CN111588655A - Algae skin barrier repair cream and preparation method thereof - Google Patents
Algae skin barrier repair cream and preparation method thereof Download PDFInfo
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- CN111588655A CN111588655A CN202010519540.6A CN202010519540A CN111588655A CN 111588655 A CN111588655 A CN 111588655A CN 202010519540 A CN202010519540 A CN 202010519540A CN 111588655 A CN111588655 A CN 111588655A
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- 239000006071 cream Substances 0.000 title claims abstract description 19
- 230000008439 repair process Effects 0.000 title claims abstract description 19
- 230000008591 skin barrier function Effects 0.000 title claims abstract description 18
- 241000195493 Cryptophyta Species 0.000 title claims description 10
- 238000002360 preparation method Methods 0.000 title abstract description 7
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 32
- 238000003756 stirring Methods 0.000 claims abstract description 30
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 21
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 241000195480 Fucus Species 0.000 claims abstract description 16
- 235000001855 Portulaca oleracea Nutrition 0.000 claims abstract description 16
- 241000219304 Portulacaceae Species 0.000 claims abstract description 16
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 claims abstract description 16
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229960005323 phenoxyethanol Drugs 0.000 claims abstract description 16
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 16
- 239000000230 xanthan gum Substances 0.000 claims abstract description 16
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 16
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 16
- 230000001804 emulsifying effect Effects 0.000 claims abstract description 13
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000001816 cooling Methods 0.000 claims abstract description 8
- 238000010438 heat treatment Methods 0.000 claims abstract description 8
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229940032094 squalane Drugs 0.000 claims abstract description 8
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract description 7
- 229940101267 panthenol Drugs 0.000 claims abstract description 7
- 235000020957 pantothenol Nutrition 0.000 claims abstract description 7
- 239000011619 pantothenol Substances 0.000 claims abstract description 7
- 238000004321 preservation Methods 0.000 claims abstract description 7
- 229940015975 1,2-hexanediol Drugs 0.000 claims abstract description 6
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 claims abstract description 6
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229940100554 isononyl isononanoate Drugs 0.000 claims abstract description 6
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims abstract description 6
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 61
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 52
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 50
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 20
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 20
- 239000003921 oil Substances 0.000 claims description 18
- 235000019198 oils Nutrition 0.000 claims description 18
- 244000144725 Amygdalus communis Species 0.000 claims description 15
- 235000011437 Amygdalus communis Nutrition 0.000 claims description 15
- 241000675108 Citrus tangerina Species 0.000 claims description 15
- 229920002670 Fructan Polymers 0.000 claims description 15
- 239000008168 almond oil Substances 0.000 claims description 15
- 229930182478 glucoside Natural products 0.000 claims description 15
- 150000008131 glucosides Chemical class 0.000 claims description 15
- 239000008172 hydrogenated vegetable oil Substances 0.000 claims description 15
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 10
- 229940075529 glyceryl stearate Drugs 0.000 claims description 10
- 235000011187 glycerol Nutrition 0.000 claims description 7
- NENOAJSZZPODGJ-OIMNJJJWSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] octanoate Chemical compound CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NENOAJSZZPODGJ-OIMNJJJWSA-N 0.000 claims description 6
- 238000004945 emulsification Methods 0.000 claims description 6
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims description 5
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 5
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 5
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 5
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 5
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 5
- 229920002125 Sokalan® Polymers 0.000 claims description 5
- 229960000458 allantoin Drugs 0.000 claims description 5
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims description 5
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 claims description 5
- 229940036350 bisabolol Drugs 0.000 claims description 5
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims description 5
- 229960001631 carbomer Drugs 0.000 claims description 5
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims description 5
- 150000004676 glycans Chemical class 0.000 claims description 5
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 5
- 229920001282 polysaccharide Polymers 0.000 claims description 5
- 239000005017 polysaccharide Substances 0.000 claims description 5
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 5
