CN111671767B - 用于口服施用的结合质子的聚合物 - Google Patents
用于口服施用的结合质子的聚合物 Download PDFInfo
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- CN111671767B CN111671767B CN202010780604.8A CN202010780604A CN111671767B CN 111671767 B CN111671767 B CN 111671767B CN 202010780604 A CN202010780604 A CN 202010780604A CN 111671767 B CN111671767 B CN 111671767B
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- 229920000642 polymer Polymers 0.000 title claims abstract description 491
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 111
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 64
- 238000003556 assay Methods 0.000 claims description 62
- 125000001931 aliphatic group Chemical group 0.000 claims description 61
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 59
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Classifications
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
- C08F226/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
- C08G73/024—Polyamines containing oxygen in the form of ether bonds in the main chain
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
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- G—PHYSICS
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- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
- G01N2001/4083—Concentrating samples by other techniques involving separation of suspended solids sedimentation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
- G01N2001/4088—Concentrating samples by other techniques involving separation of suspended solids filtration
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Priority Applications (1)
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Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102633597B1 (ko) | 2013-06-05 | 2024-02-06 | 트리시다, 인크. | 경구 투여를 위한 양성자-결합 중합체 |
| KR20240008418A (ko) * | 2014-12-10 | 2024-01-18 | 트리시다, 인크. | 경구 투여용 양성자-결합 폴리머 |
| AU2017261337A1 (en) | 2016-05-06 | 2018-11-15 | Tricida, Inc. | Compositions for and method of treating acid-base disorders |
| BR112019013364A2 (pt) | 2016-12-28 | 2020-04-14 | Fujifilm Corp | emulsão de polímero contendo átomo de nitrogênio ou sal do mesmo, método de produção para o mesmo e método de produção para partículas |
| US10934380B1 (en) | 2017-09-25 | 2021-03-02 | Tricida, Inc. | Crosslinked poly(allylamine) polymer pharmaceutical compositions |
| TW201922267A (zh) | 2017-10-16 | 2019-06-16 | 日商富士軟片股份有限公司 | 高磷血症治療劑 |
| US11266684B2 (en) | 2017-11-03 | 2022-03-08 | Tricida, Inc. | Compositions for and method of treating acid-base disorders |
| AU2018360868B2 (en) * | 2017-11-03 | 2025-01-02 | Tricida, Inc. | Method of treating acid-base disorders |
| EP3740201A4 (en) * | 2018-06-04 | 2021-03-17 | Tricida Inc. | METHOD FOR TREATMENT OF ACID-BASE DISORDER |
| JP2022540707A (ja) * | 2019-07-19 | 2022-09-16 | アカテコール・インコーポレイテッド | 分子的に十分に規定された生物付着防止ポリイオンコーティング |
| DK4053179T3 (da) | 2021-03-01 | 2025-11-17 | Renosis Inc | Farmaceutiske sammensætninger med krydsbundne poly(allylamin)-polymer |
| MX2023010252A (es) | 2021-03-01 | 2024-02-27 | Renosis Inc | Composiciones farmaceuticas de polimero de poli(alilamina) reticulado. |
| WO2023109825A1 (zh) * | 2021-12-14 | 2023-06-22 | 上海石趣医药科技有限公司 | 氧化银和/或其水合物在制备药物中的用途 |
| CN115260355A (zh) * | 2022-05-16 | 2022-11-01 | 江苏中天药业有限公司 | 一种阴离子交换树脂、其制备方法、该树脂与药物的复合物和其掩味制剂 |
