CN112006971A

CN112006971A - Skin care composition and cosmetic with effect of relieving infantile eczema

Info

Publication number: CN112006971A
Application number: CN202010920025.9A
Authority: CN
Inventors: 郑超; 羡志明; 董强; 陈萍; 李峰; 王亚南
Original assignee: TIANJIN YUMEIJING GROUP CO Ltd
Current assignee: TIANJIN YUMEIJING GROUP CO Ltd
Priority date: 2020-09-04
Filing date: 2020-09-04
Publication date: 2020-12-01

Abstract

The invention provides a skin care composition and a cosmetic with the effect of relieving infantile eczema. The skin care composition comprises cow milk, lanolin and sodium hyaluronate. Wherein the compound weight ratio of cow milk, lanolin and sodium hyaluronate is (3-30): (1-8): (0.01-1). The components in the composition are matched for use, so that a better synergistic effect can be achieved, the symptoms of skin dryness, desquamation and redness in the infantile eczema can be obviously improved, and the skin barrier function can be effectively recovered.

Description

Skin care composition and cosmetic with effect of relieving infantile eczema

Technical Field

The invention relates to a skin care composition and a cosmetic with the effect of relieving infantile eczema, in particular to a skin care composition containing cow milk, lanolin and sodium hyaluronate and having the effects of relieving infantile eczema, accelerating the elimination of the symptoms of infantile eczema and repairing skin barrier function, and the like, and a cosmetic containing the composition.

Background

Infantile eczema is allergic dermatitis caused by various internal and external factors, and is one of the most common skin diseases in the infant period. The onset of disease is caused by a variety of causes such as genetics, diet, environment, and the like. Infantile eczema usually involves the epidermis of the skin, often found on the head and face, and gradually spreads to the neck, shoulders, trunk and limbs. Skin lesions are polymorphic, and initially become erythema or papule, and with the progress of the disease, there are papules, blisters, erosion, crusting, etc., which are broken off with good time and attack repeatedly. Itching, crying and restlessness of the infant.

Treatment of infantile eczema is mainly based on treatment of barrier defects, inflammation, infection and itching. The primary treatment is to repair the impaired barrier defect by using emollients. If there is an infection in the eczema, antibiotics need to be used. Topical steroid medication is a well-tolerated treatment but is undesirable due to potential side effects. Therefore, development of skin care products capable of effectively relieving symptoms such as erythema and pruritus caused by eczema is important when the symptoms are mild.

The existing skin care products which are declared to have the effect of relieving eczema mostly adopt plant components with the effects of clearing damp, inhibiting bacteria and the like, and corresponding extracts are obtained after the treatment processes of extraction, separation, purification and the like and are added into a formula; the extraction process of the effective components is complex; although Chinese herbal medicines are mostly used for extraction, the components are complex, and the safe use risk of the formula is increased.

Disclosure of Invention

Based on the defects in the prior art, the invention aims to provide a skin care composition with the effect of relieving infantile eczema, which consists of cow milk, lanolin and sodium hyaluronate as effective components and has the effects of accelerating the elimination of the symptoms of infantile eczema and skin swelling and repairing the skin barrier function.

The invention also aims to provide a cosmetic containing the skin care composition, which can be directly acted on the surface of the infantile eczema skin to care the skin, so as to achieve the effects of accelerating the elimination of the symptoms of the infantile eczema skin redness and swelling and repairing the skin barrier function.

The purpose of the invention is realized by the following technical means:

in one aspect, the present invention provides a skin care composition having efficacy in alleviating eczema in infants, the composition comprising cow's milk, lanolin and sodium hyaluronate.

According to a specific embodiment of the invention, in the skin care composition with the effect of relieving infantile eczema, the compounding weight ratio of cow milk, lanolin and sodium hyaluronate (calculated by dry matter) is (3-30): (1-8): (0.01 to 1); preferably, the compound weight ratio of the cow milk, the lanolin and the sodium hyaluronate is (7-20): (1-4): (0.01-0.5).

