CN102219915A - Aquogel scalding surgical dressing and preparation method thereof - Google Patents
Aquogel scalding surgical dressing and preparation method thereof Download PDFInfo
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Abstract
The invention provides an aquogel scalding surgical dressing and a preparation method thereof. The method comprises the following steps of: adding dimethyl sulphone into polyvinyl alcohol solution to obtain mixed solution, wherein a weight ratio of the dimethyl sulphone to the polyvinyl alcohol solution in the mixed solution is (0.01-10):100; performing film casting on the mixed solution; and freezing and crosslinking the solution subjected to film casting repeatedly to obtain the aquogel scalding surgical dressing. The aquogel scalding surgical dressing prepared according to the method has high biocompatibility and wettability, and can promote cell neogenesis, accelerate the healing of wounds, stop bleeding, relieve pain and reduce the pain of patients.
Description
Technical field
The present invention relates to technological field of biochemistry, particularly a kind of hydrogel is scalded dressing and preparation method thereof.
Background technology
People can produce wound because of reasons such as wound, burn or operation make skin damage in daily life.For fear of extraneous harmful microorganism infected wound, the healing of accelerated in wounds need be applied medical dressing in the wound usually.Medical dressing is a kind of coverture of binding up a wound, and is mainly used in to cover sore, wound or other infringements, to reach the protection wound, absorbs secretory product, reduces the effect that infects and promote healing.
Traditional medical dressing mainly is to be the materials such as gauze, cotton of major function with cleaning or protection wound; this type of medical dressing can effectively be protected the surface of a wound; have stronger absorption sepage ability, and with low cost, raw material is easy to get, it is simple to make, reusable.But its shortcoming is also particularly outstanding: at first, traditional medical dressing permeabilities such as gauze are too high, and what can't keep that the surface of a wound continues is moistening, makes surface of a wound dehydration easily, prolongs wound healing time.Secondly, surface of a wound granulation tissue is very easily grown in the mesh or space of dressing, causes the dressing adhesion surface of a wound, can cause patient's mechanical injuries once more when changing dressings, and causes patient's pain.At last, dressing fiber, cotton-wool very easily come off, and easily cause foreign body reaction, influence the healing of wound.
In recent years, people to pathologic, physiologic research in the wound healing process deepen continuously and the continuous progress of Materials science has promoted the development of modern medical dressing.Aerogel dressing has breathable moisture permeability preferably, can not cause the secondary mechanical damage, thereby receive much attention.As application number is that 200810122438.1 Chinese patent literature discloses a kind of medical hydrogel wound dressing and preparation method thereof, the preparation method of the hydrogel wound dressing of this patent disclosure comprises the steps: 1), the batching, raw material comprises: the water of the sodium polyacrylate of 20wt%～30wt%, the polyvinyl alcohol of 2wt%～6wt% and 64wt%～78wt%; 2), casting film, the film forming of will pour into after the above-mentioned raw materials heating for dissolving lowering the temperature in the system film ware; 3), radiation processing; 4), sterilization is preserved.
Though existing aerogel dressing has better biocompatibility and breathable moisture permeability, be easy to change, but there is following defective in it as scalding dressing: lower to the healing effect of scalding wound, wound healing time is long, in addition before the wound healing often with throe, patient's pain sensation is still bigger.
Summary of the invention
The technical problem that the present invention solves is to provide a kind of hydrogel to scald the preparation method of dressing, comprising:,
A), in polyvinyl alcohol solution, add dimethyl sulfone, obtain mixing solutions, dimethyl sulfone and poly weight ratio are (0.01～10) in the described mixing solutions: 100;
B), with described mixing solutions casting film-forming;
C), the solution of casting film-forming is carried out repeatedly freezing crosslinked, obtain hydrogel and scald dressing.
Preferably, step a is specially:
A1), polyvinyl alcohol mixed with water and heat, with the cooling of the solution after the heating, obtain polyvinyl alcohol solution;
A2), under slow whipped state, carry out shaking table concussion de-bubble after dimethyl sulfone solution dropwise added described polyvinyl alcohol solution, obtain mixing solutions.
Preferably, the concentration of polyvinyl alcohol solution is 10wt%～15wt% in the described mixing solutions.
Preferably, the weight ratio of dimethyl sulfone solution and polyvinyl alcohol is (0.1～1) in the described mixing solutions: 100.
Preferably, described step c is specially: described solution with casting film-forming-10 ℃～-90 ℃ freezing more than 12 hours, place the room temperature 1h～3h that thaws again, so repeatedly for several times.
