CN114404503A

CN114404503A - Composition for treating rheumatic bone pain and traumatic injury, application and preparation method thereof

Info

Publication number: CN114404503A
Application number: CN202210116383.3A
Authority: CN
Inventors: 孔庆博; 张建华; 刘彤; 王阳
Original assignee: Guodingshanhe Hainan Pharmaceutical Group Co ltd
Current assignee: Guodingshanhe Hainan Pharmaceutical Group Co ltd
Priority date: 2022-02-07
Filing date: 2022-02-07
Publication date: 2022-04-29

Abstract

The invention discloses a composition for treating rheumatic bone pain and traumatic injury, and an application and a preparation method thereof, wherein the composition comprises the following components: radix angelicae pubescentis, asarum, homalomena occulta, anisetree bark, safflower, scorpion, saussurea involucrate, borneol, eucommia ulmoides, black nightshade, white tea, long-noded pit viper, garter snake, divaricate saposhnikovia root, rhizoma drynariae, lycopodium clavatum, garden balsam stem, nacre, combined spicebush leaf, cuttlebone, rosewood, garden burnet root, cattail pollen, hairyvein agrimony, agilawood, myrrh and frankincense. The invention also provides the application of the composition, which is used for preparing external medicaments. The invention also provides a preparation method of the medicament, which comprises the following steps: weighing the medicinal raw materials, cleaning and drying the washable raw materials, grinding all the raw materials, crushing, decocting in water, filtering to obtain medicinal liquid, cooling, filling into a container, sealing and packaging. The composition provided by the invention is used for medicaments aiming at rheumatic arthritis, traumatic injury, trauma and the like, and has the effects of diminishing inflammation, sterilizing, stopping bleeding, astringing, repairing scars, dispelling wind, dredging collaterals, strengthening tendons and bones and the like.

Description

Composition for treating rheumatic bone pain and traumatic injury, application and preparation method thereof

Technical Field

The invention relates to a pharmaceutical composition, application and a preparation method thereof, in particular to a composition for treating rheumatic bone pain and traumatic injury, and application and a preparation method thereof.

Background

Rheumatoid arthritis (rheumatoid arthritis) is a common acute or chronic inflammation of connective tissue. Generally, the rheumatic arthritis is one of the main manifestations of rheumatic fever, and is clinically characterized by joint and muscle wandering soreness, red swelling and pain. Cold, dampness and other factors can induce this disease. The large joints of the lower limbs such as the knee joints and the ankle joints are most frequently affected. Although the incidence of rheumatic fever has declined in recent decades, atypical rheumatic fever and chronic rheumatic arthritis are not uncommon.

Traumatic injury refers to injuries caused by falling, beating, knocking, bumping and the like, including knife gun, falling, beating, contusion, puncture, bruise, sports injury and the like, and the injuries mostly include pain, swelling, bleeding or fracture, dislocation and the like, and also include some internal injuries. Mainly soft tissue injuries are considered here.

Moreover, products which adopt components of Chinese herbal medicines, natural plants and the like are not produced in domestic and world markets at present, and the special-effect medicament for treating rheumatic arthritis, traumatic injury, trauma and the like is processed and produced, so that the effect of quick recovery can be achieved, and other sequelae are not produced.

Disclosure of Invention

The invention aims to provide a pharmaceutical composition, application and a preparation method thereof, the composition can solve the existing problems, is used for treating rheumatic arthritis, traumatic injury, trauma and the like, is safe to use, has obvious effect, can help a wounded person to recover quickly, and does not produce other sequelae and the like.

In order to achieve the above objects, the present invention provides a composition for rheumatic bone pain and traumatic injury, wherein the composition comprises the following raw materials: radix angelicae pubescentis, asarum, homalomena occulta, anisetree bark, safflower, scorpion, saussurea involucrate, borneol, eucommia ulmoides, black nightshade, white tea, long-noded pit viper, garter snake, divaricate saposhnikovia root, rhizoma drynariae, lycopodium clavatum, garden balsam stem, nacre, combined spicebush leaf, cuttlebone, rosewood, garden burnet root, cattail pollen, hairyvein agrimony, agilawood, myrrh and frankincense.

The composition for treating rheumatic bone pain and traumatic injury is characterized in that the raw materials of the composition comprise white tea and tea concentrated powder of the white tea.

