CN114832150A - Spray dressing for promoting barrier repair of antibacterial convergent wound - Google Patents
Spray dressing for promoting barrier repair of antibacterial convergent wound Download PDFInfo
- Publication number
- CN114832150A CN114832150A CN202210414660.9A CN202210414660A CN114832150A CN 114832150 A CN114832150 A CN 114832150A CN 202210414660 A CN202210414660 A CN 202210414660A CN 114832150 A CN114832150 A CN 114832150A
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- CN
- China
- Prior art keywords
- phase
- mass
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- wound
- spray dressing
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000007921 spray Substances 0.000 title claims abstract description 17
- 230000004888 barrier function Effects 0.000 title claims abstract description 12
- 230000001737 promoting effect Effects 0.000 title claims abstract description 12
- 230000008439 repair process Effects 0.000 title claims abstract description 12
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 7
- 206010052428 Wound Diseases 0.000 claims abstract description 18
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 18
- 238000003756 stirring Methods 0.000 claims abstract description 15
- 238000001816 cooling Methods 0.000 claims abstract description 8
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 238000001914 filtration Methods 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims abstract description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 25
- 229920001661 Chitosan Polymers 0.000 claims description 18
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 9
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 9
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 9
- 229960003237 betaine Drugs 0.000 claims description 9
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 9
- 239000008367 deionised water Substances 0.000 claims description 9
- 229910021641 deionized water Inorganic materials 0.000 claims description 9
- 150000002148 esters Chemical class 0.000 claims description 9
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 9
- 229920001542 oligosaccharide Polymers 0.000 claims description 9
- 150000002482 oligosaccharides Chemical class 0.000 claims description 9
- 239000004006 olive oil Substances 0.000 claims description 9
- 235000008390 olive oil Nutrition 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000000811 xylitol Substances 0.000 claims description 9
- 235000010447 xylitol Nutrition 0.000 claims description 9
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 9
- 229960002675 xylitol Drugs 0.000 claims description 9
- 241000894006 Bacteria Species 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000010010 raising Methods 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 230000002421 anti-septic effect Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 3
- 208000015181 infectious disease Diseases 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 3
- 210000000416 exudates and transudate Anatomy 0.000 abstract description 2
- 231100000241 scar Toxicity 0.000 abstract description 2
- 230000029663 wound healing Effects 0.000 abstract description 2
- 235000011187 glycerol Nutrition 0.000 description 6
- 239000000463 material Substances 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a spray dressing for promoting barrier repair of an antibacterial convergent wound, which comprises a phase A, a phase B and a phase C, wherein the phase A is sequentially added into a stirring pot, heated and stirred to 80-90 ℃, kept warm for 20 minutes, sterilized and dissolved. Cooling to 45 deg.C; adding phase B into a container, preheating, stirring to 45 ℃, and adding phase A; and adding the phase C into a container, stirring uniformly, adding the phase A, cooling to 30-40 ℃, and filtering by using a 400-mesh filter screen to obtain the composition. Compared with the prior art, the invention has the advantages that: the spray dressing is directly used on a wound or a scar, can quickly form a film, accelerate wound healing and quickly absorb exudate on the surface of the wound, can prevent infection when used on the wound, has reasonable raw material selection and dosage, simple preparation process and low cost, expands the effect of the spray dressing, and has good applicability and convenient popularization.
Description
Technical Field
The invention relates to a medical article, in particular to a spray dressing for promoting barrier repair of an antibacterial convergent wound.
Background
The dressing generally refers to an external material with the functions of protecting wounds and preventing secondary infection, heat loss and the like in the medical field, and at present, gauze traditional dressings and modern dressings are mainly used, and the modern dressings include sodium alginate/calcium dressings, interactive dressings, silver ion dressings, foam dressings, gel dressings and the like.
Disclosure of Invention
The invention aims to solve the technical problems that the selection of raw materials and the design of a preparation process of the existing spray dressing are not reasonable enough, so that the auxiliary material has low effect and can not meet the clinical use requirement.
