CN1115965C - Natural plant disinfectant and its preparation - Google Patents
Natural plant disinfectant and its preparation Download PDFInfo
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- CN1115965C CN1115965C CN00100334A CN00100334A CN1115965C CN 1115965 C CN1115965 C CN 1115965C CN 00100334 A CN00100334 A CN 00100334A CN 00100334 A CN00100334 A CN 00100334A CN 1115965 C CN1115965 C CN 1115965C
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- natural plant
- ethanol
- extract
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- disinfectant
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Pain & Pain Management (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to a natural plant disinfectant and a preparation method thereof. The raw material of the disinfectant of the present invention comprises the extraction liquid of spica prunellae, rhubarb, magnolia bark, mistletoe, garlic and mentha, ethanol and sterile distilled water; selected natural plants are washed, dried and pulverized firstly in preparation, and then, the processed natural plants are respectively soaked by ethanol water solution for extraction; afterwards, each kind of extraction liquid is merged, concentrated, homogenized and mixed with a certain proportional ethanol and the distilled water; the mixture is naturally precipitated, clarified and purified to obtain the disinfectant. The natural plant disinfectant of the present invention has the advantages of naturalness, nontoxicity, innocuity, security, high efficiency, sterilization, inflammation resistance and antipruritic. The preparation method of the present invention has the advantages of science, reasonability, simpleness, practicability and wide application.
Description
The present invention relates to the preparation of disinfectant, particularly a kind of method for preparing natural plant disinfectant with the supercritical fluid extraction equipment and technology.
As everyone knows, the disinfectant kind that is usually used at present environment or human body skin both at home and abroad is nearly hundreds of, but most disinfectants are synthetic, as 1,5 glutaraldehydes, quaternary amine, sulphur volt, chlorine-containing agent (84 thimerosal) or the like, they singly only do not have disinfective action, and ubiquity has certain toxic and side effect or residual contamination problem.
The objective of the invention is to from natural plants the material that extraction has disinfective action,, obtain a kind of natural plant disinfectant of safe, nontoxic, non-environmental-pollution then through scientific and reasonable preparation.
Another object of the present invention provides a kind of preparation method of above-mentioned disinfectant.
The raw material of natural plant disinfectant of the present invention comprises extract and 75-95% ethanol and the sterile distilled water of selfheal, rheum officinale, the bark of official magnolia, parasite scurrula, garlic, peppermint, and the parts by weight proportioning of wherein said each composition is:
Selfheal extract 1-4 part
Rheum officinale extract 1-3 part
Bark of official magnolia extract 1.2-3 part
Parasite scurrula extract 1-3 part
Garlic extraction liquid 0.1-1 part
Peppermint extract 0.5-2.5 part
75-95% ethanol 20-35 part
Sterile distilled water 75.2-51.5 part
Wherein, described garlic extraction liquid can be substituted by Allicin (Allifridin), as the commerical grade Allicin of Shanghai Medicine plant No. 2's production; Described peppermint extract useful commercial level menthol substitutes, and total menthol content requirement 〉=50% is as the technical grade menthol of perfumery, Shanghai, the production of perfumery, Hangzhou.
The preparation method of natural plant disinfectant of the present invention comprise earlier with selected natural plants selfheal, the bark of official magnolia, parasite scurrula, garlic, rheum officinale, peppermint grass through water clean, dry and pulverize after, soak with the 30-50% ethanol water respectively and obtain the crude drug soak, obtain each crude drug extract through supercritical fluid extraction respectively again, through concentrating, then each concentrated extract is mixed in proportion, behind the homogeneous, under stirring condition, successively add ethanol and sterile distilled water, purified again getting final product.
Wherein, the baking temperature of described each vegetable crude drug is 80 ℃-100 ℃, and moisture content is not more than 2%.
The pulverizing order number of described crude drug raw material is the 100-150 order.
Described immersion crude drug ethanolic solution is that concentration is the ethanol sterile distilled water solution of 30-50%.
