CN113876859B - A topical Chinese medicinal composition for the treatment of bone joint movement disorder - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition for treating bone joint movement disorder, which is prepared from the following raw materials in parts by weight: 14-22 parts of rhizoma atractylodis, 14-18 parts of divaricate saposhnikovia root, 10-14 parts of cassia twig, 12-20 parts of twotooth achyranthes root, 10-18 parts of honeysuckle, 15-20 parts of amur corktree bark, 10-16 parts of weeping forsythia, 14-20 parts of prepared rehmannia root, 8-14 parts of eucommia bark, 12-20 parts of Chinese wolfberry, 14-20 parts of safflower, 10-14 parts of ground beetle and 6-10 parts of peach seed, and the purposes of treating bone and joint movement disorder are achieved by dispelling cold and removing dampness, dispelling wind and removing obstruction in channels, clearing heat and removing toxicity, tonifying liver and kidney, and promoting blood circulation and removing blood stasis, and a preparation method and application are disclosed.

Description

A topical Chinese medicinal composition for the treatment of bone joint movement disorder

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating bone joint movement disorder.

Background

Osteoarticular dyskinesia is common in osteoarthritis, and is a heterogeneous group of diseases mainly characterized by articular cartilage damage and joint marginal hyperosteogeny caused by various factors, and is often accompanied by subchondral bone sclerosis, synovium inflammation and soft tissue lesions around joints. The joint movement disorder of limbs is easy to occur, the limb inversion and the flexion contracture deformity can be generated in serious cases, and finally the joint disease and the disability can occur. The symptoms are mainly redness, pain, restricted movement and joint deformity of the knee joint. Joint pain usually occurs in the weight bearing joints, the joints move more and are not movable, for example, patients suffering from knee joint pain always bend down to walk and limit movement. Osteoarthritis mostly appears in the elderly, is highly harmful, and greatly affects the late-year life of the elderly. Therefore, after the old people at home are found to suffer from osteoarthritis, the old people must seek medical treatment in time. The main treatment method at present is to delay the pathological process and reduce the load of joints by reducing the load and excessive large-amplitude movement of the joints. Current treatment involves the intraluminal injection of sodium hyaluronate into the joint to lubricate the joint and, in general, relieve pain symptoms. If the pain is severe, the joint cavity can be closed to relieve the pain, but the pain is only a symptomatic treatment, and the traditional Chinese medicine is urgently expected to be used for treating the osteoarthritis.

Disclosure of Invention

The purpose of the invention is as follows: in order to solve the above problems, the present invention aims to provide a Chinese medicinal composition for treating bone joint movement disorder.

The technical scheme is as follows: the purpose of the invention is realized by the following scheme:

a traditional Chinese medicine composition for treating bone joint movement disorder is prepared from the following raw materials in parts by weight: 14-22 parts of rhizoma atractylodis, 14-18 parts of radix sileris, 10-14 parts of cassia twig, 12-20 parts of radix achyranthis bidentatae, 10-18 parts of honeysuckle, 15-20 parts of golden cypress, 10-16 parts of fructus forsythiae, 14-20 parts of radix rehmanniae preparata, 8-14 parts of eucommia bark, 12-20 parts of medlar, 14-20 parts of safflower, 10-14 parts of ground beetle and 6-10 parts of peach kernel.

The traditional Chinese medicine composition for treating bone joint movement disorder is prepared from the following raw materials in parts by weight: 18 parts of rhizoma atractylodis, 16 parts of radix sileris, 12 parts of cassia twig, 16 parts of achyranthes, 14 parts of honeysuckle, 17 parts of phellodendron, 13 parts of fructus forsythiae, 16 parts of prepared rehmannia root, 12 parts of eucommia bark, 15 parts of medlar, 18 parts of safflower, 12 parts of ground beetle and 8 parts of peach kernel.

The use method of the traditional Chinese medicine composition for treating the bone joint movement disorder comprises the following steps: mixing the above materials, adding water into a fumigator, and heating to fumigate bone joint.

The traditional Chinese medicine composition for treating bone joint movement disorder is added with water in an amount which is 10-30 times of the weight of the medicinal materials.

The traditional Chinese medicine composition for treating bone joint movement disorder is added with water in an amount which is 20 times of the weight of the medicinal materials.

