CN117180153B - Whitening composition and preparation method and application thereof - Google Patents
Whitening composition and preparation method and application thereof Download PDFInfo
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- CN117180153B CN117180153B CN202311158810.5A CN202311158810A CN117180153B CN 117180153 B CN117180153 B CN 117180153B CN 202311158810 A CN202311158810 A CN 202311158810A CN 117180153 B CN117180153 B CN 117180153B
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- 239000000203 mixture Substances 0.000 title claims abstract description 89
- 238000002360 preparation method Methods 0.000 title abstract description 20
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- 240000001341 Reynoutria japonica Species 0.000 claims abstract description 24
- 235000018167 Reynoutria japonica Nutrition 0.000 claims abstract description 24
- 239000001198 melaleuca alternifolia leaf oil Substances 0.000 claims abstract description 22
- 240000001659 Oldenlandia diffusa Species 0.000 claims abstract description 21
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- 235000020221 chamomile extract Nutrition 0.000 claims abstract description 21
- YRJKYHIIYRGTCC-UHFFFAOYSA-M potassium;2-hydroxy-4-methoxybenzoate Chemical compound [K+].COC1=CC=C(C([O-])=O)C(O)=C1 YRJKYHIIYRGTCC-UHFFFAOYSA-M 0.000 claims abstract description 20
- 239000002904 solvent Substances 0.000 claims abstract description 19
- 239000002994 raw material Substances 0.000 claims abstract description 17
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- 238000000034 method Methods 0.000 claims description 9
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- XUDNWQSXPROHLK-OACYRQNASA-N 2-phenyl-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one Chemical class O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=CC=CC=2)OC2=CC=CC=C2C1=O XUDNWQSXPROHLK-OACYRQNASA-N 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Abstract
The invention relates to a whitening composition, a preparation method and application thereof, and belongs to the technical field of cosmetic preparation, wherein the raw materials of the whitening composition comprise: herba Hedyotidis Diffusae extract, rhizoma Polygoni Cuspidati extract, flos Matricariae Chamomillae extract, folium Melaleucae Albae oil, solvent, potassium methoxysalicylate, BAIHUZI oil and radix Glycyrrhiza glabra extract. The added oldenlandia diffusa extract, polygonum cuspidatum extract and chamomile extract have synergistic effects, and the prepared composition has a whitening effect by reducing synthesis of melanin, preventing melanin precipitation and aggregation and phagocytizing melanin; the added methoxy potassium salicylate assists the melaleuca alternifolia oil to soften and dissolve the cuticle and reduce the accumulation of grease on the surface of the skin; adding BAIHUAZI oil to assist the melaleuca alternifolia oil to degrade horny layer, and regulating exudation of hydration compound by changing keratin tissue to supplement water; the Glycyrrhiza glabra extract is added to effectively lock the water supplemented by the Begonia seed oil.
Description
Technical Field
The invention belongs to the technical field of cosmetic preparation, and particularly relates to a whitening composition, and a preparation method and application thereof.
Background
In recent years, with the improvement of the living standard of people, people have increasingly pursued beauty, and the demand for cosmetics has increased, and white skin and transparent skin are the targets of pursuing for a plurality of women all the time. At present, a plurality of whitening products exist on the market, but the functions of the whitening products are single, the problem of whitening can be solved only, the problem of oil control and water supplement which are needed to be synchronously solved by the masses is lacking, and in addition, the whitening effect of the whitening products on the market is not ideal. Therefore, in order to solve the above problems and meet the market demand, it is necessary to provide a whitening composition with good whitening effect and capable of synchronously controlling oil and water.
Disclosure of Invention
The invention aims to provide a whitening composition and a preparation method and application thereof, wherein the composition has excellent whitening effect by reducing synthesis of melanin, preventing melanin precipitation and aggregation and phagocytizing melanin by synergistic action of oldenlandia diffusa extract, polygonum cuspidatum extract and chamomile extract; the alternanthera philoxeroides leaf oil is used for degrading the stratum corneum and enhancing the diffusion effect of exogenous drugs on the skin, so that the permeation of exogenous drugs is promoted, and the whitening effect of the oldenlandia diffusa extract, the polygonum cuspidatum extract and the chamomile extract is stronger; on the basis, the potassium methoxysalicylate is used for assisting the melaleuca alternifolia oil to soften and dissolve the cuticle and reduce the accumulation of grease on the surface of the skin; the alternanthera philoxeroides leaf oil is used for assisting the alternanthera philoxeroides leaf oil to degrade the cuticle, and the exudation of the hydration compound is regulated by changing the keratin tissue so as to supplement water; finally, the Glycyrrhiza glabra extract is used for effectively locking the water supplemented by the Begonia oil; solves the problems of poor oil control, water supplementing and whitening effects existing in the prior whitening composition technology.