The present invention also provides a kind of hydrogel to scald dressing, and comprising: polyvinyl alcohol, dimethyl sulfone and water, the weight ratio of described dimethyl sulfone and polyvinyl alcohol are (0.01～10): 100
Preferably, the concentration of described polyvinyl alcohol is 10wt%～15wt%.
Preferably, the weight ratio of described dimethyl sulfone solution and polyvinyl alcohol is (0.1～1): 100.
The invention provides a kind of hydrogel and scald the preparation method of dressing, it is to add casting film-forming after the dimethyl sulfone earlier in polyvinyl alcohol solution; Then the solution of casting film-forming is carried out repeatedly freezing crosslinkedly, obtain hydrogel and scald dressing.By such scheme as can be known, it is to be raw material with polyvinyl alcohol and dimethyl sulfone that hydrogel provided by the invention is scalded dressing preparation method, cooperates and adopts freezing repeatedly crosslinking to be prepared from.Wherein polyvinyl alcohol is a main film forming substance, it has better biocompatibility and degradation property, the adding of dimethyl sulfone then improves the penetrating quality of hydrogel, the healing properties and the analgesic property of wound when guaranteeing former polyvinyl alcohol hydrogel physicals, freezing repeatedly rule guarantees the stability of dimethyl sulfone in the polyvinyl alcohol crosslinked process to greatest extent, avoids dimethyl sulfone because of the sex change loss.Therefore, the hydrogel that makes is according to the method described above scalded dressing and is had excellent biological compatibility and wettability, can promote cell new life, accelerating wound healing, and hemostatic analgesia has reduced the patient suffering.
Further, the present invention also adds the mode and the time of polyvinyl alcohol solution by the control dimethyl sulfone, and the de-bubble mode obtains the higher high-clarity hydrogel scald dressing of dimethyl sulfone content.
Description of drawings
Fig. 1 is an aerogel dressing tensile strength column diagram;
Fig. 2 is an aerogel dressing water content column diagram;
Fig. 3 is an aerogel dressing dehydration rate change curve in time;
Fig. 4 is an aerogel dressing water-intake rate change curve in time;
Fig. 5 is an aerogel dressing water vapor transmission rate (WVTR) column diagram;
Fig. 6 is a vat liquor toxicity column diagram in the cell toxicity test;
Fig. 7 is a vat liquor toxicity column diagram.
Embodiment
In order further to understand the present invention, below in conjunction with embodiment hydrogel provided by the invention being scalded dressing and preparation method thereof is described, but should be appreciated that these describe just to further specifying the features and advantages of the present invention, rather than to the restriction of claim of the present invention.
The embodiment of the invention discloses a kind of hydrogel and scald the preparation method of dressing, comprise the steps:
A), in polyethylene solution, add dimethyl sulfone, obtain mixing solutions, the weight ratio of dimethyl sulfone and polyvinyl alcohol is (0.01～10) in the described mixing solutions: 100;
B), with described mixing solutions casting film-forming;
C), the solution of casting film-forming is carried out repeatedly freezing crosslinked, obtain hydrogel and scald dressing.
By such scheme as can be known, method provided by the invention is to be the feedstock production aerogel dressing with polyvinyl alcohol (PVA) and dimethyl sulfone (MSM).The reason of the PVA that the present invention selects is: PVA has favorable biological degradability energy, biocompatibility, solvent resistance and film-forming properties, human body is had no side effect, be a kind of good bio-medical material, so the present invention's selection is a main film forming substance with PVA.Select the reason of MSM to be: MSM has good perviousness, can go deep into the skin corium of skin, plays the reinforcement blood circulation, promotes the effect of wound healing, and MSM also has good throe effect in addition; And the MSM add-on can not influence the original physical properties of PVA hydrogel when being no more than the 10wt% of PVA, can give better perviousness of PVA hydrogel and analgesia property, plays to promote the cell growth, promotes wound healing, alleviates patient suffering's effect.
Though the adding of MSM can be given better healing properties of aerogel dressing and analgesic property, but the MSM add-on too much can suppress cell enlargement on the contrary, therefore to control the weight ratio of PVA and MSM be (0.01～10) in the present invention: 100, be preferably (0.1～1): 100, the hydrogel cell growth of aforementioned proportion scope is the most useful.
