CN111494498A - 一种辅助睡眠植物饮料及其制备方法和应用 - Google Patents
一种辅助睡眠植物饮料及其制备方法和应用 Download PDFInfo
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- CN111494498A CN111494498A CN202010210038.7A CN202010210038A CN111494498A CN 111494498 A CN111494498 A CN 111494498A CN 202010210038 A CN202010210038 A CN 202010210038A CN 111494498 A CN111494498 A CN 111494498A
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Abstract
本发明公开了一种辅助睡眠植物饮料及其制备方法和应用，所述辅助睡眠植物饮料的成分包括：蜂蜜、白砂糖、五味子提取物、刺五加提取物、山楂提取物、核桃仁提取物和阿胶。本发明依据中医君臣佐使理论进行合理配伍，使保健饮料具有更好的风味、更强的辅助睡眠作用。
Description
技术领域
本发明涉及一种辅助睡眠植物饮料及其制备方法和应用。
背景技术
目前，由于环境，生活习惯的影响，如常见的有睡眠环境的突然改变(强光、噪声、高温)、睡前饮茶，饮咖啡，吸烟、摄入或接触某些物质或药物、睡眠卫生不当或情绪因素等，都可导致失眠的发生，已经成为影响健康的重大因素。相关治疗失眠药物，主要为西药的镇静剂，通过麻痹神经起到促进睡眠作用。有的效果不甚明显并且长期使用会带来一定的副作用，比如会出现精神不振、头疼和记忆力下降等情况。因此，目前急需建立更安全有效的方法。
中国专利网公开了一种缓解失眠症状的草本植物固体饮料及其制备方法(CN107088215A)，其成分组成为小麦、甘草、大枣、百合、酸枣仁、山药、茯苓、龙眼、玫瑰花。而本发明以蜂蜜、白砂糖、五味子、刺五加、山楂、核桃仁、阿胶为原料，在成分上同其有明显的不同，加入了具有促进睡眠的刺五加、五味子、阿胶等成分；在实际应用上，本发明是植物饮料，同该专利固体饮料相比，直接可以饮用，口感好，适用性更广。
通过中国知网检索未发现相关以蜂蜜、白砂糖、五味子、刺五加、山楂、核桃仁、阿胶为原料制备辅助睡眠植物饮料的相关文献。但可以查到部分成分的相关文献：1.澄清型刺五加饮料生产工艺：该篇文献主要对饮料的生产工艺进行了阐述，没有提到饮料的具体功效；2.改善睡眠功能性饮料酒的开发：该篇文献主要以酸枣仁为原料制备改善睡眠保健酒，不是以水为基质的饮料，且研究的原料成分同本发明无关；3.黄连阿胶汤治疗失眠的临床研究：该文献表明黄连阿胶汤可以改善睡眠，表明阿胶同其他中药可以起到辅助睡眠作用；4.五味子功能饮料及保健葡萄酒的研制：该文献表明五味子可以改善睡眠提高免疫力。但保健酒限制了其应用的范围，且研究成分同本发明不同，仅是其中一种成分。
总之，通过检索专利和相关文献未见体现本发明的以蜂蜜、白砂糖、五味子、刺五加、山楂、核桃仁、阿胶为原料制备辅助睡眠植物饮料的文献和专利成果。
发明内容
本发明的目的在于，克服现有技术中的存在副作用及口感不好的缺点，进而提供一种辅助睡眠植物饮料，具有很好的口感，易服用，且具有很好的辅助睡眠功效。