| KR20240128205A (ko) | 2023-02-17 | 2024-08-26 | 주식회사 쓰리디코리아 | 손잡이가 있는 운동기구용 개인별 맞춤형 그립 제조방법 및 그로써 제조된 개인별 맞춤형 그립 |
| CN117164854A (zh) * | 2023-07-07 | 2023-12-05 | 中国科学院长春应用化学研究所 | 一种交联型聚酰亚胺及其制备方法 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5534259A (en) * | 1993-07-08 | 1996-07-09 | Liposome Technology, Inc. | Polymer compound and coated particle composition |
| CN1503676A (zh) * | 2001-04-18 | 2004-06-09 | ԭ���ø� | 低盐含量的聚烯丙胺 |
| CN1540136A (zh) * | 2003-10-27 | 2004-10-27 | 华东理工大学 | 一种评价微生物驱油能力的方法 |
| CN1878822A (zh) * | 2003-11-03 | 2006-12-13 | 伊立普萨公司 | 阴离子结合聚合物以及其应用 |
| CN101065409A (zh) * | 2004-10-13 | 2007-10-31 | 伊立普萨公司 | 交联胺聚合物 |
| CN101316601A (zh) * | 2005-09-30 | 2008-12-03 | 伊立普萨公司 | 从哺乳动物的胃肠道选择性除去钾离子的方法和组合物 |
| CN101321519A (zh) * | 2005-09-30 | 2008-12-10 | 伊立普萨公司 | 制备含有交联壳的核-壳型复合物的方法及其得到的核-壳型复合物 |
Family Cites Families (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6444221B1 (en) | 1992-06-30 | 2002-09-03 | Howard K. Shapiro | Methods of treating chronic inflammatory diseases using carbonyl trapping agents |
| US20050090553A1 (en) | 1992-06-30 | 2005-04-28 | Shapiro Howard K. | Compositions and method for treatment of chronic inflammatory diseases |
| CA2202397C (en) | 1994-10-17 | 2002-07-16 | Peter W. Stacpoole | Compositions comprising carbonate/bicarbonate buffered dichloroacetic acid and methods for treatment of metabolic and cardiovascular disorders |
| US5496545A (en) | 1993-08-11 | 1996-03-05 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5667775A (en) | 1993-08-11 | 1997-09-16 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5648355A (en) | 1994-02-09 | 1997-07-15 | Kos Pharmaceutical, Inc. | Method of treatment of endogenous, painful gastrointestinal conditions of non-inflammatory, non-ulcerative origin |
| TW474813B (en) | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
| US20020006899A1 (en) | 1998-10-06 | 2002-01-17 | Pospisilik Andrew J. | Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals |
| US5753706A (en) | 1996-12-16 | 1998-05-19 | Hsu; Chen Hsing | Methods for treating renal failure |
| AUPO758297A0 (en) | 1997-06-27 | 1997-07-24 | Rowe, James Baber | Control of acidic gut syndrome |
| US6726905B1 (en) | 1997-11-05 | 2004-04-27 | Genzyme Corporation | Poly (diallylamines)-based phosphate binders |
| EP1044021B1 (en) * | 1998-01-05 | 2009-09-23 | The University of Washington | Enhanced transport using membrane disruptive agents |
| WO1999040990A1 (en) | 1998-02-17 | 1999-08-19 | University Of Maryland | Anion binding polymers and the use thereof |
| US6485703B1 (en) | 1998-07-31 | 2002-11-26 | The Texas A&M University System | Compositions and methods for analyte detection |
| US6271264B1 (en) | 1998-12-01 | 2001-08-07 | Geltex Pharmaceuticals, Inc. | Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants |
| US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
| GB9927088D0 (en) | 1999-11-17 | 2000-01-12 | Secr Defence | Use of poly(diallylamine) polymers |
| US20040059065A1 (en) | 2000-03-09 | 2004-03-25 | Takeshi Goto | Crosslinked anion-exchange resin or salt thereof |
| AU2001241077A1 (en) | 2000-03-09 | 2001-09-17 | Hisamitsu Pharmaceutical Co. Inc. | Crosslinked anion-exchange resin or salt thereof and phosphorus adsorbent comprising the same |