Consider that scalding dressing must have better mechanical property, the tensile property that especially extends is beneficial to the contraction of the control surface of a wound and distortion in order to avoid the granulation tissue hyperplasia.For this reason, the concentration that the present invention preferably controls PVA in the aerogel dressing is 10wt%～15wt%, 11wt%～13wt% more preferably, and the aerogel dressing of above-mentioned PVA content has higher extension tensile property.
Step a) is preferably carried out in the following manner:
A1), PVA mixed with water and heat, with the cooling of the solution after the heating, obtain polyvinyl alcohol solution;
A2), under slow whipped state, MSM solution dropwise added carries out shaking table concussion de-bubble in the described PVA solution behind the solution, obtain mixing solutions.
Step a1 is the process of preparation PVA solution, in order to quicken the dissolving of PVA in water, the present invention is preferably dissolved PVA with water mixing post-heating, more preferably solution is heated to boiling, but consider that MSM is a kind of chemical property Unstable Substance, be subjected to thermal lability, therefore in poly-ethanolic soln, earlier solution cooled off before the adding MSM, to keep more MSM in the hydrogel that guarantees finally to make; In addition, in the process of PVA heating for dissolving in water, also can produce a lot of bubbles in the solution, if do not eliminate the transparency that can influence the hydrogel of final preparation, the process of cooling of PVA solution still leaves standstill the process of de-bubble.
Step a2 is the process that MSM is added PVA solution, the present invention is in order to improve MSM and PVA mixing uniformity, and the present invention is configured to solution with MSM, MSM solution is dropwise splashed in the PVA solution again, and slowly stir while dripping, slowly the reason that stirs is to reduce the bubble generation.MSM solution is dropwised the back still can have bubble in the solution, but because the present invention is freezing crosslinked, bubble is more difficult removing in subsequent handling, therefore in order to improve the transparency of aerogel dressing, carry out a de-bubble again after preferably dimethyl sulfone being added PVA solution, consider that to leave standstill de-bubble speed slower, and MSM easily is deposited on the solution bottom, therefore the present invention adopts shaking table concussion de-bubble, fully removes the bubble in the mixing solutions when guaranteeing MSM and PVA mixing uniformity.
Obtain according to the method described above just the solution casting film forming to be specially behind the mixing solutions of PVA and MSM: pour mixing solutions in system film ware casting film-forming.Then film forming solution is carried out repeatedly freezing crosslinkedly, carry out repeatedly freezing crosslinked purpose and be to make PVA that the MSM sex change takes place to avoid crosslinked the time.Freezing repeatedly crosslinkedly preferably carry out in the following manner: the solution of casting film-forming more than-10 ℃～-90 ℃ freezing 12h, is placed the room temperature 1h～3h that thaws, so repeatedly for several times again.Mixing solutions is in refrigerating process, and PVA is intermolecular to form tridimensional network by intermolecular hydrogen bond and microlitic structure, and MSM is fixed in the space of tridimensional network.The refrigerated number of times is many more, and PVA is crosslinked perfect more, preferably freezing repeatedly crosslinked 3～10 times of the present invention, and the freezing repeatedly hydrogel that just obtains after crosslinked is scalded dressing.
By such scheme as can be known, it is to be raw material with PVA and MSM that hydrogel provided by the invention is scalded dressing preparation method, cooperates and adopts freezing repeatedly crosslinking to be prepared from.Wherein PVA is a main film forming substance, it has better biocompatibility and degradation property, the adding of MSM then improves the penetrating quality of hydrogel, the healing properties and the analgesic property of wound when guaranteeing former PVA hydrogel physicals, freezing repeatedly rule is the stability that guarantees MSM in the PVA cross-linking process to greatest extent, avoids MSM because of the sex change loss.The hydrogel that makes is according to the method described above scalded dressing and is had excellent biological compatibility and wettability, can promote cell new life, accelerating wound healing, and hemostatic analgesia has reduced the patient suffering.
Further, the present invention also adds the mode and the time of polyvinyl alcohol solution by control MSM, and the de-bubble mode obtains the higher high-clarity hydrogel scald dressing of MSM content.
Accordingly, the present invention also provides a kind of hydrogel to scald dressing, comprising: PVA, MSM and water, and wherein the weight ratio of PVA and MSM is (0.01～10): 100, the concentration of PVA is preferably 10wt%～15wt%, and the weight ratio of PVA and MSM is (0.1～1) more preferably: 100.As shown in the above, this hydrogel is scalded dressing except that having excellent biological compatibility and wettability, also can promote cell new life, accelerating wound healing, and hemostatic analgesia has reduced the patient suffering.