为了达到上述目的，本发明采用了以下技术手段：
本发明提供一种辅助睡眠植物饮料，所述辅助睡眠植物饮料的成分包括：蜂蜜、白砂糖、五味子提取物、刺五加提取物、山楂提取物、核桃仁提取物和阿胶。
优选的，所述辅助睡眠植物饮料的各成分所占重量百分比为：蜂蜜3-5％、白砂糖3-5％、五味子提取物2-4％、刺五加提取物2-3％、山楂提取物3-5％、核桃仁提取物1-2％、阿胶2-4％，其余为水。
优选的，所述辅助睡眠植物饮料的各成分所占重量百分比为：蜂蜜3％、白砂糖3％、五味子提取物2％、刺五加提取物3％、山楂提取物3％、核桃仁提取物1％、阿胶2％，其余为水。
本发明还提供所述辅助睡眠植物饮料的制备方法，包括以下步骤：
(1)水提取
分别将刺五加、山楂、核桃仁粉碎，并分别加入到自身重量5～10倍的水中，煎煮1～5小时，煎煮1～3次，过滤，将各滤液浓缩，分别得到刺五加水提取物、山楂水提取物和核桃仁水提取物；
(2)乙醇提取
将五味子及步骤(1)得到的各水提取物分别加入到自身重量1～5倍的乙醇中，静置12～24小时，过滤，将各滤液浓缩，分别得到五味子提取物、刺五加提取物、山楂提取物和核桃仁提取物；
(3)配置饮料
将蜂蜜、白砂糖、五味子提取物、刺五加提取物、山楂提取物、核桃仁提取物和阿胶混按照比例混匀，用水定容到100％，过滤，杀菌，灌装，即得。
本发明还提供所述辅助睡眠植物饮料在制备治疗失眠药物中的应用。
本发明所涉及原料的作用及其功效为：
蜂蜜：含有丰富的维生素和矿物质，具有安神益智、舒缓安眠、缓解压力和紧张等作用，此外可以调节饮料的口感。
白砂糖：可以提供能量，改善饮料的口感。
五味子：五味子含有丰富的维生素、有机酸、类黄酮，植物固醇、木酚素等，可以调节中枢神经系统的兴奋和抑制过程，对于工作疲劳、睡眠不足、睡眠障碍、心悸紊乱等症状有明显的调节作用，对于提高记忆力也有一定的作用。
刺五加：含有丰富的皂苷和多糖等，可以直接作用于中枢神经系统，对于神经衰弱、失眠多梦、等症状，有明显的预防和调理作用。
山楂：山楂具有可以开胃、促进消化、治疗腹泻、降血脂、降血压等作用。
核桃仁：核桃仁富含有丰富的卵磷脂和维生素E，具有润肠通便、健脑益智的功效。对于肾虚、腰冷疼痛、须发早白、记忆力减退和消化不良等症状都有明显的作用。
阿胶：阿胶具有滋阴养血补虚，能强化钙素营养，维护神经功能等作用。还能增强中枢神经功能，稳定精神情绪，消除抑郁，紧张，烦躁，起到安神功效。
相较于现有技术，本发明的有益效果在于：
1、本发明遵循“君臣佐使”理论，以阿胶为君，以五味子、刺五加共为臣，以核桃仁为佐，以山楂为使，在配以蜂蜜、白砂糖具有更好的口感，五味子、刺五加等具有促进睡眠的作用，而阿胶、山楂、核桃仁等具有补血、补气、营养神经等作用，整体具有很好的辅助睡眠功效。
2、本发明通过动物实验睡眠功效评价证明可以有效地促进睡眠。
具体实施方式
下面结合具体实施例来进一步描述本发明，本发明的优点和特点将会随着描述而更为清楚。但这些实施例仅是范例性的，并不对本发明的范围构成任何限制。本领域技术人员应该理解的是，在不偏离本发明的精神和范围下可以对本发明技术方案的细节和形式进行修改或替换，但这些修改和替换均落入本发明的保护范围内。
实施例1
本实施例的辅助睡眠植物饮料的各成分所占重量百分比为：
