CN113712846A - Composition and cosmetic composition for skin anti-inflammation and/or moisture retention, lipstick and preparation method thereof - Google Patents
Composition and cosmetic composition for skin anti-inflammation and/or moisture retention, lipstick and preparation method thereof Download PDFInfo
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- CN113712846A CN113712846A CN202110884555.7A CN202110884555A CN113712846A CN 113712846 A CN113712846 A CN 113712846A CN 202110884555 A CN202110884555 A CN 202110884555A CN 113712846 A CN113712846 A CN 113712846A
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- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/001—Preparations for care of the lips
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Abstract
The invention relates to the field of cosmetics, and discloses a composition for skin anti-inflammation and/or moisture retention, a cosmetic composition and a lipstick and a preparation method thereof, wherein the composition comprises the following active components: phytosterol esters, stearyl glycyrrhetinate, bisabolol, cochineal, tocopherol, glycolipids, and sodium hyaluronate. The cosmetic composition provided by the invention has good anti-inflammatory and moisturizing effects on skin.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to a composition and a cosmetic composition for skin anti-inflammation and moisture retention, a lipstick and a preparation method thereof.
Background
The stratum corneum and the granular layer of the lip skin are very thin, and the skin at the lip part has no melanocyte and can not effectively secrete melanin to resist photoaging; in addition, there are no sebaceous glands on the skin of the lips, and sebum cannot be secreted spontaneously to form a protective layer of a sebaceous membrane, thus causing the water loss rate of the skin of the lips to be much higher than that of the skin of the face.
Modern women use lipstick frequently for pursuit of beauty, and substances such as artificial pigments, artificial essences, heavy metals, high-polarity synthetic esters and the like contained in the lipstick can cause sensitive, fragile, dry and peeling of lip skin, and even develop into common lip problems such as chronic exfoliative cheilitis and the like.
With the improvement of the living standard of people, more and more women have the requirements on the lipstick that the lipstick is not only closed and moisturized, but also has the anti-cheilitis and deep and long-acting nourishing requirements, so that the development of a brand-new and upgraded lip essence cream is urgently needed to meet the more and more women's requirements.
Disclosure of Invention
One of the objects of the present invention is to overcome the problem of poor anti-inflammatory effect of the existing cosmetics when applied to the skin, in particular the skin of the lips.
It is another object of the present invention to overcome the problem of poor anti-inflammatory and moisturizing effects of existing cosmetics when applied to the skin, particularly the skin of the lips.
In order to achieve the above object, the present invention provides in a first aspect a composition for anti-inflammatory treatment of skin comprising a prophylactically effective amount of two or more of the following components stored in admixture or separately:
phytosterol esters, stearyl glycyrrhetinate, bisabolol, cochineal, and tocopherol;
in the composition, the content of stearyl glycyrrhetinate is 3-7 parts by weight, the content of bisabolol is 2-8 parts by weight, the content of cochineal is 15-35 parts by weight, and the content of tocopherol is 60-90 parts by weight, relative to 100 parts by weight of the phytosterol ester.
The composition provided by the invention has good anti-inflammatory effect when being applied to skin, particularly lip skin.
The second aspect of the invention provides a composition for skin anti-inflammation and moisture retention, which contains the following components with prevention and treatment effective amount, wherein the following components are stored in a mixed manner or independently:
phytosterol esters, stearyl glycyrrhetinate, bisabolol, cochineal, tocopherol, glycolipids, and sodium hyaluronate;
in the composition, the content of stearyl glycyrrhetinate is 3-7 parts by weight, the content of bisabolol is 2-8 parts by weight, the content of cochineal is 15-35 parts by weight, the content of tocopherol is 60-90 parts by weight, the content of glycolipid is 2-8 parts by weight, and the content of sodium hyaluronate is 20-30 parts by weight, relative to 100 parts by weight of the phytosterol ester.
The composition provided by the invention has good anti-inflammatory and moisturizing effects when being applied to skin, particularly lip skin.
The third aspect of the present invention provides a cosmetic composition for skin, which comprises an active ingredient and an auxiliary material, wherein the active ingredient is the above-mentioned anti-inflammatory composition and/or anti-inflammatory and moisturizing composition, and the content of the active ingredient is 4.0 wt% or more.
