CN109044901B - Whitening and skin-caring composition containing citrus seed extract - Google Patents
Whitening and skin-caring composition containing citrus seed extract Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/678—Tocopherol, i.e. vitamin E
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Abstract
The invention discloses a whitening and skin-care composition containing an orange seed extract. The whitening skin care composition comprises the following components in percentage by weight: 0.1-8.0% of citrus seed extract, 1.0-5.0% of synergist, 2.0-5.0% of emulsifier, 0.3-0.8% of thickener, 5.0-35.0% of moistening agent, 0.5-3.0% of preservative, 0.01-0.5% of essence and the balance of deionized water. The citrus seed extract contains limonin substances, especially limonin, and has antioxidant, antiinflammatory, and skin whitening effects. The skin care composition containing citrus seed extract has the effects of alleviating skin pigmentation, relieving oxidative stress of skin cells, and reducing the generation of skin wrinkles, and thus has whitening and skin caring effects.
Description
Technical Field
The invention relates to a cosmetic composition containing plant extracts, belongs to the technical field of personal care products, and particularly relates to a whitening and skin-care composition containing citrus seed extracts.
Background
Citrus is a plant of the Citrus genus (Citrus) of the Rutaceae family (Rutaceae), a tropical, subtropical evergreen fruit tree, with 3 genera used for economic cultivation: poncirus, Citrus, and Poncirus. The citrus cultivated in China and other countries in the world is mainly citrus. Annual worldwide citrus production exceeds one hundred million tons, with about 4000 million tons being used for processing. A large number of by-products, citrus seeds, are produced during citrus processing.
Related researches show that the citrus seeds are rich in active substances such as grease, protein, limonin substances and the like, wherein limonin which is one of limonin analogues has the effects of oxidation resistance, inflammation diminishing, bacteriostasis, cancer resistance and the like, and the medical and health care functions of the citrus seeds are more and more valued by people along with the deep research on the efficacy of the limonin.
In recent years, as the living standard and aesthetic standard of people are improved, more and more people worried to whiten healthy skin. While anti-oxidation is the most important method for maintaining skin whitening, it is a well-known method for delaying skin aging, pigmentation, and wrinkle generation by acting on skin cells using an antioxidant. With the increasing awareness of the side effects of chemically synthesized antioxidants, plant antioxidants from natural sources are becoming more and more popular with people due to their advantages of being green, natural and free of side effects, and the research and development of plant antioxidant whitening skin care factors are of great significance.
In fact, as the waste of the processing of the citrus industry, namely the reprocessing and utilization of citrus seeds, the problem of environmental pollution caused by the waste can be effectively solved. Then, no research report exists that citrus seeds are reprocessed and applied to whitening and skin-care products.
Disclosure of Invention
The invention aims to provide a whitening and skin-care composition containing citrus seed extract, which has the effects of relieving skin pigmentation, relieving oxidative stress pressure of skin cells and reducing skin wrinkles.
In order to achieve the above object, the present invention provides a whitening skin care composition comprising an extract of citrus seeds, comprising the following components in percentage by weight:
0.1-8.0% of citrus seed extract, 1.0-5.0% of synergist, 2.0-5.0% of emulsifier, 0.3-0.8% of thickener, 5.0-35.0% of moistening agent, 0.5-3.0% of preservative, 0.01-0.5% of essence and the balance of deionized water.
The content range of the citrus seed extract in the whitening and skin-care composition is 2.0-8.0%.
The whitening skin care composition is prepared by taking citrus seeds as raw materials and extracting and refining the citrus seeds to obtain a white crystal citrus seed extract.
The preparation process of the citrus seed extract of the whitening and skin-care composition comprises the following steps:
1) pretreatment: removing pulp from Mandarin orange, collecting Mandarin orange seed, sun drying, and pulverizing;
2) removing grease and protein: leaching oil in the citrus seed powder by using normal hexane, drying under reduced pressure, and volatilizing residual normal hexane to obtain citrus seed powder A; dissolving and leaching the protein in the citrus seed powder A by using a NaCl solution as a protein extraction solvent, centrifuging, collecting filter residue, and drying under reduced pressure to obtain citrus seed powder B;
3) primary extraction of limonin: adding the citrus seed powder B into an aqueous solution of sodium salicylate, extracting at 40-60 ℃ for 2-8h, removing residues, adding dichloromethane into the filtrate, fully mixing and extracting, and collecting a lower dichloromethane phase to obtain a solution containing limonin;
4) refining and crystallizing limonin: adding isopropanol into the dichloromethane dissolved phase, mixing uniformly, standing the solution at 10-10 deg.C for 3-48h, filtering to remove dichloromethane and isopropanol to obtain the final product.
