullness sensation in chest asthma is anxious.
Crystobalite：For the ore of oxide-based mineral quartz.It is sweet, it is warm-natured, enter lung, kidney, the heart channel of Hang-Shaoyin.With warm lung kidney, peace
The mind, the effect of diuresis, for treating lung cold cough and asthma, quenching one's thirst, the disease such as confused and worried, palpitation with fear is forgetful, difficult urination, jaundice.
BAISHASHEN：Campanulaceae adenophora tetraphylla Adenophora tetraphylla (Thunb.) Fisch. or the root of straight ladybell
A.Stricta Miq. etc. root, alias steep the root of straight ladybell, RADIX ADENOPHORAE.Sweet, slight bitter, it is cool in nature, enter lung, stomach.With clearing lung and nourishing yin,
Eliminating the phlegm, the effect of cough-relieving, for treating cough with lung heat, cough up phlegm not well, pertussis, dryness of the mouth and throat, toothache caused by fire of deficiency type.
Asiatic plantain：For plantago plant Chinese herbaceous peony Plantago asiatica L. or ordinary building Plantagodepressa
Willd. drying or fresh herb, nickname frog clothing, ox are lost, victory formal shoe.It is sweet, cold in nature, Return liver, kidney, bladder warp.With clear
Heat, diuresis, eliminating the phlegm, cool blood, the effect of removing toxic substances, for oedema oliguria, puckery pain of heat gonorrhea, summer-heat and damp rush down dysentery, phlegm-heat cough, nosebleed of spitting blood
Blood, carbuncle sore tumefacting virus.
Leaflet desmodium：For the herb of convolvulaceous plant dewdrop grass, nickname pocket grass, Boiled small dumplings with pork grass, golden key, jaundice
Grass, small membranaceous marshmarigold herb.It is bitterly, it is cool in nature, enter lung, liver two passes through.With heat-clearing, removing toxic substances, Li Shui, the effect of promoting blood circulation, for jaundice, dysentery
Disease, stranguria dne to urolithiasis pain, gonorrhoea, oedema, furuncle swelling toxin, traumatic injury.
Loguat leaf：For the leaf of rosaceous plant loquat, also known as Ba Ye, Lu Juye.Bitter, cold nature, return lung, stomach.
The effect of with removing heat from the lung to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI, it is anxious to be usually used in treating cough with lung heat, circulation of vital energy in the wrong direction asthma, and stomach energy is vomitted inverse, the disease such as dysphoria and thirsty
Disease.
Red bayberry does：The dry fruit of Myruca ceas magaphanerophytes red bayberry.Sweet, acid is warm-natured, attaches to the lung and stomach meridians.With quench the thirst,
Antidiarrheal, preventing or arresting vomiting, help digestion, diuresis the effect of, for habitual constipation, cancer, sphagitis, dysentery, enterogastritis.
Wherein, orange, pinellia, product are real, product shell, dried orange peel, rascal, Cynanchum glaucescens have the function that regulating the flow of QI to ease the stomach, relieving cough and reducing sputum,
The symptom such as coughing with a lot of sputum, not easypro, expiratory dyspnea uncomfortable in chest when can effectively alleviate asthma attack.The traditional Chinese medical science thinks, lung being a delicate viscus, happiness profit and
Dislike dry, therefore, be aided with the Chinese medicines such as almond, the tuber of stemona, fritillaria thunbergii, bulbus fritillariae cirrhosae, crystobalite, BAISHASHEN, loguat leaf, ginger, have
Gentle lung qi, clearing lung and nourishing yin, relieving cough and reducing sputum effect, from body, cough is cured from inside to outside.Cordate houttuynia, white hair
Rattan, purslane, Asiatic plantain, leaflet desmodium have the function that clearing heat and detoxicating, scattered blood detumescence, for treating airway inflammation, alleviate
The asthmas such as cough, uncomfortable in chest, shortness of breath.Raw ternip, mulberries, red bayberry dry the effect of promoting the production of body fluid to quench thirst, throat is moistened, so as to reach
To the purpose for alleviating cough.