In order further to understand the present invention, below in conjunction with embodiment hydrogel provided by the invention to be scalded dressing and be described, protection scope of the present invention is not limited by the following examples.
1, configuration concentration is the PVA solution of 8wt%, 12wt% and 15wt% respectively, and is heated to 100 ℃ while stirring, and PVA is dissolved in the water fully.
2, three kinds of PVA solution that step 1 made place-20 ℃ of freezing 20h, take out then to place the room temperature 2h that thaws, and freezing so repeatedly crosslinked 6 times, obtain the PVA aerogel dressing that concentration is respectively 8wt%, 12wt% and 15wt%.
Test the extension tensile property of above-mentioned three kinds of PVA aerogel dressings, being illustrated in figure 1 as concentration is the PVA aerogel dressing tensile strength column diagram of 8wt%, 12wt% and 15wt%, as seen from the figure, the PVA aerogel dressing of 12wt% has good extension tensile property.
1, configuration concentration is the PVA solution of 12wt%, and is heated to 100 ℃ while stirring, and PVA is dissolved fully, and PVA solution is cooled to room temperature.
2, under slow whipped state, dropwise splash into MSM solution in PVA solution, the weight ratio of PVA is 0.01: 100 in MSM in the MSM solution of adding and the PVA solution, after dropwising the solution shaking table is at the uniform velocity shaken de-bubble, obtains clarifying mixing solutions.
3, the mixing solutions that step 3 is obtained is poured casting film-forming in the system film ware into.
4, the solution after the film forming is placed freezing 20h in-20 ℃ the refrigerator, removes and place the room temperature 2h that thaws, 6 times so repeatedly, obtain hydrogel and scald dressing.
The weight ratio of PVA is 0.1: 100 in MSM in the MSM solution that the difference of present embodiment and enforcement 2 is to add in the step 2 and the PVA solution, and all the other operations are all identical with embodiment 2.
Embodiment 4
The weight ratio of PVA is 1: 100 in MSM in the MSM solution that the difference of present embodiment and enforcement 2 is to add in the step 2 and the PVA solution, and all the other operations are all identical with embodiment 2.
Embodiment 5
The weight ratio of PVA is 10: 100 in MSM in the MSM solution that the difference of present embodiment and enforcement 2 is to add in the step 2 and the PVA solution, and all the other operations are all identical with embodiment 2.
Get the PVA aerogel dressing of 12wt% of embodiment 1 preparation and the aerogel dressing of embodiment 2～5 preparations, numbering is followed successively by a, b, c, d, e.The tensile property of test a, b, d and this 4 kinds of aerogel dressings of e, Fig. 2 is an aerogel dressing tensile strength column diagram, experiment showed, that the adding of MSM does not impact the mechanical property of hydrogel.
The water content of test a, b, c, d and this 5 kinds of aerogel dressings of e, Fig. 3 is an aerogel dressing water content column diagram, experiment showed, that the adding of MSM does not impact the water content of hydrogel.
The dehydration rate of test a, b, d and this 4 kinds of aerogel dressings of e, Fig. 4 is an aerogel dressing dehydration rate change curve in time, experiment showed, that the adding of MSM does not impact the dehydration rate of hydrogel.
The water-intake rate of test a, b, c, d and this 5 kinds of aerogel dressings of e, Fig. 5 is an aerogel dressing water-intake rate change curve in time, experiment showed, that the adding of MSM does not impact the water absorbing properties of hydrogel.
The water vapor transmission rate (WVTR) of test a, b, d and this 4 kinds of aerogel dressings of e, Fig. 6 is an aerogel dressing water vapor transmission rate (WVTR) column diagram, among the figure
With
Represent the water vapor transmission rate (WVTR) of hydrogel behind 6h, 12h, 24h and the 48h respectively, experiment showed, that the adding of MSM does not impact the water vapor transmission rate (WVTR) of hydrogel.
This 4 kinds of aerogel dressings of a, b, d and e are carried out cytotoxicity experiment, are specially:
Experimental group 1: with aerogel dressing a and nutritive medium co-cultivation cell;
Experimental group 2: with aerogel dressing b and nutritive medium co-cultivation cell;
Experimental group 3: with aerogel dressing d and nutritive medium co-cultivation cell;
Experimental group 4: with aerogel dressing e and nutritive medium co-cultivation cell;
Blank group: the blank group of the nutritive medium of aqueous gel dressing not.
