CN111388580A

CN111388580A - Traditional Chinese medicine composition for treating abscess and furuncle and preparation method and application thereof

Info

Publication number: CN111388580A
Application number: CN202010396182.4A
Authority: CN
Inventors: 侯健
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-05-12
Filing date: 2020-05-12
Publication date: 2020-07-10

Abstract

The invention is suitable for the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for treating abscess and furuncle, a preparation method and an application thereof, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 10-20 parts of liquorice, 5-20 parts of rhizoma bolbostemmae, 10-20 parts of obscured homalomena rhizome, 10-25 parts of semen momordicae, 10-20 parts of frankincense, 10-25 parts of cortex schizophragmatis integrifolii radicis, 10-25 parts of myrrh, 5-20 parts of gardenia jasminoides ellis, 10-25 parts of catechu and 500-1000 parts of minium. The traditional Chinese medicine composition provided by the embodiment of the invention utilizes the synergistic effect of the traditional Chinese medicine components which complement each other according to the traditional Chinese medicine theory, achieves the efficacies of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, relieving swelling and pain, removing furuncle and converging, and removing necrotic tissue and promoting granulation together, and can be used for mainly treating diseases such as carbuncle-toxin sores and furuncles, innominate toxic swelling, various general toxic substances, inflammation and swelling, red swelling and pain, pus ulceration or no ulceration, no healing after ulceration for a long time, scald for a long time and the like.

Description

Traditional Chinese medicine composition for treating abscess and furuncle and preparation method and application thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating abscess and furuncle, and a preparation method and application thereof.

Background

Festering skin disease refers to the area of skin formed around pus (dead neutrophils) during infection, a defensive tissue reaction that prevents the spread of infectious agents to other parts of the body. The final structure of an abscess is the abscess wall, or abscess sac, formed by adjacent healthy cells to prevent the pus from infecting the surrounding tissue. Furuncle is an acute suppurative disease of pathogenic bacteria such as staphylococcus infected in hair follicle and hair structure caused by poor skin hygiene, increased production of skin seborrheic substances, trauma and high level of body hormones. The initial stage of the disease has local red swelling and pain, then the red swelling range is enlarged, the jumping pain is obvious, finally abscess is formed, if the abscess is broken, pus is discharged, but the pain is relieved. Severe patients may experience general malaise, aversion to cold, fever, elevated white blood cell counts, and the like.

At present, the pustule is mainly treated by anti-inflammatory and sterilization, a disinfection needle is used for puncturing, a sterile cotton ball is used for absorbing pustule liquid to prevent the pustule liquid from overflowing to normal skin, then antibiotic ointment such as erythromycin ointment, mupirocin ointment and the like is used for external application, and high-protein food is eaten more at the same time, so that the immunity of the organism is improved. The furuncle is mainly treated by oral administration or injection of antibiotics. If the furuncle is mature, the surface is soft and the fluctuation is generated, the boil can be cut open to discharge pus, and the boil can be smeared with antibiotics such as compound neomycin ointment after the pus is discharged. The application of antibiotics to prevent infection, followed by manual suturing of the wound, followed by multiple dressing changes, bandaging, and then stitch removal increases the pain of the patient. Moreover, the currently used antibiotic ointment treats both symptoms and root causes, is easy to relapse after stopping taking the medicine, has single effect and can only act on one disease.

In addition, the ointment is a hormone medicine, so the ointment has great side effect on human body. However, the existing Chinese medicinal dressing can only stop bleeding and reduce swelling, has no good curative effect on suppuration and sore, and is easy to generate anaphylactic reaction.

Disclosure of Invention

The embodiment of the invention aims to provide a traditional Chinese medicine composition for treating running sore and furuncle, and aims to solve the problems in the background art.