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 5
- 229940042585 tocopherol acetate Drugs 0.000 claims description 5
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
- 238000005086 pumping Methods 0.000 claims description 3
- 229920005573 silicon-containing polymer Polymers 0.000 claims description 3
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000049 pigment Substances 0.000 abstract description 10
- -1 polydimethylsiloxane Polymers 0.000 abstract description 8
- 230000007794 irritation Effects 0.000 abstract description 7
- 239000004205 dimethyl polysiloxane Substances 0.000 abstract description 5
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 abstract description 5
- 239000000463 material Substances 0.000 abstract description 2
- 238000000034 method Methods 0.000 abstract description 2
- 235000013599 spices Nutrition 0.000 abstract description 2
- 229920000392 Zymosan Polymers 0.000 abstract 1
- AIHDCSAXVMAMJH-GFBKWZILSA-N levan Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@@H]1[C@@H](O)[C@H](O)[C@](CO)(CO[C@@H]2[C@H]([C@H](O)[C@@](O)(CO)O2)O)O1 AIHDCSAXVMAMJH-GFBKWZILSA-N 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 description 35
- 230000002354 daily effect Effects 0.000 description 11
- 239000000686 essence Substances 0.000 description 6
- 230000019612 pigmentation Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010034972 Photosensitivity reaction Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 229960001484 edetic acid Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
Abstract
An algal skin barrier repair cream and a method of preparing the same, the repair cream comprising: phase A, phase B, phase C and phase D, wherein the phase A comprises caprylic/capric triglyceride, squalane, isononyl isononanoate and polydimethylsiloxane, the phase B comprises glycerol and 1, 3-propylene glycol, the phase C comprises panthenol, the phase D comprises 1, 2-hexanediol, butanediol, purslane, fucus, hexanediol, caprylyl glycol, xanthan gum, butanediol, levan, phenoxyethanol and zymosan; the preparation method comprises the following steps: (1) heating and stirring the phase A until the phase A is dissolved; (2) phase B heating, stirring and preserving heat; (3) mixing, emulsifying, homogenizing, preserving heat and stirring the phase A and the phase B; (4) after the heat preservation is finished, cooling to 60 ℃; (5) adding phase C, keeping the temperature and stirring; (6) cooling and stirring; (7) adding the phase D, stirring and inspecting the material to obtain a finished product. The product of the invention has light stability and no irritation under the condition of not adding spices and pigments.
Description
Technical Field
The invention relates to the field of daily skin care products, in particular to an algae skin barrier repair cream and a preparation method thereof.
Background
The daily skin care products on the market are very various, along with the accelerated pace of life, people pay more and more attention to the safety and the mildness of the products, the observation degree of the component safety index of the daily skin care products is also increased linearly, the daily skin care products are particularly sensitive to pigments, essences and the like related in the products, and the stimulus sources and the sensitization sources of the daily skin care products are considered to come from the essences and the pigments added in the daily skin care products for improving the appearance and changing the smell.
Studies have shown that the most dangerous component of the raw materials of everyday skin care products that cause a barrier to skin function is perfume (essence), which causes a proportion of skin damage of up to 50.6%. The daily skin care product has the characteristic that the raw materials of the daily skin care product have special tastes, so that the product has unpleasant smell in smell, and the product is greatly discounted in the mind of consumers to influence the sale. In order to obtain better product quality, essence is generally added into the existing daily skin care products in the market to meet the olfactory demands of consumers;
the second is pigment, which causes a skin injury rate of 30.9%. The existing daily skin care products can also be added with pigments to solve the problem of appearance difference of different degrees of the inner materials of the products and prevent the phenomenon of instability caused by irradiation of sunlight and ultraviolet rays in the using process. However, pigments in everyday skin care products are strongly associated with pigmentation of human skin. Pigmentation is a brown spot appearing under normal skin, seriously affects the image, runs counter to the original intention of consumers to use skin care products, and skin care products with pigments can react sensitively to light after being used for a long time, so that the phenomena of pigmentation, skin flushing, inflammation and the like are caused.
From the above analysis, the problem of benefit and disadvantage of adding essence and pigment in daily skin care products always troubles the research personnel in the skin care products industry.
Disclosure of Invention
Aiming at the defects of the prior art, the invention solves the technical problem of how to prevent the instability of the product caused by photosensitive reaction of the product and eliminate the unpleasant odor brought by the raw materials in the product under the condition of not adding essence and pigment.
