CN112006956A - Acne-removing cream and preparation process thereof - Google Patents
Acne-removing cream and preparation process thereof Download PDFInfo
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- CN112006956A CN112006956A CN202010922828.8A CN202010922828A CN112006956A CN 112006956 A CN112006956 A CN 112006956A CN 202010922828 A CN202010922828 A CN 202010922828A CN 112006956 A CN112006956 A CN 112006956A
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- 206010000496 acne Diseases 0.000 title claims abstract description 38
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 36
- 239000006071 cream Substances 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 41
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 38
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 24
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 claims abstract description 16
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims abstract description 16
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims abstract description 16
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 16
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 16
- -1 polydimethylsiloxane Polymers 0.000 claims abstract description 15
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 claims abstract description 8
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000004375 Dextrin Substances 0.000 claims abstract description 8
- 229920001353 Dextrin Polymers 0.000 claims abstract description 8
- IUMSDRXLFWAGNT-UHFFFAOYSA-N Dodecamethylcyclohexasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 IUMSDRXLFWAGNT-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000003434 Sesamum indicum Nutrition 0.000 claims abstract description 8
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 8
- FGUZFFWTBWJBIL-XWVZOOPGSA-N [(1r)-1-[(2s,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)O[C@H](CO)[C@H]1OC[C@H](O)[C@H]1O FGUZFFWTBWJBIL-XWVZOOPGSA-N 0.000 claims abstract description 8
- 150000001413 amino acids Chemical class 0.000 claims abstract description 8
- 235000019425 dextrin Nutrition 0.000 claims abstract description 8
- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract description 8
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims abstract description 8
- 235000019341 magnesium sulphate Nutrition 0.000 claims abstract description 8
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 8
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 8
- 229960004889 salicylic acid Drugs 0.000 claims abstract description 8
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 8
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 8
- 229940057429 sorbitan isostearate Drugs 0.000 claims abstract description 8
- 239000000284 extract Substances 0.000 claims description 77
- 238000003756 stirring Methods 0.000 claims description 65
- 239000000463 material Substances 0.000 claims description 60
- 238000001816 cooling Methods 0.000 claims description 48
- 230000001804 emulsifying effect Effects 0.000 claims description 35
- 238000002156 mixing Methods 0.000 claims description 30
- 238000010438 heat treatment Methods 0.000 claims description 20
- 238000005086 pumping Methods 0.000 claims description 10
- 230000002441 reversible effect Effects 0.000 claims description 10
- 241000972673 Phellodendron amurense Species 0.000 claims description 8
- 230000002829 reductive effect Effects 0.000 claims description 8
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 7
- 244000025254 Cannabis sativa Species 0.000 claims description 7
- 241000100289 Lonicera confusa Species 0.000 claims description 7
- 244000153955 Reynoutria sachalinensis Species 0.000 claims description 7
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 claims description 7
- 241000304195 Salvia miltiorrhiza Species 0.000 claims description 7
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims description 7
- 244000000231 Sesamum indicum Species 0.000 claims description 7
- 241000246044 Sophora flavescens Species 0.000 claims description 7
- 244000269722 Thea sinensis Species 0.000 claims description 7
- 229930182478 glucoside Natural products 0.000 claims description 7
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 7
- 239000001331 rosmarinus officinalis leaf Substances 0.000 claims description 7
- 229940084038 salix alba bark extract Drugs 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims description 5
- 244000042664 Matricaria chamomilla Species 0.000 claims description 5
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims description 5
- 241001470703 Picrorhiza kurrooa Species 0.000 claims description 5
- 239000010404 Scutellaria baicalensis extract Substances 0.000 claims description 5
- 239000000498 cooling water Substances 0.000 claims description 5
- 239000008367 deionised water Substances 0.000 claims description 5
- 229910021641 deionized water Inorganic materials 0.000 claims description 5