The present invention uses the aqueous extract common fermentation of mushroom parent species liquid and northern Cordyceps militaris parent species liquid and above-mentioned Chinese medicine material medicine,
Wherein, mushroom, also known as flower mushroom, mushroom, fragrant letter, fragrant bacterium, dried mushroom, fragrant wild rice, it is the fructification of Pleurotaceae plant mushroom.It is sweet, property
It is flat.The lentinan (β~1,3 glucans) contained in mushroom can improve the immunologic function of human body.Go out from the angle strengthened the body resistance to consolidate the constitution
Hair, the resistance against diseases of enhancing body in itself.For the mushroom parent species liquid of the present invention, the strain that the present invention uses is not limited to, typically
It is that may be incorporated for the present invention after liquid parent species that commercially available test tube stock, which expands numerous,.
Northern Cordyceps militaris：Also known as Cordceps militaris, northern cordyceps, Cordyceps militaris, pupa grass, it is worm, the medicinal fungi of bacterium combination, belongs to true
Bacterium door, Ascomycetes, Hypocreales, Clavicipitaceae, Cordyceps.Contain cordycepin, cordycepic acid and various amino acid in cordyceps sinensis
Deng nutriment, there is nourishing the lung and the kidney, hemostasis and phlegm, expansion tracheae, calmness, anti-all kinds of bacteriums and other effects, for asthma
There is good remission effect.For the northern Cordyceps militaris parent species liquid of the present invention, the strain that the present invention uses is not limited to, it is typically commercially available to obtain
Test tube stock expand it is numerous be liquid parent species after may be incorporated for the present invention.
Those skilled in the art, can obtain the mouth containing system of mourning product of the present invention according to present disclosure, and this is made
Product add pharmaceutically acceptable auxiliary element, such as excipient, suspending agent, sustained release agent, flavor enhancement as active ingredient, from
And the oral drugs of various formulations are made.These medicines belong to the same design of the present invention, therefore also request is given herein
Protection.
Embodiment
Below by way of specific embodiment description product of the invention and its preparation technology, it is necessary to explanation, following implementations
Example is only used as explanation of the invention, does not limit the scope of the invention.
First, material：
Mushroom test tube stock：Purchased from Chinese agriculture Microbiological Culture Collection administrative center, deposit number：50170, specification：
Test tube slant kind (test tube specification 18mm × 180mm, about 40 milliliters).The bacterium described in buy or prior art it is other
Bacterial strain is also applied for the present invention.Also there is preservation in the parent species, applicant laboratory, and are prepared into test tube mycelia parent species, from application
Day rises 20 years and can provided to the public for experimental study.
Northern Cordyceps militaris test tube stock：Purchased from Chinese agriculture Microbiological Culture Collection administrative center, deposit number：51762, rule
Lattice：Test tube slant kind (test tube specification 18mm × 180mm, about 40 milliliters).The bacterium described in buy or prior art
Other bacterial strains are also applied for the present invention.Also there is preservation in the parent species, applicant laboratory, and are prepared into test tube mycelia parent species, from
It can be provided to the public for experimental study within 20 years from the applying date.
Chinese agriculture Microbiological Culture Collection administrative center, contact method 010-68918636,010-68918651,010-
68918683, accc@caas.ac.cn, address：No.12 ,zhongguancun south street,Haidian District, Beijing.
Medicinal plant：Orange, almond, the tuber of stemona, pinellia, fritillaria thunbergii, bulbus fritillariae cirrhosae, cordate houttuynia, raw ternip, product are real, product
Shell, solanum lyratum, dried orange peel, rascal, ginger, mulberries, purslane, Cynanchum glaucescens, crystobalite, BAISHASHEN, Asiatic plantain, leaflet desmodium, Pi
Rake leaf, red bayberry do, and are commercially available in general Chinese medicine pharmacy.
2nd, hydrogen rich water：Day field day inland waters.
3rd, equipment：
Super-pressure pot：DEPCOA -500, using ultra-high pressure sterilization technology (Ultra-highpressure
Processing), abbreviation UHP；High pressure processing of food technology (highpressure processing).
Fermentation tank：For the patent No. 03270560.3, entitled " cover and culture tank of vaccine culturing-pot for edible "
Utility model patent described in fermentation tank.
Syringe：Patent No. 200320126960.X, entitled " edible fungus liquid injection rod and the note comprising the injection rod
Syringe described in the utility model patent of emitter ".