Described immersion is 2-4 with the ethanol distillation aqueous solution and by the part by weight of soak medicine: 1.
The time of described immersion crude drug is 24-72 hour.
The described extraction time is 1-3 hour, and extraction temperature is 18 ℃-100 ℃.
The temperature of described concentration process is 60 ℃-90 ℃, and being concentrated into gravity Baume concentration is 1.10-1.20.
Described homogenizing process is under 30 ℃-40 ℃ temperature, stirs in the homogenizer of 1000-3000 rev/min of speed to obtain crude drug extraction homogenizing fluid in 2-5 minute.
The mixing speed of described adding ethanol and sterile distilled water is 50-150 rev/min, and the time is 2 minutes.
Described purge process be the plant disinfectant of preparing after the natural sedimentation of 3-7 days time, again through the clarification filtration gained.
That natural plant disinfectant of the present invention has is natural, nontoxic, harmless, the effect of safety, efficient sterilizing, inflammation-resisting itch-stopping; Its preparation method is scientific and reasonable, and is simple, of many uses.
Further set forth this invention below in conjunction with embodiment.
Embodiment 1
A kind of natural plant disinfectant, its raw material comprise extract and ethanol and the sterile distilled water of selfheal, rheum officinale, the bark of official magnolia, parasite scurrula, garlic, peppermint, and the parts by weight proportioning of wherein said each composition is:
4 parts of selfheal extracts
3 parts of rheum officinale extracts
3 parts of bark of official magnolia extracts
3 parts of parasite scurrula extracts
1 part of garlic extraction liquid
2.5 parts of peppermint extracts
35 parts of 75% ethanol
46 parts of sterile distilled waters
During preparation, earlier selected vegetable crude drug selfheal, the bark of official magnolia, parasite scurrula, garlic, dried peppermint leaf, rheum officinale are cleaned twice with running water, dry in 80 ℃ of drying boxes, water content is not more than 2%, pulverize each crude drug respectively with cracker then, and by 100 eye mesh screens; Each the crude drug powder that to pulverize is placed in the ceramic vessel respectively, and add 3 times to 35% ethanol distillation water loggings of drug weight bubble, the weight ratio of crude drug powder and ethanol distillation water is 1: 3, behind the immersion 24h, uses the supercritical fluid extraction machine, extraction is 140 minutes under 20 ℃ of temperature, according to said method, every kind of crude drug soak extracting twice is during the extraction crude drug, should carry out respectively, and put respectively.The crude drug extract is concentrated into medicinal extract under 70 ℃ of temperature, be 1.15 standby with gravity Baume instrumentation concentrate proportion;
Extraction concentrate with selfheal, rheum officinale, the bark of official magnolia, parasite scurrula, garlic and peppermint mixes in normal temperature laboratory in proportion again, mixes in 2000 rev/mins of speed homogenizers and stirs 3 minutes, and temperature is 30 ℃.After mixing, press the medical grade ethanol of 75% concentration of design proportion adding 35%, when adding ethanol, the homogenizer rotating speed should be 60 rev/mins.Add back continuation stirring and reached the homogeneous purpose in 2 minutes, afterwards, add 46% sterile distilled water more in proportion, the adding method is with adding the ethanol method.At last, institute's preparation plant disinfectant is placed in the ceramic vessel.Through the natural sedimentation of 3 day time, the extracting container supernatant filters twice, can obtain finished product.
The plant disinfectant of preparing with said method shows through Disinfection Effect and safety toxicological test, and this disinfectant 3 minutes reaches 99.9% to the Escherichia coli killing rate; The staphylococcus aureus killing rate reached 99.9% in 4 minutes; 5 minutes to hepatitis B surface antigen H B sAg and H A V generation deactivation.Simultaneously, toxicological test shows, natural plant disinfectant L D
50＞25g/kg, more safer than chemosterilant, to had no corrosive effect on metals, without any side effects to human body.
