CN1114180A - 局部应用的化妆品或药物组合物 - Google Patents

局部应用的化妆品或药物组合物 Download PDF

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Publication number
CN1114180A
CN1114180A CN95105197A CN95105197A CN1114180A CN 1114180 A CN1114180 A CN 1114180A CN 95105197 A CN95105197 A CN 95105197A CN 95105197 A CN95105197 A CN 95105197A CN 1114180 A CN1114180 A CN 1114180A
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weight
pharmaceutical composition
cosmetic
compositions
topical use
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CN95105197A
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English (en)
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R·沃托里
A-M·斯科特
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Plant Ecology Laboratory
Laboratories de Biologie Vegetale Yves Rocher SA
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Plant Ecology Laboratory
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Application filed by Plant Ecology Laboratory filed Critical Plant Ecology Laboratory
Publication of CN1114180A publication Critical patent/CN1114180A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

本发明涉及局部应用的化妆品或药物组合物，它包括通过粉碎含油植物种子、在水相中乳化和过滤得到的脂类赋形剂。

Description

局部应用的化妆品或 药物组合物
本发明涉及局部应用的化妆品组合物和药物组合物，它们包括脂类赋形剂。
更详细地说，本发明涉及包括从含油植物种子中得到的脂类赋形剂的这类组合物。
在含油植物种子中，油(主要为三甘油)以油状体形式存在，油状体直径可以从0.1到10微米之间变化，并且包括一个中心油核，油核外围一层由蛋白质(含油树脂(oleosins))和磷脂组成的覆盖层(J.Tzen等，J.Cell.Bio，117,327,1992)。
这些油状体可以从含油植物提取，通过粉碎含油植物种子，在水相乳化及过滤，从含油植物中得到油状体。
本发明针对用这些油状体生产局部应用的化妆品和/或药物组合物。
因此，本发明的目的是局部应用的化妆品或药物组合物，它包括通过粉碎含油植物，在水相乳化和过滤得到的脂类赋形剂。
在本发明的优选方式中，替代将过滤后得到的乳液参入组合物，脂类赋形剂以乳液离心得到的浓缩物(具有乳油外观)形式参入组合物。
一般来说，脂类浓缩物可以以至多占组合物重量30％的量参入水相中。
可以提到的含油植物种子的实例是：大豆，乳香黄连木，昆士兰果，向日葵，油菜，花生，杏仁，榛子，芝麻，琉璃苣，麦胚和西蒙得木子。优选使用高油含量的种子(乳香黄连木，昆士兰果，花生，西蒙得木，榛子)。
乳液或浓缩物可以得到稳定，尤其是用下面技术：
细菌学稳定
—热处理种子(在不超过50℃下煮烧1小时或更长一段时间)；
—以0—10kGy照射种子；
—UHT处理油状体乳液(过滤后离心前)120℃×5秒；一任选地向乳化水中或向浓缩物稀释液的水相中加入防腐剂，例如
    ·对苯甲酸酯：    0—5％按重量计
    ·Na4EDTA：      0—0.1％按重量计
    ·抗坏血酸：      0—0.5％
    ·咪唑烷基脲：    0—0.5％按重量计
    ·脱氢乙酸钠：    0—0.5％按重量计
    ·亚硫酸钠：      0—0.5％按重量计
组合物的物理稳定性
通过调节粒子的ζ电位，向浓缩物稀释液的水相中加入最少量的化学组分，可以实现最后组合物的高度稳定性。
因此测定加入的相关组分作为该技术的结果：
在这些组分中，可以提到：
    —氯化钠            0—2％按重量计
    —柠檬酸            0—2％按重量计
    —水解果胶          0—1％按重量计
    —磷酸盐缓冲液      0—1％按重量计
本发明的这些组合物另外可以包括增稠剂如：
    —聚丙烯酸          0—1％按重量计
    —黄原胶            0—1％按重量计
    —Scleran gum       0—1％按重量计
    —膨润土及衍生物    0—2％按重量计
    —聚丙烯酰胺及衍生物    0—2％按重量计
    —卡罗布胶和鹿角菜胶    0—2％按重量计
本发明的组合物可另外含有调色剂和香料。
本发明的这些组合物相当于相存的化妆品组合物，但它们比后者具有下面优点：
—无合成的和外源的乳化体系，导致更好的皮肤耐受性；
—含油树脂具有类似于动物脂蛋白的脱辅基蛋白构型的抗原决定基。因此它们可被皮肤脂酶接受。
本发明的组合物因此通过其生物学相似性可以使权利要求比基于合成乳化剂的现存化妆品组合物具有更好的直接性。
下面给出本发明的实施例
应用实施例
实施例1
面乳
用一种叶轮破碎机研磨事先已从微生物学观点稳定的昆士兰果。
90份水，加或不加防腐剂和抗氧剂，加到10份磨碎的制剂中，在不超过35℃的温度下适中地搅拌半小时。
然后用带有冲洗装置的前沿过滤器(200微米筒)过滤上述乳化液(乳)以便除去植物粕。
然后可用离心浓缩以这种方式过滤的乳化液。优选用制酪机进行这种操作。
所得浓缩物(乳油)脂肪含量为60％(按重量计)。
然后稀释、增稠及调香这种浓缩物，形成下面组合物：
    —浓缩物        15—30％按重量计
    —黄原胶        1—2％按重量计
    —香料          0.1—0.5％按重量计
    —防腐剂        余量(qs)
    —水            余量100％按重量计实施例2
晚霜的制备
实施例1中制备的浓缩物可用于生产下面组合物：
    —浓缩物        20—30％按重量计
    —甘油          2—5.0％按重量计
    —黄原胶        1—2.0％按重量计
    —聚丙烯酰胺    5—10％按重量计
    —香料          0.1—0.5％按重量计
    —防腐剂        余量(qs)
    —水            余量100％按重量计

