CN1116624A - 改进的制备3-(4-氨基乙氧基苯甲酰)苯并[b]噻吩的方法 - Google Patents

改进的制备3-(4-氨基乙氧基苯甲酰)苯并[b]噻吩的方法 Download PDF

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Publication number
CN1116624A
CN1116624A CN95109618A CN95109618A CN1116624A CN 1116624 A CN1116624 A CN 1116624A CN 95109618 A CN95109618 A CN 95109618A CN 95109618 A CN95109618 A CN 95109618A CN 1116624 A CN1116624 A CN 1116624A
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CN
China
Prior art keywords
acid
group
benzo
thiophene
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN95109618A
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English (en)
Chinese (zh)
Inventor
C·A·奥尔特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CN1116624A publication Critical patent/CN1116624A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Photoreceptors In Electrophotography (AREA)
CN95109618A 1994-07-22 1995-07-20 改进的制备3-(4-氨基乙氧基苯甲酰)苯并[b]噻吩的方法 Pending CN1116624A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27945694A 1994-07-22 1994-07-22
US279,456 1994-07-22

Publications (1)

Publication Number Publication Date
CN1116624A true CN1116624A (zh) 1996-02-14

Family

ID=23069049

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95109618A Pending CN1116624A (zh) 1994-07-22 1995-07-20 改进的制备3-(4-氨基乙氧基苯甲酰)苯并[b]噻吩的方法

Country Status (27)

Country Link
US (2) US5523416A (enExample)
EP (1) EP0693488B1 (enExample)
JP (1) JPH0853440A (enExample)
KR (1) KR960004336A (enExample)
CN (1) CN1116624A (enExample)
AT (1) ATE205842T1 (enExample)
AU (1) AU684181B2 (enExample)
BR (1) BR9503408A (enExample)
CA (1) CA2154319A1 (enExample)
CO (1) CO4410192A1 (enExample)
CZ (1) CZ189295A3 (enExample)
DE (1) DE69522762T2 (enExample)
DK (1) DK0693488T3 (enExample)
ES (1) ES2160668T3 (enExample)
FI (1) FI953513L (enExample)
HU (1) HUT71596A (enExample)
IL (1) IL114684A (enExample)
MX (1) MXPA99010090A (enExample)
MY (1) MY131787A (enExample)
NO (1) NO952891L (enExample)
NZ (1) NZ272609A (enExample)
PE (1) PE34396A1 (enExample)
PL (1) PL309694A1 (enExample)
PT (1) PT693488E (enExample)
RU (1) RU95113269A (enExample)
TW (1) TW298592B (enExample)
ZA (1) ZA956031B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104496963A (zh) * 2014-12-02 2015-04-08 千辉药业（安徽）有限责任公司 一种盐酸雷洛昔芬的制备方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO4410190A1 (es) 1994-09-19 1997-01-09 Lilly Co Eli 3-[4-(2-AMINOETOXI)-BENZOIL]-2-ARIL-6-HIDROXIBENZO [b] TIOFENO CRISTALINO
IN183239B (enExample) * 1996-09-25 1999-10-09 Lilly Co Eli
ZA9710262B (en) * 1996-11-19 1999-05-13 Lilly Co Eli Process for the synthesis of benzothiophenes
JP2001522372A (ja) * 1997-04-30 2001-11-13 イーライ・リリー・アンド・カンパニー ベンゾチオフェンの製造方法
WO2002042289A2 (en) * 2000-11-27 2002-05-30 Eli Lilly And Company Process for preparing 3-aryl-benzo[b]thiophenes
EP1826205A1 (en) 2002-09-30 2007-08-29 A/S GEA Farmaceutisk Fabrik Novel raloxifene succinic acid addition salts and/or solvates thereof, and pharmaceutical compositions comprising these
ITMI20031333A1 (it) * 2003-06-30 2005-01-01 Erregierre Spa Processo di preparazione di raloxifene cloridrato.
WO2008047105A1 (en) * 2006-10-17 2008-04-24 Cipla Limited Crystalline form of benzothiophene compound and process for preparation thereof
CN101812002A (zh) * 2010-04-16 2010-08-25 山东新华制药股份有限公司 4-甲氧基-α-[(3-甲氧基苯基)硫代]苯乙酮的合成工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
AU509682B2 (en) * 1975-10-28 1980-05-22 Eli Lilly And Company 2-Aroyl-3-Phenylbenzothiophene Derivatives
AT364852B (de) * 1977-11-05 1981-11-25 Thomae Gmbh Dr K Verfahren zur herstellung von kondensierten isothiazol-3(2h)-on-1,1-dioxiden und von deren salzen
US4436748A (en) * 1980-10-20 1984-03-13 Hoechst-Roussel Pharmaceuticals Inc. Benzo[b]thiophenes
IL65379A0 (en) * 1981-04-03 1982-05-31 Lilly Co Eli Process for preparing acylated benzothiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
IL65378A (en) * 1981-04-03 1986-02-28 Lilly Co Eli Process for preparing 3-(4-aminoethoxybenzoyl)benzo-(b)thiophenes
NZ200204A (en) * 1981-04-03 1985-05-31 Lilly Co Eli Benzothiophene derivatives and process for preparation
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4436740A (en) * 1982-07-26 1984-03-13 Merck & Co., Inc. 3-Cycloalkylamino-2-OR-propoxycyanopyridines
DE4204969A1 (de) * 1992-02-19 1993-08-26 Basf Ag Verfahren zur herstellung von benzo(b)thiophenen
US5298630A (en) * 1992-06-03 1994-03-29 Sumitomo Seika Chemicals Co., Ltd. Processes for producing 2-substituted benzo[B]thiophene
JP3337728B2 (ja) * 1992-11-20 2002-10-21 イハラケミカル工業株式会社 ２‐アセチルベンゾ［ｂ］チオフェンの製造方法
US5426191A (en) * 1993-12-03 1995-06-20 Warner-Lambert Company Process for the synthesis of 3-chlorobenzo[b]thiophene-2-carbonyl chlorides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104496963A (zh) * 2014-12-02 2015-04-08 千辉药业（安徽）有限责任公司 一种盐酸雷洛昔芬的制备方法