In order to solve the technical problems, the technical scheme adopted by the invention is that the algae skin barrier repair cream comprises the following components in parts by mass:
phase A:
0.1 to 2 parts of a mixture of cetearyl alcohol and cetearyl glucoside,
0.5-3 parts of a mixture of glycerol stearate and PEG-100 glycerol stearate,
0.1 to 2 portions of cetearyl alcohol,
0.5-5 parts of caprylic/capric triglyceride,
0.1 to 10 portions of squalane,
0.05 to 0.5 portion of tocopherol acetate,
0.1-8 parts of isononyl isononanoate,
0.1 to 10 portions of dimethyl silicone polymer,
0.01-3 parts of sorbitan caprylate,
0.01-0.5 part of bisabolol,
0.1-5 parts of a mixture of sweet almond oil, tangerine peel oil and hydrogenated vegetable oil;
phase B:
40-90 parts of water, namely,
0.01 to 0.1 portion of EDTA disodium,
0.01 to 0.5 portion of allantoin,
0.05 to 0.5 portion of dipotassium glycyrrhizinate,
0.2 to 10 portions of glycerin,
0.02-0.5 part of carbomer,
0.1 to 5 portions of 1, 3-propylene glycol,
0.01-0.1 part of sodium hyaluronate;
and C phase:
0.1 to 1 portion of panthenol,
0.02-0.5 part of aminomethyl propanol;
phase D:
0.1 to 4 portions of 1, 2-pentanediol,
0.1 to 1 portion of 1, 2-hexanediol,
0.1-10 parts of mixture of water, butanediol and purslane flower/leaf/stem extract,
0.1-15 parts of a mixture of water, fucus extract, hexanediol, caprylyl glycol and xanthan gum,
0.1 to 10 portions of mixture of water, butanediol, fructan and phenoxyethanol,
0.1-20 parts of yeast polysaccharides.
Further, in phase a:
the mixture of cetearyl alcohol and cetearyl glucoside mainly comprises the following components in percentage by mass: cetearyl alcohol 80%, cetearyl glucoside 20%.
The mixture of the glyceryl stearate and the PEG-100 glyceryl stearate mainly comprises the following components in percentage by mass: 50% of glycerol stearate and 50% of PEG-100 glycerol stearate.
The mixture of the sweet almond oil, the tangerine peel oil and the hydrogenated vegetable oil mainly comprises the following components in percentage by mass: 30-55% of sweet almond oil, 10-35% of peel oil of the tangerines and 10-35% of hydrogenated vegetable oil, wherein the sum of the mass percentages of the components is 100%.
Further, in phase D:
the mixture of water, butanediol and the purslane flower/leaf/stem extract mainly comprises the following components in percentage by mass: 69.6% of water, 30% of butanediol and 0.4% of purslane flower/leaf/stem extract.
The mixture of the water, the fucus extract, the hexanediol, the caprylyl glycol and the xanthan gum mainly comprises the following components in percentage by mass: 90-95% of water, 4-7% of fucus extract, 0.6-2% of hexanediol, 0.3-1% of caprylyl glycol and 0.1-0.5% of xanthan gum, wherein the sum of the mass percentages of the components is 100%.
The mixture of the water, the butanediol, the fructan and the phenoxyethanol mainly comprises the following components in percentage by mass: 88-93% of water, 2% of butanediol, 2-7% of fructan and 3% of phenoxyethanol, wherein the sum of the mass percentages of the components is 100%.
The invention also provides a preparation method of the algae skin barrier repair cream.
Therefore, the technical scheme provided by the invention is a preparation method of the algae skin barrier repair cream, which comprises the following steps:
(1) adding the phase A into an oil pan, heating and stirring to 75-80 ℃, and keeping the temperature for 15 minutes until the phase A is completely dissolved;
(2) adding the phase B into an emulsifying pot, heating and stirring to 85-90 ℃, and preserving heat for 30 minutes;
(3) after the heat preservation of the phase A and the phase B is finished, slowly pumping the phase A into an emulsifying pot, stirring, emulsifying and homogenizing for 5 minutes, and then preserving the heat and stirring for 10 minutes;
(4) after the emulsification pot is insulated, the emulsification pot is started to be cooled to 60 ℃, and then the cooling is stopped;
(5) after 60 ℃, sequentially adding the phase C into an emulsifying pot, preserving the heat at 60 ℃, and stirring for 10 minutes;
(6) after stirring for 10 minutes under heat preservation, continuing to start to cool and stir to 45 ℃;
(7) cooling to 45 ℃, sequentially adding the D-phase components, stirring for 30 minutes, inspecting, and discharging to obtain a finished product.
