CN114788891A - Liquid dressing capable of protecting skin barrier and promoting barrier remodeling - Google Patents
Liquid dressing capable of protecting skin barrier and promoting barrier remodeling Download PDFInfo
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- CN114788891A CN114788891A CN202210398311.2A CN202210398311A CN114788891A CN 114788891 A CN114788891 A CN 114788891A CN 202210398311 A CN202210398311 A CN 202210398311A CN 114788891 A CN114788891 A CN 114788891A
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- barrier
- remodeling
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- 230000004888 barrier function Effects 0.000 title claims abstract description 17
- 239000007788 liquid Substances 0.000 title claims abstract description 13
- 238000007634 remodeling Methods 0.000 title claims abstract description 13
- 230000008591 skin barrier function Effects 0.000 title claims abstract description 12
- 230000001737 promoting effect Effects 0.000 title claims abstract description 10
- 238000010438 heat treatment Methods 0.000 claims abstract description 10
- 238000002156 mixing Methods 0.000 claims abstract description 4
- 238000002360 preparation method Methods 0.000 claims abstract description 4
- 238000004321 preservation Methods 0.000 claims abstract description 4
- 230000001954 sterilising effect Effects 0.000 claims abstract description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 4
- 238000003756 stirring Methods 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 27
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 18
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 claims description 18
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 18
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 13
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 10
- QZLXCFQVOCEKSX-NOCHOARKSA-N (2s,4r)-1-hexadecanoyl-4-hexadecanoyloxypyrrolidine-2-carboxylic acid Chemical compound CCCCCCCCCCCCCCCC(=O)O[C@@H]1C[C@@H](C(O)=O)N(C(=O)CCCCCCCCCCCCCCC)C1 QZLXCFQVOCEKSX-NOCHOARKSA-N 0.000 claims description 9
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims description 9
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 claims description 9
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 9
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 9
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 9
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 9
- 229960000458 allantoin Drugs 0.000 claims description 9
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 9
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 9
- 239000003995 emulsifying agent Substances 0.000 claims description 9
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 claims description 9
- 229960003415 propylparaben Drugs 0.000 claims description 9
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 9
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 9
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 9
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 9
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 6
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 6
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- 229920002545 silicone oil Polymers 0.000 claims description 5
- 230000001804 emulsifying effect Effects 0.000 claims description 3
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims 1
- 239000002994 raw material Substances 0.000 abstract description 3
- 238000001816 cooling Methods 0.000 abstract 1
- 229940008099 dimethicone Drugs 0.000 description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 4
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 4
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
Abstract
The invention discloses a liquid dressing capable of protecting a skin barrier and promoting barrier remodeling, which comprises a phase A, a phase B and a phase C, wherein the phase A is accurately weighed according to the amount, then is heated to 80 ℃ in a water bath, the phase B is accurately weighed and then is respectively heated to 80 ℃, the phase B is subjected to heat preservation and sterilization at 80 ℃ for 20 minutes, then the phase A is added into the phase B, the phase B is stirred for 5 minutes at the rotation speed of 1200, and the phase B is homogenized and emulsified for 3 minutes at the rotation speed of 35000; mixing and dissolving the C phase component, and heating to 40 ℃ for later use; A. cooling phase B to 50 deg.C, adding phase C, and stirring to 35 deg.C. Compared with the prior art, the invention has the advantages that: the product is directly applied to the skin, can generate a barrier for protecting the skin, efficiently promotes the barrier remodeling, has reasonable raw material selection and dosage, simple preparation process and low cost, expands the utility of liquid dressing, and has good applicability and convenient popularization.
Description
Technical Field
The invention relates to a medical article, in particular to a liquid dressing which can protect a skin barrier and promote barrier remodeling.
Background
The dressing generally refers to an external material with the functions of protecting wounds and preventing secondary infection, heat loss and the like in the medical field, and at present, gauze traditional dressings and modern dressings are mainly used, and the modern dressings include sodium alginate/calcium dressings, interactive dressings, silver ion dressings, foam dressings, gel dressings and the like.
Disclosure of Invention
The technical problem to be solved by the invention is that the existing dressing generally lacks the functions of antibiosis, wound convergence and barrier repair promotion due to the defects of raw material selection and process preparation, so that the clinical effect is poor and the actual requirement is not met.
