CN111417622A - 用于治疗与nlrp活性相关的病症的磺胺类及其组合物 - Google Patents

用于治疗与nlrp活性相关的病症的磺胺类及其组合物 Download PDF

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CN111417622A
CN111417622A CN201880077068.6A CN201880077068A CN111417622A CN 111417622 A CN111417622 A CN 111417622A CN 201880077068 A CN201880077068 A CN 201880077068A CN 111417622 A CN111417622 A CN 111417622A
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alkyl
aryl
membered
radical
alkoxy
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S·文卡特拉曼
S·古什
W·R·鲁什
沈东明
J·卡茨
H·M·塞德尔
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Novartis AG
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Novartis Inflammasome Research Inc
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    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D498/04—Ortho-condensed systems
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
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    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201880077068.6A 2017-10-17 2018-10-12 用于治疗与nlrp活性相关的病症的磺胺类及其组合物 Pending CN111417622A (zh)

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US201762573562P 2017-10-17 2017-10-17
US62/573,562 2017-10-17
PCT/US2018/055576 WO2019079119A1 (en) 2017-10-17 2018-10-12 SULFONAMIDES AND ASSOCIATED COMPOSITIONS FOR THE TREATMENT OF PATHOLOGICAL CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

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US (1) US11718631B2 (cg-RX-API-DMAC10.html)
EP (1) EP3697758B1 (cg-RX-API-DMAC10.html)
JP (1) JP7157804B2 (cg-RX-API-DMAC10.html)
CN (1) CN111417622A (cg-RX-API-DMAC10.html)
ES (1) ES2927851T3 (cg-RX-API-DMAC10.html)
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CN114133345A (zh) * 2020-12-17 2022-03-04 顺毅宜昌化工有限公司 一种2-氯磺酰基-4-甲磺酰胺甲基苯甲酸甲酯的制备方法
WO2022237781A1 (zh) * 2021-05-10 2022-11-17 成都百裕制药股份有限公司 酰胺衍生物及其应用
WO2023078127A1 (zh) * 2021-11-03 2023-05-11 中国药科大学 大环磺酰胺类化合物及其制备方法和医药用途

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JP2022547882A (ja) 2019-09-06 2022-11-16 インフレイゾーム リミテッド Ｎｌｒｐ３阻害剤
JP2023501319A (ja) * 2019-11-07 2023-01-18 インフレイゾーム リミテッド 神経変性疾患の処置および予防
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CN115989219B (zh) * 2020-06-29 2026-02-13 贝凯恩生物医疗技术有限公司 用于治疗炎症小体介导的肺部疾病的丙磺舒化合物
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US20240043450A1 (en) 2020-09-24 2024-02-08 Janssen Pharmaceutica Nv New compound
EP3974415A1 (en) 2020-09-24 2022-03-30 Janssen Pharmaceutica NV Nlrp3 modulators
CA3208414A1 (en) 2021-03-04 2022-09-09 Daniel Oehlrich 4-amino-6-oxo-pyridazine derivatives modulating nlrp3
KR20230152016A (ko) 2021-03-04 2023-11-02 얀센 파마슈티카 엔브이 Nlrp3을 조절하는 4-알콕시-6-옥소-피리다진 유도체
US11932630B2 (en) 2021-04-16 2024-03-19 Novartis Ag Heteroaryl aminopropanol derivatives
WO2023275230A1 (en) 2021-07-01 2023-01-05 Janssen Pharmaceutica Nv 5-oxo-pyrido[2,3-d]pyridazin-6(5h)-yl acetamides
JP2025502732A (ja) 2021-12-22 2025-01-28 エーシー・イミューン・エス・アー ジヒドロオキサゾール誘導体化合物
US20250109154A1 (en) * 2022-01-27 2025-04-03 The University Of Tokyo Lysophosphatidylserine analogue, and lysophosphatidylserine analogue-containing phamaceutical composition for treating or preventing fibrosis
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