The composition for treating rheumatic bone pain and traumatic injury comprises the following raw materials in parts by weight: 45-55 parts of radix angelicae pubescentis, 35-45 parts of asarum, 55-65 parts of homalomena occulta, 55-65 parts of anisetree bark, 25-35 parts of safflower, 20-30 parts of scorpion, 25-35 parts of borneol, 25-35 parts of eucommia bark, 20-30 parts of black nightshade, 15-25 parts of white tea concentrated powder, 35-45 parts of garter snake, 30-40 parts of divaricate saposhnikovia root, 25-35 parts of rhizoma drynariae, 25-35 parts of lycopodium clavatum, 30-40 parts of garden balsam stem, 20-30 parts of nacre, 15-25 parts of combined spicebush leaf, 15-25 parts of cuttle bone, 8-12 parts of rosewood, 10-20 parts of garden burnet root, 15-25 parts of pollen typhae, 15-25 parts of hairyvein agrimony herb, 10-20 parts of agilawood, 15-20 parts of myrrh and 15-20 parts of frankincense.

The composition for treating rheumatic bone pain and traumatic injury comprises the following raw materials: one to two snow lotus and one to three long-noded pit vipers.

The composition for treating rheumatic bone pain and traumatic injury comprises the following raw materials in parts by weight: 50g of radix angelicae pubescentis, 40g of asarum, 60g of homalomena occulta, 60g of anisetree bark, 30g of safflower, 25g of scorpion, 30g of borneol, 30g of eucommia bark, 25g of black nightshade, 20g of white tea concentrated powder, 40g of garter snake, 35g of divaricate saposhnikovia root, 30g of rhizoma drynariae, 30g of lycopodium clavatum, 35g of garden balsam stem, 25g of nacre, 20g of lindera aggregate leaf, 20g of cuttlebone bone, 10g of rosewood, 15g of sanguisorba officinalis, 20g of cattail pollen, 20g of hairyvein agrimony, 15g of agilawood, 18g of myrrh and 18g of frankincense.

The composition for treating rheumatic bone pain and traumatic injury comprises the following raw materials: one snow lotus and three long-noded pit vipers.

The invention also provides application of the composition for treating rheumatic bone pain and traumatic injury, wherein the composition is used for preparing an external medicament.

The invention also provides a preparation method of the medicament, wherein the method comprises the following steps: weighing the raw materials in proportion, cleaning and drying the washable raw materials, grinding and crushing all the raw materials, adding water, decocting, filtering to obtain liquid medicine, cooling in the air, filling into a container, sealing and packaging.

The preparation method of the medicament is characterized in that the medicament prepared by the method is used as an external spray, and is filled into bottles, and sealed and packaged, wherein each bottle contains 20-30 ml of the medicament.

The preparation method of the medicament comprises the steps of spraying the spray for a plurality of times every day, and massaging for five to ten minutes after each spraying.

The composition for rheumatic bone pain and traumatic injury, the application and the preparation method provided by the invention have the following advantages:

the invention utilizes the technologies of biological pharmacy and the like and high purification and extraction means, and the cooperation verification of the Chinese medical science college of the Chinese academy of sciences breaks through the prior art of bone injury and trauma rehabilitation treatment, prepares the medicament for treating rheumatic arthritis, traumatic injury, trauma and the like, has the effects of diminishing inflammation, sterilizing, stopping bleeding, astringing, repairing scars, dispelling wind, removing dampness, relaxing tendons, activating collaterals, strengthening the body, strengthening bones and the like, can be used for treating traumatic injury, sore, carbuncle, gall and furuncle, trauma, and the like, can also repair fracture and bone fissure, can relieve pain, diminish inflammation, dispel rheumatic and rheumatoid bone pain, repair various arthritis and the like for lumbar vertebra and cervical synovitis, has safe use, obvious effect and small toxic and side effect, can help patients to recover quickly, and does not produce other sequelae.

Detailed Description

The following further describes embodiments of the present invention.

The invention provides a composition for treating rheumatic bone pain and traumatic injury, which comprises the following raw materials: radix angelicae pubescentis, asarum, homalomena occulta, anisetree bark, safflower, scorpion, saussurea involucrate, borneol, eucommia ulmoides, black nightshade, white tea, long-noded pit viper, garter snake, divaricate saposhnikovia root, rhizoma drynariae, lycopodium clavatum, garden balsam stem, nacre, combined spicebush leaf, cuttlebone, rosewood, garden burnet root, cattail pollen, hairyvein agrimony, agilawood, myrrh and frankincense.