Compared with the prior art, the product of the invention has the advantages of light stability and no irritation under the condition of not adding spices and pigments.
Detailed Description
The following examples are given to further illustrate the embodiments of the present invention, but are not intended to limit the invention.
Example 1
An algae skin barrier repair cream comprises the following components in parts by mass:
phase A:
0.1 part of a mixture of cetearyl alcohol and cetearyl glucoside,
3 parts of a mixture of glycerol stearate and PEG-100 glycerol stearate,
0.1 part of cetearyl alcohol,
5 parts of caprylic/capric triglyceride,
0.1 part of squalane, namely,
0.5 part of tocopherol acetate, namely,
0.1 part of isononyl isononanoate,
10 parts of Polydimethylsiloxane (PDMS),
0.01 part of sorbitan caprylate,
0.5 part of bisabolol,
0.1 part of mixture of sweet almond oil, tangerine peel oil and hydrogenated vegetable oil;
phase B:
40 parts of water, namely 40 parts of water,
0.1 part of EDTA disodium salt,
0.01 part of allantoin, and the like,
0.5 part of dipotassium glycyrrhizinate,
0.2 part of glycerin, namely,
0.5 part of carbomer, namely,
0.1 part of 1, 3-propylene glycol,
0.1 part of sodium hyaluronate;
and C phase:
0.1 part of panthenol, namely,
0.5 part of aminomethyl propanol;
phase D:
0.1 part of 1, 2-pentanediol,
1 part of 1, 2-hexanediol,
0.1 part of mixture of water, butanediol and purslane flower/leaf/stem extract,
15 parts of mixture of water, fucus extract, hexanediol, caprylyl glycol and xanthan gum,
0.1 part of mixture of water, butanediol, fructan and phenoxyethanol,
20 parts of yeast polysaccharides.
Further, in phase a:
the mixture of cetearyl alcohol and cetearyl glucoside mainly comprises the following components in percentage by mass: cetearyl alcohol 80%, cetearyl glucoside 20%.
The mixture of the glyceryl stearate and the PEG-100 glyceryl stearate mainly comprises the following components in percentage by mass: 50% of glycerol stearate and 50% of PEG-100 glycerol stearate.
The mixture of the sweet almond oil, the tangerine peel oil and the hydrogenated vegetable oil mainly comprises the following components in percentage by mass: 30% of sweet almond oil, 35% of peel oil of the tangerine peel and 35% of hydrogenated vegetable oil.
Further, in phase D:
the mixture of water, butanediol and the purslane flower/leaf/stem extract mainly comprises the following components in percentage by mass: 69.6% of water, 30% of butanediol and 0.4% of purslane flower/leaf/stem extract.
The mixture of water, the fucus extract, the hexanediol, the caprylyl glycol and the xanthan gum mainly comprises the following components in percentage by mass: 90% of water, 7% of fucus extract, 1.5% of hexanediol, 1% of caprylyl glycol and 0.5% of xanthan gum.
The mixture of water, butanediol, fructan and phenoxyethanol mainly comprises the following components in percentage by mass: 88% of water, 2% of butanediol, 7% of fructan and 3% of phenoxyethanol.