- 238000007599 discharging Methods 0.000 claims description 5
- 238000007689 inspection Methods 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 238000005070 sampling Methods 0.000 claims description 5
- 241001470615 Picrorhiza Species 0.000 claims description 2
- 241000207929 Scutellaria Species 0.000 claims description 2
- 229940119217 chamomile extract Drugs 0.000 claims description 2
- 235000020221 chamomile extract Nutrition 0.000 claims description 2
- 239000003973 paint Substances 0.000 claims 2
- 210000003491 skin Anatomy 0.000 abstract description 11
- 210000002510 keratinocyte Anatomy 0.000 abstract description 5
- 230000004060 metabolic process Effects 0.000 abstract description 3
- 241000207961 Sesamum Species 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 238000012360 testing method Methods 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 230000003255 anti-acne Effects 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 102100028314 Filaggrin Human genes 0.000 description 2
- 101710088660 Filaggrin Proteins 0.000 description 2
- 102100038297 Kallikrein-1 Human genes 0.000 description 2
- 101710176219 Kallikrein-1 Proteins 0.000 description 2
- 241000186429 Propionibacterium Species 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 238000005336 cracking Methods 0.000 description 2
- 230000000593 degrading effect Effects 0.000 description 2
- 210000001047 desmosome Anatomy 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 238000009499 grossing Methods 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 238000007670 refining Methods 0.000 description 2
- 230000008591 skin barrier function Effects 0.000 description 2
- 230000003313 weakening effect Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 229940082940 phellodendron amurense bark extract Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to acne-removing cream which comprises the following components in percentage by weight: 3-10% of cyclopentasiloxane, 1-3% of sorbitan isostearate and 0.8-3% of cetyl PEG/PPG-10/1 polydimethylsiloxane; 3-10% of cyclohexasiloxane and 3-8% of isohexadecane; adding water to 100%; 3-10% of propylene glycol, 0.5-2% of p-hydroxyacetophenone, 0.5-2% of magnesium sulfate and 3-10% of glycerol; 3-10% of butanediol and 0.05-0.2% of sodium hyaluronate; 1-3% of water, 0.1-1% of dextrin, 0.1-1% of salicylic acid and 0.1-1% of sesame amino acid; polyquaternium-730.001-0.01% and butanediol 0.5-2%. The invention can accelerate the peeling of the epithelial keratinocyte normally and maintain the normal metabolism of the skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to acne-removing cream and a preparation process thereof.
Background
The acne-removing cream is a cosmetic with the functions of eliminating and relieving whelk. The acne is commonly known as acne, and is also called as whelk, pimple or comedo. The reason is that: the skin is often inflamed due to the blockage of hair follicles and sebaceous glands, accompanied by the growth of bacteria. The acne cream can effectively clean, beautify and relieve acne skin.
However, the existing acne cream has poor effects of eliminating acne red and swelling, smoothing acne marks, eliminating acne marks, improving skin pore refining effect and balancing grease secretion, so that the product has poor effects of controlling oil, removing acne and eliminating acne marks.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides acne-removing cream and a preparation process thereof.
The purpose of the invention is realized by the following technical scheme:
the acne-removing cream comprises the following components in percentage by weight:
phase A component: 3-10% of cyclopentasiloxane, 1-3% of sorbitan isostearate and 0.8-3% of cetyl PEG/PPG-10/1 polydimethylsiloxane;
phase B component: 3-10% of cyclohexasiloxane and 3-8% of isohexadecane;
phase C component: adding water to 100%;
phase D component: 3-10% of propylene glycol, 0.5-2% of p-hydroxyacetophenone, 0.5-2% of magnesium sulfate and 3-10% of glycerol;
phase E component: 3-10% of butanediol and 0.05-0.2% of sodium hyaluronate;
phase F component: 1-3% of water, 0.1-1% of dextrin, 0.1-1% of salicylic acid and 0.1-1% of sesame amino acid;
phase G component: polyquaternium-730.001-0.01% and butanediol 0.5-2%;
phase H component: 0.2-1% of white willow bark extract, 0.2-1% of salvia miltiorrhiza extract, 0.2-1% of picrorhiza extract, 0.2-1% of phellodendron bark extract, 0.2-1% of scutellaria extract, 0.2-1% of sophora flavescens extract, 0.2-1% of lonicera confusa extract and 0.2-1% of linear aspalaxyl extract;
phase I component: 0.3 to 1.5 percent of 1, 2-hexanediol;
phase J component: 0.01-0.1% of tea extract, 0.01-0.1% of dry-fruit grass root extract, 0.01-0.1% of giant knotweed root extract, 0.01-0.1% of rosemary leaf extract and 0.01-0.1% of chamomile extract;
phase K component: 0.5-2% of glycerol glucoside.