Behind culturing cell 24h, 48h and the 72h, collecting cell is cultivated vat liquor, adopts MTT colorimetry test vat liquor toxicity, and Fig. 7 is a vat liquor toxicity column diagram behind 24h, 48h and the 72h, the figure neutralization
Represent experimental group 1, experimental group 2, experimental group 3, experimental group 4 and control group respectively.By experiment as can be known, the equal nontoxicity of above-mentioned aerogel dressing, just aerogel dressing e pair cell has slight restraining effect, and the vat liquor cell growth of aerogel dressing d is useful.
With a, b, c, this 5 kinds of aerogel dressings of d and e are experimental group, nutritive medium with not aqueous gel dressing is the blank group, the fluoroscopic examination cell is in the propagation situation of hydrogel surface, experiment surface: with respect to pure PVA hydrogel, MSM/PVA hydrogel pair cell has certain proliferation function, when MSM concentration is no more than 0.1%, continuous increase along with MSM concentration, the competence for added value of cell strengthens gradually, the proliferation function of pair cell is the strongest when MSM concentration reaches 0.1%, when MSM concentration surpassed 0.1%, the proliferation function of pair cell decreased, but all is higher than pure PVA hydrogel.
Aerogel dressing to embodiment 2～embodiment 4 preparations carries out extracorporeal releasing experiment, is specially:
The aerogel dressing of embodiment 2～embodiment 4 preparations is all cut into the heavy and material block of the same size of 5mg, subsequently material block is soaked in (PB S in the centrifuge tube that purified phosphate buffered saline buffer is housed, pH=7.2), with the centrifuge tube good seal prevent with 37 ℃ of constant incubators in, slowly discharge, take out release liquid at 0.5h, 1h, 2h, 4h, 8h, 12h, 16h, 20h and 24h respectively and adopt the former transmitter of ICP-OES inductively coupled plasma to measure the burst size of MSM.Test result is as follows: along with the prolongation of time, the burst size of MSM increases gradually, and reaches balance behind the 24h, and final burst size reaches more than 55%.
The aerogel dressing of embodiment 2～embodiment 5 preparations is carried out the wound healing experiment, is specially:
The guinea pig back experimental section is removed by hair with electric shaver-for women, used 8% Na again
2The S depilation places the 6s of skin place of depilation with the homothermic electric iron, and scalding area is that diameter is the circular small area scald of 1cm.
With cavy part is four groups at random, is followed successively by experimental group one～experimental group four and control group, as follows to the processing mode of each group mouse:
Control group: the tincture of iodine cleans the surface of a wound and skin on every side, removes necrotic tissue or purulent secretion, subsequently sterile gauze is covered on the surface of a wound, and the timed interval of changing dressings once a day;
Experimental group one: clean the surface of a wound and skin on every side with the tincture of iodine, remove necrotic tissue or purulent secretion, subsequently hydrogel b is covered on the surface of a wound, the timed interval of changing dressings once a day;
Experimental group two: clean the surface of a wound and skin on every side with the tincture of iodine, remove necrotic tissue or purulent secretion, subsequently hydrogel c is covered on the surface of a wound, the timed interval of changing dressings once a day;
Experimental group three: clean the surface of a wound and skin on every side with the tincture of iodine, remove necrotic tissue or purulent secretion, subsequently hydrogel d is covered on the surface of a wound, the timed interval of changing dressings once a day;
Experimental group four: clean the surface of a wound and skin on every side with the tincture of iodine, remove necrotic tissue or purulent secretion, subsequently hydrogel e is covered on the surface of a wound, the timed interval of changing dressings once a day;
Gather photo when change dressings every day,, test in respectively at 3day in order to observe the rehabilitation situation on surface of a wound surface, 5day, 7day, 15day, 30day take the skin histology sample, adopt Paraformaldehyde 96 to fix, and make histopathology and immunohistochemistry and observe.
It is as follows that scald back 1day respectively organizes the guinea pig back skin conditions: the skin wound scald place that scalds the back cavy is light yellow, clear with the surrounding skin boundary, the scald wound periphery has red and swollen the appearance, the surface of a wound is apparently higher than normal artificial skin, the extensibility of surface of a wound skin obviously descends, and the toughness of skin strengthens.Scald back 7day and do not have apparent in view variation from outward appearance observation scald wound, surface of a wound swelling all disappears, have and the isolating trend of peripheral skin but the scald place becomes smooth, the surface of a wound begins to shrink, and diminishes than preceding area, the hardening of crust thickening, color and luster is a light tan, and what crust was still complete covers on the surface of a wound, when crust is peeled off fully, the surface of a wound is epithelization, presents graniphyric.Scald back 15day, downright bad scalded skin surface crust comes off fully, and the surface of a wound shrinks, and the surface of a wound is covered by new scab, presents garnet, catches that it is harder to touch quality, and wherein the incrustation of the mouse of experimental group one～experimental group four is less relatively and surface of a wound color healing is more shallow.Scald back 30day, the little tree wound healing of experimental group one～experimental group four is better, and incrustation comes off fully, catches that it is harder to touch, and part skin presents light red.