The aim of the invention can be achieved by the following technical scheme:
the whitening composition comprises the following raw materials in parts by weight:
as a preferable scheme of the invention, the solvent comprises any two of deionized water, ethylene glycol, 1, 3-butanediol and glycerol which are mixed according to equal mass.
As a preferable scheme of the invention, the oldenlandia diffusa extract is obtained by soaking and extracting oldenlandia diffusa with 30% alcohol as a solvent at room temperature; the polygonum cuspidatum extract is obtained by reflux-extracting the rhizome of polygonum cuspidatum with 95% ethanol; the chamomile extract is obtained by reflux-extracting chamomile with 50% alcohol.
As a preferred embodiment of the present invention, the whitening composition further comprises 1 to 1.8 parts by weight of potassium methoxysalicylate.
As a preferred embodiment of the present invention, the whitening composition further comprises 5 to 9 parts by weight of white pool flower oil.
As a preferred embodiment of the present invention, the whitening composition further comprises 7-13 parts by weight of Glycyrrhiza glabra extract.
As a preferable scheme of the invention, the glycyrrhiza glabra extract is obtained by reflux-extracting glycyrrhiza glabra rhizomes with 90% ethanol.
As a preferred scheme of the invention, the preparation method of the whitening composition comprises the following steps: and (3) stirring all raw materials of the whitening composition at a controlled temperature to obtain the whitening composition.
As a preferable scheme of the invention, the temperature of the temperature-controlled stirring is 25-29 ℃ and the time is 0.5-1h.
As a preferable scheme of the invention, the application of the whitening composition is that the whitening composition is added into a skin care product according to the mass percentage of 4-6%.
As a preferred embodiment of the present invention, the skin care product includes essence, cream, toner, mask and emulsion.
The invention has the beneficial effects that:
(1) The invention adds the oldenlandia diffusa extract, the polygonum cuspidatum extract and the chamomile extract, so that the prepared composition has excellent whitening effect. The herba Hedyotidis Diffusae extract mainly contains anthraquinone, flavone, flavonol glycoside and triterpene saponin compounds, has strong inhibition on B-16 melanocyte activity involved in regulating skin melanin synthesis process, and can reduce melanin synthesis and cytochrome generation; the polygonum cuspidatum extract is rich in quinone compounds and flavonoid compounds, and can effectively prevent melanin precipitation and aggregation; on the basis, chamomile extract containing flavonoid compounds, caffeic acid, various amino acids and the like is added, so that macrophage activity is stimulated, and the melanin phagocytic capacity and the skin self-repairing capacity of the system are enhanced. Namely, the three are synergistic, and the prepared composition has excellent whitening effect by reducing synthesis of melanin, preventing melanin precipitation and aggregation and phagocytizing melanin.
(2) The invention adds the melaleuca alternifolia leaf oil, which contains melaleuca alternifolia, p-cymene, 4-terpineol, alpha-terpineol, 1, 8-eucalyptol, y-terpinene, carvacrol, ursolic acid and other components, has the functions of degrading the stratum corneum and enhancing the diffusion of exogenous drugs on the skin, thereby promoting the permeation of exogenous drugs and further strengthening the whitening effect of oldenlandia diffusa extract, polygonum cuspidatum extract and chamomile extract; on the basis, the research and development personnel also add the potassium methoxysalicylate and the white pool flower oil, the potassium methoxysalicylate permeates deep into the horny layer, the inter-leaf cajeput oil is assisted to soften and dissolve the horny layer, and the falling of the horny layer is promoted; the ecdysone in the white pool flower oil can effectively assist the melaleuca alternifolia leaf oil to degrade the cuticle, and the exudation of the hydration compound is regulated by changing the keratin tissue, so that the moisture is absorbed again and the hydrate is formed in the epidermis layer of the skin, and the skin is moisturized; the potassium methoxysalicylate and the white pool flower oil are used for assisting in removing cutin, controlling oil and supplementing water respectively, assisting the melaleuca alternifolia oil of the inter-leaf to promote the penetration of exogenous drugs and strengthen the whitening effect of the system, and meanwhile, the prepared composition has better oil controlling and water supplementing effects.