The embodiment of the invention is realized in such a way that the traditional Chinese medicine composition for treating the running sore and the furuncle comprises the following components in parts by weight: 10-20 parts of liquorice, 5-20 parts of rhizoma bolbostemmae, 10-20 parts of obscured homalomena rhizome, 10-25 parts of semen momordicae, 10-20 parts of frankincense, 10-25 parts of cortex schizophragmatis integrifolii radicis, 10-25 parts of myrrh, 5-20 parts of gardenia jasminoides ellis, 10-25 parts of catechu and 500-1000 parts of minium.

As a preferred scheme of the embodiment of the invention, the traditional Chinese medicine composition comprises the following components in parts by weight: 14-16 parts of liquorice, 8-12 parts of rhizoma bolbostemmae, 14-16 parts of obscured homalomena rhizome, 14-16 parts of semen momordicae, 14-16 parts of frankincense, 16-20 parts of cortex schizophragmatis integrifolii radicis, 14-16 parts of myrrh, 14-16 parts of fructus gardeniae, 18-22 parts of catechu and 700-900 parts of minium.

As another preferable scheme of the embodiment of the invention, the traditional Chinese medicine composition is an external preparation.

As another preferable embodiment of the present invention, the external preparation is an ointment, and may be a liniment or an emulsion, but is not limited thereto.

Another object of the embodiments of the present invention is to provide a method for preparing the above-mentioned Chinese medicinal composition, which comprises the following steps:

weighing the liquorice, the bolbostemma paniculatum, the homalomena rhizoma, the cochinchina momordica seed, the frankincense, the cortex schizophragmatis integrifolii radicis, the myrrh, the gardenia jasminoides ellis, the catechu and the minium for later use according to the weight parts of the components;

mixing the weighed liquorice, rhizoma bolbostemmae, obscured homalomena rhizome, cochinchina momordica seed, frankincense, cortex schizophragmatis integrifolii radicis, myrrh, gardenia jasminoides and catechu to obtain a medicinal material;

frying the medicinal materials in vegetable oil, and filtering to obtain filtrate;

decocting the filtrate at a temperature not lower than 300 deg.C to obtain medicinal oil;

adding Plumbum Preparatium into the medicinal oil, and stirring to obtain unguent;

and (3) performing fire toxin removing treatment on the ointment to obtain the traditional Chinese medicine composition.

As another preferable scheme of the embodiment of the invention, the mass ratio of the medicine material to the vegetable oil is (80-200): 800-1200.

As another preferable mode of the embodiment of the present invention, the vegetable oil is one of sesame oil, cottonseed oil and peanut oil.

As another preferred scheme of the embodiment of the present invention, the step of performing detoxification treatment on the ointment to obtain the traditional Chinese medicine composition specifically includes:

and (3) putting the ointment into cold water with the temperature not higher than 30 ℃ for fire toxin removing treatment to obtain the traditional Chinese medicine composition.

In addition, the Chinese medicinal composition can be applied on kraft paper to make plaster.

Another object of the embodiments of the present invention is to provide a Chinese medicinal composition prepared by the above preparation method.

Another object of the present invention is to provide an application of the above-mentioned Chinese medicinal composition in preparing a medicament for treating abscess and/or furuncle.

In the embodiment of the invention, the drug effect and the effect of each component are as follows:

the licorice is dry root and rhizome of Glycyrrhiza uralensis Fisch, Glycyrrhiza inflata Bat or Glycyrrhiza glabra L of Leguminosae, which are distributed in northeast, North China, Shanxi, Gansu, Qinghai, Xinjiang, Shandong and the like.

Rhizoma bolbostemmae, another name: rhizoma Bolbostematis, Bulbus Fritillariae Cirrhosae, herba Elephantopi scaberis, and Bulbus Fritillariae Thunbergii. The source is dried tuber of Bolbostemma paniculatum of Cucurbitaceae. Collected in Shaanxi, Henan, Shanxi, Hebei, Gansu, Shandong, Hunan, Hubei, Sichuan and autumn, cleaned, broken, boiled to no white core, taken out and dried in the sun. It is an irregular block of varying size. The surface is light reddish brown or dark brown, and is rugged. Hard, not easy to break, and has a horny and smooth section. Bitter and slightly cold. Has the effects of removing toxic substances, dispersing pathogenic accumulation, and relieving swelling. It can be used for treating acute mastitis, scrofula, and subcutaneous nodule.