Carry out the histological stain observation in experiment beginning 1 day, 7 days, 15 days and 30 days guinea pig skin tissues respectively to experimental group two～experimental group five and control group, getting guinea pig back surface of a wound skin fixes with Paraformaldehyde 96, be made into paraffin section and carry out HE dyeing, carry out the healing state of branch surface of a wound skin from the histology angle.
Experimental result is as follows:
Test 1day: skin histology mesocuticle and high dermis be the necrosis of solidifiability, but profile remains, and hair follicle mechanism is destroyed, and fibrous tissue and reticular tissue short texture do not have obvious structure.
Test not clearly the difference of 7day and 15day:HE dyeing tissue, the skin histology structure is still loose, but part fibrous tissue and reticular tissue have had formation trend.
Test 30day: trauma skin heals gradually, and epidermal structure is more even, and wherein the cavy of experimental group two～experiment four group recovers very fast, consistent gradually with healthy skin on every side, possess complete skin texture, the skin corium fiber is formed tissue and is arranged densification, and capillary vessel is rare.
By The above results as can be known, when the add-on of MSM does not surpass the 10wt% of PVA content, the adding of MSM does not impact mechanical property, water content, dehydration rate water vapor transmission rate (WVTR) and the swelling water-intake rate of PVA hydrogel, adopt the hydrogel scald dressing of method preparation provided by the invention to have the wound healing of promotion and alleviate analgesic effect, the patient's who effectively alleviates pain.
Above embodiment's, illustrate just to be used for helping to understand method of the present invention and core concept thereof.Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention, can also carry out some improvement and modification to the present invention, these improvement and modification also fall in the protection domain of claim of the present invention.
To the above-mentioned explanation of the disclosed embodiments, make this area professional and technical personnel can realize or use the present invention.Multiple modification to these embodiment will be conspicuous concerning those skilled in the art, and defined herein General Principle can realize under the situation that does not break away from the spirit or scope of the present invention in other embodiments.Therefore, the present invention will can not be restricted to these embodiment shown in this article, but will meet and principle disclosed herein and features of novelty the wideest corresponding to scope.
Claims (8)
1. the preparation method of hydrogel scald dressing is characterized in that, comprising:
A), in polyvinyl alcohol solution, add dimethyl sulfone, obtain mixing solutions, dimethyl sulfone and poly weight ratio are (0.01～10) in the described mixing solutions: 100;
B), with described mixing solutions casting film-forming;
C), the solution of casting film-forming is carried out repeatedly freezing crosslinked, obtain hydrogel and scald dressing.
2. preparation method according to claim 1 is characterized in that step a is specially:
A1), polyvinyl alcohol mixed with water and heat, with the cooling of the solution after the heating, obtain polyvinyl alcohol solution;
A2), under slow whipped state, carry out shaking table concussion de-bubble after dimethyl sulfone solution dropwise added described polyvinyl alcohol solution, obtain mixing solutions.
3. preparation method according to claim 2 is characterized in that, the concentration of polyvinyl alcohol solution is 10wt%～15wt% in the described mixing solutions.
4. preparation method according to claim 3 is characterized in that, the weight ratio of dimethyl sulfone solution and polyvinyl alcohol is (0.1～1) in the described mixing solutions: 100.
5. preparation method according to claim 1 is characterized in that, described step c is specially: described solution with casting film-forming-10 ℃～-90 ℃ freezing more than 12 hours, place the room temperature 1h～3h that thaws again, so repeatedly for several times.
6. a hydrogel is scalded dressing, it is characterized in that comprise: polyvinyl alcohol, dimethyl sulfone and water, the weight ratio of described dimethyl sulfone and polyvinyl alcohol are (0.01～10): 100.
7. hydrogel according to claim 7 is scalded dressing, it is characterized in that the concentration of described polyvinyl alcohol is 10wt%～15wt%.
8. hydrogel according to claim 7 is scalded dressing, it is characterized in that the weight ratio of described dimethyl sulfone solution and polyvinyl alcohol is (0.1～1): 100.
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Application publication date: 20111019 |