CN1115244A - Method for prepn. of multifunctional health-care medicine by using lindera glauca fruit as main raw material - Google Patents
Method for prepn. of multifunctional health-care medicine by using lindera glauca fruit as main raw material Download PDFInfo
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- CN1115244A CN1115244A CN 94108404 CN94108404A CN1115244A CN 1115244 A CN1115244 A CN 1115244A CN 94108404 CN94108404 CN 94108404 CN 94108404 A CN94108404 A CN 94108404A CN 1115244 A CN1115244 A CN 1115244A
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Abstract
The multifunctional health-care medicine having more therapeutical functions and nutrients is made up of greyblue spicebush, other Chinese herbal medicines, nutritive additive, enzyme promoter and mineral water through pretreatment of raw materials, weighing, breaking, mixing, fermentation, immersion, filter, decolouring, concentration, drying and shaping, and contains active components of greyblue spicebush, thallodie protein, soluble protein of seaweed, trace elements and polypeptides.
Description
The invention belongs to the preparation method of medicine, particularly a kind of is the method that main material is produced medicine with the Fructus Linderae Glaucae.
Fructus Linderae Glaucae (shanhujiao) belongs to the medical herbs of canella, have another name called tendon Bovis seu Bubali tree, Ji Mifeng, ox tendon strip, the maple that shams death, Bai Yefeng, always come red or the like.The Fructus Linderae Glaucae each several part contains the ingredient of abundant ethereal oil, and for example: the fruit of Fructus Linderae Glaucae contains volatile oil 2～6%, wherein contains citral 70～90%, also has methyl heptenone, linalool, lemon etc.; The leaf of Fructus Linderae Glaucae contains volatile oil 0.20%, wherein contains 1.8-cineole 8.2%, caryophyllene 15.3%, acetic acid bornyl ester 5.4%, camphene 0.9%, nopinene 1.1%, limonene 0.8%, also has Flos Caryophylli alkene, Y-fat etc.; The root of Fructus Linderae Glaucae contains volatile oil 1.6-3%, wherein contain citral 62.5%, limonene 1.6%, australene 1.6%, camphene 3.5%, to a P-cymene 0.3%, methyl heptenone 3.1%, citronellol 7.6%, linalool 2.5%, Camphora 0.8%, geranyl acetate 0.9%, alpha-terpineol 1.5%, geraniol 7.6%, safrole 0.9%, also have α-oxalene etc.; The twig of Fructus Linderae Glaucae contains volatile oil 0.06%, wherein contains citronellal 29-40% and linalool, terpineol, citral, actinodaphnine, isocorydine, N-metbyl, magnocurarine etc.The abundant volatile oil of these content has various curative effects to human body diseases more.The Fructus Linderae Glaucae pH value is 5.4, and ribonucleic acid is 145 μ g/ml, and DNA (deoxyribonucleic acid) is 140 μ g/ml; Antibacterial culturing is negative.There is different parts (fruit, leaf, root, the twig) employing that utilizes Fructus Linderae Glaucae to fry in shallow oil soup or the headache of infusing drugs in wine orally taken for curing cold, fever for a long time among the people, symptom such as rheumatism paralysis, dissipating blood stasis blood, collateral dredging arteries and veins or get Fructus Linderae Glaucae different parts raw material (leaf, root, twig, fruit) and mash or grind into powder and transfer the Oleum Sesami customs such as controlling traumatic hemorrhage of applying ointment or plaster, Fructus Linderae Glaucae has multi-functional curative effect to the treatment human body diseases, but, be that the suitability for industrialized production medicine of main material was not met report as yet with the Fructus Linderae Glaucae.
The object of the invention is the method for the multi-function health-care medicine of main material preparation with the Fructus Linderae Glaucae providing a kind of, and this method not only keeps the effect of Fructus Linderae Glaucae treatment various diseases, and has the value of suitability for industrialized production.