Homalomena occulta, school name: homalomena occulta, a plant of the genus Homalomena of the family Araceae. The plants are distributed in the fields of Guangxi, Yunnan, Hainan, Guangdong and the like in the Central and south peninsula and the continental province of China, grow in the areas with the altitude of 80-1,100 meters, and generally grow under valley dense forests, bamboo forests and hillside irrigation clusters. The medicinal part is dried rhizome of Homalomena occulta. Collected in spring and autumn, cleaned, peeled and dried in the sun. Qiannianjin comes from Bencao gang mu Shi Yi (supplement to compendium of materia Medica), which is called Yibao needle, Qian Huo needle, Qiannian homalomena, silk ridge line, fragrant, pungent and slightly bitter in taste. Pungent and warm in nature. And (5) small toxicity. Entering the liver; a kidney; the stomach meridian. Has effects in dispelling pathogenic wind and dampness, relaxing muscles and tendons, activating collateral flow, relieving pain, and relieving swelling. It can be used for treating rheumatalgia, soreness of limbs, flaccidity of bones and muscles, traumatic injury, gastralgia, superficial infection, sore, and swelling.

Semen Momordicae, which is dry mature seed of Cucurbitaceae plant, Momoradica cochinchinensis (L our.) Spreng, has the functions of relieving swelling and resolving hard mass, removing toxic substance, dispelling pathogenic wind and relieving pain, treating carbuncle, furuncle, innominate toxic swelling, hemorrhoid, tinea, acne, morningness, mastitis, tuberculous lymphadenitis, dysentery, rheumatalgia, muscular spasm, and gingival swelling and pain.

Boswellia carterii Birdw of Boswellia genus of Burseraceae family, Boswellia Birdw [ B.sacraFluek ], Boswellia Birdw, and Boswellia latifolia B.newdajiana Birdw, and Boswellia latifolia B.negecta M.Moore, etc., are administered with oleoresin exuded from the wound of the bark of the trunk. The main function is to activate blood and promote qi; inducing menstruation to relieve menalgia; to relieve swelling and promote tissue regeneration. Dominating heart and abdominal pain; rheumatic arthralgia; amenorrhea and dysmenorrhea; traumatic blood stasis and pain; abscess, deep-rooted carbuncle and pyogenic infections; intestinal abscess; sores and ulcers do not heal.

The Geranium strictipes is root and stem of Geranium strictipes (Franch.) Oliv. Is distributed in southwest, Shaanxi, Anhui, Zhejiang, Jiangxi, Fujian, Taiwan, Hubei, Hunan, Guangdong, Guangxi, etc. Has the effects of relaxing muscles and tendons, activating collateral flow, expelling pathogenic wind, and promoting blood circulation. It is commonly used for arthralgia due to wind-dampness and soreness of joints of limbs.

Myrrh, Commiphora myrrha Engl [ C.mo Imoi Engl ] of Commiphora of Burseraceae, and oleoresin exuded from bark of trunk of other plant of the same genus. The main functions are blood stasis dispelling, swelling subsiding and pain relieving. It is indicated for traumatic injury, incised wound, pain of bones and muscles, heart and abdomen, abdominal mass, amenorrhea, carbuncle, abscess, swelling and pain, anal fistula and eye disorders.

Fructus Gardeniae is fruit of Gardenia jasminoides Ellis of Rubiaceae. It is usually in warm sparse forest in low mountains or on barren slopes, near ditches and at roadsides. Is distributed in Jiangsu, Zhejiang, Anhui, Jiangxi, Guangdong, Guangxi, Yunnan, Guizhou, Sichuan, Hubei, Fujian, Taiwan and other places. The main treatment is as follows: fever, vexation, liver fire, conjunctival congestion, headache, damp-heat, yellow malnutrition, stranguria, dysentery with blood, hematuria, aphtha, pyocutaneous disease, toxic swelling, and sprain with swelling and pain.