Example 2
An algae skin barrier repair cream comprises the following components in parts by mass:
phase A:
1 part of mixture of cetearyl alcohol and cetearyl glucoside,
2 parts of a mixture of glycerol stearate and PEG-100 glycerol stearate,
1 part of cetearyl alcohol, and the like,
2 parts of caprylic/capric triglyceride,
5 parts of squalane, namely, squalane,
0.2 part of tocopherol acetate, and the like,
5 parts of isononyl isononanoate,
5 parts of Polydimethylsiloxane (PDMS),
2 parts of sorbitan caprylate,
0.2 part of bisabolol,
1 part of a mixture of sweet almond oil, tangerine peel oil and hydrogenated vegetable oil;
phase B:
50 parts of water, namely,
0.05 part of disodium EDTA (ethylene diamine tetraacetic acid),
0.2 part of allantoin, namely,
0.2 part of dipotassium glycyrrhizinate,
2 parts of glycerol, namely 2 parts of glycerol,
0.2 part of carbomer, namely,
0.2 part of 1, 3-propylene glycol,
0.05 part of sodium hyaluronate;
and C phase:
0.5 part of panthenol, namely,
0.2 part of aminomethyl propanol;
phase D:
0.2 part of 1, 2-pentanediol,
0.2 part of 1, 2-hexanediol,
2 parts of a mixture of water, butanediol and the purslane flower/leaf/stem extract,
2 parts of a mixture of water, fucus extract, hexanediol, caprylyl glycol and xanthan gum,
2 parts of a mixture of water, butanediol, fructan and phenoxyethanol,
and 2 parts of yeast polysaccharide.
Further, in phase a:
the mixture of cetearyl alcohol and cetearyl glucoside mainly comprises the following components in percentage by mass: cetearyl alcohol 80%, cetearyl glucoside 20%.
The mixture of the glyceryl stearate and the PEG-100 glyceryl stearate mainly comprises the following components in percentage by mass: 50% of glycerol stearate and 50% of PEG-100 glycerol stearate.
The mixture of the sweet almond oil, the tangerine peel oil and the hydrogenated vegetable oil mainly comprises the following components in percentage by mass: 55% of sweet almond oil, 10% of peel oil of the big tangerine, and 35% of hydrogenated vegetable oil.
Further, in phase D:
the mixture of water, butanediol and the purslane flower/leaf/stem extract mainly comprises the following components in percentage by mass: 69.6% of water, 30% of butanediol and 0.4% of purslane flower/leaf/stem extract.
The mixture of water, the fucus extract, the hexanediol, the caprylyl glycol and the xanthan gum mainly comprises the following components in percentage by mass: 95% of water, 4% of fucus extract, 0.6% of hexanediol, 0.3% of caprylyl glycol and 0.1% of xanthan gum.
The mixture of water, butanediol, fructan and phenoxyethanol mainly comprises the following components in percentage by mass: 93% of water, 2% of butanediol, 2% of fructan and 3% of phenoxyethanol.
Example 3
An algae skin barrier repair cream comprises the following components in parts by mass:
phase A:
2 parts of a mixture of cetearyl alcohol and cetearyl glucoside,
0.5 part of a mixture of glycerol stearate and PEG-100 glycerol stearate,
2 parts of cetearyl alcohol,
0.5 part of caprylic/capric triglyceride,
10 parts of squalane, namely 10 parts of squalane,
0.05 part of tocopherol acetate, and the like,
8 parts of isononyl isononanoate,
0.1 part of dimethyl silicone polymer,
3 parts of sorbitan caprylate, namely 3 parts of sorbitan caprylate,
0.01 part of bisabolol,
5 parts of a mixture of sweet almond oil, tangerine peel oil and hydrogenated vegetable oil;
phase B:
90 parts of water, namely adding water into the mixture,
0.01 part of EDTA disodium salt,
0.5 part of allantoin, namely,
0.05 part of dipotassium glycyrrhizinate,
10 parts of glycerol, namely 10 parts of glycerol,
0.02 part of carbomer, namely,
5 parts of 1, 3-propylene glycol,
0.01 part of sodium hyaluronate;
and C phase:
1 part of panthenol, namely 1 part of panthenol,
0.02 part of aminomethyl propanol;
phase D:
4 parts of 1, 2-pentanediol,
0.1 part of 1, 2-hexanediol,
10 parts of mixture of water, butanediol and purslane flower/leaf/stem extract,
0.1 part of mixture of water, fucus extract, hexanediol, caprylyl glycol and xanthan gum,
10 parts of a mixture of water, butanediol, fructan and phenoxyethanol,
0.1 part of yeast polysaccharide.
