CN111387223A - Arbidol disinfection liquid or gel and preparation method and application thereof - Google Patents
Arbidol disinfection liquid or gel and preparation method and application thereof Download PDFInfo
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- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
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- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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Abstract
The invention provides arbidol disinfection liquid or gel and a preparation method and application thereof, wherein the disinfection liquid or gel comprises the following components of 20-30 mg/L of arbidol, 1: 120-150 of polyhexamethylene biguanide hydrochloride and arbidol by mass, 20-40 of ethanol by mass, 0.5-1.5 of solubilizer by mass, 0.1-5 of potassium sorbate and the balance of water.
Description
Technical Field
The invention belongs to the technical field of disinfection products, and particularly relates to arbidol disinfection liquid or gel and a preparation method and application thereof.
Background
Along with the progress of society, the development of economy, people also attach more and more importance to sanitation and self health, most of people now can regularly disinfect environment, house, hands, vehicles and the like, prevent the produced germs from causing harm to the body, especially face the global novel coronavirus crisis, people have a greater improvement on the protection consciousness of viruses, and the disinfectant has become the first-selected daily necessary for people. Although early disinfectants were effective in killing bacteria and viruses, they were environmentally hazardous and even harmful to humans due to some components. In recent years, disinfectants which are harmless to the environment and have quick action are mainly sought in various countries, wherein hydrogen peroxide and chlorine dioxide gas sterilization methods are more spotlighted, and the disinfection of ozone also has wide use value. The disinfectant can be divided into a sterilizing agent, a high-efficiency disinfectant, a middle-efficiency disinfectant and a low-efficiency disinfectant according to the action level.
Arbidol hydrochloride was developed by the former soviet union VNIKhFI company and was marketed in russia in 1993 for the treatment and prophylaxis of influenza and acute viral respiratory infections. The arbidol has the most obvious antiviral activity on influenza viruses with A, B-type antigens, has an immunoregulation effect, can induce and generate interferon, activate macrophages and improve the resistance of organisms to virus infection, and is a novel antiviral medicament for treating influenza and acute respiratory virus infection caused by A, B-type viruses at present.
Arbidol hydrochloride is white-like crystalline powder, has no hygroscopicity, is easy to dissolve in methanol, is slightly soluble in ethanol and chloroform, is extremely slightly soluble in acetone, is almost insoluble in water, dilute hydrochloric acid and sodium hydroxide test solution, is insoluble in ether and has an unobvious melting point. Arbidol hydrochloride has maximum absorption peaks at wavelengths of 224nm and 256nm and minimum absorption peaks at wavelengths of 245nm and 285 nm.
Arbidol hydrochloride is almost insoluble in water, the solubility is only 0.0024g/100ml, the water insolubility limits the development of disinfection liquid or gel, and arbidol tablets, granules and capsules are widely used at present. Arbidol hydrochloride is easy to dissolve in methanol, but methanol cannot be used as a disinfectant, and solvents commonly used for the disinfectant are water and ethanol with different concentrations, and then researchers try to develop injection preparations, prepare sterile powder by freeze drying and other methods, or improve the solubility of the disinfectant by inclusion, but the methods do not fundamentally solve the problem of low arbidol solubility, and the development of arbidol disinfectant liquid or gel is still limited at present.
Disclosure of Invention
The invention aims to solve the technical problems and provides arbidol disinfection liquid or gel and a preparation method and application thereof. The disinfection liquid or gel provided by the invention can really ensure that arbidol exists in a stable solution mode, can be used as a disinfection liquid product for processing and production, is convenient to use and harmless to human bodies, can stably exist in a solution mode for a long time, can be used as a daily protective article to help people disinfect viruses in the environment that the current novel coronavirus spreads all over the world, and can better guarantee the safety of people.
One of the purposes of the invention is to provide arbidol disinfection liquid or gel, and in order to realize the purpose, the technical scheme adopted by the invention is as follows:
an arbidol disinfection liquid or gel comprises the following components of 20-30 mg/L of arbidol concentration, 1:150 of polyhexamethylene biguanide hydrochloride and arbidol mass ratio, 20-40 of ethanol volume concentration, 0.5-1.5 of solubilizer mass ratio, 0.1-5 of potassium sorbate mass ratio and the balance of water.