Further, the acne-removing cream comprises the following components in percentage by weight:
phase A component: 6.5% of cyclopentasiloxane, 2% of sorbitan isostearate, and 1.9% of cetyl PEG/PPG-10/1 polydimethylsiloxane;
phase B component: 6.5% of cyclohexasiloxane and 5.5% of isohexadecane;
phase C component: adding water to 100%;
phase D component: 6.5% of propylene glycol, 1.2% of p-hydroxyacetophenone, 1.3% of magnesium sulfate and 6.5% of glycerol;
phase E component: 6.5 percent of butanediol and 0.1 percent of sodium hyaluronate;
phase F component: 2% of water, 0.5% of dextrin, 0.6% of salicylic acid and 0.5% of sesame amino acid;
phase G component: polyquaternium-730.005% and butanediol 1.2%;
phase H component: 0.6% of white willow bark extract, 0.6% of salvia miltiorrhiza extract, 0.6% of picrorhiza kurroa extract, 0.6% of phellodendron bark extract, 0.6% of scutellaria baicalensis extract, 0.6% of sophora flavescens extract, 0.6% of lonicera confusa extract and 0.6% of alsabar extract;
phase I component: 0.9 percent of 1, 2-hexanediol;
phase J component: 0.05% of tea extract, 0.05% of dry-fruit grass root extract, 0.06% of giant knotweed root extract, 0.06% of rosemary leaf extract and 0.05% of chamomile flower extract;
phase K component: 1.3% of glycerol glucoside.
Further, the water is deionized water.
The preparation process of the acne-removing cream comprises the following steps:
s1, mixing and dispersing the materials of the phase A component into larger particles for later use;
s2, mixing the materials of the phase D component, and uniformly dispersing for later use;
s3, mixing and dispersing the materials of the phase E component into non-cluster or block shape for later use;
s4, uniformly mixing the materials of the phase F component, heating to 40-43 ℃, and dissolving for later use;
s5, adding the C-phase component into a water phase pot, heating to 95-100 ℃, keeping the temperature for 15min, and then starting cooling water to cool;
s6, cooling to 85-88 ℃, adding the uniformly dispersed D-phase component into a water phase pot, stirring for 10min, and continuing to cool after all the materials are completely dissolved;
s7, cooling to 60-65 ℃, adding the F phase component obtained in the step S4 into a water phase pot, and uniformly stirring for later use;
s8, adding the phase A component obtained in the step S1 into an emulsifying pot, adding the phase B component, and heating to 40-45 ℃;
s9, adjusting the stirring speed in the emulsifying pot to 10-15rpm, and extracting the emulsifying pot with the vacuum degree of 0.2-0.3 MPa;
s10, opening the vacuum material pumping valve to 1/3, and slowly pumping the material obtained in the step S7 into an emulsifying pot;
s11, adjusting the stirring speed in the emulsifying pot to 18-22rpm, starting the homogenizing speed to 23-25rpm, homogenizing for 0.5-1.5min, closing the vacuum degree, and continuously cooling;
s12, uniformly mixing the materials of the G phase component, stirring and heating to 55-60 ℃, and keeping the temperature for 8-12min to ensure that the materials are completely dissolved for later use;
s13, when the temperature of the materials in the emulsifying pot in the step S11 is reduced to 48 ℃, adding the G-phase component obtained in the step S12 into the emulsifying pot, stirring for 4-6min, and continuously reducing the temperature;
s14, cooling to 45 ℃, sequentially adding the materials of the H-phase component, controlling the stirring speed to 15-18rpm, and continuously cooling;
s15, cooling to 40 ℃, adding the phase I component, stirring for 2-4min, and continuously cooling;
s16, cooling to below 38 ℃, sequentially adding the J-phase component and the K-phase component, adjusting the stirring speed to be 20-25rpm, the homogenizing speed to be 20-23rpm, and homogenizing for 2-4min to ensure that all materials are completely dissolved and dispersed;
and S17, sampling, inspecting, and discharging after inspection is qualified to obtain the product.
Further, in the steps S1 to S4, the stirring speed is 20 to 24rpm during the mixing and stirring.
Further, during stirring, a forward and reverse rotation alternative stirring method is adopted, and the forward and reverse rotation switching time is 1-2 min.
Furthermore, the cooling speed is 1-3 ℃/min during cooling.
The invention has the following advantages:
1. the polyquaternium-73 kills propionibacterium to achieve the acne removing effect by weakening cell membranes and cell walls and degrading the inside of cells, and even a single polyquaternium-73 molecule also has antibacterial activity.