In order to solve the technical problems, the technical scheme provided by the invention is as follows: a spray dressing for resisting bacteria, astringing wounds and promoting barrier repair comprises a phase A, a phase B and a phase C, wherein the phase A comprises 203 parts by mass of deionized water, 3.5 parts by mass of betaine, 4 parts by mass of xylitol and 5 parts by mass of glycerol; the phase B comprises 6 parts by mass of butanediol and 3 parts by mass of PEG-7 olive oil ester; the phase C comprises 4 parts by mass of N-succinyl chitosan CD-58 and 2.15 parts by mass of oligochitosan oligosaccharide;
a preparation method of the spray dressing for promoting barrier repair of the antibacterial convergent wound comprises the following steps:
firstly, sequentially adding the phase A into a stirring pot, heating, stirring, raising the temperature to 80-90 ℃, preserving the temperature for 20 minutes, sterilizing and dissolving. Cooling to 45 deg.C;
secondly, adding the phase B into a container for preheating, stirring to 45 ℃, and adding the phase A;
and step three, adding the phase C into a container, stirring uniformly, adding the phase A into the container, cooling to 30-40 ℃, and filtering by using a 400-mesh filter screen to obtain the composition.
Compared with the prior art, the invention has the advantages that: : the spray dressing is directly used on a wound or a scar, can quickly form a film, accelerate wound healing and quickly absorb exudate on the surface of the wound, can prevent infection when used on the wound, has reasonable raw material selection and dosage, simple preparation process and low cost, expands the effect of the spray dressing, and has good applicability and convenient popularization.
Further, phase a includes 153 parts by mass of deionized water, 2.5 parts by mass of betaine, 3 parts by mass of xylitol, and 4 parts by mass of glycerin; the phase B comprises 5 parts by mass of butanediol and 2 parts by mass of PEG-7 olive oil ester; the phase C comprises 3 parts by mass of N-succinyl chitosan CD-58 and 1.15 parts by mass of oligochitosan oligosaccharide.
Further, phase a comprises 103 parts by mass of deionized water, 1.5 parts by mass of betaine, 2 parts by mass of xylitol, and 3 parts by mass of glycerol; the phase B comprises 4 parts by mass of butanediol and 1 part by mass of PEG-7 olive oil ester; the phase C comprises 2 parts by mass of N-succinyl chitosan CD-58 and 0.15 part by mass of oligochitosan oligosaccharide.
Detailed Description
In specific implementation, the spray dressing for promoting barrier repair of the antibacterial convergent wound comprises an A phase, a B phase and a C phase, wherein the A phase comprises 203 parts by mass of deionized water, 3.5 parts by mass of betaine, 4 parts by mass of xylitol and 5 parts by mass of glycerol; the phase B comprises 6 parts by mass of butanediol and 3 parts by mass of PEG-7 olive oil ester; the phase C comprises 4 parts by mass of N-succinyl chitosan CD-58 and 2.15 parts by mass of oligochitosan oligosaccharide;
a preparation method of the spray dressing for resisting bacteria, astringing wounds and promoting barrier repair comprises the following steps:
firstly, sequentially adding the phase A into a stirring pot, heating, stirring, raising the temperature to 80-90 ℃, preserving the temperature for 20 minutes, sterilizing and dissolving. Cooling to 45 deg.C;
secondly, adding the phase B into a container for preheating, stirring to 45 ℃, and adding the phase A;
and step three, adding the phase C into a container, stirring uniformly, adding the phase A into the container, cooling to 30-40 ℃, and filtering by using a 400-mesh filter screen to obtain the composition.
Further, phase a includes 153 parts by mass of deionized water, 2.5 parts by mass of betaine, 3 parts by mass of xylitol, and 4 parts by mass of glycerin; the phase B comprises 5 parts by mass of butanediol and 2 parts by mass of PEG-7 olive oil ester; the phase C comprises 3 parts by mass of N-succinyl chitosan CD-58 and 1.15 parts by mass of oligochitosan oligosaccharide.
Further, phase a comprises 103 parts by mass of deionized water, 1.5 parts by mass of betaine, 2 parts by mass of xylitol, and 3 parts by mass of glycerol; the phase B comprises 4 parts by mass of butanediol and 1 part by mass of PEG-7 olive oil ester; the phase C comprises 2 parts by mass of N-succinyl chitosan CD-58 and 0.15 part by mass of oligochitosan oligosaccharide.