The inventor of the invention analyzes the structure of arbidol, which has a plurality of benzene rings and has-OH and-Br substituents; solubility indicates very little dissolution in water and ethanol, and in order to increase its solubility, a solubilizer was chosen. However, since the variety of solubilizing agents in the art is large, it is not known how to select the type and amount of solubilizing agent, and a large number of experiments are required. Through research, the addition of the solubilizer is beneficial to the arbidol in the form of solution, but the arbidol has poor stability, and the antiviral effect is difficult to exert the best. The inventor finds that the antiviral performance of the composition is greatly improved by compounding the arbidol and the polyhexamethylene biguanide hydrochloride, but the stability of the arbidol solution is deteriorated. Through a large number of researches, the inventor finally determines the dosage and proportion of each component in the arbidol disinfectant, and the arbidol disinfectant with good solubility and stable existence is obtained by using the solubilizer and potassium sorbate to be compounded together as the stabilizer, so that the synergistic effect of the two disinfectant components can kill viruses efficiently, and finally the problems of the solubility and the stability of the arbidol disinfectant are well solved.
Further, the solubilizer is a surfactant, and comprises an ionic surfactant and a non-ionic surfactant.
Further, the ionic surfactant includes anionic surfactants such as fatty acid soaps, sulfonates; and cationic surfactants such as quaternary ammonium salts.
Further, the nonionic surfactant comprises span 60 and tween 80.
Further, the arbidol comprises sulfate or hydrochloride of arbidol.
Further, the disinfection liquid or gel further comprises traditional Chinese medicine components, wherein the traditional Chinese medicine components comprise at least one of perilla, rhizoma atractylodis, honeysuckle, barbed skullcap herb, golden cypress, rhubarb, grassleaf sweelflag rhizome, baical skullcap root, golden thread, weeping forsythia, heartleaf houttuynia herb, wrinkled gianthyssop herb, Chinese mugwort leaf, common andrographis herb, lemon and spreading hedyotis herb.
The traditional Chinese medicine components can be added in the scheme of the invention, the addition of the traditional Chinese medicine components has little influence on the stability of the disinfectant, and the addition of the traditional Chinese medicine components has better sterilization and antivirus effects, so that the disinfectant is suitable for being added into the disinfectant product of the invention as a daily living article.
Further, the traditional Chinese medicine components are added in the form of traditional Chinese medicine extracting solution, and the concentration of the traditional Chinese medicine extracting solution is 0.1-5 g/L.
The invention also aims to provide a preparation method of the arbidol disinfection liquid or gel, which comprises the following steps:
(1) when the raw materials contain traditional Chinese medicine components, cleaning and cutting the traditional Chinese medicine components, adding water with 5-30 times of the amount of the raw materials, heating to boil, keeping a slightly boiling state, decocting for 0.5-5 hours, and collecting decoction; decocting the residues for 1-5 times according to the method, collecting decoction liquid for many times, mixing and concentrating the decoction liquid into extract with the relative density of 1.06-1.37, putting the extract into an alcohol precipitation tank, adding 95% ethanol, adjusting the ethanol concentration in the alcohol precipitation tank to be 50% -85%, uniformly stirring, standing for 24 hours, and collecting supernatant for later use;
(2) and (2) placing the product obtained in the step (1) into a liquid preparation tank, adding arbidol and polyhexamethylene biguanide, adding a solubilizer and water, preparing into arbidol disinfection liquid or gel finished product, and packaging and storing.
The invention also aims to provide the application of the arbidol disinfection liquid or gel in the aspects of sterilization and disinfection.
Specifically, the arbidol disinfection liquid or gel is used for killing/resisting/inhibiting staphylococcus aureus, staphylococcus albus, candida albicans, pseudomonas aeruginosa, escherichia coli, hemolytic streptococcus, mycobacteria, influenza N1, N2, filovirus, coronavirus, avian influenza virus and hand-foot-and-mouth virus.
Compared with the prior art, the invention has the following beneficial effects:
(1) the arbidol disinfection liquid or gel provided by the invention can exist in a stable manner, can be used as a daily disinfection liquid product, has long storage time, is convenient to use, and is non-toxic and harmless to human bodies;
(2) the preparation method adopted by the invention has simple process and low cost, does not add a large amount of organic solvent, only adds a small amount of ethanol, and is suitable for industrial production;
(3) the arbidol disinfection liquid or gel provided by the invention has excellent antiviral effect and can be used for broad-spectrum disinfection of various viruses.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more clearly understood, the present invention is described in detail below with reference to the following embodiments, and it should be noted that the following embodiments are only for explaining and illustrating the present invention and are not intended to limit the present invention. The invention is not limited to the embodiments described above, but rather, may be modified within the scope of the invention.
Example 1
1L arbidol disinfectant comprises arbidol hydrochloride 30mg, polyhexamethylene biguanide hydrochloride 4800mg (1:160), ethanol 400m L and water 600m L, wherein the mass ratio of a solubilizer (Tween-80) is 0.5 percent and the mass ratio of potassium sorbate is 0.1 percent, wherein the potassium sorbate and the solubilizer are both in the total mass ratio of the disinfectant.