In order to solve the technical problems, the technical scheme provided by the invention is as follows: a liquid dressing for protecting skin barrier and promoting barrier remodeling comprises an A phase, a B phase and a C phase, wherein the A phase comprises 4 mass parts of self-emulsifying monoglyceride, 3.5 mass parts of dimethyl silicone oil, 6 mass parts of Montanov-68 emulsifying agent, 3.2 mass parts of hexadecanol, 2.05 mass parts of propyl hydroxybenzoate, 10 mass parts of isohexadecane and 3 mass parts of dipalmitoyl hydroxyproline; the phase B comprises 6 parts by mass of 1, 3-butanediol, 2.2 parts by mass of allantoin, 2.03 parts by mass of EDTA-2Na, 203 parts by mass of methyl hydroxybenzoate, 2.1 parts by mass of methyl hydroxybenzoate and 7 parts by mass of NMF-50; the phase C comprises 2.2 parts by mass of sodium carboxymethylcellulose, 6 parts by mass of propylene glycol and 12 parts by mass of sodium hyaluronate;
a method for preparing a liquid dressing capable of protecting skin barrier and promoting barrier remodeling comprises the following steps:
firstly, accurately weighing phase A according to the amount, heating the phase A in a water bath to 80 ℃, accurately weighing phase B, respectively heating the phase B to 80 ℃, carrying out heat preservation and sterilization on the phase B at 80 ℃ for 20 minutes, adding the phase A into the phase B, stirring the phase A at 1200 rotation speed for 5 minutes, and homogenizing and emulsifying the phase A at 35000 rotation speed for 3 minutes;
secondly, mixing and dissolving the phase C component, and heating to 40 ℃ for later use;
step three, A, B phase is stirred and cooled to 50 ℃, then phase C component is added, and the mixture is stirred to 35 ℃, thus obtaining the product.
Compared with the prior art, the invention has the advantages that: the product is directly applied to the skin, can generate a barrier for protecting the skin, efficiently promotes the barrier to be reshaped, has reasonable raw material selection and dosage, simple preparation process and low cost, expands the utility of the liquid dressing, has good applicability and is convenient to popularize.
Further, the phase A comprises 3 parts by mass of self-emulsifying monoglyceride, 2.5 parts by mass of dimethicone, 5 parts by mass of Montanov-68 emulsifier, 2.2 parts by mass of cetostearyl alcohol, 1.05 parts by mass of propylparaben, 9 parts by mass of isohexadecane, and 2 parts by mass of dipalmitoyl hydroxyproline; the phase B comprises 5 parts by mass of 1, 3-butanediol, 1.2 parts by mass of allantoin, 1.03 parts by mass of EDTA-2Na, 153 parts by mass of methyl hydroxybenzoate and 6 parts by mass of NMF-50; the phase C includes 1.2 parts by mass of sodium carboxymethylcellulose, 5 parts by mass of propylene glycol, and 11 parts by mass of sodium hyaluronate.
Further, phase a includes 2 parts by mass of self-emulsifying monoglyceride, 1.5 parts by mass of dimethicone, 4 parts by mass of Montanov-68 emulsifier, 1.2 parts by mass of cetostearyl alcohol, 0.05 parts by mass of propylparaben, 8 parts by mass of isohexadecane, 1 part by mass of dipalmitoyl hydroxyproline; the phase B comprises 4 parts by mass of 1, 3-butanediol, 0.2 part by mass of allantoin, 0.03 part by mass of EDTA-2Na, 103 parts by mass of methyl hydroxybenzoate and 0.1 part by mass of NMF-50; the phase C includes 0.2 parts by mass of sodium carboxymethylcellulose, 4 parts by mass of propylene glycol, and 10 parts by mass of sodium hyaluronate.