2. By inhibiting the expression of tissue kallikrein 7, the expression of filaggrin of keratinocytes is increased, the maintenance of the complete skin barrier function and the epidermal hydration function is promoted, and the desmosomes of granular layers are reduced for cracking, so that the epithelial keratinocytes are normally accelerated to be peeled off, and the normal metabolism of the skin is maintained.
Detailed Description
The invention is further described below with reference to examples, but the scope of the invention is not limited to the following.
[ example 1 ]
The acne-removing cream comprises the following components in percentage by weight:
phase A component: 3% of cyclopentasiloxane, 3% of sorbitan isostearate and 0.8% of cetyl PEG/PPG-10/1 polydimethylsiloxane;
phase B component: 10% of cyclohexasiloxane and 3% of isohexadecane;
phase C component: adding water to 100%;
phase D component: 10% of propylene glycol, 0.5% of p-hydroxyacetophenone, 2% of magnesium sulfate and 10% of glycerol;
phase E component: 3% of butanediol and 0.2% of sodium hyaluronate;
phase F component: 1% of water, 1% of dextrin, 0.1% of salicylic acid and 1% of sesame amino acid;
phase G component: polyquaternium-730.001% and butanediol 2%;
phase H component: 0.2% of white willow bark extract, 1% of salvia miltiorrhiza extract, 0.2% of picrorhiza kurroa extract, 1% of phellodendron bark extract, 0.2% of scutellaria baicalensis extract, 1% of sophora flavescens extract, 0.2% of lonicera confusa extract and 1% of linear aspalata extract;
phase I component: 0.3% of 1, 2-hexanediol;
phase J component: 0.1% of tea extract, 0.01% of dry-fruit grass root extract, 0.01-0.1% of giant knotweed root extract, 0.1% of rosemary leaf extract and 0.01% of chamomile flower extract;
phase K component: 2% of glycerol glucoside.
Further, the water is deionized water.
The preparation process of the acne-removing cream comprises the following steps:
s1, mixing and dispersing the materials of the phase A component into larger particles for later use;
s2, mixing the materials of the phase D component, and uniformly dispersing for later use;
s3, mixing and dispersing the materials of the phase E component into non-cluster or block shape for later use;
s4, uniformly mixing the materials of the phase F component, heating to 40 ℃, and dissolving for later use;
s5, adding the C-phase component into a water phase pot, heating to 100 ℃, keeping the temperature for 15min, and then starting cooling water to cool;
s6, cooling to 85 ℃, adding the uniformly dispersed D-phase component into a water phase pot, stirring for 10min, and continuing cooling after ensuring that all materials are completely dissolved;
s7, cooling to 65 ℃, adding the F-phase component obtained in the step S4 into a water phase pot, and uniformly stirring for later use;
s8, adding the phase A component obtained in the step S1 into an emulsifying pot, adding the phase B component, and heating to 40 ℃;
s9, adjusting the stirring speed in the emulsifying pot to 15rpm, and extracting the emulsifying pot with the vacuum degree of 0.2 MPa;
s10, opening the vacuum material pumping valve to 1/3, and slowly pumping the material obtained in the step S7 into an emulsifying pot;
s11, adjusting the stirring speed in the emulsifying pot to 22rpm, starting the homogenizing speed to 23rpm, closing the vacuum degree after homogenizing for 1.5min, and continuously cooling;
s12, uniformly mixing the materials of the G phase component, stirring and heating to 55 ℃, and keeping the temperature for 12min to ensure that the materials are completely dissolved for later use;
s13, when the temperature of the materials in the emulsifying pot in the step S11 is reduced to 48 ℃, adding the G-phase component obtained in the step S12 into the emulsifying pot, stirring for 4min, and continuously reducing the temperature;
s14, cooling to 45 ℃, sequentially adding the materials of the H-phase component, controlling the stirring speed to be 18rpm, and continuously cooling;
s15, cooling to 40 ℃, adding the phase I component, stirring for 2min, and continuously cooling;
s16, cooling to below 38 ℃, sequentially adding the J-phase component and the K-phase component, adjusting the stirring speed to 25rpm, the homogenizing speed to 20rpm, and homogenizing for 4min to ensure that all materials are completely dissolved and dispersed;
and S17, sampling, inspecting, and discharging after inspection is qualified to obtain the product.