The preparation method of the arbidol disinfectant comprises the following steps: adding Tween-80 as solubilizer, dissolving with 95% ethanol water solution, adding potassium sorbate and polyhexamethylene biguanide hydrochloride, shaking to mix thoroughly, adding arbidol, ultrasonic treating to accelerate dissolution, diluting with water to specified volume, packaging, and storing.
Example 2
The 500m L arbidol disinfectant comprises 10mg of arbidol hydrochloride, 1200mg (1:120) of polyhexamethylene biguanide hydrochloride and 0.6 g/L of traditional Chinese medicine extract, wherein the ethanol is prepared into 20% in volume concentration, the mass ratio of a solubilizer Tween-80 is 1.5%, the mass ratio of potassium sorbate is 2%, and the balance is supplemented by water, wherein the potassium sorbate and the solubilizer are in the total mass ratio of the disinfectant, and the traditional Chinese medicine extract comprises 0.2 g/L of honeysuckle extract, 0.2 g/L of forsythia extract and 0.2 g/L of scutellaria extract.
The preparation method of the arbidol disinfectant comprises the following steps:
(1) cleaning and cutting the traditional Chinese medicine components, adding water with the amount 30 times of the material amount, heating to boil, keeping boiling for 5 hours, collecting decoction, decocting residues for 5 times according to the method, collecting decoction for many times, combining and concentrating the decoction into extract with the relative density of 1.37, putting the extract into an alcohol precipitation tank, adding 95% ethanol, adjusting the ethanol concentration in the alcohol precipitation tank to 85%, uniformly stirring, standing for 24 hours, and collecting supernatant for later use (respectively, 0.2 g/L of honeysuckle extract, 0.2 g/L of forsythia extract and 0.2 g/L of scutellaria extract);
(2) and (2) placing the product obtained in the step (1) into a liquid preparation tank, adding polyhexamethylene biguanide, a solubilizer, potassium sorbate and water in parts by weight, finally adding arbidol to prepare an arbidol disinfectant finished product, and packaging and storing the arbidol disinfectant finished product.
Example 3
An arbidol disinfection gel product comprises 25 mg/L of arbidol hydrochloride, 3750 mg/L (1:150) of polyhexamethylene biguanide hydrochloride, 2 g/L of a traditional Chinese medicine extracting solution, 30% of ethanol, 1% of solubilizer span 60, 1% of potassium sorbate and the balance of water, wherein the potassium sorbate and the solubilizer are in the total mass ratio of the disinfection solution, the water is diluted by 95% of ethanol to corresponding ethanol concentration, and the traditional Chinese medicine extracting solution is 0.4 g/L of houttuynia cordata extract, 0.6 g/L of wrinkled gianthyssop herb extract and 1 g/L of folium artemisiae argyi extract.
The preparation method of the arbidol disinfection liquid or gel comprises the following steps:
(1) cleaning and cutting the traditional Chinese medicine components, adding water with the amount of 20 times of the material amount, heating to boil, keeping the boiling state for decocting for 3 hours, collecting decoction, decocting residues for 3 times according to the method, collecting multiple decoctions, mixing and concentrating into extract with the relative density of 1.25, putting the extract into an alcohol precipitation tank, adding 95% edible ethanol, adjusting the ethanol concentration in the alcohol precipitation tank to 60%, stirring uniformly, standing for 24 hours, and collecting supernatant for later use (containing 0.4 g/L of houttuynia cordata extract, 0.6 g/L of wrinkled gianthyssop herb extract and 1 g/L of folium artemisiae argyi extract);
(2) putting the product obtained in the step (1) into a liquid preparation tank, adding polyhexamethylene biguanide, potassium sorbate, solubilizer and water in parts by weight, uniformly mixing, adding arbidol, promoting dissolution by ultrasonic waves, preparing arbidol disinfectant, performing gelation treatment to prepare gel, packaging and storing.
Comparative example 1
The arbidol disinfectant is prepared according to the formula and the process of the example 1, except that polyhexamethylene biguanide hydrochloride in the components is removed, and other methods are unchanged.
Comparative example 2
An arbidol disinfectant was prepared according to the formulation and process of example 2, except that the amount of polyhexamethylene biguanide hydrochloride in the composition was changed to 2000mg, and the other methods were unchanged.
Comparative example 3
Arbidol disinfectant was prepared according to the formulation and process of example 2, except that the amount of solubilizer was increased to 2% and the other methods were unchanged.
Comparative example 4
An arbidol disinfectant was prepared according to the formulation and process of example 2, except that the potassium sorbate was removed and the other methods were unchanged.