Further, in the step 4), the prepared citrus seed extract is limonin in white crystal shape.
The whitening and skin-care composition provided by the invention has the beneficial effects that the synergist is selected from one or more of vitamin C, vitamin E and derivatives thereof.
The whitening and skin-care composition of the invention has the emulsifier which is nonionic, anionic, cationic or amphoteric, and the combination thereof, such as: one or more of higher fatty alcohol polyoxyethylene ether series, polyethylene glycol stearate, ethoxylated methyl glucoside stearate, polyoxyethylene sorbitan monostearate series, fatty glyceride, sorbitan monofatty ester, and fatty acid citric glyceride.
The whitening skin care composition provided by the invention has the advantages that the thickening agent is one or the combination of more than two of polyacrylate and polyacrylamide copolymer, polyacrylate and polyacrylamide dimethyl taurate copolymer, hydroxyethyl acrylate and acrylic acid dimethyl taurate copolymer, xanthan gum, cellulose and hyaluronic acid.
The whitening skin care composition of the invention is prepared by mixing more than two of natural grease, modified grease or polyalcohol, such as nut oil, shea butter, lanolin, white mineral oil, vaseline, glycerol, diglycerol and 1, 3-butanediol.
The skin whitening and caring composition comprises more than two of phenoxyethanol and ethylhexyl glycerin compound, benzyl alcohol, polyhydric alcohol, chlorphenesin, parabens, DMDM hydantoin and iodopropynyl butyl carbamate.
The whitening skin care composition containing the citrus seed extract has the following technical effects:
1) the inventor of the invention researches the effect of the citrus seed extract on the skin, and the result of an effect test example shows that the citrus seed extract has the effects of relieving skin pigmentation, relieving the oxidative stress pressure of skin cells and reducing the generation of skin wrinkles, thereby realizing the invention; the effective components of the citrus seed extract are extracted through the processing treatment of the invention, and the whitening skin-care composition is prepared, which has practical significance.
2) The whitening and skin-care composition contains the citrus seed extract, can slow down skin pigmentation, improves the cell oxidation resistance of the skin, and has excellent effects of improving the skin elasticity and reducing skin wrinkles; the citrus seed extract has antibacterial effect, so that the addition amount of antiseptic is reduced, and skin irritation is reduced.
3) The citrus seed extract contains limonin substances, especially limonin, and has antioxidant, antiinflammatory, and skin whitening effects. Therefore, the composition has whitening and skin caring effects.
Drawings
FIG. 1 is a high performance liquid chromatography of the detection results of limonin standard.
FIG. 2 is a high performance liquid chromatogram of the detection results of the citrus seed extract of the present invention.
Detailed Description
The invention is further illustrated by the following specific examples, which are intended to be illustrative in more detail only and are not intended to be limiting in any way.
1. The preparation method of the citrus seed extract comprises the following steps:
the citrus seed extract used in the invention is a white crystal citrus seed extract obtained by extracting and refining citrus seeds serving as raw materials. The method comprises the following specific steps:
1) pretreatment: removing pulp from Mandarin orange, collecting Mandarin orange seeds, sun drying, pulverizing, and sieving with 40 mesh standard sieve;
2) removing grease and protein: leaching oil in the citrus seed powder with n-hexane, filtering to obtain residue, drying at 50 deg.C under reduced pressure, and volatilizing residual n-hexane to obtain citrus seed powder A; dissolving and leaching the protein in the citrus seed powder A by using 6% NaCl aqueous solution as a protein extraction solvent, centrifuging, collecting filter residue, and drying under reduced pressure at 60 ℃ to obtain citrus seed powder B;
3) primary extraction of limonin: adding the citrus seed powder B into the aqueous solution of sodium salicylate, extracting at 55 deg.C for 4 hr, removing residue, adding dichloromethane into the filtrate, mixing and extracting, and collecting the lower dichloromethane phase to obtain solution containing limonin;
4) refining and crystallizing limonin: adding isopropanol (dichloromethane: isopropanol 1:3) into dichloromethane solution containing limonin, mixing, standing at 0 deg.C for 24 hr, and filtering to remove dichloromethane and isopropanol to obtain citrus seed extract (white crystal limonin).