The milk of the invention is a very easily obtained substance, is derived from fresh milk which is not subjected to high-temperature treatment, contains abundant lactose, fat, protein, vitamins and mineral substances, and simultaneously contains various natural active ingredients. Fats and proteins can provide fatty acids and nutrients for repairing cell membranes; lactose can provide moisture-keeping effect for skin; these substances are all necessary for human growth and metabolism, and can provide almost all skin nutrients. A great deal of literature records that cow milk has the effects of moistening skin, nourishing heart and lung, removing heat toxin, delaying skin aging, keeping skin smooth, soft, white and tender and the like. Meanwhile, cow milk contains various active factors, and can play a role in immunoregulation. Therefore, the cow milk is applied to the formula of the skin care product, can help repair the skin barrier function and relieve inflammatory reactions such as dry skin, erythema and pruritus caused by eczema.

The sodium hyaluronate of the invention is a high molecular chain straight chain polysaccharide, and the molecular weight can reach several million daltons. Sodium hyaluronate contains a large amount of hydroxyl and carboxyl in molecules. In the state of an aqueous solution, a large number of water molecules can be bonded by intermolecular hydrogen bonding. A water locking film can be formed on the surface of the skin, so that the loss of skin moisture is reduced. Is internationally referred to as an ideal moisturizing factor.

The lanolin is natural grease secreted by sebaceous glands of sheep. The main component is wax ester, and has good sealing and penetrating effects.

The inventor researches and discovers that a layer of moisture-preserving and water-locking film with moisture-absorbing and sealing functions is formed on the surface of the skin by utilizing the sodium hyaluronate and the lanolin, so that the moisture loss of the skin with weak barrier function or damaged skin can be reduced, the moisture-preserving effect is achieved, and a proper environment is provided for repairing the skin barrier. Meanwhile, the penetration of the lanolin can improve the absorption and utilization of the effective components of the cow milk by the skin and provide necessary nutrient substances for repairing the skin barrier. According to the specific embodiment of the invention, the three components are matched for use, so that a better synergistic effect can be achieved, the symptoms of skin dryness, desquamation and redness in the infantile eczema can be obviously improved, and the skin barrier function can be effectively recovered.

In another aspect, the invention also provides application of the composition in preparing a cosmetic with the effect of relieving infantile eczema.

In the above application, the composition is preferably added to the cosmetic in a weight ratio of cow milk to the cosmetic 3-30%, lanolin to the cosmetic 1-8%, and sodium hyaluronate to the cosmetic 0.01-1%.

Further preferably, the composition is added into the cosmetics in a weight ratio that cow milk accounts for 7-20% of the cosmetics, lanolin accounts for 1-4% of the cosmetics, and sodium hyaluronate accounts for 0.01-0.5% of the cosmetics.

In still another aspect, the present invention provides a cosmetic composition comprising the above composition.

In the cosmetic, preferably, the milk accounts for 3-30% by weight of the cosmetic; the weight content of the lanolin is 1% -8%; the weight content of the sodium hyaluronate is 0.01-0.1%.

Further preferably, in the cosmetic, the milk accounts for 7-20% by weight; the weight content of the lanolin is 1% -4%; the weight content of the sodium hyaluronate is 0.01-0.5%.

In the invention, the skin care composition with the effect of relieving infantile eczema can be added into the cosmetic as an additive phase (the composition of the invention can be added into the cosmetic respectively in specific application, or can be added into the cosmetic after being mixed in advance). According to a specific embodiment of the present invention, the cosmetic composition of the present invention comprises, in addition to the skin care composition for alleviating infantile eczema described above, other components selected according to the conventional procedures in the art, for example, a conventional oil phase and a conventional water phase. In some emulsion type cosmetics, an emulsifier, an excipient (thickener), a base material and necessary additives usually contained in the cosmetics are usually added, such as an emollient (e.g., vegetable oil, white oil, animal fat and oil and derivatives thereof, etc.), a humectant (e.g., glycerin, propylene glycol, 1, 3-butylene glycol, etc.), a perfume, deionized water, an antioxidant, a preservative, etc., and some nutritional ingredients may be added, and the application and amount of the specific ingredients may be selected according to the specific kind of the cosmetics, or may be added in a conventional amount, which is easily known to those skilled in the art.