In this embodiment, in steps S1 to S4, the stirring speed is 20rpm during the mixing and stirring, and more preferably, the forward and reverse rotation alternate stirring method is adopted during the stirring, and the forward and reverse rotation switching time is 2 min.
In this embodiment, the cooling rate is 1 ℃/min.
[ example 2 ]
The acne-removing cream comprises the following components in percentage by weight:
phase A component: 6.5% of cyclopentasiloxane, 2% of sorbitan isostearate, and 1.9% of cetyl PEG/PPG-10/1 polydimethylsiloxane;
phase B component: 6.5% of cyclohexasiloxane and 5.5% of isohexadecane;
phase C component: adding water to 100%;
phase D component: 6.5% of propylene glycol, 1.2% of p-hydroxyacetophenone, 1.3% of magnesium sulfate and 6.5% of glycerol;
phase E component: 6.5 percent of butanediol and 0.1 percent of sodium hyaluronate;
phase F component: 2% of water, 0.5% of dextrin, 0.6% of salicylic acid and 0.5% of sesame amino acid;
phase G component: polyquaternium-730.005% and butanediol 1.2%;
phase H component: 0.6% of white willow bark extract, 0.6% of salvia miltiorrhiza extract, 0.6% of picrorhiza kurroa extract, 0.6% of phellodendron bark extract, 0.6% of scutellaria baicalensis extract, 0.6% of sophora flavescens extract, 0.6% of lonicera confusa extract and 0.6% of alsabar extract;
phase I component: 0.9 percent of 1, 2-hexanediol;
phase J component: 0.05% of tea extract, 0.05% of dry-fruit grass root extract, 0.06% of giant knotweed root extract, 0.06% of rosemary leaf extract and 0.05% of chamomile flower extract;
phase K component: 1.3% of glycerol glucoside.
Further, the water is deionized water.
The preparation process of the acne-removing cream comprises the following steps:
s1, mixing and dispersing the materials of the phase A component into larger particles for later use;
s2, mixing the materials of the phase D component, and uniformly dispersing for later use;
s3, mixing and dispersing the materials of the phase E component into non-cluster or block shape for later use;
s4, uniformly mixing the materials of the phase F component, heating to 42 ℃, and dissolving for later use;
s5, adding the C-phase component into a water phase pot, heating to 98 ℃, keeping the temperature for 15min, and then starting cooling water to cool;
s6, cooling to 87 ℃, adding the uniformly dispersed D-phase component into a water phase pot, stirring for 10min, and continuing cooling after ensuring that all materials are completely dissolved;
s7, cooling to 63 ℃, adding the F-phase component obtained in the step S4 into a water phase pot, and uniformly stirring for later use;
s8, adding the phase A component obtained in the step S1 into an emulsifying pot, adding the phase B component, and heating to 42 ℃;
s9, adjusting the stirring speed in the emulsifying pot to 12rpm, and extracting the emulsifying pot with the vacuum degree of 0.25 MPa;
s10, opening the vacuum material pumping valve to 1/3, and slowly pumping the material obtained in the step S7 into an emulsifying pot;
s11, adjusting the stirring speed in the emulsifying pot to 20rpm, starting the homogenizing speed to 24rpm, closing the vacuum degree after homogenizing for 1min, and continuously cooling;
s12, uniformly mixing the materials of the G phase component, stirring and heating to 57 ℃, and keeping the temperature for 10min to ensure that the materials are completely dissolved for later use;
s13, when the temperature of the materials in the emulsifying pot in the step S11 is reduced to 48 ℃, adding the G-phase component obtained in the step S12 into the emulsifying pot, stirring for 5min, and continuously reducing the temperature;
s14, cooling to 45 ℃, sequentially adding the materials of the H-phase component, controlling the stirring speed to be 17rpm, and continuously cooling;
s15, cooling to 40 ℃, adding the phase I component, stirring for 3min, and continuously cooling;
s16, cooling to below 38 ℃, sequentially adding the J-phase component and the K-phase component, adjusting the stirring speed to 22rpm, the homogenizing speed to 22rpm, and homogenizing for 3min to ensure that all materials are completely dissolved and dispersed;
and S17, sampling, inspecting, and discharging after inspection is qualified to obtain the product.
In this embodiment, in steps S1 to S4, the stirring speed is 22rpm during the mixing and stirring, and more preferably, the forward/reverse rotation alternate stirring method is adopted during the stirring, and the forward/reverse rotation switching time is 1.5 min.