Claims (3)

1.局部应用的化妆品或药物组合物，它包括通过粉碎含油植物种子、在水相中乳化及过滤得到的脂类赋形剂。
2.按照权利要求1的组合物，其中脂类赋形剂以通过离心得到的浓缩物形式被参入。
3.按照权利要求2的组合物，在水相中包括至多30％(按重量计)由离心得到的浓缩物。
CN95105197A 1994-05-02 1995-04-28 局部应用的化妆品或药物组合物 Pending CN1114180A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9405320A FR2719219B1 (fr) 1994-05-02 1994-05-02 Composition cosmétique ou pharmaceutique à usage topique comprenant des vésicules lipidiques.
FR9405320 1994-05-02

Publications (1)

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CN1114180A true CN1114180A (zh) 1996-01-03

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US (1) US5643583A (zh)
EP (1) EP0680750B1 (zh)
JP (1) JPH07300411A (zh)
KR (1) KR100221793B1 (zh)
CN (1) CN1114180A (zh)
AT (1) ATE187636T1 (zh)
BR (1) BR9501815A (zh)
CA (1) CA2148074C (zh)
DE (1) DE69513878T2 (zh)
DK (1) DK0680750T3 (zh)
ES (1) ES2142463T3 (zh)
FR (1) FR2719219B1 (zh)
GR (1) GR3032888T3 (zh)
PT (1) PT680750E (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1084595C (zh) * 1997-05-27 2002-05-15 塞姆柏奥希斯遗传学公司 油体的用途

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KR101332869B1 (ko) * 2005-04-15 2013-11-25 알버트 아인슈타인 컬리지 오브 메디신 오브 예쉬바 유니버시티 항-ｅｇｆｒ 치료법에 속발된 피부 발진의 예방 및 치료를위한 비타민 ｋ
EP2018144A2 (en) * 2006-04-13 2009-01-28 The Boots Company PLC Composition and uses thereof
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US9445975B2 (en) 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
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EP2228052A1 (en) * 2009-03-09 2010-09-15 Coty Deutschland GmbH Cosmetic basic composition and use thereof
FR3052064B1 (fr) * 2016-06-01 2020-01-24 Sirius Procede d'obtention d'emulsion stable a partir de graines entieres oleo-proteagineuses, l'emulsion obtenue et les compositions cosmetiques comprenant ladite emulsion

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
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Also Published As

Publication number Publication date
CA2148074A1 (en) 1995-11-03
DK0680750T3 (da) 2000-04-25
KR950031015A (ko) 1995-12-18
GR3032888T3 (en) 2000-07-31
EP0680750B1 (fr) 1999-12-15
JPH07300411A (ja) 1995-11-14
CA2148074C (en) 1999-07-13
BR9501815A (pt) 1996-03-05
DE69513878D1 (de) 2000-01-20
ES2142463T3 (es) 2000-04-16
KR100221793B1 (ko) 1999-09-15
EP0680750A1 (fr) 1995-11-08
DE69513878T2 (de) 2000-05-18
ATE187636T1 (de) 2000-01-15
US5643583A (en) 1997-07-01
FR2719219B1 (fr) 1996-06-21
PT680750E (pt) 2000-05-31
FR2719219A1 (fr) 1995-11-03

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