Embodiment 1. is used to cough and No. 1 mouth containing system of mourning product of asthma
Prepare parent species liquid：
According to the following steps, mushroom, the parent species liquid of northern Cordyceps militaris are prepared respectively：
(1) fluid nutrient medium is prepared：Magnesium sulfate 20g, dipotassium hydrogen phosphate 50g, potassium dihydrogen phosphate are added in 18L hydrogen rich waters
50g, sucrose 250g, starch 250g, hydrogen rich water is added to be settled to 20L.
(2) fluid nutrient medium is injected in 500ml vials, every bottle of 400ml, one there are 50 bottles, insert portable pressure cooker
Inherent 0.012MP/cm2, 30min, 28 DEG C~34 DEG C are cooled to after taking-up, is put into superclean bench, fluid nutrient medium is made.
(3) instrument, vessel and fluid nutrient medium are put into superclean bench, are inserted and filled with 30g potassium permanganate
In 50% formalin 30ml vessel, hook, rake, pin, the knife of inoculation are put into the vessel 30min that sterilizes.
(4) by test tube stock, 3 parts are cut into, every part is respectively connected in the fluid nutrient medium of 400ml/ bottles, stands 120min-
150min。
(5) 72-96 hours are vibrated with 20 times/min on shaking table, microscopy produces parent species liquid without miscellaneous bacteria.
The bulk drug matched：Orange 50, almond 5, the tuber of stemona 10, pinellia 5, fritillaria thunbergii 5, bulbus fritillariae cirrhosae 5, cordate houttuynia 20,
Raw ternip 50, product real 5, product shell 5, solanum lyratum 5, dried orange peel 5, rascal 5, ginger 5, mulberries 5, purslane 5, Cynanchum glaucescens 5, crystobalite 5,
BAISHASHEN 5, Asiatic plantain 5, leaflet desmodium 5, loguat leaf 5, red bayberry dry 5.
Step 1. hydrogen rich water (day field day inland waters), inactivated 10 minutes under 30 DEG C, 600mpa environment using super-pressure pot, it is complete
After will wherein 40 liters injected by aseptic silica gel pipeline it is standby in sterile fermentation tank.
The aqueous extract of step 2. preparing raw material medicine：
The bulk drug matched is mounted in 100 mesh filter screens, and hydrogen rich water and the bulk drug matched are added in super-pressure pot, rich
The weight of hydrogen water and bulk drug ratio is 4：1；
Handled 30 minutes under 30 DEG C, 800mpa environment, obtain the aqueous extract of bulk drug.
Step 3. common fermentation
During the ready fermentation for having been injected into 40 liters of hydrogen rich waters of the aqueous extract implantation step 1 of 40 liters of bulk drugs is filled.
Mushroom is implanted sequentially again, each 7 liters of the parent species liquid of northern Cordyceps militaris is fermented.When fermentation time was by 72 hours, detection
Effective solids, content put tank and stop fermentation when reaching more than 80g/L.
Step 4. concentrates：After putting tank, into alcohol precipitation extractor, the tunning 5 described in less than 30 DEG C of hydrogen-rich floodings
Hour, then boil, filter, take filtrate, the ethanol that the volume fraction for adding 4 times of filtrate volumes is 75% is infiltrated, and is stirred
After be warming up to 50 DEG C of recovery ethanol, finally precipitation is dried, is milled at a temperature of≤55 DEG C, 60 mesh sieves is crossed and obtains finished product,
Or it is spray-dried to obtain finished product.
Embodiment 2. is used to cough and No. 2 mouth containing system of mourning product of asthma
Prepare parent species liquid：Step is the same as embodiment 1.
The bulk drug matched：Orange 45, almond 4, the tuber of stemona 8, pinellia 7, fritillaria thunbergii 3, bulbus fritillariae cirrhosae 7, cordate houttuynia 23, life
Ternip 55, product real 3, product shell 7, solanum lyratum 3, dried orange peel 3, rascal 7, ginger 3, mulberries 3, purslane 7, Cynanchum glaucescens 3, crystobalite 6, in vain
The root of straight ladybell 7, Asiatic plantain 3, leaflet desmodium 7, loguat leaf 7, red bayberry dry 7.