In this embodiment, the cooling rate is 2 ℃/min.
[ example 3 ]
The acne-removing cream comprises the following components in percentage by weight:
phase A component: 10% of cyclopentasiloxane, 1% of sorbitan isostearate, and 3% of cetyl PEG/PPG-10/1 polydimethylsiloxane;
phase B component: 3% of cyclohexasiloxane and 8% of isohexadecane;
phase C component: adding water to 100%;
phase D component: 3% of propylene glycol, 2% of p-hydroxyacetophenone, 0.5% of magnesium sulfate and 3% of glycerol;
phase E component: 3% of butanediol and 0.05% of sodium hyaluronate;
phase F component: 3% of water, 0.1% of dextrin, 1% of salicylic acid and 0.1% of sesame amino acid;
phase G component: polyquaternium-730.01% and butanediol 0.5%;
phase H component: 1% of white willow bark extract, 0.2% of salvia miltiorrhiza extract, 1% of picrorhiza kurroa extract, 0.2% of phellodendron amurense bark extract, 1% of scutellaria baicalensis extract, 0.2% of sophora flavescens extract, 1% of lonicera confusa extract and 0.2% of linear aspalata extract;
phase I component: 1.5% of 1, 2-hexanediol;
phase J component: 0.01% of tea extract, 0.1% of dry-fruit grass root extract, 0.01% of giant knotweed root extract, 0.1% of rosemary leaf extract and 0.01% of chamomile flower extract;
phase K component: glycerol glucoside 0.5%.
Further, the water is deionized water.
The preparation process of the acne-removing cream comprises the following steps:
s1, mixing and dispersing the materials of the phase A component into larger particles for later use;
s2, mixing the materials of the phase D component, and uniformly dispersing for later use;
s3, mixing and dispersing the materials of the phase E component into non-cluster or block shape for later use;
s4, uniformly mixing the materials of the phase F component, heating to 43 ℃, and dissolving for later use;
s5, adding the C-phase component into a water phase pot, heating to 95 ℃, keeping the temperature for 15min, and then starting cooling water to cool;
s6, cooling to 88 ℃, adding the uniformly dispersed D-phase component into a water phase pot, stirring for 10min, and continuing cooling after ensuring that all materials are completely dissolved;
s7, cooling to 60 ℃, adding the F-phase component obtained in the step S4 into a water phase pot, and uniformly stirring for later use;
s8, adding the phase A component obtained in the step S1 into an emulsifying pot, adding the phase B component, and heating to 45 ℃;
s9, adjusting the stirring speed in the emulsifying pot to 10rpm, and extracting the emulsifying pot with the vacuum degree of 0.3 MPa;
s10, opening the vacuum material pumping valve to 1/3, and slowly pumping the material obtained in the step S7 into an emulsifying pot;
s11, adjusting the stirring speed in the emulsifying pot to 18rpm, starting the homogenizing speed to 25rpm, closing the vacuum degree after homogenizing for 0.5min, and continuously cooling;
s12, uniformly mixing the materials of the G-phase component, stirring and heating to 60 ℃, and keeping the temperature for 8min to ensure that the materials are completely dissolved for later use;
s13, when the temperature of the materials in the emulsifying pot in the step S11 is reduced to 48 ℃, adding the G-phase component obtained in the step S12 into the emulsifying pot, stirring for 6min, and continuously reducing the temperature;
s14, cooling to 45 ℃, sequentially adding the materials of the H-phase component, controlling the stirring speed to 15rpm, and continuously cooling;
s15, cooling to 40 ℃, adding the phase I component, stirring for 4min, and continuously cooling;
s16, cooling to below 38 ℃, sequentially adding the J-phase component and the K-phase component, adjusting the stirring speed to 20rpm, the homogenizing speed to 23rpm, and homogenizing for 2min to ensure that all materials are completely dissolved and dispersed;
and S17, sampling, inspecting, and discharging after inspection is qualified to obtain the product.
In this embodiment, in steps S1 to S4, the stirring speed is 24rpm during the mixing and stirring, and more preferably, the forward and reverse rotation alternate stirring method is adopted during the stirring, and the forward and reverse rotation switching time is 1 min.
In this embodiment, the cooling rate is 3 ℃/min.