The traditional Chinese medicine composition for treating the osteoarticular movement disorder is applied to the preparation of medicines for treating the osteoarticular movement disorder.

The traditional Chinese medicine composition for treating the bone joint movement disorder is characterized in that the bone joint movement disorder belongs to a cold-dampness obstruction type.

The traditional Chinese medicine composition for treating bone joint movement disorder is characterized in that a bone joint is a knee joint.

According to the traditional Chinese medicine composition for treating the bone joint movement disorder, the bone joint is a shoulder joint.

The rhizoma Atractylodis is dried rhizome of Atractylodes lancea DC or Atractylodes chinensis Koidz of Compositae. Collected in spring and autumn, removed silt, dried in the sun and removed fibrous root. Pungent and bitter with warm nature. It enters spleen, stomach and liver meridians. Dry dampness and invigorate spleen, dispel wind and cold, improve vision. Can be used for treating damp obstruction of middle warmer, abdominal distention, diarrhea, edema, tinea pedis, arthralgia due to wind-cold-evil, night blindness, blurred vision, and eye discomfort.

Radix Saposhnikoviae is the dried root of perennial herb of Umbelliferae. Mainly produced in Heilongjiang, jilin and Liaoning, etc. Unprocessed. Nature, flavor and meridian tropism: pungent, sweet and slightly warm. It enters bladder, liver and spleen meridians. The efficacy is as follows: dispel wind and relieve exterior syndrome, subdue dampness and alleviate pain, and relieve spasm. The main treatment is as follows: can be used for treating exterior syndrome due to exogenous pathogenic factor, rubella pruritus, rheumatalgia, and tetanus.

Ramulus Cinnamomi belongs to Camphorles, lauraceae, middle arbors; the annual branches are cylindrical, the terminal bud scales are wide and oval, green leaves grow mutually, and the annual branches grow in an oblong shape to be nearly acicular; flower white, about 4.5mm long; oval fruit, black purple at maturity, hairless; the flowering period is 6-8 months, and the fruit period is 10-12 months. Mainly produced in Guangxi, guangdong and Yunnan provinces. Cutting off twig in spring and summer, drying in the sun or in the shade, and cutting into slices or small sections. Pungent, sweet and warm. It enters heart, lung and bladder meridians. Has the effects of inducing sweat, expelling pathogenic factors from muscles, warming and dredging channels, supporting yang, regulating qi, and lowering qi. It is commonly used for wind-cold type common cold, abdominal cold pain, amenorrhea due to cold in blood, arthralgia, phlegm-fluid retention, edema and palpitation.

Achyranthis radix is dried root of Achyranthus bidentis Bl. Digging when stem and leaf wither in winter, removing fibrous root and silt, bundling into small bundle, drying in the sun to wrinkle, cutting the top end, and drying in the sun. Distributed throughout the country, and in some areas there are a large number of cultivars. Has the functions of removing blood stasis, stimulating the menstrual flow, nourishing the liver and the kidney, strengthening the bones and muscles, inducing diuresis, treating stranguria and leading blood to descend. Can be used for treating amenorrhea, dysmenorrhea, soreness of waist and knees, myasthenia of bones and muscles, stranguria, edema, headache, vertigo, toothache, skin ulcer, hematemesis, and epistaxis.

The flos Lonicerae is dried bud or flower with initial bloom of Lonicera japonica Thunb of Lonicera of Caprifoliaceae [4]. The honeysuckle is mostly distributed in east China, south China, southwest China, hebei, shanxi, liaoning, shaanxi, gansu and other places; lonicera confusa is mostly distributed in Guangdong, guangxi and Hainan; the lonicera aegypti is distributed in Zhejiang, anhui, fujian, jiangxi, hubei, hunan, guangdong, guangxi, sichuan, guizhou, yunnan, taiwan and the like; lonicera fulvidraco is distributed in Guangxi, guizhou and Yunnan provinces. Has the effects of clearing away heat and toxic materials. Can be used for treating wind-heat common cold or fever due to epidemic febrile disease, sunstroke, toxic heat, dysentery, carbuncle, furuncle, pharyngitis, and various infectious diseases.