Embodiment 2
A kind of natural plant disinfectant, its raw material comprises the extract of selfheal, the extract of rheum officinale, the extract of the bark of official magnolia, extract, Allicin, menthol and 95% ethanol and the sterile distilled water of parasite scurrula, and the parts by weight proportioning of wherein said each composition is:
2 parts of selfheal extracts
2 parts of rheum officinale extracts
2 parts of bark of official magnolia extracts
3 parts of parasite scurrula extracts
1 part of Allicin
1.5 parts of menthols
30 parts of 95% ethanol
58.5 parts of sterile distilled waters
During preparation, with selected vegetable crude drug selfheal, the bark of official magnolia, parasite scurrula, rheum officinale cleans twice with running water, in 90 ℃ of drying boxes, dry, water content is not more than 2%, then, dried each crude drug is crushed to 130 orders, puts into ceramic vessel, add the distilled water immersion that contains 30% ethanol, the weight ratio of crude drug powder and ethanol distillation water is 1: 3, after the crude drug powder soaked 48h, with supercritical fluid extraction equipment and technology, extraction was 120 minutes under 18 ℃ of temperature, press every kind of crude drug soak of this condition re-extract twice, during extraction, each crude drug part should be carried out respectively, puts respectively.At last extract is concentrated into medicinal extract under 80 ℃ of temperature, gravity Baume is 1.12 standby; The commodity Allicin that used garlic P.E directly adopts Shanghai Medicine plant No. 2 to produce replaces; The peppermint extract directly adopts the commercial goods menthol to replace, total menthol content 〉=50%, (manufacturer be perfumery, Shanghai, Hangzhou get the raw materials ready factory), used concentration of alcohol is 95% medical commodity.
Crude drug extraction concentrated extract and Allicin, menthol with selfheal, the bark of official magnolia, parasite scurrula, rheum officinale mixes in normal temperature laboratory in proportion again, in 1000 rev/mins of speed homogenizers, mix and stirred 2 minutes, temperature is 36 ℃, after waiting to finish the mixing stirring, require the medical ethanol of 95% concentration of 30 parts of addings more in proportion, when adding ethanol, the homogenizer rotating speed is 160 rev/mins, mixing time is 2 minutes, afterwards, the sterile distilled water that adds 58.5 parts again by design proportion, the adding method is as adding the ethanol method; At last, institute preparation plant disinfectant is placed in the glass container,, gets supernatant and filter twice through the natural sedimentation of 5 day time, get final product plant disinfectant finished product of the present invention.
The natural plant disinfectant of preparing with said method does Disinfection Effect and the safety toxicological test shows: this disinfectant 2 minutes reaches 99.9% to the Escherichia coli killing rate; Golden yellow grape ball killing rate reached 99.9%, 5 minute and can go out in 3 minutes and control hepatitis B surface antigen HBsAg and HAV.Simultaneously, toxicological test shows that this product LD50＞26g/kg compares than chemosterilant, and security performance is more superior, to had no corrosive effect on metals; Without any side effects to human body.
Embodiment 3
A kind of natural plant disinfectant, its raw material comprise extract and 75% medical ethanol and the sterile distilled water of selfheal, rheum officinale, the bark of official magnolia, parasite scurrula, garlic, peppermint, and the parts by weight proportioning of wherein said each composition is:
4 parts of selfheal extracts
3 parts of rheum officinale extracts
1.5 parts of bark of official magnolia extracts
3 parts of parasite scurrula extracts
0.1 part of garlic extraction liquid
2.5 parts of peppermint extracts
30 parts of 80% medical ethanols
54.9 parts of sterile distilled waters
During preparation, earlier with the used selfheal of natural plant disinfectant, the bark of official magnolia, parasite scurrula, garlic, dried peppermint leaf, rheum officinale cleans twice with running water, in 100 ℃ of drying boxes, dry then, water content is not more than 2%, pulverize each crude drug to 150 order with cracker again, be placed in the ceramic vessel respectively, and add 3 times of distilled water to 30% concentration of alcohol of drug weight, soak the crude drug powder, the weight ratio of the crude drug powder and the ethanol distillation aqueous solution is 1: 3, use supercritical fluid extraction equipment and technology after soaking 72h, under 30 ℃ of temperature, extraction crude drug soak 180 minutes, by this operation sequence, every kind of crude drug soak re-extract 3 times, during the extraction crude drug, each extract should carry out respectively and put respectively.Each extract is concentrated into medicinal extract under 85 ℃ of temperature, gravity Baume instrumentation concentrate proportion is 1.20 standby.