Further, in phase a:
the mixture of cetearyl alcohol and cetearyl glucoside mainly comprises the following components in percentage by mass: cetearyl alcohol 80%, cetearyl glucoside 20%.
The mixture of the glyceryl stearate and the PEG-100 glyceryl stearate mainly comprises the following components in percentage by mass: 50% of glycerol stearate and 50% of PEG-100 glycerol stearate.
The mixture of the sweet almond oil, the tangerine peel oil and the hydrogenated vegetable oil mainly comprises the following components in percentage by mass: 55% of sweet almond oil, 35% of peel oil of the big tangerine, and 10% of hydrogenated vegetable oil.
Further, in phase D:
the mixture of water, butanediol and the purslane flower/leaf/stem extract mainly comprises the following components in percentage by mass: 69.6% of water, 30% of butanediol and 0.4% of purslane flower/leaf/stem extract.
The mixture of water, the fucus extract, the hexanediol, the caprylyl glycol and the xanthan gum mainly comprises the following components in percentage by mass: 92.2% of water, 5% of fucus extract, 2% of hexanediol, 0.5% of caprylyl glycol and 0.3% of xanthan gum.
The mixture of water, butanediol, fructan and phenoxyethanol mainly comprises the following components in percentage by mass: 90.5% of water, 2% of butanediol, 4.5% of fructan and 3% of phenoxyethanol.
The preparation method of the above embodiments 1 to 3 comprises the following steps:
(1) adding the phase A into an oil pan, heating and stirring to 75-80 ℃, and keeping the temperature for 15 minutes until the phase A is completely dissolved;
(2) adding the phase B into an emulsifying pot, heating and stirring to 85-90 ℃, and preserving heat for 30 minutes;
(3) after the heat preservation of the phase A and the phase B is finished, slowly pumping the phase A into an emulsifying pot, stirring, emulsifying and homogenizing for 5 minutes, and then preserving the heat and stirring for 10 minutes;
(4) after the emulsification pot is insulated, the emulsification pot is started to be cooled to 60 ℃, and then the cooling is stopped;
(5) after 60 ℃, sequentially adding the phase C into an emulsifying pot, preserving the heat at 60 ℃, and stirring for 10 minutes;
(6) after stirring for 10 minutes under heat preservation, continuing to start to cool and stir to 45 ℃;
(7) cooling to 45 ℃, sequentially adding the D-phase components, stirring for 30 minutes, inspecting, and discharging to obtain a finished product.
To better illustrate the beneficial effects of the present invention, the following efficacy evaluation experiments were performed:
30 volunteers with age of 21-40 years are selected, and the product of the invention is compared with the similar products on the market for the safety, the light stability, the irritation and the using effect of the product for one month, and the results are as follows:
| test product | Safety feature | Stability to light | Irritation property | Has no effect |
| Commercially available product | In general | General/instability | Slight irritation | 0 |
| Products of the invention | Security | Stabilization | Has no irritation | 0 |
As can be seen from the above table, the product of the invention has stability to light and no irritation, and is superior to the commercial product.
The embodiments of the present invention have been described in detail with reference to the examples, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention.
Claims (8)
1. The algae skin barrier repair cream is characterized by comprising the following components in parts by mass:
phase A:
0.1 to 2 parts of a mixture of cetearyl alcohol and cetearyl glucoside,
0.5-3 parts of a mixture of glycerol stearate and PEG-100 glycerol stearate,
0.1 to 2 portions of cetearyl alcohol,
0.5-5 parts of caprylic/capric triglyceride,
0.1 to 10 portions of squalane,
0.05 to 0.5 portion of tocopherol acetate,
0.1-8 parts of isononyl isononanoate,
0.1 to 10 portions of dimethyl silicone polymer,
0.01-3 parts of sorbitan caprylate,
0.01-0.5 part of bisabolol,
0.1-5 parts of a mixture of sweet almond oil, tangerine peel oil and hydrogenated vegetable oil;
phase B:
40-90 parts of water, namely,
0.01 to 0.1 portion of EDTA disodium,
0.01 to 0.5 portion of allantoin,
0.05 to 0.5 portion of dipotassium glycyrrhizinate,
0.2 to 10 portions of glycerin,
0.02-0.5 part of carbomer,
0.1 to 5 portions of 1, 3-propylene glycol,
0.01-0.1 part of sodium hyaluronate;
and C phase:
0.1 to 1 portion of panthenol,
0.02-0.5 part of aminomethyl propanol;
phase D:
0.1 to 4 portions of 1, 2-pentanediol,
0.1 to 1 portion of 1, 2-hexanediol,
0.1-10 parts of mixture of water, butanediol and purslane flower/leaf/stem extract,
0.1-15 parts of a mixture of water, fucus extract, hexanediol, caprylyl glycol and xanthan gum,
0.1 to 10 portions of mixture of water, butanediol, fructan and phenoxyethanol,
0.1-20 parts of yeast polysaccharides.