(3) The Glycyrrhiza glabra extract is added, so that the prepared composition has excellent water supplementing and locking effects. This is because the Glycyrrhiza glabra extract promotes the production of aquaporin, and the increase of aquaporin is beneficial to the maintenance of the moisture on the skin surface, so that the Glycyrrhiza glabra extract can effectively lock the moisture supplemented by the Begonia oil, and the obtained composition has excellent moisturizing and water locking effects.
Detailed Description
The technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The used oil of the mutually-grown leaf cajeput leaves is purchased from Hubei Shuai Yanli high biological medicine company, and the white pool flower seed oil is purchased from Hubei Yi Jia chemical industry company; the oldenlandia diffusa extract is prepared by soaking and extracting oldenlandia diffusa with 30% alcohol as a solvent at room temperature by a conventional method, the polygonum cuspidatum extract is prepared by reflux-extracting polygonum cuspidatum rhizome with 95% alcohol by a conventional method, and the chamomile extract is prepared by reflux-extracting chamomile with 50% alcohol by a conventional method; the Glycyrrhiza glabra extract is obtained by reflux-extracting Glycyrrhiza glabra rhizome with 90% ethanol by conventional method; the above description is omitted.
Example 1
The whitening composition comprises the following raw materials in parts by weight:
the solvent is deionized water and ethylene glycol which are mixed according to equal mass.
The preparation method of the whitening composition comprises the following steps: and (3) stirring the oldenlandia diffusa extract, the polygonum cuspidatum extract, the chamomile extract, the melaleuca alternifolia leaf oil, deionized water and ethylene glycol at the temperature of 25 ℃ for 1h to obtain the whitening composition.
Example 2
The whitening composition comprises the following raw materials in parts by weight:
the solvent is glycerol and 1, 3-butanediol which are mixed according to equal mass.
The preparation method of the whitening composition comprises the following steps: and (3) stirring the oldenlandia diffusa extract, the polygonum cuspidatum extract, the chamomile extract, the melaleuca alternifolia leaf oil, the glycerol and the 1, 3-butanediol at the temperature of 27 ℃ for 0.5h to obtain the whitening composition.
Example 3
The whitening composition comprises the following raw materials in parts by weight:
the solvent is deionized water and glycerol which are mixed according to equal mass.
The preparation method of the whitening composition comprises the following steps: and (3) stirring the oldenlandia diffusa extract, the polygonum cuspidatum extract, the chamomile extract, the melaleuca alternifolia leaf oil, the deionized water and the glycerol for 1h at the temperature of 29 ℃ to obtain the whitening composition.
Example 4
The whitening composition comprises the following raw materials in parts by weight:
the solvent is deionized water and glycerol which are mixed according to equal mass.
The preparation method of the whitening composition comprises the following steps: and (3) stirring the oldenlandia diffusa extract, the polygonum cuspidatum extract, the chamomile extract, the melaleuca alternifolia leaf oil, the potassium methoxysalicylate, the deionized water and the glycerol for 1h at the temperature of 29 ℃ to obtain the whitening composition.
Example 5
The whitening composition comprises the following raw materials in parts by weight:
the solvent is deionized water and glycerol which are mixed according to equal mass.
The preparation method of the whitening composition comprises the following steps: and (3) stirring the oldenlandia diffusa extract, the polygonum cuspidatum extract, the chamomile extract, the melaleuca alternifolia leaf oil, the potassium methoxysalicylate, the deionized water and the glycerol for 1h at the temperature of 29 ℃ to obtain the whitening composition.
Example 6
The whitening composition comprises the following raw materials in parts by weight:
the solvent is deionized water and glycerol which are mixed according to equal mass.