Catechu is dry paste of Acacia catechu (L. f.) of Leguminosae, which is prepared by removing skin and branch, collecting branch and trunk in winter, removing skin, cutting into large blocks, decocting with water, concentrating, drying, and spreading in south Yunnan area.

Plumbum preparatium is a lead tetraoxide prepared from pure lead by processing. The functional indications are as follows: remove toxicity and promote tissue regeneration, kill parasites and relieve itching. Can be used for treating pyocutaneous disease, ulcer, skin eczema, epilepsy, and malaria.

According to the traditional Chinese medicine theory, the 10 traditional Chinese medicine components supplement each other to achieve the effects of clearing heat and removing toxicity, promoting blood circulation and removing blood stasis, relieving swelling and pain, removing furuncle and converging, and removing necrotic tissue and promoting granulation together, and the traditional Chinese medicine composition for treating carbuncle-toxin sores and furuncles, innominate toxic swelling, various general toxic materials, inflammation, red swelling, pain, pus formation, ulceration or non-ulceration, non-healing after scald and the like can be mainly used.

Drawings

Fig. 1 is a diagram showing a comparison of affected parts of a patient a before and after administration of the Chinese medicinal composition provided in example 9 of the present invention.

Fig. 2 is a diagram showing the affected part of patient B before and after using the Chinese medicinal composition provided in example 9 of the present invention.

Fig. 3 is a diagram showing the affected part of patient C before and after using the Chinese medicinal composition provided in example 9 of the present invention.

Fig. 4 is a comparison of affected parts of patient D before and after administration of the Chinese medicinal composition provided in example 9 of the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

Example 1

The embodiment provides a traditional Chinese medicine composition for treating abscess and furuncle, which is an ointment, and the preparation method comprises the following steps:

s1, weighing 10g of liquorice, 5g of paniculate Bolbostemma rhizome, 10g of obscured homalomena rhizome, 10g of cochinchina momordica seed, 10g of frankincense, 10g of herb of common corydalis, 10g of myrrh, 5g of fructus gardeniae, 10g of catechu, 1000g of minium and 1200g of vegetable oil for later use.

S2, mixing the above weighed radix Glycyrrhizae, rhizoma Bolbostematis, rhizoma homalomenae, semen Momordicae, Olibanum, cortex Schizophragmatis Integrifolii Radicis, Myrrha, fructus Gardeniae, and Catechu to obtain the medicinal materials.

S3, placing the weighed vegetable oil into a pot, slightly heating, placing the medicinal materials into the vegetable oil, heating, stirring, frying until the surfaces of the medicinal materials become dark brown and the interiors of the medicinal materials become brown, filtering, and removing residues to obtain filtrate.

S4, putting the filtrate at 300 ℃ for decocting treatment to obtain the medicinal oil.

S5, removing the fire and stirring the medicinal oil, adding Plumbum preparatium while stirring, and stirring to obtain viscous ointment.

S6, soaking the above paste in cold water at 30 deg.C for removing fire toxin, and replacing cold water once a day, and getting the Chinese medicinal composition fifteen days later. Wherein the Chinese medicinal composition can be applied on kraft paper to make plaster. Wherein, the kraft paper is natural plant fiber, so the plaster has the advantages of environmental protection, health, no allergy, good air permeability, no heat generation, no scald, no skin irritation and the like.

Example 2

s1, weighing 20g of liquorice, 20g of paniculate Bolbostemma rhizome, 20g of obscured homalomena rhizome, 25g of cochinchina momordica seed, 20g of frankincense, 25g of herb of common corydalis, 25g of myrrh, 20g of fructus gardeniae, 25g of catechu, 500g of minium and 800g of vegetable oil for later use.

S4, putting the filtrate at 400 ℃ for boiling treatment to obtain the medicinal oil.

S6, soaking the above paste in cold water at 20 deg.C for removing fire toxin, and replacing cold water once a day, and getting the Chinese medicinal composition fifteen days later. Wherein the Chinese medicinal composition can be applied on kraft paper to make plaster.