FIG. 1 shows a high performance liquid chromatogram of the detection result of limonin standard. Fig. 2 shows the hplc detection results of limonin, which shows that the peak time of the citrus seed extract of the present invention is consistent with that of the hplc of the standard. The limonin can be extracted by the operation steps of the invention.
2. And (3) testing cytotoxicity and melanogenesis inhibition effects of the citrus seed extract:
the above citrus seed extract was used as a test sample to evaluate the cytotoxicity and melanogenesis inhibitory effect in the following manner (3 parallel experiments in total).
1) Cell inoculation, addition of test substances:
mouse B16 melanoma cells were seeded into 6-well plates at 100,000 cells/well. The next day, a test substance solution (DMSO as solvent) was added at a certain concentration.
2) Cell proliferation assay
After 3 days of addition of the test substance solution, the medium was removed by suction, and then 1ml of EMEM medium containing 10% of Amani blue solution was added and allowed to react at 37 ℃. After 30 minutes, 100. mu.l of the solution was transferred to a 96-well plate, and fluorescence was measured under excitation at 544nm and measurement at 590 nm. The ratio of the number of cells (% cell number) of the test substance added group to the solvent group was calculated using this value as a relative value of the number of cells. Higher% cell number means lower cytotoxicity, and less than 80% is judged as "toxic".
3) Determination of the amount of melanin
After removing the medium by suction, the cells were washed with a buffer (phosphate buffer 50mM, pH 6.8), and then dissolved with 1M NaOH to measure the absorbance at 475 nm. The ratio (%) of the amount of melanin in the test substance addition group to the solvent group was calculated as a relative value of the amount of melanin. The lower the melanin amount ratio, the higher the melanogenesis inhibitory effect.
The results of testing citrus seed extracts at various concentrations are shown in table 1.
TABLE 1 cytotoxic and melanogenesis inhibitory Effect of Citrus seed extract at various concentrations
As can be seen from table 1, the citrus seed extract of the present invention has no significant cytotoxicity, and at the same time, has an excellent melanin inhibiting effect, and is effective in reducing skin cytochrome deposition.
The citrus seed extract of the present invention can be used in cosmetic compositions of various formulations such as lotions, milky lotions, creams, etc., and the formulation is not particularly limited.
Example 1
An essence or skin lotion added with an orange seed extract comprises the following raw materials in percentage by weight:
the preparation process comprises the following steps:
1) fully cleaning a preparation pot with 75% ethanol solution before production to ensure the cleanness of a preparation container;
2) putting propylene glycol, glycerol and diglycerol into a preparation pot, and then sequentially putting hydroxyethyl cellulose, hyaluronic acid,
Stirring vitamin C and citrus seed extract for 30min to dissolve the materials;
3) adding phenoxyethanol, ethylhexyl glycerol and fatty glyceride (premixed with essence), and stirring for 10min to obtain whitening essence or skin care water composition containing citrus seed extract.
Example 2
An emulsion added with a citrus seed extract comprises the following raw materials in percentage by weight:
the preparation process comprises the following steps:
1) preparing a water phase: dissolving xanthan gum in propylene glycol, adding glycerol, hydroxyethyl urea, EDTA-2Na, allantoin and deionized water, stirring, heating to 85 deg.C, dissolving completely, and stirring for 30 min;
2) oil phase preparation: stirring and heating hexadecanol/octadecanol, high-carbon fatty alcohol dextran emulsifier, mixture of PEG-100 stearate and monoglyceride, 26# white mineral oil, caprylic/capric triglyceride, methyl hydroxybenzoate and propyl hydroxybenzoate to 85 ℃, dissolving completely, and stirring for 30min under heat preservation;
3) adding the oil phase into the water phase at 85 deg.C, stirring and emulsifying for 10min, homogenizing at 10000-20000rpm for 3-5min with a homogenizer, slowly adding polyacrylate and polyacrylamide copolymer, and vitamin E acetate, and further homogenizing for 2 min;
4) slowly cooling to below 40 deg.C, adding essence and citrus seed extract, and stirring for 30min to obtain whitening emulsion composition containing citrus seed extract.