In a specific embodiment of the invention, the invention provides a skin cream with an effect of relieving infantile eczema, and the skin cream comprises the following components in percentage by weight of 100 percent:

in the above cosmetic, it is further preferable that the skin cream comprises the following components by weight percentage of 100%:

in still another aspect, the present invention also provides a method for preparing the cosmetic, wherein the raw material composition of the cosmetic comprises an oil phase, a water phase and the skin care composition with the effect of alleviating infantile eczema, and the method comprises the following steps:

firstly, emulsifying an oil phase and a water phase (except a cow milk component) in the raw materials of the cosmetics, wherein the oil phase comprises the lanolin as an effective component, and the water phase comprises the sodium hyaluronate as an effective component. The emulsification method comprises the following steps: adding the oil phase into an oil phase reaction kettle, adding the water phase into a water phase reaction kettle, starting stirring, heating while stirring to 85-95 ℃ to completely melt the oil phase, filtering, sequentially adding the oil phase and the water phase into an emulsification tank, emulsifying and homogenizing, adding the functional component cow milk of the application when the temperature of an emulsification system is adjusted to be lower than 50 ℃, uniformly stirring, adding other raw materials such as a preservative when the temperature of the emulsification system is lower than 45 ℃, uniformly stirring, and discharging.

The invention has the beneficial effects that:

the invention provides a skin care composition with an effect of relieving infantile eczema, which is applied to the production of cosmetics and plays a synergistic role in relieving infantile eczema, improving dry, desquamation and redness symptoms of skin in infantile eczema and effectively recovering the skin barrier function; the skin barrier function damage caused by the infantile eczema and skin erythema, dryness and the like caused by the skin barrier function damage can be relieved to a certain extent; the skin moisture content is provided while the skin barrier function is recovered, the elimination of eczema symptoms is accelerated, and the soothing effect is good. In addition, the appearance and the internal quality of the cosmetic product produced by the invention can be kept stable for a long time.

Drawings

FIG. 1 shows the evaluation of the eczema skin lesion symptoms of rats in example 4 and a control sample according to the present invention;

FIG. 2A is a graph showing the effect of example 1 and control 6 of the present invention on the rate of change of moisture content in stratum corneum;

FIG. 2B is a graph showing the effect of example 1 and control 7 of the present invention on the rate of change of moisture content in stratum corneum;

FIG. 2C is a graph showing the effect of example 1 and control 8 of the present invention on the rate of change of moisture content in stratum corneum;

FIG. 2D is a graph showing the effect of example 1 and control 9 on the rate of change of moisture content in stratum corneum;

FIG. 2E is a graph showing the effect of example 1 of the present invention and the control 10 on the rate of change of the moisture content of the stratum corneum;

FIG. 3A is a graph showing the effect of example 1 of the present invention and control 6 on the rate of change of the transdermal moisture loss value (TWEL) of skin;

FIG. 3B is a graph showing the effect of example 1 of the present invention and control 7 on the rate of change of the transdermal moisture loss value (TWEL) of skin;

FIG. 3C is a graph showing the effect of example 1 of the present invention and control 8 on the rate of change of the transdermal moisture loss value (TWEL) of skin;

FIG. 3D is a graph showing the effect of example 1 of the present invention and control 9 on the rate of change of the transdermal moisture loss value (TWEL) of skin;

FIG. 3E is a graph showing the effect of example 1 of the present invention and control 10 on the rate of change of the transdermal moisture loss value (TWEL) of skin;

FIG. 4A is a graph showing the change in erythema index over time for skin using example 5 of the present invention and controls 11, 12, and 15;

FIG. 4B is a graph showing the change in erythema index over time for the skin of example 5 of the present invention and controls 13, 14, and 15.

Detailed Description

The technical solutions of the present invention will be described in detail below in order to clearly understand the technical features, objects, and advantages of the present invention, but the present invention is not limited to the practical scope of the present invention.

Example 1:

the embodiment provides a skin cream for relieving infantile eczema, which comprises the following components in percentage by weight of 100 percent:

the preparation of the cosmetic of this example was carried out according to the following process:

firstly, emulsifying an oil phase and a water phase (except a cow milk component) in the cosmetic raw materials, wherein the oil phase comprises the lanolin serving as an effective component, and the water phase comprises the sodium hyaluronate serving as an effective component. The emulsification method comprises the following steps: adding the oil phase into an oil phase reaction kettle, adding the water phase into a water phase reaction kettle, starting stirring, heating while stirring to 85-95 ℃ to completely melt the oil phase, filtering, sequentially adding the oil phase and the water phase into an emulsification tank, emulsifying and homogenizing, adding the functional component cow milk of the application when the temperature of an emulsification system is adjusted to be lower than 50 ℃, uniformly stirring, adding other raw materials when the temperature of the emulsification system is lower than 45 ℃, uniformly stirring, and discharging.

