CN111630148A - 在防止乳酸积累的同时繁殖细胞培养物的过程和系统 - Google Patents

在防止乳酸积累的同时繁殖细胞培养物的过程和系统 Download PDF

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Publication number
CN111630148A
CN111630148A CN201880087141.8A CN201880087141A CN111630148A CN 111630148 A CN111630148 A CN 111630148A CN 201880087141 A CN201880087141 A CN 201880087141A CN 111630148 A CN111630148 A CN 111630148A
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China
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concentration
cell culture
lactic acid
lactate
controller
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CN201880087141.8A
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English (en)
Chinese (zh)
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B·J·唐尼
J·M·施密特
J·F·布赖特
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Lonza AG
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Lonza AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Computer Hardware Design (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201880087141.8A 2017-11-20 2018-11-20 在防止乳酸积累的同时繁殖细胞培养物的过程和系统 Pending CN111630148A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762588464P 2017-11-20 2017-11-20
US62/588,464 2017-11-20
US201862747311P 2018-10-18 2018-10-18
US62/747,311 2018-10-18
PCT/US2018/061912 WO2019100040A1 (en) 2017-11-20 2018-11-20 Process and system for propagating cell cultures while preventing lactate accumulation

Publications (1)

Publication Number Publication Date
CN111630148A true CN111630148A (zh) 2020-09-04

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CN201880087141.8A Pending CN111630148A (zh) 2017-11-20 2018-11-20 在防止乳酸积累的同时繁殖细胞培养物的过程和系统

Country Status (8)

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US (1) US11634680B2 (ja)
EP (1) EP3714036A1 (ja)
JP (2) JP7391840B2 (ja)
KR (1) KR102589415B1 (ja)
CN (1) CN111630148A (ja)
CA (1) CA3083124A1 (ja)
IL (1) IL274776A (ja)
WO (1) WO2019100040A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112662551A (zh) * 2020-12-29 2021-04-16 上海药明生物医药有限公司 一种细胞培养控制方法以及系统

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JP7451546B2 (ja) * 2019-09-24 2024-03-18 富士フイルム株式会社 情報処理装置、情報処理方法、及び情報処理プログラム
JPWO2021166824A1 (ja) * 2020-02-19 2021-08-26
AU2021257589A1 (en) * 2020-04-16 2022-09-22 Abb Schweiz Ag Method for an intelligent alarm management in industrial processes
CA3194021A1 (en) 2020-09-03 2022-03-10 Melonfrost, Inc. Machine learning and control systems and methods for learning and steering evolutionary dynamics
AU2021355381A1 (en) * 2020-10-01 2023-05-04 Amgen Inc. Predictive modeling and control of cell culture
GB202015861D0 (en) 2020-10-07 2020-11-18 National Institute For Bioprocesisng Res And Training Method and system for predicting the performance for biopharmaceutical manufacturing processes
KR20230060189A (ko) * 2021-10-27 2023-05-04 프레스티지바이오로직스 주식회사 인공지능을 이용하여 세포 배양조건을 결정하기 위한 장치 및 장치의 동작 방법
WO2024048079A1 (ja) * 2022-08-31 2024-03-07 富士フイルム株式会社 有用物質を産生するクローンの産生安定性を予測する方法、情報処理装置、プログラムおよび予測モデル生成方法

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CN1557948A (zh) * 2004-02-12 2004-12-29 陈志南 动物细胞无血清悬浮培养工艺过程控制参数的方法
JP2007244341A (ja) * 2006-03-20 2007-09-27 Hitachi Ltd 生体細胞の培養制御方法及び培養制御装置
CN102112876A (zh) * 2008-05-28 2011-06-29 普罗瑟拉生物制剂有限责任公司 来自血液的间-α抑制物蛋白的制备和组合物
CN102604884A (zh) * 2012-03-01 2012-07-25 江苏太平洋美诺克生物药业有限公司 细胞的发酵培养方法
US20170130186A1 (en) * 2014-07-02 2017-05-11 Biogen Ma Inc. Cross-scale modeling of bioreactor cultures using raman spectroscopy

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JP2007202500A (ja) * 2006-02-03 2007-08-16 Hitachi Ltd 培養槽の運転制御装置
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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1557948A (zh) * 2004-02-12 2004-12-29 陈志南 动物细胞无血清悬浮培养工艺过程控制参数的方法
JP2007244341A (ja) * 2006-03-20 2007-09-27 Hitachi Ltd 生体細胞の培養制御方法及び培養制御装置
CN102112876A (zh) * 2008-05-28 2011-06-29 普罗瑟拉生物制剂有限责任公司 来自血液的间-α抑制物蛋白的制备和组合物
CN102604884A (zh) * 2012-03-01 2012-07-25 江苏太平洋美诺克生物药业有限公司 细胞的发酵培养方法
US20170130186A1 (en) * 2014-07-02 2017-05-11 Biogen Ma Inc. Cross-scale modeling of bioreactor cultures using raman spectroscopy

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112662551A (zh) * 2020-12-29 2021-04-16 上海药明生物医药有限公司 一种细胞培养控制方法以及系统

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US20230279330A1 (en) 2023-09-07
JP2021503291A (ja) 2021-02-12
JP7391840B2 (ja) 2023-12-05
JP2023166410A (ja) 2023-11-21
US20200354666A1 (en) 2020-11-12
CA3083124A1 (en) 2019-05-23
IL274776A (en) 2020-07-30
US11634680B2 (en) 2023-04-25
KR20200086348A (ko) 2020-07-16
WO2019100040A1 (en) 2019-05-23
KR102589415B1 (ko) 2023-10-16
EP3714036A1 (en) 2020-09-30

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