CN111542335A - 炎症性肠病的治疗药 - Google Patents

炎症性肠病的治疗药 Download PDF

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Publication number
CN111542335A
CN111542335A CN201880084992.7A CN201880084992A CN111542335A CN 111542335 A CN111542335 A CN 111542335A CN 201880084992 A CN201880084992 A CN 201880084992A CN 111542335 A CN111542335 A CN 111542335A
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China
Prior art keywords
inflammatory bowel
bowel disease
peptide
amino acid
dss
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Pending
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CN201880084992.7A
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English (en)
Chinese (zh)
Inventor
玉井克人
新保敬史
山崎尊彦
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Stremium GmbH
University of Osaka NUC
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Stremium GmbH
Osaka University NUC
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Publication of CN111542335A publication Critical patent/CN111542335A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201880084992.7A 2017-12-01 2018-11-30 炎症性肠病的治疗药 Pending CN111542335A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762593310P 2017-12-01 2017-12-01
US62/593,310 2017-12-01
JP2018020686 2018-02-08
JP2018-020686 2018-02-08
PCT/JP2018/044122 WO2019107530A1 (ja) 2017-12-01 2018-11-30 炎症性腸疾患の治療薬

Publications (1)

Publication Number Publication Date
CN111542335A true CN111542335A (zh) 2020-08-14

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ID=66664517

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880084992.7A Pending CN111542335A (zh) 2017-12-01 2018-11-30 炎症性肠病的治疗药

Country Status (5)

Country Link
US (1) US11298403B2 (https=)
EP (1) EP3718561A4 (https=)
JP (2) JPWO2019107530A1 (https=)
CN (1) CN111542335A (https=)
WO (1) WO2019107530A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023138644A1 (zh) * 2022-01-21 2023-07-27 四川好医生攀西药业有限责任公司 多肽化合物及其治疗肠炎的用途
CN116693612A (zh) * 2023-06-28 2023-09-05 禾美生物科技(浙江)有限公司 一种环肽及其用途
CN117224655A (zh) * 2023-09-14 2023-12-15 大连医科大学 蝎毒耐热合成肽(svhrsp)在制备治疗肠道炎症的药物中的应用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2654542T3 (es) 2008-04-30 2018-02-14 Genomix Co., Ltd. Procedimiento de recolección de células funcionales in vivo con alta eficiencia
US11191786B2 (en) 2009-10-28 2021-12-07 StemRIM Inc. Agents for promoting tissue regeneration by recruiting bone marrow mesenchymal stem cells and/or pluripotent stem cells into blood
US11969459B2 (en) 2017-01-27 2024-04-30 StemRIM Inc. Therapeutic agent for cardiomyopathy, old myocardial infarction and chronic heart failure
CA3084013A1 (en) 2017-12-01 2019-06-06 StemRIM Inc. Ectodermal mesenchymal stem cells and method for producing same
WO2019156137A1 (ja) 2018-02-08 2019-08-15 株式会社ステムリム 乾癬の治療薬
US12304933B2 (en) 2018-10-05 2025-05-20 StemRIM Inc. Disease treatment drug based on mesenchymal-stem-cell mobilization
JP7405345B2 (ja) * 2018-10-05 2023-12-26 株式会社ステムリム 間葉系幹細胞の動員活性を有するペプチド
WO2020085506A1 (ja) * 2018-10-25 2020-04-30 国立大学法人大阪大学 軟骨疾患の治療薬
IL296982B2 (en) * 2020-04-03 2026-04-01 Stemrim Inc Peptide with mesenchymal stem cell migration activity
EP4147711A4 (en) * 2020-04-20 2024-04-24 Shionogi & Co., Ltd FORMULATION WITH A HMGB1 PARTIAL PEPTIDE

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004046345A2 (en) * 2002-11-20 2004-06-03 Critical Therapeutics, Inc. Use of hmgb fragments as anti-inflammatory agents
WO2005025604A2 (en) * 2003-09-10 2005-03-24 The General Hospital Corporation Use of hmgb and hmgb fragments to decrease specific immune response
US20080038309A1 (en) * 2004-09-03 2008-02-14 Creabilis Therapeutics S.P.A. Use of polypeptides obtained through systematic mutations of single amino acids of human and non-human Box-A of HMGB1 to prevent and/or antagonize pathologies induced by HMGB1
CN107188948A (zh) * 2011-04-26 2017-09-22 吉诺米克斯股份有限公司 用于诱导组织再生的肽及其应用

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023138644A1 (zh) * 2022-01-21 2023-07-27 四川好医生攀西药业有限责任公司 多肽化合物及其治疗肠炎的用途
CN116693612A (zh) * 2023-06-28 2023-09-05 禾美生物科技(浙江)有限公司 一种环肽及其用途
CN116693612B (zh) * 2023-06-28 2025-02-18 禾美生物科技(浙江)有限公司 一种环肽及其用途
CN117224655A (zh) * 2023-09-14 2023-12-15 大连医科大学 蝎毒耐热合成肽(svhrsp)在制备治疗肠道炎症的药物中的应用
CN117224655B (zh) * 2023-09-14 2024-05-14 大连医科大学 蝎毒耐热合成肽(svhrsp)在制备治疗肠道炎症的药物中的应用

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Publication number Publication date
EP3718561A4 (en) 2021-07-21
WO2019107530A1 (ja) 2019-06-06
US20200384074A1 (en) 2020-12-10
JP7590724B2 (ja) 2024-11-27
JP2023134616A (ja) 2023-09-27
EP3718561A1 (en) 2020-10-07
US11298403B2 (en) 2022-04-12
JPWO2019107530A1 (ja) 2020-11-26

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