According to the object of the invention, the disclosed a kind of method that with the Fructus Linderae Glaucae is main material prepares the multi-function health-care medicine of inventor be on the various effect bases of curing the disease of Fructus Linderae Glaucae with relevant Chinese herbal medicine reasonable compatibility, add nutrient and enzyme accelerator simultaneously.Utilize basidiomycetes cellulase, hemicellulase, Ascomycetes yeast, Fungi Imperfecti aspergillosis, the Phycomycetes rhizopus synergism of prescription in forming, the Fructus Linderae Glaucae in the prescription and the macromole cellulose in the Chinese herbal medicine and the protein in the nourishing additive agent, carbohydrate etc. are resolved into small molecular protein and the polypeptide nutrition metabolite with cytoactive.Medicine of the present invention is with 40-70% Fructus Linderae Glaucae (or leaf or root or fruit or twig), 10-30% compatibility Chinese herbal medicine, 15-35% nourishing additive agent, 1-5% enzyme accelerator, adding proper quantity of mineral water is raw material, through pretreatment of raw material, weigh, pulverize, mix, ferment, soak filtration, adsorption bleaching, concentrate, operations such as drying, preparation type, packing are prepared from.Above-mentioned nourishing additive agent comprises edible fungi (as Lentinus Edodes, Rhizoma sagittariae sagittifoliae, Tremella, Auricularia etc.), Sargassum (as Thallus Laminariae (Thallus Eckloniae), Thallus Porphyrae, deliver vegetables etc.), plant class nutrient (as: Semen Glycines, Oleum Sesami, wheat bran, thin bran, rice etc.).Animal class nutrient (as: Ungula Sus domestica etc.), contain nitrogenous source material (as carbamide, peptone, Tween 80 etc.), carbon source material (as: saccharide, Mel etc.), and phosphorous, calcium, potassium, magnesium, selenium, the inorganic salt of zinc, mineral (as: calcium sulfate, magnesium sulfate, potassium dihydrogen phosphate, diammonium phosphate, sodium selenite, zinc sulfate etc.), above-mentioned enzyme accelerator can be yeast, yeast extract etc.More than the kind of each formula material select and content can be according to clinical flexible variation compatibility situation in prescription.Concrete step of preparation process of the present invention is as follows:
1, pretreatment of raw material: raw material of the present invention all must pass through impurity such as rinsing, shakeout, dust removal, dries or dries through the sun again, and temperature is no more than 65 ℃;
2, take by weighing each raw material weight: take by weighing each raw material weight by the actual prescription composition of curing the disease;
3, pulverize: it is Powdered that above-mentioned bulk raw siccative is ground into the 40 order left and right sides through pulverizer; For holozoic nutrition such as pig's feet, earlier well-done, remove slag, filtered juice continues to employ; Can pulverize for the big nutrient of water content such as Radix Raphani etc. and to remove slag, filtered juice is continued to employ;
4, mix to stir: form by prescription and fully stir and make it uniform mixing through pulverizing raw material nourishing additive agent and enzyme accelerator and proper quantity of mineral water above-mentioned, the mixture water content is about 65-75%;
5, fermentation process: the present invention adopts deep liquid aerobic fementation method fermentation, and being controlled at temperature 30-50 ℃, pH value is 4.0-6.2 condition bottom fermentation 5-7 days;
6. soak and filter: soaked 24 hours with yellow wine through the fermentation process raw material above-mentioned, filter with flame filter press, obtain filtrate, a small amount of yellow wine of filtering residue reuse is soaked after-filtration, waste merges the secondary medicinal liquid;
7, adsorption bleaching: the above-mentioned medicinal liquid that makes with aperture 18-20A ° activated carbon adsorption, is removed unsaturated fatty acid and decolouring, or adopted the S column system to achieve the goal;
8, concentrating under reduced pressure: the medicinal liquid handled of will decolouring records concentrated solution water content 20-35% being lower than concentrating under reduced pressure under 70 ℃ the temperature, concentrated solution is cooled to 20 ℃ again, obtains medicine crystal;
9, drying: the said medicine crystal under vacuum condition, is placed the crystalline solid medicine that got water content 2-3% under the drying baker 40-50 ℃ temperature in dry 4-8 hour;
10, dosage form is made: according to clinical needs, adopt conventional making dosage form technology to make oral tablet or adhesive tape, or injection uses;
11, finished product packing:
1. tablet: become the bottle packing by 100 slices/bottle content;
2. injection: contain powder 10mg by every bottle, 10 bottle/boxes carry out the box packing;
3. coated tablet:, 100/box, carry out the box packing by every 10mg.