Step 1. carries out 10 points of inactivation under 30 DEG C, 600mpa environment using super-pressure pot to hydrogen rich water (day field day inland waters)
Clock, after the completion of will wherein 50 liters injected by aseptic silica gel pipeline it is standby in sterile fermentation tank.
The aqueous extract of step 2. preparing raw material medicine：
The bulk drug matched is mounted in 100 mesh filter screens, and hydrogen rich water and the bulk drug matched are added in super-pressure pot, rich
The weight of hydrogen water and bulk drug ratio is 3：1；
Handled 50 minutes under 25 DEG C, 800mpa environment, obtain the aqueous extract of bulk drug.
Step 3. common fermentation
During the ready fermentation for having been injected into 50 liters of hydrogen rich waters of the aqueous extract implantation step 1 of 30 liters of bulk drugs is filled.
Mushroom is implanted sequentially again, each 5 liters of the parent species liquid of northern Cordyceps militaris is fermented.When fermentation time was by 72 hours, detection
Effective solids, content put tank and stop fermentation when reaching more than 80g/L.
Step 4. concentrates：After putting tank, into alcohol precipitation extractor, tunning 5 hours described in less than 30 DEG C of floodings,
Then boil, filter, take filtrate, the ethanol that the volume fraction for adding 4 times of filtrate volumes is 75% is infiltrated, and is heated up after stirring
To 50 DEG C of recovery ethanol, finally precipitation is dried at a temperature of≤55 DEG C, is milled, 60 mesh sieves excessively obtain finished product, or spraying
Dry finished product.
Embodiment 3. is used to cough and No. 3 mouth containing system of mourning product of asthma
Prepare parent species liquid：Step is the same as embodiment 1.
The bulk drug matched：Orange 55, almond 6, the tuber of stemona 15, pinellia 3, fritillaria thunbergii 7, bulbus fritillariae cirrhosae 3, cordate houttuynia 19,
Raw ternip 45, product real 7, product shell 3, solanum lyratum 7, dried orange peel 7, rascal 3, ginger 7, mulberries 7, purslane 3, Cynanchum glaucescens 7, crystobalite 4,
BAISHASHEN 3, Asiatic plantain 7, leaflet desmodium 3, loguat leaf 3, red bayberry dry 3.
Step 1. carries out 10 points of inactivation under 30 DEG C, 600mpa environment using super-pressure pot to hydrogen rich water (day field day inland waters)
Clock, after the completion of will wherein 30 liters injected by aseptic silica gel pipeline it is standby in sterile fermentation tank.
The aqueous extract of step 2. preparing raw material medicine：
The bulk drug matched is mounted in 100 mesh filter screens, and hydrogen rich water and the bulk drug matched are added in super-pressure pot, rich
The weight of hydrogen water and bulk drug ratio is 6：1；
Handled 30 minutes under 35 DEG C, 800mpa environment, obtain the aqueous extract of bulk drug.
Step 3. common fermentation
During the ready fermentation for having been injected into 30 liters of hydrogen rich waters of the aqueous extract implantation step 1 of 50 liters of bulk drugs is filled.
Mushroom is implanted sequentially again, each 10 liters of the parent species liquid of northern Cordyceps militaris is fermented.When fermentation time was by 72 hours, detection
Effective solids, content put tank and stop fermentation when reaching more than 80g/L.
Step 4. concentrates：After putting tank, into alcohol precipitation extractor, tunning 5 hours described in less than 30 DEG C of floodings,
Then boil, filter, take filtrate, the ethanol that the volume fraction for adding 4 times of filtrate volumes is 75% is infiltrated, and is heated up after stirring
To 50 DEG C of recovery ethanol, finally precipitation is dried at a temperature of≤55 DEG C, is milled, 60 mesh sieves excessively obtain finished product, or spraying
Dry finished product.
Embodiment 4. is used to cough and No. 4 mouth containing system of mourning product of asthma
Prepare parent species liquid：In addition to fluid nutrient medium being prepared except replacing hydrogen rich water with water in step (1), remaining step
With embodiment 1.