Also Published As

Publication number Publication date
JPH0853440A (ja) 1996-02-27
HU9502176D0 (en) 1995-09-28
FI953513A0 (fi) 1995-07-20
ES2160668T3 (es) 2001-11-16
US5512684A (en) 1996-04-30
DE69522762T2 (de) 2002-07-04
CZ189295A3 (en) 1996-02-14
DE69522762D1 (de) 2001-10-25
US5523416A (en) 1996-06-04
AU684181B2 (en) 1997-12-04
IL114684A0 (en) 1995-11-27
DK0693488T3 (da) 2001-11-12
KR960004336A (ko) 1996-02-23
EP0693488B1 (en) 2001-09-19
RU95113269A (ru) 1997-06-10
PL309694A1 (en) 1996-02-05
PE34396A1 (es) 1996-09-26
MY131787A (en) 2007-08-30
TW298592B (enExample) 1997-02-21
FI953513A7 (fi) 1996-01-23
HUT71596A (en) 1996-01-29
IL114684A (en) 1999-06-20
NO952891D0 (no) 1995-07-20
AU2506895A (en) 1996-02-01
NZ272609A (en) 1997-05-26
ZA956031B (en) 1997-01-20
BR9503408A (pt) 1996-02-27
FI953513L (fi) 1996-01-23
ATE205842T1 (de) 2001-10-15
MXPA99010090A (es) 2004-09-01
EP0693488A1 (en) 1996-01-24
PT693488E (pt) 2002-02-28
CA2154319A1 (en) 1996-01-23
CO4410192A1 (es) 1997-01-09
NO952891L (no) 1996-01-23

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