Example 3
A cream added with an orange seed extract comprises the following raw materials in percentage by weight:
the preparation process comprises the following steps:
1) preparing a water phase: dissolving sodium hyaluronate and xanthan gum in propylene glycol, adding glycerol, diglycerol and deionized water, stirring and heating to 85 ℃, dissolving completely, and continuing to keep the temperature and stir for 25 min;
2) oil phase preparation: stirring and heating hexadecanol/octadecanol, high-carbon fatty alcohol dextran emulsifier, monoglyceride and isomeric hexadecane to 80-85 ℃, dissolving completely, and stirring for 30min under heat preservation;
3) adding the oil phase into the water phase at 80-85 deg.C, stirring and emulsifying for 10-15min, homogenizing for 7min at 10000-;
4) slowly cooling to below 45 deg.C, adding citrus seed extract, iodopropynyl butyl carbamate, phenoxyethanol and essence, and stirring for 30min to obtain whitening cream composition containing citrus seed extract.
2. Efficacy testing
2.1 test method:
the volunteer requires: the test method is characterized in that the test method is aged 40-50 years, half of male and half of female have no history of skin diseases and skin allergy, the male and the female voluntarily participate in the test, an informed consent is signed before the test, no cosmetics can be used 2 days before the test, and no cosmetics except for a test sample can be used in the test process.
After washing the face with warm water, the skin care composition of example 1, example 2 or example 3 (selected according to the skin properties) was applied to one face once in the morning and once in the evening, and the skin care composition was tried for 5 weeks. Control cream was applied to the other half of the face.
2.2 evaluation criteria:
the test subjects evaluated their own skin changes.
2.3 evaluation results:
90% of the subjects evaluated themselves for a greater improvement in facial skin, specifically, facial gloss and improvement in skin wrinkles using the skin care composition. As evaluated by professional doctors, 85% of the tested patients have improved facial wrinkles, improved skin glossiness, smooth skin and obvious whitening effect.
The above results demonstrate that: the whitening skin care composition containing the citrus seed extract can effectively improve the skin glossiness and wrinkles.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that any simple modification, equivalent change and modification made to the above embodiment according to the technical spirit of the present invention are within the scope of the technical solution of the present invention.
Claims (8)
1. A whitening and skin-care composition containing an orange seed extract is characterized by being prepared from the following components in percentage by weight:
0.1-8.0% of citrus seed extract, 1.0-5.0% of synergist, 2.0-5.0% of emulsifier, 0.3-0.8% of thickener, 5.0-35.0% of moistening agent, 0.5-3.0% of preservative, 0.01-0.5% of essence and the balance of deionized water;
the citrus seed extract is a white crystal citrus seed extract obtained by taking citrus seeds as raw materials and carrying out solvent extraction, refining and crystallization.
2. The whitening skin care composition containing citrus seed extract according to claim 1, wherein: the content range of the citrus seed extract is 2.0-8.0%.
3. The whitening skin care composition containing citrus seed extract according to claim 1, wherein: the preparation process of the citrus seed extract comprises the following steps:
1) pretreatment: removing pulp from Mandarin orange, collecting Mandarin orange seed, sun drying, and pulverizing;
2) removing grease and protein: leaching oil in the citrus seed powder by using normal hexane, drying under reduced pressure, and volatilizing residual normal hexane to obtain citrus seed powder A; dissolving and leaching the protein in the citrus seed powder A by using a NaCl solution as a protein extraction solvent, centrifuging, collecting filter residue, and drying under reduced pressure to obtain citrus seed powder B;
3) primary extraction of limonin: adding the citrus seed powder B into an aqueous solution of sodium salicylate, extracting at 40-60 ℃ for 2-8h, removing residues, adding dichloromethane into the filtrate, fully mixing and extracting, and collecting a lower dichloromethane phase to obtain a solution containing limonin;
4) refining and crystallizing limonin: adding isopropanol into the dichloromethane dissolved phase, mixing uniformly, standing the solution at the temperature of 10-10 ℃, standing for 3-48h, and filtering to remove dichloromethane and isopropanol to obtain the citrus seed extract.
4. The whitening skin care composition containing citrus seed extract according to claim 1, wherein: in the step 4), the prepared citrus seed extract is the limonin in a white crystal shape.
