CN111936499B - Mat2a的杂二环抑制剂和用于治疗癌症的方法 - Google Patents

Mat2a的杂二环抑制剂和用于治疗癌症的方法 Download PDF

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Publication number
CN111936499B
CN111936499B CN201980023557.8A CN201980023557A CN111936499B CN 111936499 B CN111936499 B CN 111936499B CN 201980023557 A CN201980023557 A CN 201980023557A CN 111936499 B CN111936499 B CN 111936499B
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cancer
pharmaceutically acceptable
pyrimidin
acceptable salt
pyrido
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Chinese (zh)
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CN111936499A (zh
Inventor
Z.D.康泰蒂斯
李明宗
刘朋
M.梅戴罗斯
S.K.雷兹尼克
隋治华
J.M.特拉文斯
J.波波维奇-穆勒
周树宝
马光宁
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Les Laboratoires Servier SAS
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Les Laboratoires Servier SAS
Agios Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN201980023557.8A 2018-03-30 2019-03-28 Mat2a的杂二环抑制剂和用于治疗癌症的方法 Active CN111936499B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018081328 2018-03-30
CNPCT/CN2018/081328 2018-03-30
PCT/US2019/024645 WO2019191470A1 (en) 2018-03-30 2019-03-28 Heterobicyclic inhibitors of mat2a and methods of use for treating cancer

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CN111936499A CN111936499A (zh) 2020-11-13
CN111936499B true CN111936499B (zh) 2023-09-19

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US (1) US11524960B2 (https=)
EP (1) EP3774805B1 (https=)
JP (2) JP7350005B2 (https=)
KR (1) KR102736073B1 (https=)
CN (1) CN111936499B (https=)
AR (1) AR115326A1 (https=)
AU (1) AU2019243289B2 (https=)
BR (1) BR112020020104A2 (https=)
CA (1) CA3094476C (https=)
EA (1) EA202092320A1 (https=)
ES (1) ES2973114T3 (https=)
HU (1) HUE066282T2 (https=)
IL (1) IL277665B2 (https=)
MA (1) MA52232A (https=)
MX (1) MX2020010005A (https=)
PH (1) PH12020551507A1 (https=)
PL (1) PL3774805T3 (https=)
SG (1) SG11202009195WA (https=)
TW (1) TWI719437B (https=)
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WO2021252680A1 (en) * 2020-06-10 2021-12-16 Ideaya Biosciences, Inc. 4-arylquinazoline derivatives as methionine adenosyltransferase 2a inhibitors
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TW202214630A (zh) * 2020-09-12 2022-04-16 大陸商成都倍特藥業股份有限公司 甲硫胺酸腺苷轉移酶抑制劑、其製備方法及應用
CN115960099A (zh) * 2020-09-24 2023-04-14 上海凌达生物医药有限公司 一类芳环或芳基杂环并吡啶酮类化合物、药物组合物及其应用
CN114507231B (zh) * 2020-11-17 2025-06-03 南京再明医药有限公司 内酰胺类化合物及其制备方法
CN114634521A (zh) * 2020-12-15 2022-06-17 首药控股(北京)股份有限公司 Dna-pk选择性抑制剂及其制备方法和用途
WO2022143864A1 (zh) 2020-12-31 2022-07-07 江苏先声药业有限公司 三环类化合物及用途
CN115141202A (zh) * 2021-03-29 2022-10-04 武汉人福创新药物研发中心有限公司 嘧啶并吡嗪酮化合物及其用途
WO2022222911A1 (zh) * 2021-04-19 2022-10-27 武汉人福创新药物研发中心有限公司 嘧啶酮化合物及其用途
CN117412967A (zh) * 2021-06-02 2024-01-16 南京正大天晴制药有限公司 蛋氨酸腺苷转移酶2a抑制剂
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CN118265700A (zh) * 2021-11-09 2024-06-28 上海海雁医药科技有限公司 取代的萘啶酮衍生物、其药物组合物及应用
CN114028572B (zh) * 2021-11-30 2022-11-25 清华大学 Mat2a抑制剂用于治疗哮喘的新应用
CN118414338A (zh) * 2021-12-21 2024-07-30 南京正大天晴制药有限公司 蛋氨酸腺苷转移酶2a的杂环抑制剂
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MX2020010005A (es) 2020-10-14
WO2019191470A1 (en) 2019-10-03
JP2021519783A (ja) 2021-08-12
ES2973114T3 (es) 2024-06-18
UA127059C2 (uk) 2023-03-29
KR20200138769A (ko) 2020-12-10
EP3774805A1 (en) 2021-02-17
AU2019243289A1 (en) 2020-09-24
NZ767697A (en) 2025-02-28
JP2023101762A (ja) 2023-07-21
SG11202009195WA (en) 2020-10-29
US20210115045A1 (en) 2021-04-22
TW201946629A (zh) 2019-12-16
MA52232A (fr) 2021-02-17
IL277665B2 (en) 2023-06-01
BR112020020104A2 (pt) 2021-01-26
CA3094476C (en) 2025-05-06
AU2019243289B2 (en) 2023-01-12
WO2019191470A8 (en) 2019-12-12
EA202092320A1 (ru) 2021-03-09
TWI719437B (zh) 2021-02-21
CA3094476A1 (en) 2019-10-03
JP7350005B2 (ja) 2023-09-25
PH12020551507A1 (en) 2021-09-13
AR115326A1 (es) 2020-12-23
CN111936499A (zh) 2020-11-13
KR102736073B1 (ko) 2024-12-02
US11524960B2 (en) 2022-12-13
IL277665A (en) 2020-11-30
HUE066282T2 (hu) 2024-07-28
PL3774805T3 (pl) 2024-05-06
EP3774805B1 (en) 2024-01-10

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