The preparation method of the whitening composition comprises the following steps: and (3) stirring the oldenlandia diffusa extract, the polygonum cuspidatum extract, the chamomile extract, the melaleuca alternifolia leaf oil, the potassium methoxysalicylate, the deionized water and the glycerol for 1h at the temperature of 29 ℃ to obtain the whitening composition.
Example 7
The whitening composition comprises the following raw materials in parts by weight:
the solvent is deionized water and glycerol which are mixed according to equal mass.
The preparation method of the whitening composition comprises the following steps: mixing herba Hedyotidis Diffusae extract, rhizoma Polygoni Cuspidati extract, flos Matricariae Chamomillae extract, folium Melaleucae Alternifoliae oil, potassium methoxysalicylate, BAIHUAZI oil, deionized water and glycerol at 29 deg.C under stirring for 1 hr to obtain whitening composition.
Example 8
The whitening composition comprises the following raw materials in parts by weight:
the solvent is deionized water and glycerol which are mixed according to equal mass.
The preparation method of the whitening composition comprises the following steps: mixing herba Hedyotidis Diffusae extract, rhizoma Polygoni Cuspidati extract, flos Matricariae Chamomillae extract, folium Melaleucae Alternifoliae oil, potassium methoxysalicylate, BAIHUAZI oil, deionized water and glycerol at 29 deg.C under stirring for 1 hr to obtain whitening composition.
Example 9
The whitening composition comprises the following raw materials in parts by weight:
the solvent is deionized water and glycerol which are mixed according to equal mass.
The preparation method of the whitening composition comprises the following steps: mixing herba Hedyotidis Diffusae extract, rhizoma Polygoni Cuspidati extract, flos Matricariae Chamomillae extract, folium Melaleucae Alternifoliae oil, potassium methoxysalicylate, BAIHUAZI oil, deionized water and glycerol at 29 deg.C under stirring for 1 hr to obtain whitening composition.
Example 10
The whitening composition comprises the following raw materials in parts by weight:
the solvent is deionized water and glycerol which are mixed according to equal mass.
The preparation method of the whitening composition comprises the following steps: and (3) stirring the oldenlandia diffusa extract, the polygonum cuspidatum extract, the chamomile extract, the melaleuca alternifolia leaf oil, the potassium methoxysalicylate, the white pool flower oil, the licorice root extract, the deionized water and the glycerol for 1h at the temperature of 29 ℃ to obtain the whitening composition.
Example 11
The whitening composition comprises the following raw materials in parts by weight:
the solvent is deionized water and glycerol which are mixed according to equal mass.
The preparation method of the whitening composition comprises the following steps: and (3) stirring the oldenlandia diffusa extract, the polygonum cuspidatum extract, the chamomile extract, the melaleuca alternifolia leaf oil, the potassium methoxysalicylate, the white pool flower oil, the licorice root extract, the deionized water and the glycerol for 1h at the temperature of 29 ℃ to obtain the whitening composition.
Example 12
The whitening composition comprises the following raw materials in parts by weight:
the solvent is deionized water and glycerol which are mixed according to equal mass.
The preparation method of the whitening composition comprises the following steps: and (3) stirring the oldenlandia diffusa extract, the polygonum cuspidatum extract, the chamomile extract, the melaleuca alternifolia leaf oil, the potassium methoxysalicylate, the white pool flower oil, the licorice root extract, the deionized water and the glycerol for 1h at the temperature of 29 ℃ to obtain the whitening composition.
Example 13
The whitening composition prepared in example 12 was added to a skin care product, which was essence, at a mass percentage of 5%.
Example 14
The whitening composition prepared in example 12 was added to a skin care product, which was toner, at a mass percentage of 4%.
Example 15
The whitening composition prepared in example 12 was added to a skin care product which was a cream in terms of mass percentage of 6%.
Comparative examples 1 to 3
The difference compared with example 12 is that the parts by weight of the oldenlandia diffusa extract, the polygonum cuspidatum extract and the chamomile extract in comparative examples 1 to 3 are shown in table 1, and the remaining parameters and the operation steps are not changed.
TABLE 1
Comparative example 4
In comparison with example 12, the difference is that in comparative example 4, the inter-leaf melaleuca alternifolia oil was not added, and the remaining parameters and the procedure were unchanged.