Cortex Phellodendri is dried bark of Phellodendron chinense Schneid of Rutaceae. This is commonly called Chuan Huang Bai. Peeling the bark, removing the coarse bark, and drying in the sun. Bitter taste and cold nature. It enters kidney and bladder meridians. Has the effects of clearing heat, eliminating dampness, purging fire, removing steam, removing toxic substance and treating sore. Can be used for treating dysentery due to damp-heat pathogen, jaundice, dark urine, leukorrhagia, pudendal pruritus, stranguria with heat, tinea pedis, asthenia, bone steaming, fatigue, night sweat, spermatorrhea, pyocutaneous disease, toxic swelling, and eczema. Salted phellodendron bark, cortex Phellodendri, etc. has the functions of nourishing yin and lowering fire. Can be used for treating hyperactivity of fire due to yin deficiency, night sweat and steaming bone.

Forsythia fruit, fructus forsythiae, bitter in taste, mild in smell, slightly cold in nature, light and floating in nature, ascending and descending, and also yang, is nontoxic. Enter the heart meridian of shaoyin, hand and foot shaoyang and yangming. Purging heart-fire, damp-heat in spleen and stomach, removing abscess, and being vital in treating ascariasis in sores department. Dredge menstruation, descend five stranguria and disperse all menstrual blood and qi stagnation.

The radix rehmanniae Preparata is rhizome of Scrophulariaceae plant rehmanniae radix or rehmanniae radix, and is prepared by processing, steaming and drying in the sun. The main functions are nourishing yin and enriching blood. It is indicated for deficiency of yin and blood, atrophy and weakness of the loins and knees, fatigue cough with steaming sensation in the bone, spermatorrhea, metrorrhagia, irregular menstruation, diabetes, scanty urine, deafness and blurred vision.

The Eucommiae cortex is bark of eucommia ulmoides Oliver of Eucommiaceae. In order to protect resources, a partial peeling method is generally adopted. Selecting plants growing for more than 15-20 years from Qingming to summer, peeling off barks according to the size of the medicinal materials, planing off coarse barks, and drying in the sun. Placing the container in a ventilated and dry place. The main function is as follows: tonify liver and kidney, strengthen tendons and bones, prevent abortion. It is indicated for soreness and pain of lumbar and knees, atrophy and weakness of feet and knees, dribbling urination, itching of vulva, vaginal bleeding, threatened abortion, and hypertension. The book Jing: it can be used for treating lumbago, backache, invigorating middle warmer, replenishing vital essence, strengthening tendons and bones, improving intelligence, relieving itching and dampness, and draining urine. The bibliography: aching pain in the chief foot, not to be practised. The treatise on herb Property: it is indicated for lumbago due to kidney cold and hip, and also for lumbar deficiency with straight body and wind. It is not used for waist. Rihuazi Ben Cao: it is indicated for kidney fatigue and lumbar spinal spasm. It is used after stir-baked with herbs. Wang Hao Gu: moisten liver dryness, nourish liver meridian wind deficiency. The book materia Medica is as follows: stopping nocturnal emission, warming uterus, and calming fetus. Yu mountain ash Yao Jie (Yao Jie): benefiting liver and kidney, nourishing bones and muscles, and eliminating dampness of joints. It is indicated for soreness of the waist and knees and spasm of the legs and feet. (8) The "Renzai of materia Medica": strengthen the muscles and tendons and the yang.

The fructus Lycii is mature fruit of Solanaceae plant fructus Lycii or Ningxia fructus Lycii. Picking in summer and autumn when the fruit is ripe, removing fruit stalks, drying in the shade until the peel wrinkles, and insolating until the outer skin is dry and hard and the pulp is soft. Drying with slow fire in rainy days. The main functions are nourishing kidney, moistening lung, tonifying liver and improving vision. It is indicated for liver and kidney yin deficiency, soreness and weakness of waist and knees, dizziness, blurred vision, hyperdacryosis, cough due to asthenia, diabetes, and spermatorrhea.

The Carthami flos is dried flower of Carthamus tinctorius L. Collected in the shade or dried in the sun when the flowers turn yellow and red in summer. The cultivation is widely carried out all over the country. Has the functions of promoting blood circulation to restore menstrual flow, eliminating blood stasis and relieving pain. Can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, thoracic obstruction, cardialgia, abdominal pain due to blood stasis, pricking pain in chest and hypochondrium, traumatic injury, and swelling and pain due to pyocutaneous disease.