The skin cream of the embodiment is subjected to repeated heat resistance (40 +/-1 ℃, after the room temperature is recovered for 24 hours, the cream is normal, no oil-water separation phenomenon exists), cold resistance (from minus 5 ℃ to minus 10 ℃, after the room temperature is recovered for 24 hours, no obvious character difference exists before the test), and all sensory indexes and physical and chemical indexes of the product meet the corresponding national standards.

Example 2:

the preparation process is the same as in example 1.

Example 3:

the preparation process is the same as in example 1.

Example 4:

the preparation process is the same as in example 1.

Example 5:

the preparation process is the same as in example 1.

Design of a comparative experiment:

1. animal experiments:

SD rats are selected for experiments (160 rats, healthy, female, clean and 280 +/-7G in weight after 4-5 weeks of age), and are randomly divided into 8 groups after being raised for 1 week, wherein each group comprises 20 rats, the group A is a negative control group (without modeling), the group B is a placebo vaseline group, the group C is a composition formula group (example 4), the group D is a control 1, the group E is a control 2, the group F is a control 3, the group G is a control 4, and the group H is a control 5.

A control was prepared with reference to the formulation of example 4, wherein control 1 was a control group containing no cow's milk, lanolin and sodium hyaluronate; control 2 was a control group containing no cow milk; control 3 was a control group containing no sodium hyaluronate; control 4 was a control without lanolin and control 5 was a control without lanolin and sodium hyaluronate. The details of cow milk, sodium hyaluronate and lanolin in the experimental sample (formulation in example 4) and the control formulation are shown in table 1, and the other components such as water phase, oil phase and the like are the same as in example 4.

Table 1:

the rats were depilated in selected areas of their backs, with depilating areas of 2cm by 2 cm. Group A had only depilatory but no other treatment, and groups B-H had depilatory sites molded with 0.7% 2, 4-Dinitrochlorobenzene (DCNB) in acetone (2 times with 3 days in between). The next day after molding, the dehaired parts were each smeared with different samples from table 1 above and gently massaged until not sticky, and the samples were smeared 2 times a day.

The scoring of skin lesions is carried out by Zhao dialectic ESI scoring method, and the overall curative effect standard of skin lesions is performed according to the guiding principles of clinical research on new Chinese medicine (Beijing: Chinese medicine science and technology publishing Co., 2002) compiled by Zheng Xiao Yu, and further the changes of eczema model erythema, epidermal exfoliation, etc. are observed. The results of the experiment are shown in FIG. 1.

FIG. 1 shows the evaluation of the symptoms of eczema skin lesions in rats. As can be seen from fig. 1: in the petrolatum only group (B), at the end of the observation period, the symptoms of skin lesions in the rats were not completely eliminated. The symptoms of the skin lesions were completely eliminated at the end of the 28-day observation period for both the experimental sample group and each control sample group. Among them, the recovery of skin damage symptoms was slightly faster in the four groups of the experimental sample (C), the control sample 3(F), the control sample 4(G), and the control sample 5(H) than in the two groups of the control sample 1(D) and the control sample 2(E), indicating that the elimination of skin damage symptoms could not be accelerated significantly without the composition components or with lanolin and hyaluronic acid alone. The cow milk formula has a beneficial effect on eliminating the skin damage symptoms. Meanwhile, only the test sample group (C) completely eliminated the symptoms of skin lesions at day 24. In the whole period, the recovery condition of the skin damage symptom of the group C is superior to that of other sample groups, so that the synergistic effect of the cow milk, the lanolin and the sodium hyaluronate is proved, the skin damage symptom can be relieved more quickly, the skin damage recovery is accelerated, and the effect is superior to that of the combination of any single component or two components in the composition.

2. Human efficacy testing experiment:

2.1, moisture retention and skin barrier function recovery evaluation experiment:

although the pathogenesis of infantile eczema is not clear, the skin barrier dysfunction is closely related to the infantile eczema. Infant eczema is often accompanied by symptoms of dry skin, which is characterized by low moisture content in the skin stratum corneum and higher transdermal moisture loss value of the skin. Therefore, reducing the water loss of the eczematous skin and increasing the water content of the eczematous skin are the basis for alleviating the symptoms of skin eczema. The experiment was performed by collecting 40 volunteers with weak skin barrier function (positive response to 5% lactic acid stimulation) and selecting the area on both sides of the nasal wing to test to study the repair ability of the skin barrier function of the skin care product containing the composition of the invention. A control was prepared with reference to the formulation of example 1, wherein control 6 was a control group that did not contain cow's milk, lanolin, and sodium hyaluronate; control 7 was a control without cow's milk; control 8 was a control group containing no sodium hyaluronate; control 9 was a control without lanolin and control 10 was a control without lanolin and sodium hyaluronate. The details of cow milk, sodium hyaluronate and lanolin in the experimental sample (formulation in example 1) and the control formulation are shown in table 2, and the other components such as water phase, oil phase and the like are the same as in example 1.