| AU2001241095A1 (en) | 2000-03-13 | 2001-09-24 | Hisamitsu Pharmaceutical Co. Inc. | Preventives and/or remedies for hyperphosphatemia |
| JP2002028737A (ja) | 2000-07-07 | 2002-01-29 | Fujitsu Ltd | プレス打ち抜き加工方法及びプレス打ち抜き加工装置 |
| BR0209133A (pt) | 2001-04-18 | 2004-06-15 | Genzyme Corp | Método para tratar gota e para reduzir os nìveis de ácido úrico n0 sangue |
| BR0308316A (pt) | 2002-03-11 | 2004-12-28 | Novartis Ag | Sais de nateglinida |
| JP2007523599A (ja) | 2003-02-10 | 2007-08-23 | オートゲン リサーチ ピーティーワイ エルティーディー． | 治療用分子 |
| TWI335218B (en) | 2003-02-19 | 2011-01-01 | Panion & Bf Biotech Inc | Ferric organic compounds, uses thereof and methods of making same |
| US7459502B2 (en) | 2003-11-03 | 2008-12-02 | Ilypsa, Inc. | Pharmaceutical compositions comprising crosslinked polyamine polymers |
| US7608674B2 (en) * | 2003-11-03 | 2009-10-27 | Ilypsa, Inc. | Pharmaceutical compositions comprising cross-linked small molecule amine polymers |
| US7449605B2 (en) | 2003-11-03 | 2008-11-11 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7335795B2 (en) | 2004-03-22 | 2008-02-26 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7767768B2 (en) | 2003-11-03 | 2010-08-03 | Ilypsa, Inc. | Crosslinked amine polymers |
| AU2004311849B2 (en) | 2003-12-31 | 2009-04-02 | Genzyme Corporation | Enteric coated aliphatic amine polymer bile acid sequestrants |
| AU2004314652A1 (en) | 2004-01-29 | 2005-08-11 | Keio University | Erythrocyte function modifying substance |
| US7429394B2 (en) | 2004-03-30 | 2008-09-30 | Relypsa, Inc. | Ion binding compositions |
| US7854924B2 (en) | 2004-03-30 | 2010-12-21 | Relypsa, Inc. | Methods and compositions for treatment of ion imbalances |
| US8192758B2 (en) | 2004-03-30 | 2012-06-05 | Relypsa, Inc. | Ion binding compositions |
| US8282960B2 (en) | 2004-03-30 | 2012-10-09 | Relypsa, Inc. | Ion binding compositions |
| EP1732523B9 (en) | 2004-03-30 | 2010-06-02 | Relypsa, Inc. | Potassium binding polymers and uses thereof |
| US7556799B2 (en) | 2004-03-30 | 2009-07-07 | Relypsa, Inc. | Ion binding polymers and uses thereof |
| US8399025B2 (en) | 2004-06-04 | 2013-03-19 | Board Of Regents, The University Of Texas System | Polyamine modified particles |
| EP2705849B1 (en) | 2004-07-19 | 2018-04-04 | N.V. Nutricia | A preparation for use of aspartate for regulating glucose levels in blood |
| DE102004035808A1 (de) | 2004-07-21 | 2006-03-16 | Kasch, Helmut, Dr. | Ammoniumsalze und Ammoniumsalz-Mineralsalzchlatrate als Transport- und Wirkform für pharmazeutische-medizinische und als Phasentransfermittel für chemische Anwendungen |
| US8569277B2 (en) | 2004-08-11 | 2013-10-29 | Palo Alto Investors | Methods of treating a subject for a condition |
| US20070293429A1 (en) | 2004-10-08 | 2007-12-20 | Therapei Pharmaceuticals, Inc. | Vasoactive Intestinal Polypeptide Compositions |
| US20080214440A1 (en) | 2004-10-08 | 2008-09-04 | Forbes Medi-Tech (Research), Inc. | Vasoactive intestinal polypeptide compositions |
| US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| ITME20040015A1 (it) | 2004-12-07 | 2005-03-07 | Vincenzo Savica | Chewing gum, caramelle gommose, pastiglie, compresse a lento rilascio di chelanti fosfato e/o fosforo salivare e capsule a lento rilascio di chelanti fosfato e/o fosforo a livello gastroenterico. |
| WO2006078629A2 (en) * | 2005-01-18 | 2006-07-27 | Duke University | In-situ crosslinkable elastin-like polypeptides for defect filling in cartilaginous tissue repair |