蜂蜜3％、白砂糖3％、五味子提取物2％、刺五加提取物3％、山楂提取物3％、核桃仁提取物1％、阿胶2％，其余为水。
本实施例的辅助睡眠植物饮料的制备方法为：
(1)水提取
分别将刺五加、山楂、核桃仁粉碎，并分别加入到自身重量7倍的水中，煎煮3小时，煎煮2次，过滤，将各滤液浓缩，分别得到刺五加水提取物、山楂水提取物和核桃仁水提取物；
(2)乙醇提取
将五味子及步骤(1)得到的各水提取物分别加入到自身重量3倍的乙醇中，静置18小时，过滤，将各滤液浓缩，分别得到五味子提取物、刺五加提取物、山楂提取物和核桃仁提取物；
(3)配置饮料
将蜂蜜、白砂糖、五味子提取物、刺五加提取物、山楂提取物、核桃仁提取物和阿胶混按照比例混匀，用水定容到100％，过滤，杀菌，灌装，即得。
实施例2
本实施例的辅助睡眠植物饮料的各成分所占重量百分比为：
蜂蜜4％、白砂糖4％、五味子提取物3％、刺五加提取物3％、山楂提取物4％、核桃仁提取物2％、阿胶4％，其余为水。
本实施例的辅助睡眠植物饮料的制备方法为：
(1)水提取
分别将刺五加、山楂、核桃仁粉碎，并分别加入到自身重量5倍的水中，煎煮1小时，煎煮两次，过滤，将各滤液浓缩，分别得到刺五加水提取物、山楂水提取物和核桃仁水提取物；
(2)乙醇提取
将五味子及步骤(1)得到的各水提取物分别加入到自身重量1倍的乙醇中，静置12小时，过滤，将各滤液浓缩，分别得到五味子提取物、刺五加提取物、山楂提取物和核桃仁提取物；
(3)配置饮料
将蜂蜜、白砂糖、五味子提取物、刺五加提取物、山楂提取物、核桃仁提取物和阿胶混按照比例混匀，用水定容到100％，过滤，杀菌，灌装，即得。
实施例3
本实施例的辅助睡眠植物饮料的各成分所占重量百分比为：
蜂蜜5％、白砂糖5％、五味子提取物4％、刺五加提取物3％、山楂提取物5％、核桃仁提取物2％、阿胶4％，其余为水。
本实施例的辅助睡眠植物饮料的制备方法为：
(1)水提取
分别将刺五加、山楂、核桃仁粉碎，并分别加入到自身重量10倍的水中，煎煮5小时，煎煮两次，过滤，将各滤液浓缩，分别得到刺五加水提取物、山楂水提取物和核桃仁水提取物；
(2)乙醇提取
将五味子及步骤(1)得到的各水提取物分别加入到自身重量5倍的乙醇中，静置24小时，过滤，将各滤液浓缩，分别得到五味子提取物、刺五加提取物、山楂提取物和核桃仁提取物；
(3)配置饮料
将蜂蜜、白砂糖、五味子提取物、刺五加提取物、山楂提取物、核桃仁提取物和阿胶混按照比例混匀，用水定容到100％，过滤，杀菌，灌装，即得。
实验例
按照实施例1的辅助睡眠植物饮料配方配置成所需要浓度进行辅助睡眠实验。
1、实验设计
本实验包含3个部分。KM品系小白鼠90只，体重21～25g。将动物分成三个实验组，每组30只，分别进行延长戊巴比妥钠睡眠时间实验、戊巴比妥钠阈下剂量催眠实验和巴比妥钠睡眠潜伏期实验。每个实验分为3组，每组10只，分别为空白对照组(灌胃蒸馏水)、低剂量饮料组(灌胃低剂量饮料)和高剂量饮料组(灌胃高剂量饮料)。按照实施例1配方配置饮料的浓缩膏，人体推荐剂量为50ml/人/天(50ml/60kg·bw)，相当于摄入浓缩膏12.5g/60kg，即0.208g/kg·bw。以人推荐剂量的10倍(2.08g/kg·bw)和30倍(6.25g/kg·bw)为低剂量和高剂量。低剂量和高剂量受试物配置时，分别取样品浓缩膏20.8g和62.5g加蒸馏水配置成100ml溶液。灌胃体积均为0.1ml/10g·bw，连续30天。
