CN111909130B - 作为突变型异柠檬酸脱氢酶抑制剂的吡啶-2(1h)-酮喹啉酮衍生物 - Google Patents

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Publication number

CN111909130B

CN111909130B CN202010391529.6A CN202010391529A CN111909130B CN 111909130 B CN111909130 B CN 111909130B CN 202010391529 A CN202010391529 A CN 202010391529A CN 111909130 B CN111909130 B CN 111909130B

Authority

CN

China

Prior art keywords

oxo

methyl

chloro

amino

dihydroquinolin

Prior art date

2014-09-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 108010075869 Isocitrate Dehydrogenase Proteins 0.000 title claims abstract description 26
• 102000012011 Isocitrate Dehydrogenase Human genes 0.000 title claims abstract description 26
• 239000003112 inhibitor Substances 0.000 title abstract description 10
• WJJMNDUMQPNECX-UHFFFAOYSA-N dipicolinic acid Chemical class OC(=O)C1=CC=CC(C(O)=O)=N1 WJJMNDUMQPNECX-UHFFFAOYSA-N 0.000 title description 2
• 150000001875 compounds Chemical class 0.000 claims description 245
• 239000000203 mixture Substances 0.000 claims description 194
• 238000000034 method Methods 0.000 claims description 134
• 239000000460 chlorine Substances 0.000 claims description 58
• -1 6-chloro-8-fluoro-2-oxo-1, 2-dihydroquinolin-3-yl Chemical group 0.000 claims description 52
• 229910052736 halogen Inorganic materials 0.000 claims description 45
• 150000002367 halogens Chemical class 0.000 claims description 44
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 31
• 125000001072 heteroaryl group Chemical group 0.000 claims description 26
• 229910052739 hydrogen Inorganic materials 0.000 claims description 26
• 201000010099 disease Diseases 0.000 claims description 24
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 21
• 229910052757 nitrogen Inorganic materials 0.000 claims description 19
• 125000000217 alkyl group Chemical group 0.000 claims description 16
• 229910052799 carbon Inorganic materials 0.000 claims description 16
• 125000003545 alkoxy group Chemical group 0.000 claims description 15
• 239000003814 drug Substances 0.000 claims description 14
• 238000011282 treatment Methods 0.000 claims description 13
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
• 150000003839 salts Chemical class 0.000 claims description 12
• 238000004519 manufacturing process Methods 0.000 claims description 11
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