The Eupolyphaga Seu Steleophaga is female dry body of Eupolyph, aga sin, ensis Walker or Stelephaga Plancyi (Boleny) of Eupolyphaga Seu Steleophaga. After catching, the mixture is blanched in boiling water, dried in the sun or baked. Is distributed in Hebei, shaanxi, gansu, qinghai, shandong, henan, jiangsu, zhejiang, hunan, etc. Has the effects of breaking blood and removing stasis, and promoting reunion of fractured bones. Can be used for treating traumatic injury, injury of tendons and bones, amenorrhea due to blood stasis, puerperal abdominal pain due to blood stasis, and abdominal lump.

Peach kernel is dried mature seed of Prunus persica (L.) Batsch or Prunus davidiana (Carr.) Franch of Rosaceae. Harvesting after the fruits are ripe, removing pulp and nucleocapsid, taking out seeds, and drying in the sun. Is generally cultivated all over the country. Has the effects of promoting blood circulation, removing blood stasis, loosening bowel to relieve constipation, and relieving cough and asthma. Can be used for treating amenorrhea, dysmenorrhea, abdominal mass, pulmonary abscess, intestinal carbuncle, traumatic injury, constipation due to intestinal dryness, cough, and asthma.

Has the advantages that: the invention relates to a cold-dampness arthralgia type osteoarthritis, which is characterized in that the cold-dampness arthralgia type osteoarthritis often has limb joint pain or swelling, pain is fixed, flexion and extension are not easy, the osteoarthritis is aggravated in rainy days, limbs are sore and heavy, the tongue is light red, the coating is thin and white, and the pulse is wiry and tense.

According to the traditional Chinese medicine composition, the rhizoma atractylodis, the divaricate saposhnikovia root, the cassia twig and the twotooth achyranthes root are used for dispelling wind and eliminating dampness, warming channels and dispelling cold are used as monarch drugs, the honeysuckle, the amur corktree bark and the weeping forsythia are used for clearing heat and removing toxicity as ministerial drugs, the prepared rehmannia root, the eucommia bark and the medlar are used for tonifying liver and kidney as adjuvant drugs, and the safflower, the ground beeltle and the peach kernel are used as conductant drugs, so that the whole formula can treat osteoarthritis and improve bone joint movement disorder.

Detailed Description

The present invention is described in further detail below by way of examples, but it should not be construed that the scope of the subject matter of the present invention is limited to the examples below, and that techniques realized based on the above contents of the present invention are within the scope of the present invention.

Example 1: taking 14-22g of rhizoma atractylodis, 14-18g of divaricate saposhnikovia root, 10-14g of cassia twig, 12-20g of twotooth achyranthes root, 10-18g of honeysuckle, 15-20g of amur corktree bark, 10-16g of weeping forsythia, 14-20g of prepared rehmannia root, 8-14g of eucommia bark, 12-20g of Chinese wolfberry, 14-20g of safflower, 10-14g of ground beeltle and 6-10g of peach seed, wherein the using method comprises the following steps: mixing the above materials, adding water 10 times of the weight of the materials in a fumigator, and heating to fumigate bone joint.

Example 2: taking 14-22g of rhizoma atractylodis, 14-18g of divaricate saposhnikovia root, 10-14g of cassia twig, 12-20g of twotooth achyranthes root, 10-18g of honeysuckle, 15-20g of amur corktree bark, 10-16g of weeping forsythia, 14-20g of prepared rehmannia root, 8-14g of eucommia bark, 12-20g of Chinese wolfberry, 14-20g of safflower, 10-14g of ground beetle and 6-10g of peach kernel, and the using method comprises the following steps: mixing the above materials, adding water in an amount of 20 times of the weight of the materials, and heating to fumigate bone joint.