2、实验方法
(1)延长戊巴比妥钠睡眠时间试验
小鼠末次灌胃15min后，腹腔注射戊巴比妥钠50mg/kg(预实验得到的能使100％小鼠均能产生翻正反射消失的剂量)。以翻正反射消失至恢复时间为睡眠时间，记录各组小鼠睡眠时间。
(2)戊巴比妥钠阈下剂量催眠试验
小鼠末次灌胃15min后，腹腔注射戊巴比妥钠28mg/kg(预实验得到的能使90％小鼠翻正反射不消失的戊巴比妥钠阈下剂量)，以翻正反射消失持续超过60s为入睡标志，记录30min内各组入睡动物数。
(3)巴比妥钠睡眠潜伏期试验
小鼠末次灌胃15min后，腹腔注射巴比妥钠240mg/kg(预实验得到的能使100％小鼠均能产生翻正反射消失的剂量)，以翻正反射消失为入睡标志，记录动物睡眠潜伏期(由注射巴比妥钠到动物翻正反射消失所需时间)。
3、数据处理
睡眠时间属计量资料，采用t检验；入睡动物数属计数资料，采用卡方检验，组间比较P<0.05为有统计学意义。
4、实验结果
低剂量饮料组和高剂量饮料组小鼠在给予样品后，部分小鼠表现为安静和活动减少，但没有小鼠翻正反射消失，而阴性对照组动物全部清醒，提示受试物对动物无直接睡眠作用。此外，与空白对照组相比，饮料组小鼠睡眠时间延长、睡眠潜伏期时间缩短，差异有统计学意义(P＜0.05)。实验数据参见表1。
表1饮料对小鼠改善睡眠的影响
*与对照组比较，有显著性差异P＜0.05。
结果：本发明的辅助睡眠植物饮料能明显延长戊巴比妥钠诱导的小鼠睡眠时间、缩短巴比妥钠睡眠潜伏期，表明有促进睡眠的功效。
Claims (5)
1.一种辅助睡眠植物饮料，其特征在于，所述辅助睡眠植物饮料的成分包括：蜂蜜、白砂糖、五味子提取物、刺五加提取物、山楂提取物、核桃仁提取物和阿胶。
2.根据权利要求1所述的辅助睡眠植物饮料，其特征在于，所述辅助睡眠植物饮料的各成分所占重量百分比为：蜂蜜3-5％、白砂糖3-5％、五味子提取物2-4％、刺五加提取物2-3％、山楂提取物3-5％、核桃仁提取物1-2％、阿胶2-4％，其余为水。
3.根据权利要求1所述的辅助睡眠植物饮料，其特征在于，所述辅助睡眠植物饮料的各成分所占重量百分比为：蜂蜜3％、白砂糖3％、五味子提取物2％、刺五加提取物3％、山楂提取物3％、核桃仁提取物1％、阿胶2％，其余为水。
4.制备如权利要求1-3任一项所述的辅助睡眠植物饮料的方法，其特征在于，包括以下步骤：
(1)水提取
分别将刺五加、山楂、核桃仁粉碎，并分别加入到自身重量5～10倍的水中，煎煮1～5小时，煎煮1～3次，过滤，将各滤液浓缩，分别得到刺五加水提取物、山楂水提取物和核桃仁水提取物；
(2)乙醇提取
将五味子及步骤(1)得到的各水提取物分别加入到自身重量1～5倍的乙醇中，静置12～24小时，过滤，将各滤液浓缩，分别得到五味子提取物、刺五加提取物、山楂提取物和核桃仁提取物；
(3)配置饮料
将蜂蜜、白砂糖、五味子提取物、刺五加提取物、山楂提取物、核桃仁提取物和阿胶混按照比例混匀，用水定容到100％，过滤，杀菌，灌装，即得。
5.如权利要求1-3任一项所述的辅助睡眠植物饮料在制备治疗失眠药物中的应用。
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