| CA2613875C (en) | 2005-07-04 | 2018-09-25 | Ramu Krishnan | Improved drug or pharmaceutical compounds and a preparation thereof |
| HUE025264T2 (en) | 2005-08-18 | 2016-02-29 | Panion & Bf Biotech Inc | Pharmaceutical-grade ferric citrate for medical use |
| EP1951266A2 (en) | 2005-09-02 | 2008-08-06 | Genzyme Corporation | Method for removing phosphate and polymer used therefore |
| WO2007038801A2 (en) | 2005-09-30 | 2007-04-05 | Ilypsa, Inc. | Monovalent cation-binding compositions comprising core-shell particles having crosslinked poly-vinylic shells, and methods of use thereof |
| US20090162314A1 (en) | 2005-11-08 | 2009-06-25 | Huval Chad C | Magnesium-Containing Polymers for the Treatment of Hyperphosphatemia |
| CN102600202A (zh) | 2005-11-08 | 2012-07-25 | 味之素株式会社 | 麻醉苏醒促进剂 |
| ITMI20052461A1 (it) | 2005-12-22 | 2007-06-23 | Univ Degli Studi Milano | Sistemi microparticellari per la somministrazione orale di sostanze biologicamente attive |
| RU2008136081A (ru) | 2006-02-14 | 2010-03-20 | Тева Фармасьютикл Индастриес Лтд. (Il) | Фармацевтические составы с алифатическими аминными полимерами и способы их производства |
| JP2009536246A (ja) | 2006-05-05 | 2009-10-08 | ゲンズイメ コーポレーション | ホスフェート捕捉剤としてのアミン縮合重合体 |
| JP2009542653A (ja) | 2006-07-05 | 2009-12-03 | ジェンザイム コーポレーション | リン酸塩過剰血症のための鉄（ｉｉ）含有治療剤 |
| MX2009000611A (es) | 2006-07-18 | 2009-04-16 | Genzyme Corp | Dendrimeros de amina. |
| CN101541235A (zh) * | 2006-07-18 | 2009-09-23 | 基酶有限公司 | 胺类树状物 |
| US8391873B2 (en) | 2006-07-21 | 2013-03-05 | Qualcomm Incorporated | Systems and methods for coordinating supplementary services for voice telephone calls in a centralized fashion |
| EP2046284A1 (en) | 2006-08-04 | 2009-04-15 | Nastech Pharmaceutical Company Inc. | Compositions for intranasal delivery of human insulin and uses thereof |
| CA2661987C (en) | 2006-09-01 | 2012-11-06 | Usv Limited | Process for the preparation of sevelamer hydrochloride and formulation thereof |
| US7964182B2 (en) * | 2006-09-01 | 2011-06-21 | USV, Ltd | Pharmaceutical compositions comprising phosphate-binding polymer |
| WO2008027551A2 (en) * | 2006-09-01 | 2008-03-06 | Genzyme Corporation | Dendrimer compositions |
| EP2059247A1 (en) | 2006-09-06 | 2009-05-20 | Sucampo AG | Method and composition for promoting gastrointestinal bicarbonate secretion |
| EP2066293A2 (en) | 2006-09-29 | 2009-06-10 | Genzyme Corporation | Amide dendrimer compositions |
| WO2008076242A1 (en) | 2006-12-14 | 2008-06-26 | Genzyme Corporation | Amido-amine polymer compositions |
| JP2010519298A (ja) | 2007-02-23 | 2010-06-03 | ゲンズイメ コーポレーション | アミンポリマー組成物 |
| US20080207766A1 (en) | 2007-02-27 | 2008-08-28 | Agi Therapeutics Research Ltd. | Methods and compositions for treating at least one upper gastrointestinal symptom |
| EP2131820A1 (en) | 2007-03-08 | 2009-12-16 | Genzyme Corporation | Sulfone polymer compositions |
| TWI445540B (zh) | 2007-04-20 | 2014-07-21 | Ajinomoto Kk | 抗低體溫組成物 |
| WO2008133954A1 (en) | 2007-04-27 | 2008-11-06 | Genzyme Corporation | Amido-amine dendrimer compositions |
| US8273384B2 (en) | 2007-07-02 | 2012-09-25 | Stephen Ray Wurzberger | Process for the preparation of a non-corrosive base solution and methods of using same |
| KR20100045965A (ko) * | 2007-07-11 | 2010-05-04 | 도레이 카부시키가이샤 | 가교 폴리알릴아민 또는 그 산부가염 및 그 의약 용도 |