All crude drug concentrated extracts are mixed in normal temperature laboratory in proportion again, stirred 3 minutes through 1500 rev/mins of speed homogeneous, temperature is 35 ℃, after waiting to stir homogeneous, add the medical ethanol of 30% 80% concentration again by design proportion, the homogenizer rotating speed is 160 rev/mins, and stirring homogenizing time is 3 minutes.At last, institute preparation plant disinfectant is placed in the ceramic vessel,, gets supernatant and filter twice through the natural sedimentation of 6 day time, get final product finished product of the present invention.
Through showing that with said method institute preparing natural Disinfection Effect that plant disinfectant is tested, practical function and safety toxicity effect this product not only has better safety (LD than chemosterilant
50Result of the test＞25g/kg) to skin, mucous membrane nonirritant, to the metal non-corrosiveness; With the sterile distilled water diluted concentration is 1: 4 o'clock, the Escherichia coli eradicative rate is reached 99.8% in 2 minutes; 2.5 minute the staphylococcus aureus eradicative rate being reached 99.9%, 5 minute reaches 99.9% to the candida albicans rate of killing; 1: 2 dilution plant disinfectant 5 minutes produces deactivation to hepatitis B surface antigen HBsAg and HAV; Confirm through practicality, smear mosquito with 1: 4 dilution and sting the flood dragon place, but 3 minutes relieving itching and eliminating swellings.
Claims (8)
1, a kind of natural plant disinfectant is characterized in that this natural plant disinfectant is made up of the extract of selfheal, rheum officinale, the bark of official magnolia, parasite scurrula, garlic, peppermint and 75-95% ethanol and sterile distilled water, and the parts by weight proportioning of wherein said each composition is:
Selfheal extract 1-4 part
Rheum officinale extract 1-3 part
Bark of official magnolia extract 1.2-3 part
Parasite scurrula extract 1-3 part
Garlic extraction liquid 0.1-1 part
Peppermint extract 0.5-2.5 part
75-95% ethanol 20-35 part
Sterile distilled water 75.2-51.5 part
2, natural plant disinfectant as claimed in claim 1 is characterized in that described garlic extraction liquid is substituted by Allicin.
3, natural plant disinfectant as claimed in claim 1 is characterized in that described peppermint extract substitutes with the commerical grade menthol, total menthol content requirement 〉=50%.
4, as the preparation method of one of claim 1-3 described natural plant disinfectant, the preparation method who it is characterized in that this natural plant disinfectant comprise earlier with selected natural plants selfheal, the bark of official magnolia, parasite scurrula, garlic, rheum officinale, peppermint grass through water clean, dry and pulverize after, soak with ethanol water respectively and obtain each crude drug soak, obtain the effective extract of crude drug through extraction respectively again, then all extracts are mixed, after concentrating, stirring homogeneous, successively add ethanol and sterile distilled water, get final product through the natural sedimentation clarification again; Described immersion ethanolic solution is that concentration is the ethanol sterile distilled water solution of 30-40%; Described immersion is 2-4 with the ethanol distillation aqueous solution and by the part by weight of soak medicine: 1; Described soak time is 24-72 hour; The temperature of described concentration process is 60 ℃-90 ℃, and being concentrated into gravity Baume concentration is 1.10-1.20.
5, the preparation method of natural plant disinfectant as claimed in claim 4, the temperature that it is characterized in that described dry run is at 80 ℃-100 ℃.
