CN111406046A - 戊唑醇的多晶型及其制备方法 - Google Patents

戊唑醇的多晶型及其制备方法 Download PDF

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CN111406046A
CN111406046A CN201880074392.2A CN201880074392A CN111406046A CN 111406046 A CN111406046 A CN 111406046A CN 201880074392 A CN201880074392 A CN 201880074392A CN 111406046 A CN111406046 A CN 111406046A
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crystal
degrees
tebuconazole
preparation
compound
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CN111406046B (zh
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李忠
任国宾
徐晓勇
齐明辉
胡健
龚成予
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East China University of Science and Technology
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dentistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

本发明提供了戊唑醇的多晶型及其制备方法。具体地，本发明涉及(RS)‑1‑(4‑氯苯基)‑4,4‑二甲基‑3‑(1H‑1,2,4‑三唑‑1‑基甲基)戊‑3‑醇的多晶型物、制备方法和用途。本发明的戊唑醇多晶型物具有高纯度、优良结晶性能，在高湿、高温、光照条件下很稳定，溶解性非常优异，制剂加工性能、生物活性高、杀菌效果很好。所述制备方法简单、工艺稳定，可规模化生产。所述多晶型物可极大地改善含戊唑醇的农药的质量控制和工业应用。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201880074392.2A 2017-11-17 2018-10-10 戊唑醇的多晶型及其制备方法 Active CN111406046B (zh)

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CN2017111470362 2017-11-17
CN201711147036 2017-11-17
PCT/CN2018/109675 WO2019095891A1 (zh) 2017-11-17 2018-10-10 戊唑醇的多晶型及其制备方法

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WO (1) WO2019095891A1 (zh)

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PE20231302A1 (es) 2020-07-30 2023-08-24 Pi Industries Ltd Composicion de metominostrobina, tebuconazol y propineb

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Publication number Priority date Publication date Assignee Title
CN1202089C (zh) * 2000-02-09 2005-05-18 拜尔公司 制备2－(1,2,4－三唑－1－基)乙醇类化合物的方法
RU2256655C1 (ru) * 2004-01-27 2005-07-20 Закрытое акционерное общество Фирма "Август" Способ получения 1-(4-хлорфенил)-3-(1,2,4-триазол-1-ил-метил)-4,4-диметилпентан-3-ола
CN1760187A (zh) * 2005-11-08 2006-04-19 湖南大学 高纯度戊唑醇的制备方法
CN101130522A (zh) * 2006-08-22 2008-02-27 上海生农生化制品有限公司 一种合成杀菌剂戊唑醇的新方法
CN102432556A (zh) * 2010-10-25 2012-05-02 南通派斯第农药化工有限公司 一种戊唑醇的提纯工艺
CN103435564A (zh) * 2013-08-22 2013-12-11 上虞颖泰精细化工有限公司 一种戊唑醇的制备方法
CN103588730A (zh) * 2013-11-14 2014-02-19 江苏剑牌农化股份有限公司 一种制备三唑类杀菌剂式(iii)化合物的合成方法
CN104529917A (zh) * 2014-12-10 2015-04-22 青岛无为保温材料有限公司 一种杀菌剂戊唑醇的合成方法
CN106588791A (zh) * 2016-11-01 2017-04-26 盐城辉煌化工有限公司 一种无溶剂合成杀菌剂戊唑醇的新工艺
CN106699675A (zh) * 2016-12-26 2017-05-24 盐城辉煌化工有限公司 一种戊唑醇异构体转化为戊唑醇的制备方法
CN107176929A (zh) * 2017-05-05 2017-09-19 江苏剑牌农化股份有限公司 一种高效制备高纯度1h‑戊唑醇的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3733755A1 (de) 1987-10-06 1989-04-20 Bayer Ag Verfahren zur herstellung von 2-(4-chlorphenyl-ethyl)-2-tert.-butyl-oxiran

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1202089C (zh) * 2000-02-09 2005-05-18 拜尔公司 制备2－(1,2,4－三唑－1－基)乙醇类化合物的方法
RU2256655C1 (ru) * 2004-01-27 2005-07-20 Закрытое акционерное общество Фирма "Август" Способ получения 1-(4-хлорфенил)-3-(1,2,4-триазол-1-ил-метил)-4,4-диметилпентан-3-ола
CN1760187A (zh) * 2005-11-08 2006-04-19 湖南大学 高纯度戊唑醇的制备方法
CN101130522A (zh) * 2006-08-22 2008-02-27 上海生农生化制品有限公司 一种合成杀菌剂戊唑醇的新方法
CN102432556A (zh) * 2010-10-25 2012-05-02 南通派斯第农药化工有限公司 一种戊唑醇的提纯工艺
CN103435564A (zh) * 2013-08-22 2013-12-11 上虞颖泰精细化工有限公司 一种戊唑醇的制备方法
CN103588730A (zh) * 2013-11-14 2014-02-19 江苏剑牌农化股份有限公司 一种制备三唑类杀菌剂式(iii)化合物的合成方法
CN104529917A (zh) * 2014-12-10 2015-04-22 青岛无为保温材料有限公司 一种杀菌剂戊唑醇的合成方法
CN106588791A (zh) * 2016-11-01 2017-04-26 盐城辉煌化工有限公司 一种无溶剂合成杀菌剂戊唑醇的新工艺
CN106699675A (zh) * 2016-12-26 2017-05-24 盐城辉煌化工有限公司 一种戊唑醇异构体转化为戊唑醇的制备方法
CN107176929A (zh) * 2017-05-05 2017-09-19 江苏剑牌农化股份有限公司 一种高效制备高纯度1h‑戊唑醇的方法

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US11186552B2 (en) 2021-11-30
CN111406046B (zh) 2022-12-23
US20210087152A1 (en) 2021-03-25
EP3712136A4 (en) 2021-02-17
EP3712136A1 (en) 2020-09-23
WO2019095891A1 (zh) 2019-05-23
BR112020009870A2 (pt) 2020-11-03

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