| EP2016947A1 (en) | 2007-07-17 | 2009-01-21 | Chemo Ibérica, S.A. | Novel one step process for preparing cross-linked poly(allylamine) polymers |
| WO2009023544A2 (en) | 2007-08-10 | 2009-02-19 | Ilypsa, Inc. | Dosage unit anion-exchange polymer pharmaceutical compositions |
| US20090181359A1 (en) * | 2007-10-25 | 2009-07-16 | Lou Sheng C | Method of performing ultra-sensitive immunoassays |
| US20090156647A1 (en) | 2007-12-12 | 2009-06-18 | Iovate T. & P. Inc. | Method for maintaining physiological pH levels during intensive physical exercise |
| EP2217215A1 (en) | 2007-12-14 | 2010-08-18 | Genzyme Corporation | Coated pharmaceutical compositions |
| PA8807201A1 (es) | 2007-12-14 | 2009-07-23 | Genzyme Corp | Composiciones farmaceuticas |
| WO2009097127A1 (en) | 2008-01-31 | 2009-08-06 | Genzyme Corporation | Pharmaceutical compositions |
| US20100035992A1 (en) | 2008-03-11 | 2010-02-11 | Rajiv Bhushan | Methods and Compositions for Treating Inflammation and Inflammation-Related Pathologies |
| RU2010145166A (ru) | 2008-04-08 | 2012-05-20 | Юсв Лимитед (In) | Способ получения соли аминополимера |
| CN102014843B (zh) | 2008-04-11 | 2013-06-19 | Gp合资有限公司 | 用于人体组织的超声处理的机头 |
| US20110142952A1 (en) | 2008-06-20 | 2011-06-16 | Harris David J | Pharmaceutical Compositions |
| DE102008030046A1 (de) | 2008-06-25 | 2009-12-31 | Ratiopharm Gmbh | Kompaktiertes Polyallylamin-Polymer |
| US20100008988A1 (en) | 2008-07-14 | 2010-01-14 | Glenmark Generics, Ltd. | Tablet compositions of amine polymers |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| US8337824B2 (en) | 2008-08-22 | 2012-12-25 | Relypsa, Inc. | Linear polyol stabilized polyfluoroacrylate compositions |
| WO2010022381A1 (en) | 2008-08-22 | 2010-02-25 | Relypsa, Inc. | Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties |
| CA2737452C (en) | 2008-09-25 | 2018-05-22 | Vive Nano Inc. | Methods to produce polymer nanoparticles and formulations of active ingredients |
| US20110268666A1 (en) | 2008-09-29 | 2011-11-03 | Yissum Research Development Company of the Research University of Jerusalem, Ltd. | Novel gastroretentive delivery system |
| US20100113479A1 (en) | 2008-10-30 | 2010-05-06 | Anusuya Choudhury | Process for the preparation of tri-substituted pyridine and tri-substituted pyrimidine derivatives useful as gdir agonists |
| US20100166861A1 (en) | 2008-12-29 | 2010-07-01 | Kelly Noel Lynch | Pharmaceutical formulations of sevalamer, or salts thereof, and copovidone |
| CA2749397A1 (en) | 2009-01-22 | 2010-08-05 | Usv Limited | Pharmaceutical compositions comprising phosphate-binding polymer |
| WO2011059609A2 (en) | 2009-10-13 | 2011-05-19 | The Regents Of The University Of Michigan | Dendrimer compositions and methods of synthesis |
| WO2011047700A1 (en) | 2009-10-22 | 2011-04-28 | Synthon B.V. | Pharmaceutical compositions of sevelamer |
| WO2011071927A2 (en) | 2009-12-07 | 2011-06-16 | Ironwood Pharmaceuticals, Inc. | Treatments for gastrointestinal disorders |
| JP5865847B2 (ja) * | 2010-02-24 | 2016-02-17 | レリプサ， インコーポレイテッド | 胆汁酸捕捉剤として使用するための架橋されたポリビニルアミン、ポリアリルアミンおよびポリエチレンイミン |
| BR112012021448A2 (pt) | 2010-02-24 | 2016-05-31 | Relypsa Inc | polímero de amina, método para tratar doença, método de remoção de sais biliares de um indivíduo animal, método para melhorar o controle glicêmico em um indivíduo, e, processo para preparar o polímero de amina. |