Detailed Description
In specific implementation, the liquid dressing capable of protecting the skin barrier and promoting barrier remodeling comprises an A phase, a B phase and a C phase, wherein the A phase comprises 4 parts by mass of self-emulsifying monoglyceride, 3.5 parts by mass of dimethyl silicone oil, 6 parts by mass of Montanov-68 emulsifier, 3.2 parts by mass of hexadecanol, 2.05 parts by mass of propyl hydroxybenzoate, 10 parts by mass of isohexadecane and 3 parts by mass of dipalmitoyl hydroxyproline; phase B comprises 6 parts by mass of 1, 3-butanediol, 2.2 parts by mass of allantoin, 2.03 parts by mass of EDTA-2Na, 203 parts by mass of methyl hydroxybenzoate, 2.1 parts by mass of NMF-50; the phase C comprises 2.2 parts by mass of sodium carboxymethylcellulose, 6 parts by mass of propylene glycol and 12 parts by mass of sodium hyaluronate;
a method for preparing a liquid dressing capable of protecting skin barrier and promoting barrier remodeling comprises the following steps:
firstly, accurately weighing phase A, heating the phase A to 80 ℃ in a water bath, accurately weighing phase B, heating the phase B to 80 ℃ respectively, carrying out heat preservation and sterilization on the phase B at 80 ℃ for 20 minutes, adding the phase A into the phase B, stirring at 1200 rotation speed for 5 minutes, and homogenizing and emulsifying at 35000 rotation speed for 3 minutes;
secondly, mixing and dissolving the phase C component, and heating to 40 ℃ for later use;
step three, A, B phase is stirred and cooled to 50 ℃, then phase C component is added, and the mixture is stirred to 35 ℃, thus obtaining the product.
Further, phase a includes 3 parts by mass of self-emulsifying monoglyceride, 2.5 parts by mass of dimethicone, 5 parts by mass of Montanov-68 emulsifier, 2.2 parts by mass of cetostearyl alcohol, 1.05 parts by mass of propylparaben, 9 parts by mass of isohexadecane, 2 parts by mass of dipalmitoyl hydroxyproline; the phase B comprises 5 parts by mass of 1, 3-butanediol, 1.2 parts by mass of allantoin, 1.03 parts by mass of EDTA-2Na, 153 parts by mass of methyl hydroxybenzoate 1.1 parts by mass and 6 parts by mass of NMF-50; the phase C includes 1.2 parts by mass of sodium carboxymethylcellulose, 5 parts by mass of propylene glycol, and 11 parts by mass of sodium hyaluronate.
Further, the phase A comprises 2 parts by mass of self-emulsifying monoglyceride, 1.5 parts by mass of dimethicone, 4 parts by mass of Montanov-68 emulsifier, 1.2 parts by mass of cetostearyl alcohol, 0.05 part by mass of propylparaben, 8 parts by mass of isohexadecane, and 1 part by mass of dipalmitoyl hydroxyproline; the phase B comprises 4 parts by mass of 1, 3-butanediol, 0.2 part by mass of allantoin, 0.03 part by mass of EDTA-2Na, 103 parts by mass of methyl hydroxybenzoate and 0.1 part by mass of NMF-50; the phase C includes 0.2 parts by mass of sodium carboxymethylcellulose, 4 parts by mass of propylene glycol, and 10 parts by mass of sodium hyaluronate.
While there have been shown and described what are at present considered to be the fundamental and essential features of the invention and advantages thereof, it will be understood by those skilled in the art that the invention is not limited by the details of the foregoing embodiments, which are provided as an illustration of the principles of the invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the invention as hereinafter claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (3)
1. A liquid dressing for protecting skin barrier and promoting barrier remodeling is characterized by comprising an A phase, a B phase and a C phase, wherein the A phase comprises 4 mass parts of self-emulsifying monoglyceride, 3.5 mass parts of dimethyl silicone oil, 6 mass parts of Montanov-68 emulsifier, 3.2 mass parts of hexadecanol, 2.05 mass parts of propyl hydroxybenzoate, 10 mass parts of isohexadecane and 3 mass parts of dipalmitoyl hydroxyproline; the phase B comprises 6 parts by mass of 1, 3-butanediol, 2.2 parts by mass of allantoin, 2.03 parts by mass of EDTA-2Na, 203 parts by mass of methyl hydroxybenzoate and 2.1 parts by mass of NMF-50; the phase C comprises 2.2 parts by mass of sodium carboxymethylcellulose, 6 parts by mass of propylene glycol and 12 parts by mass of sodium hyaluronate;
the preparation method of the liquid dressing capable of protecting the skin barrier and promoting barrier remodeling comprises the following steps:
firstly, accurately weighing phase A, heating the phase A to 80 ℃ in a water bath, accurately weighing phase B, heating the phase B to 80 ℃ respectively, carrying out heat preservation and sterilization on the phase B at 80 ℃ for 20 minutes, adding the phase A into the phase B, stirring at 1200 rotation speed for 5 minutes, and homogenizing and emulsifying at 35000 rotation speed for 3 minutes;
secondly, mixing and dissolving the phase C components, and heating to 40 ℃ for later use;
step three, A, B phase is stirred and cooled to 50 ℃, then phase C component is added, and the mixture is stirred to 35 ℃, thus obtaining the product.