Comparative example 5
In comparison with example 12, the difference is that in comparative example 5, potassium methoxysalicylate was not added, and the remaining parameters and the procedure were unchanged.
Comparative example 6
The difference compared to example 12 is that no white Chi Huazi oil was added in comparative example 6, and the remaining parameters and operating procedures were unchanged.
Comparative example 7
The difference compared to example 12 is that no Glycyrrhiza glabra extract was added in comparative example 7, and the remaining parameters and procedures were unchanged.
Test example 1
The skin health and no harm of 90 volunteers in the age range of 28-38 years are selected, wherein 45 volunteers are randomly divided into 9 groups, the obtained face cream is prepared by using the whitening compositions in examples 10-12 and comparative examples 1-6 (the addition amount of the whitening composition is 5%), a 4cm multiplied by 4cm area on the inner side of the left forearm of the volunteer is used as a tested area to apply face cream sample, and the volunteers cannot apply any cosmetics on the tested area during the experiment, and the application method is that the face cream is used once a day in the morning and evening for 28 days.
Cleaning the smearing parts before and after use, testing the skin melanin content of the tested area by adopting a pigment test probe after 0 day and 28 days of using the product, testing for three times, and taking an average value of the results;
the results are shown in Table 2.
TABLE 2
As can be seen from table 2, the creams prepared with the whitening compositions of examples 10 to 12 can significantly reduce M I values, and the melanin content in the skin is significantly reduced; while the creams prepared with the whitening compositions of comparative examples 1 to 6 had a reduced M I value, the reduction was less and the melanin content in the skin was still greater. According to research, the invention is found that the synergistic effect of the oldenlandia diffusa extract, the polygonum cuspidatum extract and the chamomile extract is added, and the prepared composition has excellent whitening effect by reducing melanin synthesis, preventing melanin precipitation and aggregation and phagocytizing melanin and proceeding gradually.
Test example 2
The age range is 25-35 years, and the skin health is not damaged, wherein 20 skin-friendly oily or mixed skin volunteers are selected, the 40 skin-friendly oily or mixed skin-friendly skin is prepared by randomly dividing the 40 skin-friendly volunteers into 4 groups, and the obtained face cream (the addition amount of the whitening composition is 5%) is prepared by using the whitening compositions in examples 10-12 and comparative example 5, and the face forehead area of the volunteer is used as a test area to be smeared with the face cream sample, wherein the use method is carried out once a day in the morning and evening for 28 days.
Detecting the oil content of the skin surface of the forehead part for 3 times by using an oil measuring instrument after 0 day and 28 days of using the product, taking an average value, and calculating the reduction amount of the oil content of the skin surface;
the results are shown in Table 3.
TABLE 3 Table 3
As can be seen from Table 3, the creams prepared with the whitening compositions of examples 10 to 12 of the present invention were effective in reducing the skin surface oil secretion, whereas the cream prepared with the whitening composition of comparative example 5 of the present invention was low in the reduction of the skin surface oil secretion. The invention is because the potassium methoxysalicylate is added on the basis of the melaleuca alternifolia oil, and the potassium methoxysalicylate penetrates deep into the horny layer to assist the melaleuca alternifolia oil to soften and dissolve the horny layer and promote the falling of the horny layer, and simultaneously, the potassium methoxysalicylate can also inhibit excessive secretion of sebaceous glands and reduce accumulation of grease on the surface of skin, thereby improving oily skin problem and reducing pore blockage.
Test example 3
50 volunteers 30-45 years old, 25 men and women, were randomly divided into 5 groups of 10, and the obtained creams were prepared using the whitening compositions of examples 10-12 and comparative examples 6-7, respectively (the addition amount of the whitening composition was 5%), and the face area of the volunteer was used as a test area to apply a cream sample once a day for 28 days.
Skin moisture content was measured using a skin moisture content tester Corneometer CM825 after 0 and 28 days of product use, and the moisture content of the skin before and after application of the cream was evaluated;
the results are shown in Table 4.