Comparative experiment:
1. the test conditions are as follows: because the whelk is mostly seen in oily skin teenagers with vigorous grease secretion, 40 volunteers with 15-25 years old and severe facial whelk are selected as test volunteers, wherein 20 men and 20 women have 20 volunteers, all the volunteers are randomly divided into 4 groups, each group comprises 10 persons, including 5 men and 5 women, and no other skin care products or drug treatment is carried out on the whelk during the test period of the volunteers, and no other existing skin diseases exist. Each group was tested by using the corresponding anti-acne cream, and the volunteers used the cream once a day in the morning and at night for 56 days, and the experiments were performed by using the cream of examples 1-3 and the existing anti-acne cream product (the product is anti-acne cream produced by a company of Guangzhou).
2. In the experiment, each group of volunteers smears the corresponding test sample 2 times in the morning and evening every day, the test samples are evenly smeared according to the dosage of 1.0mg/cm2 every time, the feeling after use is truly reflected in the process of continuously using the comparative experiment product, and meanwhile, the time of eliminating the red swelling, smoothening the pockmarks and eliminating the pox marks is recorded by matching with the experiment staff.
3. The pore fineness and the oil improvement condition of the skin of each volunteer are measured by a Visia skin detector (USA) and a skin oil tester SM815-MPA (Germany) before and after the use, the measurement is repeated for 5 times respectively to obtain the average value of the pore fineness and the oil degree of each volunteer, and then the data is processed to obtain the average value of the pore fineness and the oil improvement value before and after all the volunteers in each group use the product.
And (3) test results:
according to the table, the test products in the examples 1-3 of the invention have obviously higher effects on eliminating whelk red swelling, smoothing pockmarks, eliminating pockmarks, improving skin pore refining effect and balancing oil secretion than the reference product. The comparison of the examples shows that the addition of polyquaternium-73 or PHELLODENDRON AMURENSE (PHELLODENDRON AMURENSE) bark extract can improve the effects of controlling oil, removing acne and eliminating acne marks of the product.
1. The polyquaternium-73 kills propionibacterium to achieve the acne removing effect by weakening cell membranes and cell walls and degrading the inside of cells, and even a single polyquaternium-73 molecule also has antibacterial activity.
2. By inhibiting the expression of tissue kallikrein 7, the expression of filaggrin of keratinocytes is increased, the maintenance of the complete skin barrier function and the epidermal hydration function is promoted, and the desmosomes of granular layers are reduced for cracking, so that the epithelial keratinocytes are normally accelerated to be peeled off, and the normal metabolism of the skin is maintained.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. An acne-removing cream is characterized in that: the paint consists of the following components in percentage by weight:
phase A component: 3-10% of cyclopentasiloxane, 1-3% of sorbitan isostearate and 0.8-3% of cetyl PEG/PPG-10/1 polydimethylsiloxane;
phase B component: 3-10% of cyclohexasiloxane and 3-8% of isohexadecane;
phase C component: adding water to 100%;
phase D component: 3-10% of propylene glycol, 0.5-2% of p-hydroxyacetophenone, 0.5-2% of magnesium sulfate and 3-10% of glycerol;
phase E component: 3-10% of butanediol and 0.05-0.2% of sodium hyaluronate;
phase F component: 1-3% of water, 0.1-1% of dextrin, 0.1-1% of salicylic acid and 0.1-1% of sesame amino acid;
phase G component: polyquaternium-730.001-0.01% and butanediol 0.5-2%;
phase H component: 0.2-1% of white willow bark extract, 0.2-1% of salvia miltiorrhiza extract, 0.2-1% of picrorhiza extract, 0.2-1% of phellodendron bark extract, 0.2-1% of scutellaria extract, 0.2-1% of sophora flavescens extract, 0.2-1% of lonicera confusa extract and 0.2-1% of linear aspalaxyl extract;
phase I component: 0.3 to 1.5 percent of 1, 2-hexanediol;
phase J component: 0.01-0.1% of tea extract, 0.01-0.1% of dry-fruit grass root extract, 0.01-0.1% of giant knotweed root extract, 0.01-0.1% of rosemary leaf extract and 0.01-0.1% of chamomile extract;
phase K component: 0.5-2% of glycerol glucoside.