2. A fluid dressing for protecting a skin barrier and promoting barrier remodeling according to claim 1, wherein: the phase A comprises 3 parts by mass of self-emulsifying monoglyceride, 2.5 parts by mass of dimethyl silicone oil, 5 parts by mass of Montanov-68 emulsifier, 2.2 parts by mass of cetostearyl alcohol, 1.05 parts by mass of propyl hydroxybenzoate, 9 parts by mass of isohexadecane and 2 parts by mass of dipalmitoyl hydroxyproline; the phase B comprises 5 parts by mass of 1, 3-butanediol, 1.2 parts by mass of allantoin, 1.03 parts by mass of EDTA-2Na, 153 parts by mass of methyl hydroxybenzoate and 1.1 parts by mass of NMF-50; the phase C comprises 1.2 parts by mass of sodium carboxymethylcellulose, 5 parts by mass of propylene glycol and 11 parts by mass of sodium hyaluronate.
3. A liquid dressing for protecting a skin barrier against the promotion of barrier remodeling as claimed in claim 2 wherein: the phase A comprises 2 parts by mass of self-emulsifying monoglyceride, 1.5 parts by mass of dimethyl silicone oil, 4 parts by mass of Montanov-68 emulsifier, 1.2 parts by mass of cetostearyl alcohol, 0.05 part by mass of propyl hydroxybenzoate, 8 parts by mass of isohexadecane and 1 part by mass of dipalmitoyl hydroxyproline; the phase B comprises 4 parts by mass of 1, 3-butanediol, 0.2 part by mass of allantoin, 0.03 part by mass of EDTA-2Na, 103 parts by mass of methyl hydroxybenzoate and 0.1 part by mass of NMF-50; the phase C comprises 0.2 part by mass of sodium carboxymethylcellulose, 4 parts by mass of propylene glycol and 10 parts by mass of sodium hyaluronate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210398311.2A CN114788891A (en) | 2022-04-15 | 2022-04-15 | Liquid dressing capable of protecting skin barrier and promoting barrier remodeling |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210398311.2A CN114788891A (en) | 2022-04-15 | 2022-04-15 | Liquid dressing capable of protecting skin barrier and promoting barrier remodeling |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114788891A true CN114788891A (en) | 2022-07-26 |
Family
ID=82462399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210398311.2A Pending CN114788891A (en) | 2022-04-15 | 2022-04-15 | Liquid dressing capable of protecting skin barrier and promoting barrier remodeling |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114788891A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107982099A (en) * | 2016-10-27 | 2018-05-04 | 天津嘉氏堂科技有限公司 | A kind of face cream and preparation method thereof |
| CN109481377A (en) * | 2018-11-28 | 2019-03-19 | 黄犟兵 | A kind of skin barrier remediation composition and preparation method thereof |
| CN111494703A (en) * | 2020-05-29 | 2020-08-07 | 绽妍生物科技有限公司 | Moisturizing dressing capable of promoting skin barrier repair and nursing and preparation method thereof |
| CN111588655A (en) * | 2020-06-09 | 2020-08-28 | 广州市轩颜化妆品有限公司 | Algae skin barrier repair cream and preparation method thereof |
| CN113476346A (en) * | 2021-06-16 | 2021-10-08 | 西安德诺海思医疗科技有限公司 | Skin barrier repair composition |
-
2022
- 2022-04-15 CN CN202210398311.2A patent/CN114788891A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107982099A (en) * | 2016-10-27 | 2018-05-04 | 天津嘉氏堂科技有限公司 | A kind of face cream and preparation method thereof |
| CN109481377A (en) * | 2018-11-28 | 2019-03-19 | 黄犟兵 | A kind of skin barrier remediation composition and preparation method thereof |
| CN111494703A (en) * | 2020-05-29 | 2020-08-07 | 绽妍生物科技有限公司 | Moisturizing dressing capable of promoting skin barrier repair and nursing and preparation method thereof |
| CN111588655A (en) * | 2020-06-09 | 2020-08-28 | 广州市轩颜化妆品有限公司 | Algae skin barrier repair cream and preparation method thereof |
| CN113476346A (en) * | 2021-06-16 | 2021-10-08 | 西安德诺海思医疗科技有限公司 | Skin barrier repair composition |
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Application publication date: 20220726 |