The bulk drug matched：Orange 48, almond 3, the tuber of stemona 9, pinellia 6, fritillaria thunbergii 4, bulbus fritillariae cirrhosae 6, cordate houttuynia 18, life
Ternip 53, product real 4, product shell 6, solanum lyratum 4, dried orange peel 4, rascal 6, ginger 4, mulberries 4, purslane 6, Cynanchum glaucescens 4, crystobalite 7, in vain
The root of straight ladybell 6, Asiatic plantain 4, leaflet desmodium 6, loguat leaf 6, red bayberry dry 6.
Step 1. using super-pressure pot under 30 DEG C, 600mpa environment to water carry out inactivation 10 minutes, after the completion of will wherein
45 liters by standby in the sterile fermentation tank of aseptic silica gel pipeline injection.
The aqueous extract of step 2. preparing raw material medicine：
The bulk drug matched is mounted in 100 mesh filter screens, and water and the bulk drug matched, water and original are added in super-pressure pot
The weight ratio for expecting medicine is 5：1；
Handled 40 minutes under 28 DEG C, 800mpa environment, obtain the aqueous extract of bulk drug.
Step 3. common fermentation
During the ready fermentation for having been injected into 45 liters of water of the aqueous extract implantation step 1 of 35 liters of bulk drugs is filled.
Mushroom is implanted sequentially again, each 8 liters of the parent species liquid of northern Cordyceps militaris is fermented.When fermentation time was by 72 hours, detection
Effective solids, content put tank and stop fermentation when reaching more than 80g/L.
Step 4. concentrates：After putting tank, into alcohol precipitation extractor, tunning 5 hours described in less than 30 DEG C of floodings,
Then boil, filter, take filtrate, the ethanol that the volume fraction for adding 4 times of filtrate volumes is 75% is infiltrated, and is heated up after stirring
To 50 DEG C of recovery ethanol, finally precipitation is dried at a temperature of≤55 DEG C, is milled, 60 mesh sieves excessively obtain finished product, or spraying
Dry finished product.
Embodiment 5. is used to cough and No. 5 mouth containing system of mourning product of asthma
Prepare parent species liquid：In addition to fluid nutrient medium being prepared except replacing hydrogen rich water with water in step (1), remaining step
With embodiment 1.
The bulk drug matched：Orange 54, almond 7, the tuber of stemona 13, pinellia 4, fritillaria thunbergii 6, bulbus fritillariae cirrhosae 4, cordate houttuynia 25,
Raw ternip 47, product real 6, product shell 4, solanum lyratum 6, dried orange peel 6, rascal 4, ginger 6, mulberries 6, purslane 4, Cynanchum glaucescens 6, crystobalite 3,
BAISHASHEN 4, Asiatic plantain 6, leaflet desmodium 4, loguat leaf 4, red bayberry dry 4.
Step 1. using super-pressure pot under 30 DEG C, 600mpa environment to water carry out inactivation 10 minutes, after the completion of will wherein
35 liters by standby in the sterile fermentation tank of aseptic silica gel pipeline injection.
The aqueous extract of step 2. preparing raw material medicine：
The bulk drug matched is mounted in 100 mesh filter screens, and water and the bulk drug matched, water and original are added in super-pressure pot
The weight ratio for expecting medicine is 4：1；
Handled 35 minutes under 32 DEG C, 800mpa environment, obtain the aqueous extract of bulk drug.
Step 3. common fermentation
During the ready fermentation for having been injected into 35 liters of water of the aqueous extract implantation step 1 of 45 liters of bulk drugs is filled.
Mushroom is implanted sequentially again, each 6 liters of the parent species liquid of northern Cordyceps militaris is fermented.When fermentation time was by 72 hours, detection
Effective solids, content put tank and stop fermentation when reaching more than 80g/L.
Step 4. concentrates：After putting tank, into alcohol precipitation extractor, tunning 5 hours described in less than 30 DEG C of floodings,
Then boil, filter, take filtrate, the ethanol that the volume fraction for adding 4 times of filtrate volumes is 75% is infiltrated, and is heated up after stirring
To 50 DEG C of recovery ethanol, finally precipitation is dried at a temperature of≤55 DEG C, is milled, 60 mesh sieves excessively obtain finished product, or spraying
Dry finished product.
Clinical efficacy
1. clinical data
The asthmatic patient 78 that 2012.4-2016.4 is accepted for medical treatment, wherein, male patient 36, female patient 42, the age
31-74 year, course of disease 1-23.
