CN1116284C - α,α'－二氨基醇及其制备方法 - Google Patents

α,α'－二氨基醇及其制备方法 Download PDF

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Publication number
CN1116284C
CN1116284C CN95116887A CN95116887A CN1116284C CN 1116284 C CN1116284 C CN 1116284C CN 95116887 A CN95116887 A CN 95116887A CN 95116887 A CN95116887 A CN 95116887A CN 1116284 C CN1116284 C CN 1116284C
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CN
China
Prior art keywords
formula
same meaning
generated
tert
butyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN95116887A
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English (en)
Chinese (zh)
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CN1127251A (zh
Inventor
H·海尔伯特
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN1127251A publication Critical patent/CN1127251A/zh
Application granted granted Critical
Publication of CN1116284C publication Critical patent/CN1116284C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN95116887A 1994-09-23 1995-09-21 α,α'－二氨基醇及其制备方法 Expired - Lifetime CN1116284C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CH290494 1994-09-23
CH2904/1994 1994-09-23
CH2904/94 1994-09-23
CH373694 1994-12-09
CH3736/94 1994-12-09
CH3736/1994 1994-12-09

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CNB991274121A Division CN1133620C (zh) 1994-09-23 1999-12-30 α—氨基醇及其制备方法
CN99127411A Division CN1111156C (zh) 1994-09-23 1999-12-30 α,α＇—二氨基醇及其制备方法

Publications (2)

Publication Number Publication Date
CN1127251A CN1127251A (zh) 1996-07-24
CN1116284C true CN1116284C (zh) 2003-07-30

Family

ID=25691689

Family Applications (3)

Application Number Title Priority Date Filing Date
CN95116887A Expired - Lifetime CN1116284C (zh) 1994-09-23 1995-09-21 α,α'－二氨基醇及其制备方法
CN99127411A Expired - Lifetime CN1111156C (zh) 1994-09-23 1999-12-30 α,α＇—二氨基醇及其制备方法
CNB991274121A Expired - Lifetime CN1133620C (zh) 1994-09-23 1999-12-30 α—氨基醇及其制备方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN99127411A Expired - Lifetime CN1111156C (zh) 1994-09-23 1999-12-30 α,α＇—二氨基醇及其制备方法
CNB991274121A Expired - Lifetime CN1133620C (zh) 1994-09-23 1999-12-30 α—氨基醇及其制备方法

Country Status (9)

Country Link
US (5) US5591885A (https=)
EP (1) EP0710651B1 (https=)
JP (1) JP3819955B2 (https=)
KR (1) KR100418237B1 (https=)
CN (3) CN1116284C (https=)
AT (1) ATE198740T1 (https=)
DE (1) DE59508973D1 (https=)
DK (1) DK0710651T3 (https=)
ES (1) ES2154310T3 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523463A (en) * 1994-09-23 1996-06-04 Hoffmann-La Roche Inc. Method of producing halogenated and alpha-aminoalchohols
CA2186483A1 (en) * 1995-02-03 1996-08-08 Akira Nishiyama Processes for producing .alpha.-halo ketones, .alpha.-halohydrins and epoxides
HUP9800085A3 (en) * 1996-01-29 1998-06-29 Kaneka Corp Processes for the reduction of carbonyl compounds and producing alfa-amino-alcohol derivatives
EP0847994B1 (de) 1996-12-11 2003-04-09 F. Hoffmann-La Roche Ag Verfahren zur Herstellung gemischter Anhydride
WO2000044706A1 (en) * 1999-01-28 2000-08-03 Ajinomoto Co., Inc. PROCESS FOR THE PREPARATION OF α-AMINOKETONES
US6605732B1 (en) * 1999-05-03 2003-08-12 Aerojet Fine Chemicals Llc Clean, high-yield preparation of S,S and R,S amino acid isosteres
JP4143787B2 (ja) * 1999-07-28 2008-09-03 味の素株式会社 α−アミノハロメチルケトン誘導体の製造方法
DE10143742A1 (de) 2001-09-06 2003-03-27 Consortium Elektrochem Ind Verfahren zur Herstellung von alpha-Halogenketonen
US7038553B2 (en) * 2002-10-03 2006-05-02 International Business Machines Corporation Scalable computer system having surface-mounted capacitive couplers for intercommunication
EP1604662A1 (en) * 2004-06-08 2005-12-14 Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus
CN102164906A (zh) * 2008-09-24 2011-08-24 Zach系统股份公司 用于制备奈必洛尔的方法
CN102127061B (zh) * 2010-01-15 2016-02-17 浙江华海药业股份有限公司 一种制备6-氟-3，4-二氢-2h-1-苯并吡喃-2-环氧乙烷的改进方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0432695A2 (en) * 1989-12-11 1991-06-19 F. Hoffmann-La Roche Ag Amino acid derivatives
EP0543343A2 (de) * 1991-11-19 1993-05-26 Lonza Ag Verfahren zur Herstellung von alpha-Hydroxy-beta-aminocarbonsäuren

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
GB8927915D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Novel alcohols
US5430041A (en) * 1991-05-10 1995-07-04 Hoffmann-La Roche Inc. Amino acid derivatives having antiviral activity
JP2551901B2 (ja) * 1991-07-26 1996-11-06 エフ エム シー コーポレーション 接触アルキル化方法
US5380849A (en) * 1992-11-09 1995-01-10 Merck & Co., Inc. Process for optically pure decahydroisoqiunolines
US5455353A (en) * 1993-03-24 1995-10-03 Hoffmann-La Roche Inc. 4-(benzyl-2-oxo-oxazolidin-5 ylmethyl)N tertbutyl-decahydroisoquinoline-3-carboxamides
ATE172970T1 (de) * 1993-07-15 1998-11-15 Hoffmann La Roche Verfahren zur herstellung eines n-tert.butylamids
US5523463A (en) * 1994-09-23 1996-06-04 Hoffmann-La Roche Inc. Method of producing halogenated and alpha-aminoalchohols

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0432695A2 (en) * 1989-12-11 1991-06-19 F. Hoffmann-La Roche Ag Amino acid derivatives
EP0543343A2 (de) * 1991-11-19 1993-05-26 Lonza Ag Verfahren zur Herstellung von alpha-Hydroxy-beta-aminocarbonsäuren

Also Published As

Publication number Publication date
EP0710651A1 (de) 1996-05-08
EP0710651B1 (de) 2001-01-17
CN1111156C (zh) 2003-06-11
US5847144A (en) 1998-12-08
CN1133620C (zh) 2004-01-07
JPH0899959A (ja) 1996-04-16
ES2154310T3 (es) 2001-04-01
US5965733A (en) 1999-10-12
CN1275562A (zh) 2000-12-06
DK0710651T3 (da) 2001-05-14
CN1127251A (zh) 1996-07-24
KR100418237B1 (ko) 2004-07-23
US5591885A (en) 1997-01-07
US5684176A (en) 1997-11-04
DE59508973D1 (de) 2001-02-22
KR960010629A (ko) 1996-04-20
US5977388A (en) 1999-11-02
ATE198740T1 (de) 2001-02-15
CN1275563A (zh) 2000-12-06
JP3819955B2 (ja) 2006-09-13

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