The invention provides a lipstick, which consists of a mixture A, a mixture B and a mixture C,
the mixture A contains white beeswax, carnauba wax, candelilla wax, shea butter, squalane, jojoba oil, white pond flower seed oil and camellia oil;
the mixture B contains phytosterol ester, stearyl glycyrrhetinate, ascorbyl palmitate, oil-dispersed sodium hyaluronate and glycolipid;
the mixture C contains bisabolol, wheat germ oil, rose hip oil, pomegranate seed oil, tocopherol, cochineal and rose essential oil;
in the lipstick, relative to 100 parts by weight of the phytosterol ester, the white beeswax is 850 parts by weight, the carnauba wax is 80-120 parts by weight, the candelilla wax is 240 parts by weight, the shea butter is 270 parts by weight, the squalane is 80-120 parts by weight, the jojoba oil is 950-1050 parts by weight, the meadowfoam seed oil is 80-120 parts by weight, and the camellia oil is 1650-1850 parts by weight;
3-7 parts of stearyl glycyrrhetinate, 7-12 parts of ascorbyl palmitate, 20-30 parts of oil-dispersed sodium hyaluronate and 2-8 parts of glycolipid;
2-8 parts of bisabolol, 80-120 parts of wheat germ oil, 175 parts of 125-mangosteen oil, 80-120 parts of pomegranate seed oil, 60-90 parts of tocopherol, 15-35 parts of cochineal and 10-20 parts of rose essential oil.
In a fifth aspect, the present invention provides a method of making a lipstick as described above, the method comprising:
(1) melting all components in the mixture A and then carrying out first mixing to obtain a mixture A1;
(2) secondly mixing the mixture B and the mixture A1 to obtain a mixture A1B;
(3) performing third mixing on the mixture C and the mixture A1B;
the conditions of the first mixing include: the temperature is 90-110 ℃, the stirring speed is 30-40rpm, and the time is 30-40 min;
the conditions of the second mixing include: the temperature is 75-85 ℃, the stirring speed is 30-40rpm, and the stirring time is 20-30 min;
the third mixing conditions include: the temperature is 65-75 ℃, the stirring speed is 30-40rpm, and the stirring time is 20-30 min.
More preferably, the composition provided by the invention can solve the problem of poor anti-cheilitis effect of the existing cosmetics. Particularly preferably, the composition provided by the invention has the advantages of deep long-term moisture retention and natural healthy color when being applied to skin.
Preferably, when the composition of the present invention is prepared into a lipstick form, the problems of poor anti-inflammatory and moisturizing effects caused by the use of the existing commercially available cosmetics can be improved.
Other features and advantages of the present invention will be described in more detail in the detailed description that follows.
Drawings
FIG. 1 is a graph comparing red areas on the lips of subjects before and after 4 weeks using the lipstick of preferred embodiment 1 of the present invention.
Detailed Description
The endpoints of the ranges and any values disclosed herein are not limited to the precise range or value, and such ranges or values should be understood to encompass values close to those ranges or values. For ranges of values, between the endpoints of each of the ranges and the individual points, and between the individual points may be combined with each other to give one or more new ranges of values, and these ranges of values should be considered as specifically disclosed herein.
It should be noted that, in various aspects of the present invention, the present invention is described only once in one aspect thereof without repeated description with respect to the same components in the aspects, and those skilled in the art should not be construed as limiting the present invention.
It should be noted that in the present invention, raw materials that are not described can be obtained commercially, and those skilled in the art can purchase the raw materials as needed, and in the present invention, detailed description is omitted.
First aspect
As described above, the first aspect of the present invention provides an anti-inflammatory composition for skin, which comprises the following components stored in admixture or separately in a prophylactically effective amount:
phytosterol esters, stearyl glycyrrhetinate, bisabolol, cochineal, and tocopherol;
in the composition, the content of stearyl glycyrrhetinate is 3-7 parts by weight, the content of bisabolol is 2-8 parts by weight, the content of cochineal is 15-35 parts by weight, and the content of tocopherol is 60-90 parts by weight, relative to 100 parts by weight of the phytosterol ester.
Preferably, the content of stearyl glycyrrhetinate is 4-6 parts by weight, the content of bisabolol is 4-6 parts by weight, the content of cochineal is 20-30 parts by weight, and the content of tocopherol is 70-80 parts by weight, relative to 100 parts by weight of the phytosterol ester. The inventors have found in the course of their research that the compositions provided by the present invention in this preferred aspect have a better anti-inflammatory effect when applied to the skin, in particular the skin of the lips.
The phytosterol ester contained in a specific amount in the composition disclosed by the invention enables the scheme disclosed by the invention to resist ultraviolet rays and photo-aging, and meanwhile, the composition also has a good anti-inflammatory effect; in addition, the scheme of the invention can increase the synthesis of collagen and hyaluronic acid of the dermal layer of the skin, and the long-acting moisturizing effect of silky and elegant is achieved.
Preferably, the phytosterol ester is an alcohol ester obtained by reacting a sterol with oleic acid, wherein the sterol is at least one selected from the group consisting of β -sitosterol, stigmasterol, campesterol and brassicasterol.
The present invention does not require any particular method of operation for obtaining alcohol esters from sterols reacted with oleic acid, and those skilled in the art can perform this method by using various methods known in the art.