4. soft gelatin capsule: every 250mg, by 100/bottle, carry out bottle and pack.
Characteristics compared with prior art of the present invention are: 1, the pharmaceutical formulation compatibility is scientific and reasonable, and not only the Fructus Linderae Glaucae drug effect is able to best performance, but also contains tropina, the unicellular soluble protein of seaweeds and abundant trace element, peptide material, curative effect height.Order the bed checking through facing: this medicine closes disease, asthma, traumatic hemorrhage, headache due to common cold heating, malignant boil toxic swelling, various inflammation to the treatment apoplexy, and rheumatism paralysis, dish bone pain, trusted subordinate's cold type of pain all have good efficacy; 2, preparation is simple in the present invention, and equipment is simple, raw material is easy to get, has suitability for industrialized production and is worth.
Specifically describe the present invention below by embodiment.
Embodiment 1, take by weighing Fructus Linderae Glaucae fruit 500 gram, 4 liters of Fructus Viticis Negundo 150 grams, Lentinus Edodes 150 grams, Semen Glycines 50 grams, thin bran 100 grams, yeast 30 grams, calcium carbonate 20 grams, carbamide 2 grams, potassium dihydrogen phosphate 0.3 gram, magnesium sulfate 0.2 gram, ferrous sulfate 0.01 gram, Tween 80 0.01 gram, Mel 5 grams, agar 1.5 grams, mineral water, Fructus Linderae Glaucae fruit, Fructus Viticis Negundo, Lentinus Edodes, analysis for soybean powder are broken into 40 order powder, add mineral water, accent is mixed even back and was adopted the bioreactor submerged aerobic fermentation 5 days, and it is about 6 with lactic acid adjusting pH value that fermentation temperature is 45 ℃.To soak with yellow wine (in right amount) through the raw mix that fermentation process is crossed and filter with filter press in 24 hours, get medicinal liquid, with medicinal liquid aperture 18A ° activated carbon adsorption, obtain the drug crystallization powder under 20 ℃ of temperature to remove unsaturated fatty acid and decolouring, then medicinal liquid to be placed to be lower than to place again behind the concentrating under reduced pressure under 70 ℃ of temperature.It is 5% medicated powder that medicated powder is obtained moisture content at last at vacuum drying oven (baking temperature is controlled at 45 ℃), promptly get this finished product, through clinical verification, this product to the treatment apoplexy close disease, rough, two hold solid, accumulation and obstruction of sputum throat, unable to speak, the strong person of rolling and forceful pulse have original effect.
Embodiment 2, press Fructus Linderae Glaucae twig fork 500 gram, Radix Serissae 200 grams, Radix Raphani 100 grams, Semen Glycines 50 grams, Thallus Porphyrae 50 grams, Auricularia 50 grams, thin bran 30 grams, yeast 20 restrains, calcium carbonate 1 restrains, dipotassium hydrogen phosphate 2 restrains, ammonium sulfate 0.3 restrains, magnesium sulfate 0.05 restrains, yeast extract 0.2 restrains, adds 4 liters of mineral waters, its preparation technology admixes the use with mineral water together except that radish Juice, and other technology is with embodiment 1.Make symptoms such as finished product can be used for treating flu, fever and headache clinically, pharynx is red and swollen bitterly, cough is not well, physical weakness with present embodiment.