Example 3

s1, weighing 12g of liquorice, 7g of paniculate Bolbostemma rhizome, 12g of obscured homalomena rhizome, 22g of cochinchina momordica seed, 15g of frankincense, 12g of herb of common corydalis, 12g of myrrh, 8g of fructus gardeniae, 22g of catechu, 600g of minium and 1100g of vegetable oil for later use.

S4, putting the filtrate at 320 ℃ for decocting treatment to obtain the medicinal oil.

S6, soaking the above paste in cold water at 25 deg.C for removing fire toxin, and replacing cold water once a day, and getting the Chinese medicinal composition fifteen days later. Wherein the Chinese medicinal composition can be applied on kraft paper to make plaster.

Example 4

s1, weighing 18g of liquorice, 18g of paniculate Bolbostemma rhizome, 18g of obscured homalomena rhizome, 12g of cochinchina momordica seed, 19g of frankincense, 13g of herb of common corydalis, 21g of myrrh, 18g of fructus gardeniae, 22g of catechu, 900g of minium and 1150g of vegetable oil for later use.

S6, soaking the above paste in cold water at 30 deg.C for removing fire toxin, and replacing cold water once a day, and getting the Chinese medicinal composition fifteen days later. Wherein the Chinese medicinal composition can be applied on kraft paper to make plaster.

Example 5

s1, weighing 14g of liquorice, 8g of paniculate Bolbostemma rhizome, 14g of obscured homalomena rhizome, 14g of cochinchina momordica seed, 14g of frankincense, 16g of herb of common corydalis, 14g of myrrh, 14g of fructus gardeniae, 18g of catechu, 900g of minium and 1100g of vegetable oil for later use.

S4, putting the filtrate at 350 ℃ for decocting treatment to obtain the medicinal oil.

Example 6

s1, weighing 16g of liquorice, 12g of paniculate Bolbostemma rhizome, 16g of obscured homalomena rhizome, 16g of cochinchina momordica seed, 16g of frankincense, 20g of herba schizophragmatis, 16g of myrrh, 16g of fructus gardeniae, 22g of catechu, 700g of minium and 900g of vegetable oil for later use.

Example 7

s1, weighing 14g of liquorice, 11g of paniculate Bolbostemma rhizome, 16g of obscured homalomena rhizome, 14g of cochinchina momordica seed, 16g of frankincense, 17g of herb of common corydalis, 14g of myrrh, 16g of fructus gardeniae, 19g of catechu, 750g of minium and 950g of vegetable oil for later use.

Example 8

s1, weighing 16g of liquorice, 9g of paniculate Bolbostemma rhizome, 14g of obscured homalomena rhizome, 16g of cochinchina momordica seed, 14g of frankincense, 19g of cortex schizophragmatis integrifolii radicis, 16g of myrrh, 14g of fructus gardeniae, 21g of catechu, 850g of minium and 1050g of vegetable oil for later use.

Example 9

s1, weighing 15g of liquorice, 10g of paniculate Bolbostemma rhizome, 15g of obscured homalomena rhizome, 15g of cochinchina momordica seed, 15g of frankincense, 18g of herb of common corydalis, 15g of myrrh, 15g of fructus gardeniae, 20g of catechu, 800g of minium and 1000g of vegetable oil for later use.

Experimental example:

selecting 100 patients with abscess and furuncle, randomly dividing into experimental group and control group, wherein each group comprises 50 patients, wherein the experimental group comprises 32 men and 18 women; control group men were 30 and women 20. The treatment method of the experimental group is as follows: the patch containing the Chinese medicinal composition provided in example 9 is applied to the affected part, and the patch is changed every 2 days for 10 days without raw, cold, and spicy taste, and other Chinese and western medicines and health products are stopped. The control group treatment method was: applying the existing commercially available ichthyol ointment to affected part three times a day for 10 days, wherein the ointment is prohibited from being raw, cold and spicy, and other Chinese and western medicines and health products are stopped.