5. The whitening skin care composition containing citrus seed extract according to claim 1, wherein: the synergist is selected from one or more of vitamin C, vitamin E and derivatives thereof;
the emulsifier is selected from one or more of nonionic, anionic, cationic, amphoteric emulsifiers and combinations thereof.
6. The whitening skin care composition containing citrus seed extract according to claim 5, wherein: the emulsifier is selected from one or more of high-carbon fatty alcohol polyoxyethylene ether series, polyethylene glycol stearate, ethoxylated methyl glucoside stearate, polyoxyethylene sorbitan monostearate series, fatty glyceride, sorbitan monofatty ester and fatty acid citric glyceride;
the thickening agent is one or the combination of more than two of polyacrylate and polyacrylamide copolymer, polyacrylate and polyacrylamide dimethyl taurate copolymer, hydroxyethyl acrylate and acrylic acid dimethyl taurate copolymer, xanthan gum, cellulose and hyaluronic acid;
the moistening agent is natural oil, modified oil or polyalcohol;
the antiseptic is a mixture of more than two of phenoxyethanol and ethylhexyl glycerin compound, benzyl alcohol, polyalcohol, chlorphenesin, parabens, DMDM hydantoin and iodopropynyl butyl carbamate.
7. The whitening skin care composition containing citrus seed extract according to claim 6, wherein: the moisturizer is selected from nut oil, shea butter, lanolin, white mineral oil, vaseline, glycerol, diglycerol, 1, 3-butanediol, hydroxyethyl urea, and allantoin.
8. The whitening skin care composition containing citrus seed extract according to claim 1, wherein: the whitening skin care composition can be prepared into cosmetic water or essence, lotion and cream.
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| CN111481487B (en) * | 2020-04-22 | 2023-11-03 | 名臣健康用品股份有限公司 | Whitening skin care composition containing herba Violae extract and preparation method thereof |
| CN112107507A (en) * | 2020-10-20 | 2020-12-22 | 何凡 | Oil-control moisturizing facial cleanser and processing technology thereof |
| CN118557456A (en) * | 2024-08-01 | 2024-08-30 | 广东冠清柠生物科技有限公司 | Anti-inflammatory composition containing limonin, anti-inflammatory cosmetic preparation and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000000A (en) * | 2009-09-01 | 2011-04-06 | 刘凤丹 | Application method of tangerine seed oil |
| CN102586004A (en) * | 2012-02-15 | 2012-07-18 | 北京航空航天大学 | Method for continuously extracting orange oil and limonin from citrus reticulata |
| CN103169641A (en) * | 2013-03-14 | 2013-06-26 | 金红叶纸业集团有限公司 | Acne-removing and skin-clearing composition and tissue applying same |
| CN104327153A (en) * | 2014-10-20 | 2015-02-04 | 陕西天谷生物科技集团有限公司 | Method for extracting limonin analogues from tangerine seeds |
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- 2018-08-08 CN CN201810895772.4A patent/CN109044901B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000000A (en) * | 2009-09-01 | 2011-04-06 | 刘凤丹 | Application method of tangerine seed oil |
| CN102586004A (en) * | 2012-02-15 | 2012-07-18 | 北京航空航天大学 | Method for continuously extracting orange oil and limonin from citrus reticulata |
| CN103169641A (en) * | 2013-03-14 | 2013-06-26 | 金红叶纸业集团有限公司 | Acne-removing and skin-clearing composition and tissue applying same |
| CN104327153A (en) * | 2014-10-20 | 2015-02-04 | 陕西天谷生物科技集团有限公司 | Method for extracting limonin analogues from tangerine seeds |
Non-Patent Citations (1)
| Title |
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| 《陈皮柑橘籽中柠檬苦素类物质提取工艺的比较研究》;曾育聪等;《食品工业科技》;20121231;第33卷(第21期);第265-272页 * |
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Effective date of registration: 20221026 Address after: 515834 Liannan Industrial Zone, Chenghai District, Shantou City, Guangdong Province Patentee after: Guangdong Mingchen Daily Chemical Co.,Ltd. Address before: 515834 Liannan Industrial Zone, Lianxia Town, Chenghai District, Shantou City, Guangdong Province Patentee before: MINGCHEN HEALTH Co.,Ltd. |