6, the preparation method of natural plant disinfectant as claimed in claim 4 is characterized in that it is the 100-150 order that described crude drug is pulverized the order number.
7, the preparation method of natural plant disinfectant as claimed in claim 4 is characterized in that the described crude drug soak extraction time is 1-3 hour, and extraction temperature is 18 ℃-100 ℃.
8, the preparation method of natural plant disinfectant as claimed in claim 4 is characterized in that described homogenizing process is to stir 2-5 minute gained homogeneous mixed liquor under 30 ℃-40 ℃ temperature, in the homogenizer of 1000-3000 rev/min speed; The mixing speed of the whipping process of described adding ethanol and sterile distilled water is 50-150 rev/min, and the time is 2 minutes.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00100334A CN1115965C (en) | 2000-01-18 | 2000-01-18 | Natural plant disinfectant and its preparation |
| DE10037590A DE10037590A1 (en) | 2000-01-18 | 2000-08-02 | Natural plant disinfectant and its preparation |
| JP2000385988A JP2001199824A (en) | 2000-01-18 | 2000-12-19 | Sterilizing agent derived from natural plant and method for producing the agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00100334A CN1115965C (en) | 2000-01-18 | 2000-01-18 | Natural plant disinfectant and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1258450A CN1258450A (en) | 2000-07-05 |
| CN1115965C true CN1115965C (en) | 2003-07-30 |
Family
ID=4575393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00100334A Expired - Fee Related CN1115965C (en) | 2000-01-18 | 2000-01-18 | Natural plant disinfectant and its preparation |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP2001199824A (en) |
| CN (1) | CN1115965C (en) |
| DE (1) | DE10037590A1 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101849560B (en) * | 2010-06-01 | 2013-12-11 | 赵长贵 | Plant source pesticide and preparation method thereof |
| CN102266578A (en) * | 2011-01-10 | 2011-12-07 | 于秉礼 | Plant chestnut flower liquid preparation |
| CN102972384B (en) * | 2012-11-23 | 2014-04-16 | 郑凤芹 | Intelligent meloidogyne drip-irrigation preventing device |
| CN105028501A (en) * | 2015-08-03 | 2015-11-11 | 孔令军 | Disinfectant for pharmacy |
| KR101721007B1 (en) * | 2016-07-08 | 2017-03-29 | 김원주 | Antidotes composition for venom of venomous insects |
| JP6053241B1 (en) * | 2016-08-31 | 2016-12-27 | 株式会社ニイタカ | Disinfectant and sanitary materials |
| CN107182903A (en) * | 2017-04-25 | 2017-09-22 | 蚌埠农兴现代农业专业合作社 | A kind of cultural method for improving layer chicken in summer anti-stress ability |
| CN108094823A (en) * | 2018-02-07 | 2018-06-01 | 合肥华盖生物科技有限公司 | A kind of safe and efficient liquid-state feed mould inhibitor and preparation method thereof |
| CN108543105A (en) * | 2018-05-31 | 2018-09-18 | 四川建源节能科技有限公司 | A kind of air freshener and preparation method thereof absorbing peculiar smell |
| CN111110628A (en) * | 2020-02-12 | 2020-05-08 | 药肽医学研究(济南)有限公司 | Sterilization disinfectant and preparation method thereof |
| CN115559121B (en) * | 2022-10-24 | 2024-04-30 | 高梵(浙江)信息技术有限公司 | Preparation method of antibacterial goose down |
-
2000
- 2000-01-18 CN CN00100334A patent/CN1115965C/en not_active Expired - Fee Related
- 2000-08-02 DE DE10037590A patent/DE10037590A1/en not_active Ceased
- 2000-12-19 JP JP2000385988A patent/JP2001199824A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| vol. 1, 1 June 1986 (1986-06-01) * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1258450A (en) | 2000-07-05 |
| JP2001199824A (en) | 2001-07-24 |
| DE10037590A1 (en) | 2001-07-26 |
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