Experimental example 1
The stability of the arbidol disinfectant liquids or gels obtained in examples 1 to 3 and comparative examples 1 to 4 was examined, the formulations were stored at normal temperature for 1 month, and whether color change occurred and precipitation occurred inside was observed, and as a result, it was found that the arbidol disinfectant liquids in comparative examples 1 to 4 were dark brown in color, darker than the pale yellow ones in examples 1 to 3, and that precipitation occurred at the bottom of the liquids in comparative examples 1 to 4. The products of examples 1-3 showed essentially no change in color after 1 year of storage, with no visible sedimentation at the bottom of the liquid.
Example 2
The antiviral performance of the arbidol disinfection liquid or gel is examined, the types of viruses are selected from influenza N1, N2, coronavirus, filovirus, avian influenza virus and hand-foot-and-mouth virus, and a professional organization is entrusted to antiviral tests, so that the arbidol disinfection liquid or gel obtained in examples 1-3 is found to have better resistance to the viruses, and in addition, the antiviral performance of example 1 is more than one time that of comparative example 1, which shows that the formula of the invention plays a synergistic effect.
Claims (10)
1. An arbidol disinfection liquid or gel is characterized by comprising the following components of arbidol with the concentration of 20-30 mg/L, polyhexamethylene biguanide hydrochloride and arbidol with the mass ratio of 1: 120-160, ethanol with the volume ratio of 20-40%, solubilizer with the mass ratio of 0.5-1.5%, potassium sorbate with the mass ratio of 0.1-5%, and the balance of water.
2. An arbidol disinfecting liquid or gel according to claim 1 wherein the solubilising agent is a surfactant including ionic and non-ionic surfactants.
3. An arbidol disinfecting liquid or gel according to claim 2 wherein said ionic surfactant comprises an anionic surfactant and a cationic surfactant; such as fatty acid soaps, sulfonates, quats.
4. An arbidol disinfecting liquid or gel according to claim 2 wherein the non-ionic surfactant comprises span 60 or tween 80.
5. An arbidol disinfecting liquid or gel according to claim 1 wherein said arbidol comprises a sulfate or hydrochloride salt of arbidol.
6. The arbidol disinfecting liquid or gel according to claim 1, wherein said disinfecting liquid or gel further comprises a herbal component comprising at least one of perilla, atractylodes, honeysuckle, barbat skullcap, phellodendron, rhubarb, grassleaf sweelflag rhizome, scutellaria, coptis, forsythia, houttuynia, wrinkled gianthyssop herb, mugwort leaf, andrographis, lemon, and oldenlandia.
7. The arbidol disinfection liquid or gel according to claim 3, wherein the herbal ingredients are added in the form of herbal extract, the concentration of herbal extract being 0.1-5 g/L.
8. A process for the preparation of an arbidol disinfecting liquid or gel according to any one of claims 1 to 7, comprising the steps of:
(1) when the raw materials contain traditional Chinese medicine components, the traditional Chinese medicine components are cleaned, cut into pieces, added with water with 5-30 times of the amount of the raw materials, heated to boiling, kept in a slightly boiling state, decocted for 0.5-5 hours, and the decoction is collected; decocting the residues for 1-5 times according to the method, collecting decoction liquid for many times, mixing and concentrating the decoction liquid into extract with the relative density of 1.06-1.37, putting the extract into an alcohol precipitation tank, adding 95% ethanol, adjusting the ethanol concentration in the alcohol precipitation tank to be 50% -85%, uniformly stirring, standing for 24 hours, and collecting supernatant for later use;
(2) and (2) placing the product obtained in the step (1) into a liquid preparation tank, adding arbidol and polyhexamethylene biguanide, adding a solubilizer and water, preparing into arbidol disinfection liquid or gel finished product, and packaging and storing.
9. Use of the arbidol disinfecting liquid or gel according to any one of claims 1 to 7 or prepared by the method according to claim 8 for destroying viruses.
10. The use according to claim 9, wherein said arbidol disinfectant liquid or gel is for use in a composition comprising killing/inhibiting/suppressing staphylococcus aureus, staphylococcus albus, candida albicans, pseudomonas aeruginosa, escherichia coli, streptococcus hemolyticus, mycobacterium, and influenza N1, N2, filovirus, coronavirus, avian influenza virus, hand-foot-and-mouth virus.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111956616A (en) * | 2020-09-08 | 2020-11-20 | 山西振东泰盛制药有限公司 | Arbidol hydrochloride composite dry powder preparation, spray, gel and preparation method thereof |
| CN112289378A (en) * | 2020-11-02 | 2021-01-29 | 博奥生物集团有限公司 | Method for determining Chinese medicinal composition and method for determining medicinal effect thereof |
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