2. diagnostic criteria
(1) patient it is uncomfortable in chest, it is out of breath, pant and recurrent exerbation of coughing, expiratory dyspnea, more with contacting allergen, cold air, thing
Reason, chemical irritation and viral infection of upper respiratory tract etc. are relevant；
(2) fullness in the chest with rough breath when breaking out, sound pitch breath gush, unable to lie due to dyspnea；
(3) asthma is broken out in seasonal, and asthma of cold type or heat are roared；
(4) above-mentioned symptom can be alleviated through treatment or voluntarily alleviate.
Meet above symptom, you can be diagnosed as asthma.
3. treatment method
No. 1-5 mouth containing system of mourning product prepared using embodiment 1-5, every kind of mouth containing system of mourning product are used at least 15 patients, often
Day take three times, postprandial its slag can be told and can receive after buccal 2 grams, ten minutes every time.
4. the standard of curative effect evaluation
(1) fully recover：It is discontinued more than 1 year, no clinical symptoms and sign；
(2) effectively：Symptom mitigation during asthma attack, number are reduced, decreased duration；
(3) it is invalid：The state of an illness is unchanged or aggravates.
5. treatment results
Through treatment, fully recovered for 64 in 78 patients, 13 effectively 1 invalid, and effective percentage is 98.7%.During treatment, disease
People is without other adverse reactions.
Individual example
Mrs Huang, female, 55 years old New Zealand countrymen residing abroad, firmly Auckland East, obtains slight chronic obstructive pulmonary disease, takes clinical symptoms after 35 days
It is obvious to mitigate.
Mr. Cai, man, 96 years old Bay, Ningde, Fujian Province people, retired professor, firmly peaceful DS Jiaocheng Districts, containing taking 3 days, clinical symptoms improve
Disable one week afterwards, after being used continuously one month, symptom substantially mitigates.
Claims (10)
- A kind of 1. mouth containing system of mourning product for being used for cough and asthma, it is characterised in that：It is that the aqueous extract of following bulk drug carries out the product obtained by common fermentation with mushroom parent species liquid and northern Cordyceps militaris parent species liquid；The weight of the bulk drug is：Orange 45-55, almond 3-7, tuber of stemona 8-15, pinellia 3-7, fritillaria thunbergii 3-7, bulbus fritillariae cirrhosae 3-7, cordate houttuynia 18-25 are raw white Radish 45-55, the real 3-7 of product, product shell 3-7, solanum lyratum 3-7, dried orange peel 3-7, rascal 3-7, ginger 3-7, mulberries 3-7, purslane 3-7, Cynanchum glaucescens 3-7, crystobalite 3-7, BAISHASHEN 3-7, Asiatic plantain 3-7, leaflet desmodium 3-7, loguat leaf 3-7, red bayberry do 3-7.
- 2. mouth containing system of mourning product according to claim 1, it is characterised in that：The aqueous extract of the bulk drug uses hydrogen rich water For Extraction solvent, the hydrogen rich water is day field day inland waters.