Wherein radix Angelicae Pubescentis is dried root of Angelica gigas nakai of Umbelliferae. Digging in early spring or late autumn, removing fibrous root and silt, piling for 2-3 days, softening, and drying. Sliced and unprocessed. Pungent, bitter and slightly warm in nature; it enters kidney and bladder meridians. Has the effects of dispelling wind-damp, relieving pain and relieving exterior syndrome. It can be used for treating arthralgia due to wind-cold-dampness, exterior syndrome due to wind-cold-dampness, headache due to yin deficiency, and skin pruritus.

Asarum belongs to the order Aristolochiales, and belongs to the family Aristolochiaceae, a perennial herb. Pungent, warm and slightly toxic. It enters heart, lung and kidney meridians. Has the effects of expelling wind, clearing away cold, promoting diuresis, inducing resuscitation, relieving exterior syndrome, expelling cold, expelling wind, relieving pain, inducing resuscitation, warming lung, and eliminating phlegm. It is commonly used for wind-cold headache, nasosinusitis, toothache, phlegm-fluid cough, wind-cold type common cold, headache, toothache, wind-damp type arthralgia, nasosinusitis, cough due to lung cold, etc. The asarum can not only externally disperse wind-cold but also internally dispel yin-cold, and has better effects of relieving pain and cough.

Rhizoma homalomenae is dried rhizome of Homalomena occulta of Araceae. Collected in spring and autumn, cleaned, peeled and dried in the sun. Sliced and unprocessed. Bitter and pungent in property and warm in nature; it enters liver and kidney meridians. Has the effects of dispelling pathogenic wind, removing dampness, and strengthening tendons and bones. It can be used for treating arthralgia due to wind-cold-dampness. Pungent, bitter, dry and warm in nature, it can dispel wind-damp, enter liver and kidney, strengthen tendons and bones, and is very suitable for the elderly.

The cortex Illicii Lanceolati is dried bark of Illicium chinense of Magnoliaceae. Divided into Guangxi, southwest, Duan, Mashan, Debao to Longzhou, etc. Peeling in spring and autumn, and drying in the sun or at low temperature. The product is in roll shape or groove shape, the outer surface is gray brown to dark brown, some of the products can be seen as gray-white lichen spots, the crude skin is easy to peel off or fall off, and the fallen part is brownish red. The inner surface is brown or brownish red, and has obvious fine longitudinal wrinkles. The texture is crisp, the fracture is easy to break, and the section is granular. Slightly fragrant smell and slightly astringent taste. Removing impurities, washing, crushing, and drying. Slightly pungent and astringent taste, warm in nature. It enters bladder and kidney meridians. Has effects of dispelling pathogenic wind, removing dampness, activating qi-flowing and relieving pain. Can be used for treating rheumatic arthralgia and lumbago due to strain.

The Carthami flos is dried flower of Carthamus Tinctorius of Compositae. Collected in the shade or dried in the sun when the flowers turn yellow and red in summer. The cultivation is widely carried out all over the country. Pungent flavor and warm nature. It enters heart and liver meridians. Has the functions of promoting blood circulation to restore menstrual flow, eliminating blood stasis and relieving pain. Can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, thoracic obstruction, cardialgia, abdominal pain due to blood stasis, pricking pain in chest and hypochondrium, traumatic injury, and pyocutaneous disease with swelling and pain.

The Scorpio is dried body of Buthus martensii Karsch of Buthidae. Catching in spring to autumn, removing silt, decocting in boiling water or boiling saline water until the whole body is stiff, taking out, placing in ventilated place, and drying in shade. It is pungent and mild in nature and flavor and enters liver meridian. Has the effects of calming endogenous wind, relieving spasm, dredging collaterals, relieving pain, counteracting toxic substances and resolving masses. Can be used for treating liver wind stirring, spasm, convulsion, infantile convulsion, and apoplexy

Hemiplegia, tetanus, stubborn rheumatism, migraine, sore and ulcer, scrofula.