| EP2539389B1 (en) * | 2010-02-24 | 2017-12-20 | Relypsa, Inc. | Amine polymers for use as bile acid sequestrants |
| RU2417782C1 (ru) * | 2010-03-03 | 2011-05-10 | Федеральное государственное образовательное учреждение высшего профессионального образования "Белгородская государственная сельскохозяйственная академия" | Способ лечения ацидоза рубца |
| IT1406068B1 (it) | 2010-07-22 | 2014-02-06 | Medestea Int Spa | Polidesossiribonucleotidi (pdrn) per l'impiego nel trattamento di condizioni di acidosi e composizioni a base di polidesossiribonucleotidi per il suddetto impiego |
| US20140072983A1 (en) * | 2010-08-10 | 2014-03-13 | Amgen Inc. | Dual function in vitro target binding assay for the detection of neutralizing antibodies against target antibodies |
| WO2012027331A1 (en) | 2010-08-27 | 2012-03-01 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| KR101238210B1 (ko) | 2011-06-30 | 2013-03-04 | 엘지전자 주식회사 | 이동 단말기 |
| US20130137772A1 (en) | 2011-11-29 | 2013-05-30 | Raymond J. Bergeron | Hydroxypolyamine salts |
| SG11201408521WA (en) | 2012-06-21 | 2015-01-29 | Keryx Biopharmaceuticals Inc | Use of ferric citrate in the treatment of chronic kidney disease patients |
| EP2916851B1 (en) | 2012-10-08 | 2025-12-17 | Vifor (International) Ltd. | Potassium-binding agents for treating hypertension and hyperkalemia |
| KR102633597B1 (ko) * | 2013-06-05 | 2024-02-06 | 트리시다, 인크. | 경구 투여를 위한 양성자-결합 중합체 |
| CN105873583A (zh) | 2013-11-04 | 2016-08-17 | 凯克斯生物制药公司 | 用于降低慢性肾病患者的心力衰竭的枸橼酸铁 |
| KR20240008418A (ko) | 2014-12-10 | 2024-01-18 | 트리시다, 인크. | 경구 투여용 양성자-결합 폴리머 |
| AU2017261337A1 (en) | 2016-05-06 | 2018-11-15 | Tricida, Inc. | Compositions for and method of treating acid-base disorders |
| AU2018360868B2 (en) | 2017-11-03 | 2025-01-02 | Tricida, Inc. | Method of treating acid-base disorders |
| US11266684B2 (en) | 2017-11-03 | 2022-03-08 | Tricida, Inc. | Compositions for and method of treating acid-base disorders |
| EP3740201A4 (en) | 2018-06-04 | 2021-03-17 | Tricida Inc. | METHOD FOR TREATMENT OF ACID-BASE DISORDER |
| WO2019236124A1 (en) | 2018-06-04 | 2019-12-12 | Tricida, Inc. | Method of treating acid-base disorders |
| WO2019236639A1 (en) | 2018-06-04 | 2019-12-12 | Tricida, Inc. | Method of treating acid-base disorders |
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Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5534259A (en) * | 1993-07-08 | 1996-07-09 | Liposome Technology, Inc. | Polymer compound and coated particle composition |
| CN1503676A (zh) * | 2001-04-18 | 2004-06-09 | ԭ���ø� | 低盐含量的聚烯丙胺 |
| CN1540136A (zh) * | 2003-10-27 | 2004-10-27 | 华东理工大学 | 一种评价微生物驱油能力的方法 |
| CN1878822A (zh) * | 2003-11-03 | 2006-12-13 | 伊立普萨公司 | 阴离子结合聚合物以及其应用 |
| CN101065409A (zh) * | 2004-10-13 | 2007-10-31 | 伊立普萨公司 | 交联胺聚合物 |
| CN101316601A (zh) * | 2005-09-30 | 2008-12-03 | 伊立普萨公司 | 从哺乳动物的胃肠道选择性除去钾离子的方法和组合物 |
| CN101321519A (zh) * | 2005-09-30 | 2008-12-10 | 伊立普萨公司 | 制备含有交联壳的核-壳型复合物的方法及其得到的核-壳型复合物 |
Non-Patent Citations (2)
| Title |
|---|
| Nataliya V. Nukolova et al.，.Polyelectrolyte Nanogels Decorated with Monoclonal Antibody for Targeted Drug Delivery.《React Funct Polym .》.第71卷(第3期),第315-323页. * |
| 氨基树脂及其涂料;无;《氮基树脂救其涂料 》;20031231(第3期);第44-46页 * |
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