Preferably, the sterol is obtained by extracting at least one natural material selected from pine, soybean, and rapeseed.
Preferably, the phytosterol ester is selected from Healthful Biotech
Of phytosterol esters, Vitae Naturals
At least one of Esterified phytosterol esters and BESTEROL-E phytosterol esters of TS-BIOTECH.
The specific content of the stearyl glycyrrhetinate in the present invention provides the present invention with superior anti-allergy and skin defense enhancing effects.
Preferably, the stearyl glycyrrhetinate is obtained from stearyl glycyrrhetinate of phytochemistry group pan-vegetal, Gansu, or the stearyl glycyrrhetinate is obtained from stearyl glycyrrhetinate of Nippon Bolus pharmaceutical Co.
The bisabolol with a specific content in the scheme has the effects of resisting inflammation and inhibiting bacteria, is good in stability and skin compatibility, is beneficial to reducing skin inflammation and improving skin irritation resistance, and can effectively repair chronic cheilitis, calm and relieve and promote neogenesis.
Preferably, the bisabolol is natural bisabolol having a purity of 85 wt% or more.
More preferably, the natural bisabolol is isomeric levorotatory α -bisabolol having a purity of 88 wt% or more. Particularly preferably, the bisabolol is a high activity levobisabolol of natural origin, available from merck MERK, germany.
The cochineal red with a specific content in the scheme provided by the invention has a coloring effect and also has an obvious repairing effect on DNA damage caused by carcinogens.
Preferably, the cochineal red is natural cochineal red with a purity of 60 wt% or more. More preferably, the cochineal is native cochineal with a purity of 60-75 wt%. Particularly preferably, the cochineal is cochineal purchased from Sensin chemical Technologes, France.
The tocopherol with a specific content in the scheme of the invention is oil-soluble, so that the scheme of the invention has excellent oxidation resistance, can help the lip skin to resist photoaging and prevent the lip skin from being damaged by ultraviolet rays, can deeply nourish and moisturize the lip skin, promotes wound healing and prevents cheilitis, and has mild property and high skin-friendly property.
Preferably, the tocopherol is natural tocopherol having a purity of 85 wt% or more. More preferably, the tocopherol is natural tocopherol having a purity of 90 wt% or more. Particularly preferably, the tocopherol is purchased from jagil et al.
Second aspect of the invention
As described above, the second aspect of the present invention provides an anti-inflammatory and moisturizing composition for skin, which comprises the following components stored in a mixed manner or independently in a prophylactic and therapeutic effective amount:
phytosterol esters, stearyl glycyrrhetinate, bisabolol, cochineal, tocopherol, glycolipids, and sodium hyaluronate;
in the composition, the content of stearyl glycyrrhetinate is 3-7 parts by weight, the content of bisabolol is 2-8 parts by weight, the content of cochineal is 15-35 parts by weight, the content of tocopherol is 60-90 parts by weight, the content of glycolipid is 2-8 parts by weight, and the content of sodium hyaluronate is 20-30 parts by weight, relative to 100 parts by weight of the phytosterol ester.
Preferably, the stearyl glycyrrhetinate is present in an amount of 4 to 6 parts by weight, the bisabolol is present in an amount of 4 to 6 parts by weight, the cochineal is present in an amount of 20 to 30 parts by weight, the tocopherol is present in an amount of 70 to 80 parts by weight, the glycolipid is present in an amount of 4 to 6 parts by weight, and the sodium hyaluronate is present in an amount of 22 to 28 parts by weight, based on 100 parts by weight of the phytosterol ester. The inventor finds in the process of research that under the preferable condition, the composition provided by the invention has better anti-inflammatory and moisturizing effects when being applied to the skin, particularly the lip skin.
The specific amount of glycolipid contained in the composition of the invention enables the scheme of the invention to effectively relieve the skin water loss, increase the water content of the horny layer of the lip skin and relieve the dry and itchy conditions of the skin.
Preferably, the glycolipid has a purity of 95 wt.% or more; more preferably, the glycolipid is purified by yeast fermentation of olive oil; particularly preferably, the glycolipid is CERAMELA-HG manufactured by eastern Japan.
Preferably, the sodium hyaluronate is selected from at least one of microencapsulated sodium hyaluronate and oil-dispersed sodium hyaluronate.
The specific amount of the sodium hyaluronate contained in the composition enables the scheme of the invention to have good skin affinity, and the micromolecule HA released after the microspheres break can quickly permeate into skin, so that the horny layer of the lip skin can be effectively softened, water is locked and supplemented in the deep layer, the lip skin is moisturized and smooth from inside to outside, the transdermal absorption rate is up to more than 30%, and the composition HAs a remarkable lip plumping effect; particularly, the oil-dispersed sodium hyaluronate can ensure that the scheme of the invention has the advantages of firm water locking, high-efficiency moisture retention, dryness alleviation, easier spreading and smoother and finer skin feel.
Particularly preferably, the sodium hyaluronate is purchased from Hyacolor oil dispersed sodium hyaluronate of Shandong Furuida.
Third aspect of the invention
As described above, the third aspect of the present invention provides a cosmetic composition for skin, which comprises an active ingredient and an adjuvant, wherein the active ingredient is any one of the compositions described above, and the content of the active ingredient is 4.0 wt% or more based on the total weight of the cosmetic composition.
Preferably, the content of the active ingredient is 4.0 to 35.0 wt%. Illustratively, the active component is present in an amount of 5 wt%, 10 wt%, 15 wt%, 20 wt%, 25 wt%, 30 wt%, 35 wt%.
Preferably, the cosmetic composition provided by the third aspect of the present invention has a better anti-inflammatory and moisturizing effect.
Preferably, the auxiliary materials are selected from at least one of wax, extracted oil and plant essential oil; the wax is at least one selected from beeswax, carnauba wax and candelilla wax; the extracted oil is at least one of squalane, jojoba oil, shea butter, camellia oil, sweet almond oil, meadowfoam seed oil, wheat germ oil, rose hip oil, pomegranate seed oil and oat kernel oil, and the plant essential oil is at least one of rose essential oil.
In the present invention, preferably, the beeswax is selected from at least one of medium beeswax and west beeswax. More preferably, in the embodiment of the present invention, the beeswax is white beeswax obtained by oxidation bleaching and refining at least one selected from medium beeswax and western beeswax.
Preferably, the squalane is sucrose squalane available from NikkO CHEMICAL, Japan.
Preferably, the jojoba oil is cold pressed virgin jojoba oil available from VANTAGE of lebao kang, usa.
Particularly preferably, the rose hip oil, the pomegranate seed oil and the oat seed oil are obtained by supercritical extraction process flow. The specific flow of the supercritical extraction process is not particularly limited in the present invention, and those skilled in the art can perform the supercritical extraction process known in the art, for example, the supercritical extraction process provided in example 1 in CN 105038945A.
Preferably, the plant essential oil is at least one selected from rose essential oils.
Preferably, the rose essential oil is at least one selected from the group consisting of damascus rose essential oil, bulgaria rose essential oil, and turkish rose essential oil.
Preferably, the cosmetic composition is in a dosage form selected from at least one of lipstick, lip cream, lip gloss, lip mask, lip gloss, and lip gloss. It is particularly preferred that the cosmetic composition is in the form of a lipstick.
Fourth aspect of the invention
As mentioned above, the fourth aspect of the invention provides a lipstick, which consists of a mixture A, a mixture B and a mixture C,
the mixture A contains white beeswax, carnauba wax, candelilla wax, shea butter, squalane, jojoba oil, white pond flower seed oil and camellia oil;
the mixture B contains phytosterol ester, stearyl glycyrrhetinate, ascorbyl palmitate, oil-dispersed sodium hyaluronate and glycolipid;
the mixture C contains bisabolol, wheat germ oil, rose hip oil, pomegranate seed oil, tocopherol, cochineal and rose essential oil;
in the lipstick, relative to 100 parts by weight of the phytosterol ester, the white beeswax is 850 parts by weight, the carnauba wax is 80-120 parts by weight, the candelilla wax is 240 parts by weight, the shea butter is 270 parts by weight, the squalane is 80-120 parts by weight, the jojoba oil is 950-1050 parts by weight, the meadowfoam seed oil is 80-120 parts by weight, and the camellia oil is 1650-1850 parts by weight;
3-7 parts of stearyl glycyrrhetinate, 7-12 parts of ascorbyl palmitate, 20-30 parts of oil-dispersed sodium hyaluronate and 2-8 parts of glycolipid;
2-8 parts of bisabolol, 80-120 parts of wheat germ oil, 175 parts of 125-mangosteen oil, 80-120 parts of pomegranate seed oil, 60-90 parts of tocopherol, 15-35 parts of cochineal and 10-20 parts of rose essential oil.
The lipstick provided by the fourth aspect of the invention can be used for anti-inflammation and moisture retention of lip skin.
Fifth aspect of the invention
As previously mentioned, a fifth aspect of the invention provides a method of preparing a lipstick as previously described, the method comprising:
(1) melting all components in the mixture A and then carrying out first mixing to obtain a mixture A1;
(2) secondly mixing the mixture B and the mixture A1 to obtain a mixture A1B;
(3) performing third mixing on the mixture C and the mixture A1B;
the conditions of the first mixing include: the temperature is 90-110 ℃, the stirring speed is 30-40rpm, and the time is 30-40 min;
the conditions of the second mixing include: the temperature is 75-85 ℃, the stirring speed is 30-40rpm, and the stirring time is 20-30 min;
the third mixing conditions include: the temperature is 65-75 ℃, the stirring speed is 30-40rpm, and the stirring time is 20-30 min.
In the invention, the preparation methods of the A1 mixture and the A1B mixture can be conventional in the field and can be realized by stirring.
In the present invention, when the components contained in the mixture a are first mixed, the components contained in the mixture B are second mixed with the mixture A1, and the components contained in the mixture C are third mixed with the mixture A1B, the order of addition of the components contained in the mixture a, the mixture B, and the mixture C is not particularly limited, and the components may be added in any order.
In the invention, preferably, the preparation method of the lipstick further comprises the steps of uniformly mixing the mixture C and the mixture A1B (namely, the third mixing), filling into a mold, demolding, and tubing to obtain the lipstick.
The present invention will be described in detail below by way of examples.
In the following examples of the present invention,
sterol ester 1 is a commercial product of Healthful Biotech
A phytosterol ester.
Sterol ester 2 is a commercially available product of Vitae Naturals
Esterifided phytosterol esters.
Sterol ester 3 is a commercial product of TS-BIOTECH, BESTEROL-E phytosterol ester.
Stearyl glycyrrhetinate is a commercial product of phytochemical group of Panzhi plants in Gansu province.
Bisabolol is a commercial product of merck MERK, germany.
Cochineal is a commercially available product of Sensin COSMETIC TECHNOLOGIES, France.
Tocopherols are commercially available from jagil et al.
The glycolipid is CERAMELA-HG commercially available from Toyobo Co., Japan.
The sodium hyaluronate is commercially available Hyacolor oil dispersed sodium hyaluronate of Shandong Furuida.
White beeswax, carnauba wax and candelilla wax are all commercially available from kahlWax, germany.
Squalane is sucrose squalane, a commercial product of NikkO CHEMICAL, Japan.
Jojoba oil is commercially available cold pressed virgin jojoba oil from VANTAGE, Laibaokang.
Potentilla chinensis seed oil is commercially available from Elementis Specialties company.
Camellia oil is commercially available from Yonghe biological company.
Ascorbyl palmitate is commercially available from Source chemical products Ltd of Zhengzhou hundred million.
The wheat germ oil is commercially available from VANTAGE of Laibaokang.
The pomegranate seed oil and the rose hip oil are both sold by jump trade company Limited in Guangzhou.
The rose essential oil is the Damascus rose essential oil which is a commercial product of Bulgaria.
The formulations applied in each example are listed below in table 1 and table 2, respectively.
Table 1: examples of active compositions with anti-inflammatory efficacy
Table 1 (continuation): comparative example of active composition with anti-inflammatory efficacy
Table 2: examples of active compositions with anti-inflammatory and moisturizing efficacy
Table 2 (continuation): comparative example of active composition with anti-inflammatory and moisturizing efficacy
Preparation example 1
(1) Sample preparation
The active compositions provided in the foregoing examples in tables 1 and 2, respectively, were formulated with the following adjuvants:
the auxiliary materials comprise a mixture A, a mixture B and a mixture C:
phase A1: 800g of white beeswax, 100g of carnauba wax, 200g of candelilla wax, 250g of shea butter, 100g of squalane, 1000g of jojoba oil, 100g of meadowfoam seed oil and 1700g of camellia oil.
B1 phase: 10g of ascorbyl palmitate.
C1 phase: 100g of wheat germ oil, 150g of rose hip oil, 100g of pomegranate seed oil and 15g of rose essential oil.
Active composition (b): see the foregoing tables 1 to 2
(1) Putting the raw materials in the phase A1 in a reaction kettle, heating to 90 ℃, stirring and dissolving uniformly to obtain a mixture A for later use;
(2) the temperature of the mixture A was controlled at 80 ℃, the components of the active composition provided in tables 1 to 3 and the raw materials in the phase B1 were added to the mixture A, respectively, and the mixture A was stirred at 30rpm for 20min to obtain a mixture A1B.
(3) Cooling the A1B mixture to 60 ℃, adding C1 phase raw material components into the A1B mixture, stirring for 20min at the rotation speed of 30rpm, discharging, filling into a mold, cooling, sterilizing and packaging to obtain the lipstick.
The lipsticks prepared by the active compositions provided in the table 1 are sequentially named CG-S1, CG-S2, CG-S3, CG-S4, CG-S5, CG-S6, CG-S7, CG-D-S1, CG-D-S2, CG-D-S3 and CG-D-S4;
the lipsticks prepared from the active compositions provided in Table 2 were designated CG-SB1, CG-SB2, CG-SB3, CG-SB4, CG-SB5, CG-D-SB1, CG-D-SB2, and CG-D-SB3 in that order.
Test example 1: measurement of physical and chemical Properties
The physicochemical properties of the lipstick were determined according to the standard QB/T1977-2004.
The results show that the lipstick prepared by all the preparation examples has good sensory indexes, smooth appearance, no air bubbles, no obvious impurities, uniform paste color, no layering phenomenon and attractive fragrance. The lipstick prepared by the method has good cold resistance and heat resistance, is taken out and restored to room temperature after being placed for 24 hours at minus 5 ℃ to minus 10 ℃ (cold resistance) and 45 ℃ (heat resistance), has no softening and crack, has no obvious adverse effect on the use effect and the state, and reaches the standards of all microbial indexes.
Test example 2: anti-inflammatory Effect test
The lipsticks prepared in the examples and comparative examples were tested in 30 subjects each of them, healthy women (i.e. non-allergic constitution) aged between 20 and 50 years, and mainly manifested by chapped and inflamed skin of the lips.
The use method comprises the following steps: after the face of the subject was cleaned for 15min, the lipstick was applied to the lips once after breakfast, lunch, dinner and before sleep.
After the subjects used for 1 week, after face cleaning for 10min, the lips of the subjects were examined using a skin Imaging and beauty management system Visia (model Generation 7, Canfield Imaging Systems, USA), the examination results of the subjects were recorded, the characteristic number of the red color zone of the lips of the subjects was analyzed and recorded based on the examination results collected each time, and the improvement rate of the red color zone was calculated, and the results are shown in Table 3. FIG. 1 is a graph showing a comparison of red areas on the lips of subjects before and after 4 weeks using the lipstick of preferred embodiment 1 of the present invention. The red area of the lips before use is shown on the left of fig. 1, and the red area of the lips after 4 weeks of use is shown on the right.
As can be seen from FIG. 1, the red lip color area characteristic numbers of the right image in FIG. 1 are significantly less than those of the left image in FIG. 1, indicating that the lipstick provided by the present invention has significant anti-inflammatory effects.
Wherein, the calculation formula of the improvement rate of the red area is as follows: { (characteristic number of red region of lips of subject before lipstick-characteristic number of red region of lips of the same subject after 4 weeks using lipstick)/characteristic number of red region of lips of subject before lipstick }. times.100%.
TABLE 3
| Before use | After 1 week | After 2 weeks | After 3 weeks | After 4 weeks | Rate of improvement | |
| S1 | 20 | 18 | 17 | 15 | 12 | 40.00 |
| S2 | 25 | 21 | 21 | 19 | 16 | 36.00 |
| S3 | 21 | 19 | 18 | 16 | 13 | 38.10 |
| S4 | 27 | 25 | 21 | 20 | 19 | 29.63 |
| S5 | 26 | 24 | 21 | 20 | 19 | 26.92 |
| S6 | 19 | 18 | 16 | 13 | 13 | 31.58 |
| S7 | 15 | 14 | 12 | 12 | 11 | 26.67 |
| SB1 | 18 | 16 | 14 | 11 | 10 | 44.44 |
| SB2 | 15 | 13 | 12 | 10 | 9 | 40.00 |
| SB3 | 19 | 17 | 15 | 14 | 12 | 36.84 |
| SB4 | 23 | 21 | 20 | 18 | 16 | 30.43 |
| SB5 | 24 | 21 | 20 | 18 | 17 | 29.17 |
| DS1 | 28 | 26 | 25 | 23 | 23 | 17.86 |
| DS2 | 27 | 27 | 25 | 24 | 23 | 14.81 |
| DS3 | 24 | 24 | 22 | 21 | 20 | 16.67 |
| DS4 | 20 | 19 | 18 | 17 | 17 | 15.00 |
| DSB1 | 21 | 19 | 18 | 18 | 18 | 14.29 |
| DSB2 | 23 | 22 | 22 | 21 | 20 | 13.04 |
| DSB3 | 19 | 19 | 18 | 17 | 16 | 15.79 |
As can be seen from Table 3, the anti-inflammatory effect of the lipstick provided by the present invention was significant, while almost none of the lipsticks used for comparison had anti-inflammatory effects.
Test example 3: test of moisturizing Effect
The test subjects of test example 3 were the same as those of test example 2, except for the detection method, specifically, as follows:
the specific detection method comprises the following steps: considering that lip application has a large influence on the transdermal water loss rate test due to factors such as expiration, the test is performed by replacing the lip with the inner side of the arm (specifically, the middle part of the forearm), the subject applies lipstick after cleaning the inner side of the arm, the transdermal water loss rate test is performed on the inner side of the arm of the subject 2h, 4h and 6h after the application by using a skin test system (dermab Series skin lab Combo, denmark Cortex technologies), the test results of the subject are recorded, and the transdermal water loss rate on the inner side of the arm of the subject is analyzed and recorded according to the test results collected each time, and the results are shown in table 4.
Wherein, the calculation formula of the improvement rate of the percutaneous water loss rate is as follows: { (transdermal water loss rate on the medial side of the arm of the subject before lipstick application-transdermal water loss rate on the medial side of the arm of the same subject after 6h with lipstick)/transdermal water loss rate on the medial side of the arm of the subject before lipstick application }. times.100%.
TABLE 4
| Before use (g/m)2/h) | After 2h (g/m)2/h) | After 4h (g/m)2/h) | After 6h (g/m)2/h) | Improvement Rate (%) | |
| SB1 | 9.5 | 5.4 | 6.1 | 4.0 | 57.89 |
| SB2 | 6.7 | 4.2 | 3.8 | 3.1 | 53.73 |
| SB3 | 5.1 | 3.0 | 2.4 | 2.3 | 54.90 |
| SB4 | 5.8 | 4.2 | 3.7 | 3.4 | 41.38 |
| SB5 | 6.0 | 4.6 | 4.4 | 3.3 | 45.00 |
| DSB1 | 4.9 | 4.4 | 4.2 | 3.9 | 20.41 |
| DSB2 | 5.3 | 4.9 | 4.5 | 4.6 | 13.21 |
| DSB3 | 6.5 | 5.9 | 5.6 | 5.5 | 15.38 |
As can be seen from Table 4, the lipstick provided by the invention has a good moisturizing effect.
After the lipstick formed by the composition provided by the invention is used for one week, cheilitis is obviously improved, the effect of repairing lip chaps is more obvious, the effects of brightening the lips, preserving moisture and the like can be achieved, and the quality of the lipstick is better. Meanwhile, in the using process, the safety is high, and no phenomena such as allergy, skin discomfort and the like occur in a reaction.
The preferred embodiments of the present invention have been described above in detail, but the present invention is not limited thereto. Within the scope of the technical idea of the invention, many simple modifications can be made to the technical solution of the invention, including combinations of various technical features in any other suitable way, and these simple modifications and combinations should also be regarded as the disclosure of the invention, and all fall within the scope of the invention.
Claims (10)
1. The composition for skin anti-inflammation is characterized by comprising the following components which are stored in a mixing way or independently in a prevention and treatment effective amount:
phytosterol esters, stearyl glycyrrhetinate, bisabolol, cochineal, and tocopherol;
in the composition, the content of stearyl glycyrrhetinate is 3-7 parts by weight, the content of bisabolol is 2-8 parts by weight, the content of cochineal is 15-35 parts by weight, and the content of tocopherol is 60-90 parts by weight, relative to 100 parts by weight of the phytosterol ester;
preferably, the content of stearyl glycyrrhetinate is 4-6 parts by weight, the content of bisabolol is 4-6 parts by weight, the content of cochineal is 20-30 parts by weight, and the content of tocopherol is 70-80 parts by weight, relative to 100 parts by weight of the phytosterol ester.
2. The composition according to claim 1, wherein the phytosterol ester is an alcohol ester obtained by reacting a sterol with oleic acid, wherein the sterol is at least one selected from the group consisting of beta sitosterol, stigmasterol, campesterol and brassicasterol;
preferably, the sterol is derived from at least one natural material selected from pine, soybean, and rapeseed.
3. The composition according to claim 1 or 2, wherein the bisabolol is natural bisabolol having a purity of 85 wt% or more;
preferably, the cochineal red is natural cochineal red with purity of more than 60 wt%;
preferably, the tocopherol is natural tocopherol having a purity of 85 wt% or more.
4. The composition for skin anti-inflammation and moisturizing is characterized by comprising the following components which are stored in a mixed manner or independently in a prevention and treatment effective amount:
phytosterol esters, stearyl glycyrrhetinate, bisabolol, cochineal, tocopherol, glycolipids, and sodium hyaluronate;
in the composition, the content of stearyl glycyrrhetinate is 3-7 parts by weight, the content of bisabolol is 2-8 parts by weight, the content of cochineal red is 15-35 parts by weight, the content of tocopherol is 60-90 parts by weight, the content of glycolipid is 2-8 parts by weight, and the content of sodium hyaluronate is 20-30 parts by weight, relative to 100 parts by weight of the phytosterol ester;
preferably, the stearyl glycyrrhetinate is present in an amount of 4 to 6 parts by weight, the bisabolol is present in an amount of 4 to 6 parts by weight, the cochineal is present in an amount of 20 to 30 parts by weight, the tocopherol is present in an amount of 70 to 80 parts by weight, the glycolipid is present in an amount of 4 to 6 parts by weight, and the sodium hyaluronate is present in an amount of 22 to 28 parts by weight, based on 100 parts by weight of the phytosterol ester.
5. The composition of claim 4, wherein the sodium hyaluronate is selected from at least one of microencapsulated sodium hyaluronate and oil dispersed sodium hyaluronate.
6. A cosmetic composition for skin, characterized in that it consists of an active ingredient and an adjuvant, the active ingredient being a composition according to any one of claims 1 to 5 and the total content of the active ingredients being 4.0% by weight or more.
7. The cosmetic composition according to claim 6, wherein the auxiliary material is at least one selected from the group consisting of wax, extracted oil selected from at least one of squalane, jojoba oil, shea butter, camellia oil, sweet almond oil, meadowfoam seed oil, wheat germ oil, rose hip oil, pomegranate seed oil, and oat kernel oil, the wax is at least one selected from the group consisting of beeswax, carnauba wax, and candelilla wax, and the plant essential oil is at least one selected from the group consisting of rose essential oil.
8. The cosmetic composition according to claim 6 or 7, wherein the formulation of the cosmetic composition is at least one selected from the group consisting of lipstick, lip cream, lip gloss, lip mask, lip gloss.
9. A lipstick is characterized in that the lipstick consists of a mixture A, a mixture B and a mixture C,
the mixture A contains white beeswax, carnauba wax, candelilla wax, shea butter, squalane, jojoba oil, white pond flower seed oil and camellia oil;
the mixture B contains phytosterol ester, stearyl glycyrrhetinate, ascorbyl palmitate, oil-dispersed sodium hyaluronate and glycolipid;
the mixture C contains bisabolol, wheat germ oil, rose hip oil, pomegranate seed oil, tocopherol, cochineal and rose essential oil;
in the lipstick, relative to 100 parts by weight of the phytosterol ester,
850 parts by weight of the white beeswax, 80-120 parts by weight of the carnauba wax, 240 parts by weight of the candelilla wax, 270 parts by weight of the shea butter, 80-120 parts by weight of the squalane, 950-1050 parts by weight of the jojoba oil, 80-120 parts by weight of the white Poisson seed oil and 1650-1850 parts by weight of the camellia oil;
the content of stearyl glycyrrhetinate is 3-7 parts by weight, the content of ascorbyl palmitate is 7-12 parts by weight, the content of oil-dispersed sodium hyaluronate is 20-30 parts by weight, and the content of glycolipid is 2-8 parts by weight;
2-8 parts of bisabolol, 80-120 parts of wheat germ oil, 125-120 parts of rose hip oil, 80-120 parts of pomegranate seed oil, 60-90 parts of tocopherol, 15-35 parts of cochineal and 10-20 parts of rose essential oil.
10. A method of making the lipstick of claim 9, the method comprising:
(1) melting all components in the mixture A and then carrying out first mixing to obtain a mixture A1;
(2) secondly mixing the mixture B and the mixture A1 to obtain a mixture A1B;
(3) performing third mixing on the mixture C and the mixture A1B;
the conditions of the first mixing include: the temperature is 90-110 ℃, the stirring speed is 30-40rpm, and the time is 30-40 min;
the conditions of the second mixing include: the temperature is 75-85 ℃, the stirring speed is 30-40rpm, and the stirring time is 20-30 min;
the third mixing conditions include: the temperature is 65-75 ℃, the stirring speed is 30-40rpm, and the stirring time is 20-30 min.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114177120A (en) * | 2021-12-16 | 2022-03-15 | 成都卓阳生物科技有限公司 | Composition for lip care |
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| CN108186542A (en) * | 2018-03-21 | 2018-06-22 | 广州贵有日用品有限公司 | Lip care lipstick with antiallergic effect of releiving |
| MX2017012577A (en) * | 2017-09-29 | 2019-04-01 | Univ Guanajuato | Cosmetic composition with antioxidant action based on prickly pear seed oil and cochineal carmine. |
| CN109620744A (en) * | 2019-01-03 | 2019-04-16 | 山东珂诺恩生物科技有限公司 | A kind of natural lipstick and preparation method thereof |
| CN109939017A (en) * | 2019-04-30 | 2019-06-28 | 广东三好科技有限公司 | One kind pure oil lipstick product having repairing effect and preparation method thereof |
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| MX2017012577A (en) * | 2017-09-29 | 2019-04-01 | Univ Guanajuato | Cosmetic composition with antioxidant action based on prickly pear seed oil and cochineal carmine. |
| CN108186542A (en) * | 2018-03-21 | 2018-06-22 | 广州贵有日用品有限公司 | Lip care lipstick with antiallergic effect of releiving |
| CN109620744A (en) * | 2019-01-03 | 2019-04-16 | 山东珂诺恩生物科技有限公司 | A kind of natural lipstick and preparation method thereof |
| CN109939017A (en) * | 2019-04-30 | 2019-06-28 | 广东三好科技有限公司 | One kind pure oil lipstick product having repairing effect and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114177120A (en) * | 2021-12-16 | 2022-03-15 | 成都卓阳生物科技有限公司 | Composition for lip care |
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