Embodiment 3, press 4 liters of Folium Linderae Glaucae 700 grams, Semen oryzae sativae 50 grams, Oryza glutinosa 50 grams, Fructus Momordicae charantiae 50 grams, Folium Camelliae sinensis 50 grams, thin bran 50 grams, yeast 30 grams, Oleum Sesami 20 grams, yeast extract 1 gram, Mel 1 gram, Tween 80 0.01 gram, mineral water, preparation technology removes the Fructus Momordicae charantiae extracting juice and adds with the mineral water blending, with embodiment 1, the medicine for preparing with present embodiment can be used for treating symptoms such as malignant boil toxic swelling clinically in technology for it.
Embodiment 4, press Folium Linderae Glaucae 600 gram, Radix Glycyrrhizae 100 grams, Talcum 100 grams, Poria 100 grams, white sugar 50 grams, thin bran 20 grams, yeast 30 grams, calcium carbonate 1 gram, Tween 80 0.01 gram, Carnis Bovis seu Bubali cream 1 gram, 4 liters of mineral waters.Present embodiment preparation technology can be used for treating various inflammation diseases such as acute and chronic tonsillitis, lymphadenitis, pharyngitis, tracheitis clinically with the medicine of embodiment 1. usefulness present embodiments preparation.
Embodiment 5, add in the raw material mixture of having pulverized with pig's feet filter soup by 4 liters of Radix Linderae Glaucae 700 grams, pig's feet (seven cun) three tools (well-done, filtering residue soup), Auricularia 100 grams, Thallus Laminariae (Thallus Eckloniae) 100 grams, wheat bran 50 grams, yeast 30 grams, Mel 20 grams, magnesium sulfate 0.1 gram, Tween 80 0.01 gram, Carnis Bovis seu Bubali cream 0.1 gram, mineral water, all the other preparation technologies are with embodiment 1.Medicine with the present embodiment preparation can be used for treating the rheumatism paralysis symptom clinically, and curative effect is fine.
Embodiment 6, press 4 liters of Folium Linderae Glaucae 500 grams, Radix Glycyrrhizae 100 grams, Tremella 300 grams, Stichopus japonicus 100 grams, yeast 20 grams, sodium chloride 20 grams, thin bran 60 grams, Oleum Sesami 500 grams, Mel 2 grams, yeast extract 1 gram, calcium carbonate 2 grams, agar 2 grams, Tween 80 0.01 gram, mineral water, removing Oleum Sesami and mineral water among the preparation technology adds together and has pulverized in the raw material mixture, all the other preparation technologies are with embodiment 1, medicine with the present embodiment preparation can be used for treating swelling and pain due to blood stasis clinically, or wound symptoms such as The blood streamed down.
Claims (7)
1, a kind of is the method that main material prepares the multi-function health-care medicine with the Fructus Linderae Glaucae, it is characterized in that this medicine adopts 40-70% Fructus Linderae Glaucae (or leaf or root or fruit or twig), 10-30% compatibility Chinese herbal medicine, 15-35% nourishing additive agent, 1-5% enzyme accelerator and proper quantity of mineral water are raw material, through pretreatment of raw material, weigh, pulverize, mix, ferment, soak filtration, adsorption bleaching, concentrate, operations such as drying, preparation type, packing are prepared from.
2, method according to claim 1 is characterized in that being used for the treatment of apoplexy and closes the medicine material of disease and form and be: Fructus Linderae Glaucae fruit, Fructus Viticis Negundo, Lentinus Edodes, Semen Glycines, thin bran, yeast, calcium carbonate, carbamide, potassium dihydrogen phosphate, magnesium sulfate, ferrous sulfate, Tween 80, Mel, agar, mineral water.
3, method according to claim 1 is characterized in that the raw material composition that is used for the treatment of cold, fever symptom medicine is: Fructus Linderae Glaucae twig fork, Radix Serissae, Radix Raphani, Semen Glycines, Thallus Porphyrae, Auricularia, thin bran, yeast, calcium carbonate, dipotassium hydrogen phosphate, ammonium sulfate, magnesium sulfate, yeast extract, mineral water.