Table 2:

during testing, subjects were randomized into 5 groups of 10 individuals, with group a using sample and control 6 on each side of the face, group B using sample and control 7 on each side of the face, group C using sample and control 8 on each side of the face, group D using sample and control 9 on each side of the face, and group E using sample and control 10 on each side of the face. Samples were tested for short and long term moisturizing ability. The test was carried out in a constant temperature and humidity environment (22+2 ℃, 50% humidity). Data acquisition was performed using a Corneometer (stratum corneum moisture content) and a Tewameter TM 300 (transdermal moisture loss, TWEL) from Courage & Khazaka. Before testing, the subjects sit quietly for 0.5h and then test. And collecting corresponding data according to the specified time point. The experimental results are shown in fig. 2A, fig. 2B, fig. 2C, fig. 2D, fig. 2E, fig. 3A, fig. 3B, fig. 3C, fig. 3D and fig. 3E; fig. 2A to 2E show the effect of different control and samples on the rate of change of water content in stratum corneum (28 days,. p <0.05,. p < 0.01). Fig. 3A to 3E show the effect of different controls and samples on the rate of change of TWEL values (28 days,. p <0.05,. p < 0.01).

The experimental results show that: the skin moisture content in the area of the subject sample application was more or less higher than the control sample used for 28 days of continuous application of the sample, and the rate of change of TWEL was significantly higher in the area of the subject sample application than in the control sample used. Sample group >

control

8, 9, 10>

control

6, 7 in terms of the degree of increase in skin moisture content. There were significant differences between groups. Indicating that long term use of the sample containing the composition of the present invention significantly increased skin moisture content. The significant difference between the sample groups >

control

8, 9, 10>

control

6, 7 in terms of lowering skin moisture TWEL values indicates that the TEWL values can be significantly lowered by using the samples containing the composition of the invention for a long time, which has a beneficial effect on the repair of the skin barrier. In the aspect of synergistic effect, the sample group is better than the total of the control group 7+ the control group 10 in the aspects of increasing the skin moisture content and reducing the skin moisture TWEL value, which shows that the skin care product using the composition provided by the invention can play a good moisturizing effect on skin dryness caused by skin barrier dysfunction, repair the skin barrier and reduce the percutaneous moisture loss of the skin.

2.2, relieving effect evaluation experiment:

in order to study the effect of the composition on alleviating symptoms such as skin redness caused by eczema, the soothing effect of the formula is evaluated by a human histamine stimulation experiment. Selecting 30 Chinese healthy subjects with dry skin and self-identified skin sensitivity and positive lactic acid reaction (the lactic acid stabbing pain test score is more than or equal to 3 points), wherein the age range is 18-55 years old.

A control was prepared with reference to the formulation of example 5, wherein control 11 was a control group that did not contain cow's milk, lanolin, and sodium hyaluronate; control 12 was a control without cow's milk; control 13 was a control group containing no sodium hyaluronate; control 14 was a control without lanolin and control 15 was a control without lanolin and sodium hyaluronate. The details of cow milk, sodium hyaluronate and lanolin in the experimental sample (formulation in example 5) and the control formulation are shown in table 3, and the other components such as water phase, oil phase and the like are the same as in example 5.