Example 3: taking 18g of rhizoma atractylodis, 16g of divaricate saposhnikovia root, 12g of cassia twig, 16g of achyranthes bidentata, 14g of honeysuckle, 17g of golden cypress, 13g of fructus forsythiae, 16g of prepared rehmannia root, 12g of eucommia bark, 15g of medlar, 18g of safflower, 12g of ground beeltle and 8g of peach kernel, and the using method comprises the following steps: mixing the above materials, adding water 30 times of the weight of the materials in a fumigator, and heating to fumigate bone joint.

Example 4: clinical study of the invention for treating osteoarticular dyskinesia

4.1 the observed cases in this study were 50 cases of osteoarticular activity disorder collected in the national hospital of Henan province from 5 months to 1 month in 2019.

4.2 inclusion criteria: 1. diagnosis based on the patient's symptoms: the patient with the older age has joint stiffness pain in the morning, pain is relieved after slight movement, and then the pain caused by friction of joints and crunchiness are caused. 2. X-ray shooting inspection: the X-ray photograph can show that the joint clearance is narrow, the joint surface is uneven, the subchondral bone is loose, the cystic change is caused, the lip-like hyperosteogeny is caused at the joint edge, and the free body, the joint deformity and the subluxation change can be seen in the joint cavity. 3. Laboratory examination: indexes such as blood routine, protein electrophoresis, immune complex and serum complement are generally in a normal range. And screening out cold-dampness obstruction type osteoarthritis through traditional Chinese medicine diagnosis: the symptoms are frequent arthralgia of limbs, swelling, fixed pain, difficulty in bending and stretching, aggravation in rainy days, soreness and heaviness of limbs, pale red tongue, thin and white fur and wiry and tense pulse.

4.3 methods of treatment: patients were randomized into test and control groups. The test group was fumigated with the herbal composition of the present invention prepared in example 3 for 45 minutes each time for 1 time/day.

4.4 observation indexes and curative effect evaluation standards: 1. clinical cure: the knee pain and swelling disappear completely, and the walking up and down stairs have no uncomfortable feeling. 2. The effect is shown: the knee pain and swelling are avoided when the patient is at rest, the pain is avoided when the patient moves occasionally, the pain is avoided when the patient walks, and the work and the life are not influenced. 3. The method has the following advantages: knee pain can be stopped when the patient suffers from pain, the patient still suffers from slight pain when walking, the patient feels a little inconvenient to go upstairs and downstairs, and the joint movement is limited slightly. 4. And (4) invalidation: knee pain, swelling and pain during movement were not significantly improved.

4.5 effective rate the traditional Chinese medicine fumigation treatment group improves the bone joint movement disorder, 5 cases are cured clinically, 26 cases are obviously effective, 14 cases are effective, 5 cases are ineffective, and the effective rate reaches 90%.

Example 5: typical cases

Case 1: wang Shi, female, 58 years old, retirement. Patient history of osteoarthritis 5 years, symptoms: often, pain in joints of large joints of limbs is fixed, especially when the knee joint is heavy, cold is aggravated, the limbs are difficult to move, the tongue is pale, the tongue coating is thin and white, and the pulse is tight. The pain can be relieved by taking various western medicines, and the medicine is repeatedly stopped. In 2019, 5, 15 days, the clinic visits are described by the introduction, and the diagnosis is as follows: osteoarthritis and arthralgia (arthritis of cold), when the product of the invention is used for 2 months, the pain of the knee joint basically disappears, the product of the invention is discontinuously used for fumigation in the embodiment 3, the joint movement is complained and the pain basically disappears after the consultation is carried out for 3 months and 1 day in 2020, and the phenomenon does not appear after the consultation is carried out for half a year.

Case 2: zhao, women, age 69, the worker retired. Symptoms are: pain and swelling of the knee joint, aggravation in the morning, obvious pain in rainy days, inability to go up and down stairs in case of pain, pale red tongue with thin and white coating, and deep and tense pulse. The disease is 9 months. 2, month and 8 days of 2020, the patient is shown in the magnetic resonance examination: the knee joint degenerates, and the current walking is carried out in a short distance, but the movement is occasionally unfavorable. The pain and swelling of the knee joints basically disappear after the patient applies the product of the invention for 2 months, the movement is unfavorable during walking is basically improved, the symptom disappears after the patient continuously uses the product of the invention in the embodiment 3 for fumigation for 2 months, the patient feels good, and the movement of the knee joints basically disappears.