The saussurea involucrate is a herb plant of saussurea of Compositae, and grows on a mountain river rockslope with the altitude of 4800-5800 meters and between broken stones near a snow line. Saussurea involucrate is a rare medicinal plant in high mountains. Saussurea involucrate is divided into jellyfish saussurea involucrate, saussurea sericea, saussurea pilosa, Tibet saussurea involucrate, etc. Because of the uniqueness and physiological characteristics of the growing environment, the efficacy of saussurea involucrate is also very unique, and roots, stems, leaves, flowers and seeds of saussurea involucrate can be used as the medicine. It is warm in nature, slightly bitter in taste and enters liver, spleen and kidney meridians. Has effects in clearing away heat and toxic materials, promoting blood circulation, dispelling blood stasis, relieving inflammation and pain, expelling pathogenic wind, removing dampness, invigorating kidney, supporting yang, regulating menstruation, stopping bleeding, and contracting uterus. Can be used for treating rheumatic arthritis, menoxenia, lumbago due to kidney deficiency, cough due to lung cold, retained fetal membranes, neurasthenia, altitude anoxia, spermatorrhea, sexual impotence, measles without adequate eruption, traumatic hemorrhage, snow blindness, toothache, and skin anthrax.

The Borneolum Syntheticum is prepared from stems and leaves of blumea balsamifera of Compositae or branches and leaves of Cinnamomum camphora of Lauraceae by steam distillation and recrystallization. Colorless, transparent or semitransparent flaky crisp crystals with faint scent, pungent taste and cool taste; it is volatile, and can be ignited to produce thick smoke and flame with light. Contains Borneolum (not less than 55.0%). Pungent, bitter and slightly cold in nature. It enters heart, spleen and lung meridians. The product has effects of inducing resuscitation, refreshing mind, clearing heat, removing toxic substances, improving eyesight, and removing nebula, and can be used for treating hemorrhoid, fever, hyperpyrexia, coma, apoplexy, phlegm syncope, convulsion, summer-heat dampness covering resuscitation, pharyngitis, deafness, aphtha, swelling of teeth, skin ulcer, carbuncle, malnutritional hemorrhoid, conjunctival congestion, swelling and pain, nebula, and eye covering.

The Eucommiae cortex is bark of eucommia ulmoides Oliver of Eucommiaceae. In order to protect resources, a partial peeling method is generally adopted. Selecting plants growing for more than 15-20 years from Qingming to summer, peeling off barks according to the size of the medicinal materials, planing off coarse barks, and drying in the sun. Placing the container in a ventilated and dry place. Sweet, slightly pungent and warm in nature. Enter liver and kidney meridians. The main functional indications are as follows: tonify liver and kidney, strengthen tendons and bones, prevent abortion. It is indicated for soreness and pain of lumbar and knees, atrophy and weakness of feet and knees, dribbling urination, itching of vulva, vaginal bleeding, threatened abortion, and hypertension.

The herba Solani Nigri is whole plant of Solanum Nigri of Solanaceae, and is also called herba Sonchi Oleracei. All over the country. It is born by roadside or in the field. Is widely distributed in the temperate zone of Europe, Asia and America to tropical regions. Collected in summer and autumn. Bitter in property and cold in nature. The main functional indications are as follows: clearing away heat and toxic material, promoting blood circulation and eliminating swelling. It can be used for treating furuncle, carbuncle, erysipelas, traumatic injury, sprain, chronic tracheitis, and acute nephritis. Can be used for treating skin sore, carbuncle, toxic swelling, skin eczema, dysuria, senile chronic tracheitis, leukorrhagia, prostatitis, and dysentery.

The white tea is tea concentrated powder of white tea, belongs to micro-fermented tea, and is a special treasure in Chinese tea. The finished tea is mostly bud heads, is full of pekoe, is named after snow-like silver, and is one of six Chinese teas. The white tea is processed by drying in the sun or drying with slow fire without deactivating enzyme or twisting. The white tea has good drug effect. The health-care tea has the effects of relieving alcoholism and sobering up, clearing heat and moistening lung, calming liver and benefiting blood, diminishing inflammation and detoxifying, reducing blood pressure and fat, eliminating fatigue and the like, and particularly has unique and smart health-care effect on symptoms such as discomfort, digestive dysfunction and the like caused by excessive smoking and drinking, excessive greasiness and excessive liver fire.

The Agkistrodon acutus is whole body of Agkistrodon halys (Agkistrodon halys) of Agkistrodon family or Bungarus multicinctus of Elapidae family with viscera removed. The long bamboo poles and iron wires are generally used as a set of ropes for catching the five-step snakes in summer. After catching, cutting open abdomen and removing viscera, making the dish into a round shape, baking after opening with bamboo chips, or baking directly without opening with bamboo chips. Collectively referred to as big long-noded pit viper. Spreading and baking the dried product, also called Agkistrodon Gnathagnus; the one baked directly to dry is called Agkistrodon stick. Catching young Agkistrodon in summer, laparotomy, removing viscera, coiling into round shape, spreading with bamboo stick, and baking. It is called Bungarus Parvus. Sweet, salty, warm and toxic in nature. Enter liver and spleen meridians. Has the effects of dispelling pathogenic wind and removing dampness, penetrating into bones and muscles, and arresting convulsion. Can be used for treating rheumatism, paralysis, arthralgia, leprosy, scabies, tetany, tetanus, syphilitic sore, lymphoid tuberculosis, and malignant sore.