- 3. mouth containing system of mourning product according to claim 1, it is characterised in that：The bulk drug has following any group of parts by weight Proportioning：Orange 50, almond 5, the tuber of stemona 10, pinellia 5, fritillaria thunbergii 5, bulbus fritillariae cirrhosae 5, cordate houttuynia 20, raw ternip 50, product real 5, product shell 5, solanum lyratum 5, dried orange peel 5, rascal 5, ginger 5, mulberries 5, purslane 5, Cynanchum glaucescens 5, crystobalite 5, BAISHASHEN 5, Asiatic plantain 5, leaflet Desmodium 5, loguat leaf 5, red bayberry dry 5；Orange 45, almond 4, the tuber of stemona 8, pinellia 7, fritillaria thunbergii 3, bulbus fritillariae cirrhosae 7, cordate houttuynia 23, raw ternip 55, product real 3, product shell 7, solanum lyratum 3, dried orange peel 3, rascal 7, ginger 3, mulberries 3, purslane 7, Cynanchum glaucescens 3, crystobalite 6, BAISHASHEN 7, Asiatic plantain 3, leaflet Desmodium 7, loguat leaf 7, red bayberry dry 7；Orange 55, almond 6, the tuber of stemona 15, pinellia 3, fritillaria thunbergii 7, bulbus fritillariae cirrhosae 3, cordate houttuynia 19, raw ternip 45, product real 7, product shell 3, solanum lyratum 7, dried orange peel 7, rascal 3, ginger 7, mulberries 7, purslane 3, Cynanchum glaucescens 7, crystobalite 4, BAISHASHEN 3, Asiatic plantain 7, leaflet Desmodium 3, loguat leaf 3, red bayberry dry 3；Orange 48, almond 3, the tuber of stemona 9, pinellia 6, fritillaria thunbergii 4, bulbus fritillariae cirrhosae 6, cordate houttuynia 18, raw ternip 53, product real 4, product shell 6, solanum lyratum 4, dried orange peel 4, rascal 6, ginger 4, mulberries 4, purslane 6, Cynanchum glaucescens 4, crystobalite 7, BAISHASHEN 6, Asiatic plantain 4, leaflet Desmodium 6, loguat leaf 6, red bayberry dry 6；OrOrange 54, almond 7, the tuber of stemona 13, pinellia 4, fritillaria thunbergii 6, bulbus fritillariae cirrhosae 4, cordate houttuynia 25, raw ternip 47, product real 6, product shell 4, solanum lyratum 6, dried orange peel 6, rascal 4, ginger 6, mulberries 6, purslane 4, Cynanchum glaucescens 6, crystobalite 3, BAISHASHEN 4, Asiatic plantain 6, leaflet Desmodium 4, loguat leaf 4, red bayberry dry 4.
- A kind of 4. raw material drug composition for being used to prepare cough and asthma mouth containing system of mourning product, it is characterised in that：Including A bulk drugs, Its weight is：Orange 45-55, almond 3-7, tuber of stemona 8-15, pinellia 3-7, fritillaria thunbergii 3-7, bulbus fritillariae cirrhosae 3-7, cordate houttuynia 18-25 are raw white Radish 45-55, the real 3-7 of product, product shell 3-7, solanum lyratum 3-7, dried orange peel 3-7, rascal 3-7, ginger 3-7, mulberries 3-7, purslane 3-7, Cynanchum glaucescens 3-7, crystobalite 3-7, BAISHASHEN 3-7, Asiatic plantain 3-7, leaflet desmodium 3-7, loguat leaf 3-7, red bayberry do 3-7.
- 5. raw material drug composition according to claim 4, it is characterised in that：The A bulk drugs have following any group of weight Measure part proportioning：Orange 50, almond 5, the tuber of stemona 10, pinellia 5, fritillaria thunbergii 5, bulbus fritillariae cirrhosae 5, cordate houttuynia 20, raw ternip 50, product real 5, product shell 5, solanum lyratum 5, dried orange peel 5, rascal 5, ginger 5, mulberries 5, purslane 5, Cynanchum glaucescens 5, crystobalite 5, BAISHASHEN 5, Asiatic plantain 5, leaflet Desmodium 5, loguat leaf 5, red bayberry dry 5；Orange 45, almond 4, the tuber of stemona 8, pinellia 7, fritillaria thunbergii 3, bulbus fritillariae cirrhosae 7, cordate houttuynia 23, raw ternip 55, product real 3, product shell 7, solanum lyratum 3, dried orange peel 3, rascal 7, ginger 3, mulberries 3, purslane 7, Cynanchum glaucescens 3, crystobalite 6, BAISHASHEN 7, Asiatic plantain 3, leaflet Desmodium 7, loguat leaf 7, red bayberry dry 7；Orange 55, almond 6, the tuber of stemona 15, pinellia 3, fritillaria thunbergii 7, bulbus fritillariae cirrhosae 3, cordate houttuynia 19, raw ternip 45, product real 7, product shell 3, solanum lyratum 7, dried orange peel 7, rascal 3, ginger 7, mulberries 7, purslane 3, Cynanchum glaucescens 7, crystobalite 4, BAISHASHEN 3, Asiatic plantain 7, leaflet Desmodium 3, loguat leaf 3, red bayberry dry 3；Orange 48, almond 3, the tuber of stemona 9, pinellia 6, fritillaria thunbergii 4, bulbus fritillariae cirrhosae 6, cordate houttuynia 18, raw ternip 53, product real 4, product shell 6, solanum lyratum 4, dried orange peel 4, rascal 6, ginger 4, mulberries 4, purslane 6, Cynanchum glaucescens 4, crystobalite 7, BAISHASHEN 6, Asiatic plantain 4, leaflet Desmodium 6, loguat leaf 6, red bayberry dry 6；OrOrange 54, almond 7, the tuber of stemona 13, pinellia 4, fritillaria thunbergii 6, bulbus fritillariae cirrhosae 4, cordate houttuynia 25, raw ternip 47, product real 6, product shell 4, solanum lyratum 6, dried orange peel 6, rascal 4, ginger 6, mulberries 6, purslane 4, Cynanchum glaucescens 6, crystobalite 3, BAISHASHEN 4, Asiatic plantain 6, leaflet Desmodium 4, loguat leaf 4, red bayberry dry 4.