Case 3: wangzhi, woman 45 years old, farmer, pain in knees and shoulder joints for 1 year, movement disorder, aggravation in cloudy days and rainy days. The disease condition is not obviously improved after long-time comprehensive western medicine treatment, joint cavity injection and the like. Symptoms are: pain in the knees and shoulder joints, no obvious swelling, fixed pain, difficult movement, soreness and heaviness of limbs, red tongue, thin and white fur and wiry and tense pulse. The diagnosis is as follows: the pain symptom disappears after 10 times of fumigation of the arthralgia (cold-dampness arthralgia), the patient is diagnosed again in 12 months and 15 days in 2020 without obvious complaints and abnormalities, and then the patient is followed for 1 year, so that the phenomenon does not exist at present.

Case 4: zhao, male, 51 years old, the farmer and the folk worker, pain of the limbs and repeated stiffness feel for more than 1 year. Symptoms are as follows: limb dyskinesia, debilitation, arthroncus, morning pain, relief after movement, pale tongue with thin and white coating, and deep, tense and forceful pulse. Once hospitalized, analgesic and joint cavity injection treatments were given with slight relief, and were repeated after discharge. In the prior art, the limbs are difficult to move in the morning, the limbs feel weak and stiff, the limbs become aggravated after blowing, the tongue is pale red, the tongue coating is thin and white, and the pulse is wiry and tense. The diagnosis is as follows: arthralgia syndrome (arthralgia due to cold-dampness). When the product of the invention example 1 is used for fumigating for 1 month, the self-complaint of the limb stiffness and the non-forceful feeling are obviously improved before the re-diagnosis, the movement is not limited, no obvious discomfort exists in the morning, and the self-complaint of the phone follow-up in 9 and 2 days in 2020 has no obvious pain and stiffness, and the above basically disappears.

In conclusion, the traditional Chinese medicine fumigation formula has a good curative effect on improvement of bone joint movement disorder and has an effect of treating osteoarthritis.

Claims (8)

1. An external traditional Chinese medicine composition for treating bone joint movement disorder is characterized by being prepared from the following raw materials in parts by weight: 14-22 parts of rhizoma atractylodis, 14-18 parts of divaricate saposhnikovia root, 10-14 parts of cassia twig, 12-20 parts of radix achyranthis bidentatae, 10-18 parts of honeysuckle, 15-20 parts of golden cypress, 10-16 parts of fructus forsythiae, 14-20 parts of prepared rehmannia root, 8-14 parts of eucommia bark, 12-20 parts of medlar, 14-20 parts of safflower, 10-14 parts of ground beetle and 6-10 parts of peach kernel, and the bone and joint movement disorder belongs to the cold-dampness arthralgia-syndrome type.

2. The external traditional Chinese medicine composition for treating bone joint movement disorder according to claim 1, which is prepared from the following raw materials in parts by weight: 18 parts of rhizoma atractylodis, 16 parts of divaricate saposhnikovia root, 12 parts of cassia twig, 16 parts of achyranthes root, 14 parts of honeysuckle flower, 17 parts of phellodendron, 13 parts of forsythia, 16 parts of prepared rehmannia root, 12 parts of eucommia bark, 15 parts of medlar, 18 parts of safflower, 12 parts of ground beeltle and 8 parts of peach seed.

3. The topical Chinese medicinal composition for treating bone joint movement disorder according to claim 1 or 2, wherein the use method comprises the following steps: mixing the above materials, adding water into a fumigator, and heating to fumigate bone joint.

4. The topical Chinese medicinal composition for treating bone joint movement disorder according to claim 3, wherein the water is 10-30 times of the medicinal materials.

5. The topical Chinese medicinal composition for the treatment of bone and joint movement disorder according to claim 4, wherein the water is 20 times of the medicinal materials.

6. Use of the topical Chinese medicinal composition for the treatment of osteoarticular movement disorder according to claim 1 or 2 in the preparation of a medicament for the treatment of osteoarticular movement disorder.

7. The topical Chinese medicinal composition for treating bone joint movement disorder according to claim 1 or 2, wherein the bone joint is knee joint.

8. The topical Chinese medicinal composition for treating bone joint movement disorder according to claim 1 or 2, wherein the bone joint is a shoulder joint.