2. The acne-removing cream according to claim 1, characterized in that: the paint consists of the following components in percentage by weight:
phase A component: 6.5% of cyclopentasiloxane, 2% of sorbitan isostearate, and 1.9% of cetyl PEG/PPG-10/1 polydimethylsiloxane;
phase B component: 6.5% of cyclohexasiloxane and 5.5% of isohexadecane;
phase C component: adding water to 100%;
phase D component: 6.5% of propylene glycol, 1.2% of p-hydroxyacetophenone, 1.3% of magnesium sulfate and 6.5% of glycerol;
phase E component: 6.5 percent of butanediol and 0.1 percent of sodium hyaluronate;
phase F component: 2% of water, 0.5% of dextrin, 0.6% of salicylic acid and 0.5% of sesame amino acid;
phase G component: polyquaternium-730.005% and butanediol 1.2%;
phase H component: 0.6% of white willow bark extract, 0.6% of salvia miltiorrhiza extract, 0.6% of picrorhiza kurroa extract, 0.6% of phellodendron bark extract, 0.6% of scutellaria baicalensis extract, 0.6% of sophora flavescens extract, 0.6% of lonicera confusa extract and 0.6% of alsabar extract;
phase I component: 0.9 percent of 1, 2-hexanediol;
phase J component: 0.05% of tea extract, 0.05% of dry-fruit grass root extract, 0.06% of giant knotweed root extract, 0.06% of rosemary leaf extract and 0.05% of chamomile flower extract;
phase K component: 1.3% of glycerol glucoside.
3. The acne-removing cream according to claim 1 or 2, characterized in that: the water is deionized water.
4. The preparation process of the acne-removing cream according to any one of claims 1 to 3, characterized by comprising the following steps: comprises the following steps:
s1, mixing and dispersing the materials of the phase A component into larger particles for later use;
s2, mixing the materials of the phase D component, and uniformly dispersing for later use;
s3, mixing and dispersing the materials of the phase E component into non-cluster or block shape for later use;
s4, uniformly mixing the materials of the phase F component, heating to 40-43 ℃, and dissolving for later use;
s5, adding the C-phase component into a water phase pot, heating to 95-100 ℃, keeping the temperature for 15min, and then starting cooling water to cool;
s6, cooling to 85-88 ℃, adding the uniformly dispersed D-phase component into a water phase pot, stirring for 10min, and continuing to cool after all the materials are completely dissolved;
s7, cooling to 60-65 ℃, adding the F phase component obtained in the step S4 into a water phase pot, and uniformly stirring for later use;
s8, adding the phase A component obtained in the step S1 into an emulsifying pot, adding the phase B component, and heating to 40-45 ℃;
s9, adjusting the stirring speed in the emulsifying pot to 10-15rpm, and extracting the emulsifying pot with the vacuum degree of 0.2-0.3 MPa;
s10, opening the vacuum material pumping valve to 1/3, and slowly pumping the material obtained in the step S7 into an emulsifying pot;
s11, adjusting the stirring speed in the emulsifying pot to 18-22rpm, starting the homogenizing speed to 23-25rpm, homogenizing for 0.5-1.5min, closing the vacuum degree, and continuously cooling;
s12, uniformly mixing the materials of the G phase component, stirring and heating to 55-60 ℃, and keeping the temperature for 8-12min to ensure that the materials are completely dissolved for later use;
s13, when the temperature of the materials in the emulsifying pot in the step S11 is reduced to 48 ℃, adding the G-phase component obtained in the step S12 into the emulsifying pot, stirring for 4-6min, and continuously reducing the temperature;
s14, cooling to 45 ℃, sequentially adding the materials of the H-phase component, controlling the stirring speed to 15-18rpm, and continuously cooling;
s15, cooling to 40 ℃, adding the phase I component, stirring for 2-4min, and continuously cooling;
s16, cooling to below 38 ℃, sequentially adding the J-phase component and the K-phase component, adjusting the stirring speed to be 20-25rpm, the homogenizing speed to be 20-23rpm, and homogenizing for 2-4min to ensure that all materials are completely dissolved and dispersed;
and S17, sampling, inspecting, and discharging after inspection is qualified to obtain the product.
5. The preparation process of the acne-removing cream according to claim 4, characterized in that: in steps S1 to S4, the stirring speed is 20 to 24rpm during the mixing and stirring.
6. The preparation process of the acne-removing cream according to claim 5, characterized in that: and during stirring, a forward and reverse rotation alternative stirring method is adopted, and the forward and reverse rotation switching time is 1-2 min.
7. The preparation process of the acne-removing cream according to claim 4, characterized in that: and when the temperature is reduced, the temperature reduction speed is 1-3 ℃/min.
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