2. The algal skin barrier repair cream of claim 1, wherein in phase a: the mixture of cetearyl alcohol and cetearyl glucoside mainly comprises the following components in percentage by mass: cetearyl alcohol 80%, cetearyl glucoside 20%.
3. The algal skin barrier repair cream of claim 1, wherein in phase a: the mixture of the glyceryl stearate and the PEG-100 glyceryl stearate mainly comprises the following components in percentage by mass: 50% of glycerol stearate and 50% of PEG-100 glycerol stearate.
4. The algal skin barrier repair cream of claim 1, wherein in phase a: the mixture of the sweet almond oil, the tangerine peel oil and the hydrogenated vegetable oil mainly comprises the following components in percentage by mass: 30-55% of sweet almond oil, 10-35% of peel oil of the tangerines and 10-35% of hydrogenated vegetable oil, wherein the sum of the mass percentages of the components is 100%.
5. The algal skin barrier repair cream of claim 1, wherein in phase D: the mixture of water, butanediol and the purslane flower/leaf/stem extract mainly comprises the following components in percentage by mass: 69.6% of water, 30% of butanediol and 0.4% of purslane flower/leaf/stem extract.
6. The algal skin barrier repair cream of claim 1, wherein in phase D: the mixture of the water, the fucus extract, the hexanediol, the caprylyl glycol and the xanthan gum mainly comprises the following components in percentage by mass: 90-95% of water, 4-7% of fucus extract, 0.6-2% of hexanediol, 0.3-1% of caprylyl glycol and 0.1-0.5% of xanthan gum, wherein the sum of the mass percentages of the components is 100%.
7. The algal skin barrier repair cream of claim 1, wherein in phase D: the mixture of the water, the butanediol, the fructan and the phenoxyethanol mainly comprises the following components in percentage by mass: 88-93% of water, 2% of butanediol, 2-7% of fructan and 3% of phenoxyethanol, wherein the sum of the mass percentages of the components is 100%.
8. A method of making an algal skin barrier repair cream according to any one of claims 1 to 7, comprising the steps of:
(1) adding the phase A into an oil pan, heating and stirring to 75-80 ℃, and keeping the temperature for 15 minutes until the phase A is completely dissolved;
(2) adding the phase B into an emulsifying pot, heating and stirring to 85-90 ℃, and preserving heat for 30 minutes;
(3) after the heat preservation of the phase A and the phase B is finished, slowly pumping the phase A into an emulsifying pot, stirring, emulsifying and homogenizing for 5 minutes, and then preserving the heat and stirring for 10 minutes;
(4) after the emulsification pot is insulated, the emulsification pot is started to be cooled to 60 ℃, and then the cooling is stopped;
(5) after 60 ℃, sequentially adding the phase C into an emulsifying pot, preserving the heat at 60 ℃, and stirring for 10 minutes;
(6) after stirring for 10 minutes under heat preservation, continuing to start to cool and stir to 45 ℃;
(7) cooling to 45 ℃, sequentially adding the D-phase components, stirring for 30 minutes, inspecting, and discharging to obtain a finished product.
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| CN114404310A (en) * | 2021-12-30 | 2022-04-29 | 原田(苏州)技术研发有限公司 | Preservative composition containing tangerine peel |
| CN114788891A (en) * | 2022-04-15 | 2022-07-26 | 北京天珠药业有限公司 | Liquid dressing capable of protecting skin barrier and promoting barrier remodeling |
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