TABLE 4 Table 4
As can be seen from Table 4, the creams prepared with the whitening compositions of examples 10 to 12 of the present invention effectively increased the skin moisture content, whereas the creams prepared with the whitening compositions of comparative examples 6 to 7 of the present invention also increased the skin moisture content, but the effect of the increase was relatively insignificant. The invention is characterized in that white pool flower seed oil is added on the basis of the melaleuca alternifolia oil, ecdysone in the melaleuca alternifolia oil can effectively assist the melaleuca alternifolia oil to degrade the cuticle, and the exudation of the hydration compound is regulated by changing the keratin tissue, so that the moisture is absorbed again and the hydrate is formed on the skin epidermis layer, thereby the skin is moisturized; the added licorice extract can promote the generation of aquaporin and is beneficial to the maintenance of moisture on the surface of skin, so that the licorice extract can effectively lock the moisture supplemented by the white pool flower oil, and the prepared composition has excellent moisturizing and water locking effects.
In the description of the present specification, the descriptions of the terms "one embodiment," "example," "specific example," and the like, mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing is merely illustrative and explanatory of the invention, as various modifications and additions may be made to the particular embodiments described, or in a similar manner, by those skilled in the art, without departing from the scope of the invention or exceeding the scope of the invention as defined in the claims.
Claims (5)
1. The whitening composition is characterized by comprising the following raw materials in parts by weight:
12-21 parts by weight of oldenlandia diffusa extract
9-17 parts by weight of polygonum cuspidatum extract
11-19 parts by weight of chamomile extract
3-6 parts by weight of melaleuca alternifolia leaf oil
30-55 parts by weight of a solvent;
the whitening composition further comprises 1-1.8 parts by weight of potassium methoxysalicylate;
the whitening composition further comprises 5-9 parts by weight of white pool flower oil;
the whitening composition further comprises 7-13 parts by weight of licorice extract;
the solvent is any two of deionized water, ethylene glycol, 1, 3-butanediol and glycerol, which are mixed according to equal mass;
the herba Hedyotidis Diffusae extract is prepared by soaking herba Hedyotidis Diffusae in 30% alcohol as solvent at room temperature; the polygonum cuspidatum extract is obtained by reflux-extracting the rhizome of polygonum cuspidatum with 95% ethanol; the chamomile extract is obtained by reflux-extracting chamomile with 50% alcohol; the Glycyrrhiza glabra extract is obtained by reflux-extracting Glycyrrhiza glabra rhizome with 90% ethanol.
2. A method of preparing a whitening composition according to claim 1, wherein the method of preparing the whitening composition comprises: and (3) stirring all raw materials of the whitening composition at a controlled temperature to obtain the whitening composition.
3. The method for preparing the whitening composition according to claim 2, wherein the temperature of the temperature-controlled stirring is 25-29 ℃ for 0.5-1h.
4. Use of a whitening composition according to claim 1, wherein the whitening composition is added to a skin care product in an amount of 4-6% by mass.
5. The use of a whitening composition according to claim 4, wherein the skin care product comprises essence, cream, toner, mask and emulsion.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103405377A (en) * | 2013-08-15 | 2013-11-27 | 江南大学 | Natural skin whitening and protecting composition and application thereof in cosmetics |
| CN108078881A (en) * | 2017-12-29 | 2018-05-29 | 广州宸极生物科技有限公司 | A kind of skin repair liquid |
| CN111603427A (en) * | 2020-06-04 | 2020-09-01 | 山东哈工生物科技有限公司 | Whitening and relieving mask |
| CN114533613A (en) * | 2022-02-23 | 2022-05-27 | 厦门金泰生物科技有限公司 | Whitening cosmetic composition and preparation method and application thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103405377A (en) * | 2013-08-15 | 2013-11-27 | 江南大学 | Natural skin whitening and protecting composition and application thereof in cosmetics |
| CN108078881A (en) * | 2017-12-29 | 2018-05-29 | 广州宸极生物科技有限公司 | A kind of skin repair liquid |
| CN111603427A (en) * | 2020-06-04 | 2020-09-01 | 山东哈工生物科技有限公司 | Whitening and relieving mask |
| CN114533613A (en) * | 2022-02-23 | 2022-05-27 | 厦门金泰生物科技有限公司 | Whitening cosmetic composition and preparation method and application thereof |
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