4, method according to claim 1 is characterized in that the raw material composition that is used for the treatment of malignant boil toxic swelling disease drug is: Folium Linderae Glaucae, Semen oryzae sativae, Oryza glutinosa, Fructus Momordicae charantiae, Folium Camelliae sinensis, thin bran, yeast, Oleum Sesami, yeast extract, Mel, Tween 80, mineral water.
5, method according to claim 1 is characterized in that the raw material composition that is used for the treatment of various inflammation medicines is: Folium Linderae Glaucae, Radix Glycyrrhizae, Talcum, Poria, white sugar, thin bran, yeast, calcium carbonate, Tween 80, Carnis Bovis seu Bubali cream, mineral water.
6, method according to claim 1 is characterized in that the raw material composition that is used for the treatment of rheumatism paralysis medicine is: Radix Linderae Glaucae, pig's feet, Auricularia, Thallus Laminariae (Thallus Eckloniae), wheat bran, yeast, Mel, magnesium sulfate, Tween 80, Carnis Bovis seu Bubali cream, mineral water.
7, method according to claim 1 is characterized in that the raw material composition that is used for the treatment of blood stasis, wound disease drug is: Folium Linderae Glaucae, Radix Glycyrrhizae, Tremella, Stichopus japonicus, yeast, sodium chloride, thin bran, Oleum Sesami, Mel, yeast extract, calcium carbonate, agar, Tween 80, mineral water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94108404 CN1115244A (en) | 1994-07-16 | 1994-07-16 | Method for prepn. of multifunctional health-care medicine by using lindera glauca fruit as main raw material |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94108404 CN1115244A (en) | 1994-07-16 | 1994-07-16 | Method for prepn. of multifunctional health-care medicine by using lindera glauca fruit as main raw material |
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| CN1115244A true CN1115244A (en) | 1996-01-24 |
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| CN 94108404 Pending CN1115244A (en) | 1994-07-16 | 1994-07-16 | Method for prepn. of multifunctional health-care medicine by using lindera glauca fruit as main raw material |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101690572B (en) * | 2009-09-30 | 2011-09-28 | 张昌杰 | Litsea sauce-making method |
| CN104291884A (en) * | 2013-07-18 | 2015-01-21 | 许恒瑞 | Method for extracting organic phenol ester alcohol and sugar fermentation enzyme natural organic vitamin from Mountain Litsea Fragrant Litsea fruit |
| CN104543832A (en) * | 2014-12-29 | 2015-04-29 | 徐州绿之野生物食品有限公司 | Preparation method and application of garlic fermented cell protein concentrated liquor |
| CN109588634A (en) * | 2018-12-29 | 2019-04-09 | 陈小平 | A kind of instant rice cracker, preparation method and eating method |
-
1994
- 1994-07-16 CN CN 94108404 patent/CN1115244A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101690572B (en) * | 2009-09-30 | 2011-09-28 | 张昌杰 | Litsea sauce-making method |
| CN104291884A (en) * | 2013-07-18 | 2015-01-21 | 许恒瑞 | Method for extracting organic phenol ester alcohol and sugar fermentation enzyme natural organic vitamin from Mountain Litsea Fragrant Litsea fruit |
| CN104543832A (en) * | 2014-12-29 | 2015-04-29 | 徐州绿之野生物食品有限公司 | Preparation method and application of garlic fermented cell protein concentrated liquor |
| CN109588634A (en) * | 2018-12-29 | 2019-04-09 | 陈小平 | A kind of instant rice cracker, preparation method and eating method |
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Address after: 353000 Nanping City, Fujian province Meifeng Road No. 5 No. 56 Taiji Group Ltd Applicant after: Lin Lushan Applicant after: Liu Biqiang Applicant after: Zhang Dianqin Applicant before: Lin Lushan Applicant before: Liu Biqiang |
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