Table 3:

during testing, the subjects were randomly divided into A, B groups of 15 persons each, the test samples in group A were experimental, control 11 and control 12 and control 15, and the test samples in group B were experimental, control 13, control 14 and control 15. The subjects selected 6 blocks of 3 x 3cm each at equal positions on the inner sides of the bent arms²The size skin was used as the test area and labeled, and the skin erythema index EI value was determined as the baseline value; randomly selecting 5 areas, stimulating the skin by using 1.7mg/ml histamine, dividing the 5 test areas into a negative control, an experimental sample group and 3 control products after the anaphylactic reaction is generated, selecting areas with the same size from the adjacent positions of 1 control sample as the experimental sample group, and measuring each skin index of each area as a baseline value after the anaphylactic reaction is generated; the test product was then applied: experimental samples were run with the composition formula, controls were run with controls 11, 12 and 15 (or 13, 14 and 15), respectively, and negative controls were left untreated to observe the natural repair process of the skin barrier; and applying the product before and after stimulation for 30min and 1h&Collecting data by a skin melanin and heme tester Mexameter MX 18 of Khazaka company; the experimental results are shown in fig. 4A and 4B. FIG. 4A and FIG. 4B are graphs showing the change of skin erythema index with time of different groups ((^bp<0.05 statistically different from the experimental group).

The experimental results show that: after the modeling is successful, the change trend of the erythema index EI value of the control products 11 and 12 groups is basically the same as that of the negative group, and the skin can be restored to the state before the treatment at 60min after the use. The erythema indices of

controls

13, 14 and 15 improved slowly over time, with the skin erythema index EI values at each time point after stimulation still being significantly higher than the baseline value. After 30min of use, the EI values decreased slightly, but were still above the baseline. The skin can be recovered to the state before treatment at 60min after application. Indicating that

control

13, 14 and 15 are able to provide some rejuvenation to the skin. After the model building of the experimental sample group is successful, the skin erythema index is slowly improved along with the time, and the EI value is obviously reduced after 30min, so that the experimental sample group can promote the repair of the skin barrier and the skin redness state, and the repair effect is obviously better than that of the

reference products

13, 14 and 15. The sample containing the composition has good skin barrier repair function and the effect of improving skin redness (erythema reaction), and the effect is better than the combination of any two components in the composition.

The results of the animal and human efficacy evaluation show that the composition and the formula containing the composition can obviously accelerate the improvement of eczema skin damage symptoms and effectively recover the skin barrier function.

3. Subjective evaluation of subjects

To evaluate the actual remission of the eczema symptoms by the composition of the invention, 20 children 3-12 years old with mild eczema were selected. Samples were used when mild symptoms appeared (example 4). The preparation is taken twice a day, and other medicines and skin care products are not used in the period. The effect of the sample on actually relieving the eczema symptom is evaluated in the using process. The evaluation results are shown in Table 4.

TABLE 4

The above results show that the composition in the ratio range of the invention can obviously relieve the skin eczema, and the composition outside the ratio range does not have the effect of relieving the skin eczema.

Claims

1. A skin care composition for alleviating infantile eczema comprises cow milk, lanolin and sodium hyaluronate.

2. The composition according to claim 1, wherein the formulation weight ratio of cow's milk, lanolin and sodium hyaluronate is (3-30): (1-8): (0.01-1).

3. The composition according to claim 2, wherein the formulation weight ratio of cow's milk, lanolin and sodium hyaluronate is (7-20): (1-4): (0.01-0.5).

4. Use of the composition of any one of claims 1 to 3 for preparing a cosmetic with efficacy of alleviating infantile eczema.

5. The use according to claim 4, wherein the composition is added to the cosmetic in a proportion by weight wherein cow's milk is 3% to 30% of the cosmetic, lanolin is 1% to 8% of the cosmetic, sodium hyaluronate is 0.01% to 1% of the cosmetic;

preferably, the composition is added into the cosmetics in a weight ratio that cow milk accounts for 7-20% of the cosmetics, lanolin accounts for 1-4% of the cosmetics, and sodium hyaluronate accounts for 0.01-0.5% of the cosmetics.

6. A cosmetic comprising the composition according to any one of claims 1 to 3.

7. The cosmetic according to claim 6, wherein the milk is contained in the cosmetic in an amount of 3 to 30% by weight; the weight content of the lanolin is 1% -8%; the weight content of the sodium hyaluronate is 0.01-1%;

preferably, in the cosmetic, the weight content of the cow milk is 7-20%; the weight content of the lanolin is 1% -4%; the weight content of the sodium hyaluronate is 0.01-0.5%.

8. The cosmetic according to claim 6 or 7, wherein the cosmetic is a skin cream.

9. The cosmetic according to claim 8, wherein the skin cream comprises the following components in percentage by weight of 100 percent:

10. the cosmetic according to claim 9, wherein the skin cream comprises the following components in percentage by weight of 100 percent: