CN112004824B - 生产工程化t细胞组合物的过程 - Google Patents

生产工程化t细胞组合物的过程 Download PDF

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CN112004824B
CN112004824B CN201880088430.XA CN201880088430A CN112004824B CN 112004824 B CN112004824 B CN 112004824B CN 201880088430 A CN201880088430 A CN 201880088430A CN 112004824 B CN112004824 B CN 112004824B
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cells
composition
cell
recombinant
day
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CN112004824A (zh
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M·穆贾西奇
A·拉哈乔
P·波切斯尼
K·邱-东
I·艾芙娃
C·陈
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Juno Therapeutics Inc
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/0636—T lymphocytes
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
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    • A61K40/41—Vertebrate antigens
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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CN201880088430.XA 2017-12-08 2018-12-07 生产工程化t细胞组合物的过程 Active CN112004824B (zh)

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CN202411174931.3A CN119193493A (zh) 2017-12-08 2018-12-07 生产工程化t细胞组合物的过程

Applications Claiming Priority (17)

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US201762596774P 2017-12-08 2017-12-08
US62/596,774 2017-12-08
US201862614965P 2018-01-08 2018-01-08
US62/614,965 2018-01-08
US201862716971P 2018-08-09 2018-08-09
US62/716,971 2018-08-09
US201862721604P 2018-08-22 2018-08-22
US62/721,604 2018-08-22
US201862740903P 2018-10-03 2018-10-03
US62/740,903 2018-10-03
US201862754564P 2018-11-01 2018-11-01
US62/754,564 2018-11-01
US201862774165P 2018-11-30 2018-11-30
US62/774,165 2018-11-30
US201862774855P 2018-12-03 2018-12-03
US62/774,855 2018-12-03
PCT/US2018/064628 WO2019113557A1 (en) 2017-12-08 2018-12-07 Process for producing a composition of engineered t cells

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CN112004824B true CN112004824B (zh) 2024-09-13

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EP (1) EP3720874A1 (enExample)
JP (2) JP2021505168A (enExample)
KR (2) KR20250136416A (enExample)
CN (2) CN112004824B (enExample)
AU (1) AU2018379092A1 (enExample)
BR (1) BR112020011215A2 (enExample)
CA (1) CA3084445A1 (enExample)
IL (1) IL275111A (enExample)
MA (1) MA51114A (enExample)
MX (1) MX2020005908A (enExample)
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PL3704230T3 (pl) * 2017-11-01 2025-02-24 Juno Therapeutics, Inc. Proces wytwarzania kompozycji terapeutycznych z komórek zmodyfikowanych genetycznie
US12444491B2 (en) 2019-08-30 2025-10-14 Juno Therapeutics, Inc. Machine learning methods for classifying cells
WO2021046432A1 (en) * 2019-09-06 2021-03-11 The Regents Of The University Of California Chimeric antigen receptors and related methods and compositions for the treatment of cancer
US20220412954A1 (en) 2019-11-05 2022-12-29 Juno Therapeutics, Inc. Methods of determining attributes of therapeutic t cell compositions
KR20220146480A (ko) * 2020-01-28 2022-11-01 주노 쎄러퓨티크스 인코퍼레이티드 Ｔ 세포 형질도입 방법
BR112022015968A2 (pt) * 2020-02-12 2022-10-11 Juno Therapeutics Inc Composições de células t do receptor de antígeno quimérico direcionado a bcma e métodos e usos das mesmas
WO2022005462A1 (en) * 2020-06-30 2022-01-06 Tr1X, Inc. Poly-donor cd4+ t cells expressing il-10 and uses thereof
US12144827B2 (en) 2021-02-25 2024-11-19 Lyell Immunopharma, Inc. ROR1 targeting chimeric antigen receptor
CN113207871A (zh) * 2021-05-20 2021-08-06 新乡医学院 一种用于体外保存t记忆性干细胞的储存液及其应用
CN114478726B (zh) * 2022-02-14 2023-09-05 西南大学 链霉亲和素第27位丝氨酸突变的突变蛋白及其应用
WO2024097315A2 (en) * 2022-11-02 2024-05-10 Sana Biotechnology, Inc. Cell therapy products and methods for producing same
KR20250121074A (ko) 2022-12-09 2025-08-11 주노 쎄러퓨티크스 인코퍼레이티드 홀로그래픽 이미징을 사용하여 세포 표현형을 예측하기 위한 기계 학습 방법
AU2024262636A1 (en) * 2023-04-26 2025-11-06 Assistance Publique - Hôpitaux De Paris T cell immunotherapy derived from autologous stem cell memory t cells
WO2025151923A1 (en) * 2024-01-17 2025-07-24 Newsouth Innovations Pty Limited Apparatus for production of engineered cells
CN118272305B (zh) * 2024-04-29 2025-04-08 深圳泽医细胞治疗集团有限公司 一种免疫细胞的培养基及其应用

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