The criteria for the treatment effect are as follows:

and (3) curing: the swelling and pain disappeared and the skin healed.

The effect is shown: the swelling pain is weakened.

And (4) invalidation: the primary symptoms are not relieved, and the red, swollen and painful condition worsens to form abscess.

The statistical results show that the treatment effects of the experimental group and the control group are shown in the following table 1.

TABLE 1

Group of	Experimental group	Control group
			Therapeutic agents	The Chinese medicinal composition of example 9	Ichthyol ointment on the market
The number of cured people (human)	48	34
			Number of effective people (human)	2	14
Invalid number of people (human)	0	2
			Cure rate	96％	68％
Total effective rate	100％	96％

As can be seen from the above table 1, the cure rate of the traditional Chinese medicine composition provided by the embodiment of the invention for treating patients with running sore and furuncle is up to 96%. Compared with the existing commercially available ichthyol ointment, the traditional Chinese medicine composition provided by the embodiment of the invention has a more remarkable treatment effect on abscess and furuncle.

In addition, the disease symptoms of the affected part before treatment and 3 days or 7 days after treatment of 3 patients with abscess and furuncle (designated as patient A, patient B and patient C) in the experimental group are shown in the attached figures 1-3. As can be seen from the figure, the abscess of a patient suffering from the abscess furuncle is basically disappeared and the skin is basically healed after the patient uses the traditional Chinese medicine composition provided by the embodiment of the invention for 7 days, which shows that the traditional Chinese medicine composition provided by the embodiment of the invention can effectively treat diseases such as the abscess furuncle and the like.

In addition, the plaster containing the Chinese medicinal composition provided in example 9 was applied to the affected part of the scald of patient D to treat the scald, and the comparison results of the affected part before and after 15 days of treatment are shown in fig. 4. As can be seen from fig. 4, the traditional Chinese medicine composition provided by the embodiment of the invention also has a better treatment effect on scalds.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims

1. The traditional Chinese medicine composition for treating the running sore and the furuncle is characterized by comprising the following components in parts by weight: 10-20 parts of liquorice, 5-20 parts of rhizoma bolbostemmae, 10-20 parts of obscured homalomena rhizome, 10-25 parts of semen momordicae, 10-20 parts of frankincense, 10-25 parts of cortex schizophragmatis integrifolii radicis, 10-25 parts of myrrh, 5-20 parts of gardenia jasminoides ellis, 10-25 parts of catechu and 500-1000 parts of minium.

2. The traditional Chinese medicine composition for treating abscesses and furuncles as claimed in claim 1, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 14-16 parts of liquorice, 8-12 parts of rhizoma bolbostemmae, 14-16 parts of obscured homalomena rhizome, 14-16 parts of semen momordicae, 14-16 parts of frankincense, 16-20 parts of cortex schizophragmatis integrifolii radicis, 14-16 parts of myrrh, 14-16 parts of fructus gardeniae, 18-22 parts of catechu and 700-900 parts of minium.

3. The traditional Chinese medicine composition for treating abscess furuncle according to claim 1 or 2, which is an external preparation.

4. The traditional Chinese medicine composition for treating abscess furuncle as claimed in claim 3, wherein the external preparation is an ointment.

5. A method for preparing a Chinese medicinal composition according to any one of claims 1 to 3, comprising the steps of:

6. The preparation method of a Chinese medicinal composition according to claim 5, wherein the mass ratio of the medicinal material to the vegetable oil is (80-200): (800-1200).

7. The method for preparing a Chinese medicinal composition according to claim 5, wherein the vegetable oil is one of sesame oil, cottonseed oil and peanut oil.

8. The method for preparing a Chinese medicinal composition according to claim 5, wherein the step of removing fire toxin from the ointment to obtain the Chinese medicinal composition comprises:

9. A Chinese medicinal composition prepared by the preparation method of any one of claims 5-8.

10. Use of a Chinese medicinal composition as claimed in any one of claims 1 to 4 and claim 9 in the manufacture of a medicament for the treatment of abscesses and/or boils.