- 6. the preparation method of any described mouth containing system of mourning product for being used for cough and asthma of claim 1-3, it is characterised in that：Bag Include following steps：(1) aqueous extract of preparing raw material medicine；(2) aqueous extract of bulk drug and mushroom parent species liquid and northern Cordyceps militaris parent species liquid are subjected to common fermentation, obtain tunning；Characterized in that, the extraction process of the aqueous extract of the bulk drug is as follows：In extraction vessel, water and raw material are added Medicine；The part by weight of water and the bulk drug is 3-6：1, under 25-35 DEG C, 800mpa environment extract 30-50 minutes obtain institute State the aqueous extract of bulk drug.
- 7. preparation method according to claim 6, it is characterised in that：The water is hydrogen rich water, and hydrogen rich water and the part by weight of the bulk drug are 4-5：1, under 28-32 DEG C, 800mpa environment Extraction 30-40 minutes obtain the aqueous extract of the bulk drug.
- 8. preparation method according to claim 6, it is characterised in that：The progress common fermentation refers toIn fermentation tank, by 30-50：30-50：5-10：5-10 volume ratio adds aqueous extract, water, the perfume (or spice) of the bulk drug Mushroom parent species liquid and northern Cordyceps militaris parent species liquid, ferment and put tank when reaching more than 80g/L to effective solid contents.
- 9. preparation method according to claim 8, it is characterised in that：By 35-45：35-45：6-8：6-8 volume ratio adds aqueous extract, water, mushroom parent species liquid and the northern pupa of the bulk drug Cordyceps sinensis parent species liquid.
- 10. according to any described preparation methods of claim 6-9, it is characterised in that：After fermentation ends put tank, tunning enters alcohol precipitation extractor, and tunning 5 is small described in less than 30 DEG C of floodings When, then boil, filter, take filtrate, the ethanol that the volume fraction for adding 4 times of filtrate volumes is 75% is infiltrated, after stirring 50 DEG C of recovery ethanol are warming up to, finally precipitation is dried, is milled at a temperature of≤55 DEG C, 60 mesh sieves is crossed and obtains finished product, or It is spray-dried to obtain finished product.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103638412A (en) * | 2013-12-16 | 2014-03-19 | 王文兮 | Multi-effect traditional Chinese medicine formula for quickly eliminating chronic lung diseases and preparation method of multi-effect traditional Chinese medicine formula |
| CN104068379A (en) * | 2014-06-26 | 2014-10-01 | 天津和治友德制药有限公司 | Health-care oral solution |
| CN104187587A (en) * | 2014-07-21 | 2014-12-10 | 宁波北仑锐晟明杰生物科技发展有限公司 | Edible fungus healthcare oral liquid and preparing method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103638412A (en) * | 2013-12-16 | 2014-03-19 | 王文兮 | Multi-effect traditional Chinese medicine formula for quickly eliminating chronic lung diseases and preparation method of multi-effect traditional Chinese medicine formula |
| CN104068379A (en) * | 2014-06-26 | 2014-10-01 | 天津和治友德制药有限公司 | Health-care oral solution |
| CN104187587A (en) * | 2014-07-21 | 2014-12-10 | 宁波北仑锐晟明杰生物科技发展有限公司 | Edible fungus healthcare oral liquid and preparing method thereof |
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