While there have been shown and described the fundamental principles and principal features of the invention and advantages thereof, it will be understood by those skilled in the art that the invention is not limited by the embodiments described above, which are given by way of illustration of the principles of the invention, but is susceptible to various changes and modifications without departing from the spirit and scope of the invention as defined by the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (3)
1. The spray dressing for resisting bacteria, astringing wounds and promoting barrier repair is characterized by comprising an A phase, a B phase and a C phase, wherein the A phase comprises 203 parts by mass of deionized water, 3.5 parts by mass of betaine, 4 parts by mass of xylitol and 5 parts by mass of glycerol; the phase B comprises 6 parts by mass of butanediol and 3 parts by mass of PEG-7 olive oil ester; the phase C comprises 4 parts by mass of N-succinyl chitosan CD-58 and 2.15 parts by mass of oligochitosan oligosaccharide;
the preparation method of the spray dressing for promoting barrier repair of the antibacterial convergent wound comprises the following steps:
firstly, sequentially adding the phase A into a stirring pot, heating, stirring, raising the temperature to 80-90 ℃, preserving the temperature for 20 minutes, sterilizing and dissolving. Cooling to 45 deg.C;
secondly, adding the phase B into a container for preheating, stirring to 45 ℃, and adding the phase A;
and step three, adding the phase C into a container, stirring uniformly, adding the phase A into the container, cooling to 30-40 ℃, and filtering by using a 400-mesh filter screen to obtain the composition.
2. The antiseptic convergent wound spray dressing for promoting barrier repair of claim 1, wherein: the phase A comprises 153 parts by mass of deionized water, 2.5 parts by mass of betaine, 3 parts by mass of xylitol and 4 parts by mass of glycerol; the phase B comprises 5 parts by mass of butanediol and 2 parts by mass of PEG-7 olive oil ester; the phase C comprises 3 parts by mass of N-succinyl chitosan CD-58 and 1.15 parts by mass of oligochitosan oligosaccharide.
3. The antiseptic convergent wound spray dressing for promoting barrier repair of claim 2, wherein: the phase A comprises 103 parts by mass of deionized water, 1.5 parts by mass of betaine, 2 parts by mass of xylitol and 3 parts by mass of glycerol; the phase B comprises 4 parts by mass of butanediol and 1 part by mass of PEG-7 olive oil ester; the phase C comprises 2 parts by mass of N-succinyl chitosan CD-58 and 0.15 part by mass of oligochitosan oligosaccharide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210414660.9A CN114832150A (en) | 2022-04-15 | 2022-04-15 | Spray dressing for promoting barrier repair of antibacterial convergent wound |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210414660.9A CN114832150A (en) | 2022-04-15 | 2022-04-15 | Spray dressing for promoting barrier repair of antibacterial convergent wound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114832150A true CN114832150A (en) | 2022-08-02 |
Family
ID=82565318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210414660.9A Pending CN114832150A (en) | 2022-04-15 | 2022-04-15 | Spray dressing for promoting barrier repair of antibacterial convergent wound |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114832150A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106474528A (en) * | 2016-11-30 | 2017-03-08 | 江苏经纬技术创新咨询有限公司 | A kind of preparation method of absorbable antibacterial medical dressing |
| CN110812328A (en) * | 2019-11-27 | 2020-02-21 | 苏州汇涵医用科技发展有限公司 | Pet spray dressing and preparation method thereof |
| CN111973507A (en) * | 2020-08-04 | 2020-11-24 | 杨军 | External-use skin ointment and preparation method thereof |
| CN114129649A (en) * | 2021-09-24 | 2022-03-04 | 北京天珠药业有限公司 | Cold compress gel capable of promoting skin barrier repair and nursing |
-
2022
- 2022-04-15 CN CN202210414660.9A patent/CN114832150A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106474528A (en) * | 2016-11-30 | 2017-03-08 | 江苏经纬技术创新咨询有限公司 | A kind of preparation method of absorbable antibacterial medical dressing |
| CN110812328A (en) * | 2019-11-27 | 2020-02-21 | 苏州汇涵医用科技发展有限公司 | Pet spray dressing and preparation method thereof |
| CN111973507A (en) * | 2020-08-04 | 2020-11-24 | 杨军 | External-use skin ointment and preparation method thereof |
| CN114129649A (en) * | 2021-09-24 | 2022-03-04 | 北京天珠药业有限公司 | Cold compress gel capable of promoting skin barrier repair and nursing |
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Legal Events
| Date | Code | Title | Description |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220802 |
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| RJ01 | Rejection of invention patent application after publication |