Zaocys refers to the whole body of Zaocys dhumnades of Colubridae except viscera. Taking raw medicinal materials, removing impurities, head, scale and dust, and cutting into segments. Storing in a drying container, sealing, and placing in a shady and dry place. Moth-proofing and mildew-proofing. Sweet in flavor and neutral in nature. Enter lung, spleen and liver meridians. Has the functions of dispelling wind-damp, dredging meridian and relieving spasm. It can be used for treating rheumatism, numbness of skin, spasm of muscles and tendons, paralysis of limbs, tetanus, leprosy, rubella, scabies, and tinea.

Radix Saposhnikoviae is root of radix Saposhnikoviae belonging to family Umbelliferae. Perennial herbaceous plants like cool climate, cold resistance and drought resistance, and are mainly produced in Hebei, Heilongjiang, Sichuan, inner Mongolia and other places. Unprocessed Fang Feng Gen. Pungent and sweet in flavor, slightly warm in nature. It enters bladder, lung, spleen and liver meridians. Has the effects of dispelling pathogenic wind, relieving exterior syndrome, eliminating dampness, relieving pain, and relieving spasm. Can be used for treating exterior syndrome due to exogenous pathogenic factor, rubella pruritus, rheumatalgia, tetanus, and spleen deficiency with excessive dampness.

The rhizoma Drynariae is rhizome of Drynariae rhizoma of Polypodiaceae. Collected all the year round, mainly in winter and spring. Removing leaves and scales, cleaning, moistening, slicing, and drying. Unprocessed or scalded with sand. Bitter taste and warm nature; it enters liver and kidney meridians. Has effects of promoting blood circulation, promoting wound healing, invigorating kidney, and strengthening bone. Can be used for treating traumatic injury or wound, bone and muscle injury, blood stasis, swelling and pain, lumbago, asthenia, tinnitus, deafness, toothache, and chronic diarrhea.

Herba Lycopodii is dry whole plant of Lycopodium clavatum of Lycopodiaceae. Live in the shade under the sparse forest. Distributed in northeast, eastern China, southern China, southwest China, inner Mongolia, Henan, etc. It is produced in Zhejiang, Hubei and Jiangsu provinces, as well as in Hunan and Sichuan provinces. Collected in summer and autumn when the stem and leaf are flourishing, removed impurities and dried in the sun. The preparation method comprises removing impurities, cleaning, cutting, and drying. The whole plant is used as the medicine. Bitter and slightly pungent in flavor and warm in nature. It enters liver, spleen and kidney meridians. Has effects of dispelling pathogenic wind, removing dampness, relieving rigidity of muscles and activating collaterals. Can be used for treating joint pain and difficulty in flexion and extension.

The herba Speranskiae Tuberculatae is whole plant of radix Sangusorbae leaf of Euphorbia leaf of Euphorbiaceae. The plant radix seu folium Broussonetiae is distributed in Liaoning, Jilin, inner Mongolia, Hebei, Henan, Shanxi, Gansu, Shandong, Jiangsu, Anhui, and Sichuan of China. Pungent flavor and warm nature. Enter liver and kidney meridians. Has the effects of dispelling pathogenic wind, removing dampness, relaxing muscles and tendons, promoting blood circulation, removing blood stasis, relieving swelling, removing toxic substance, and relieving pain. It can be used for treating rheumatic arthralgia, contracture of tendons and bones, cold-dampness, tinea pedis, lumbar sprain, paralysis, amenorrhea, eczema of scrotum, skin ulcer, furuncle, and pyogenic infections.

The Concha Margaritifera is shell Margarita layer of Hyriopsis cumingii, Cristaria plicata or Pteriidae Pinctada martensii. Can be collected all the year round. Decocting shell with alkaline water, rinsing, removing outer black skin, and calcining to crisp. Sweet and salty in nature, cold and nontoxic. Enter heart and liver meridians. The main functional indications are as follows: pacify liver, subdue yang, arrest convulsion and stop bleeding. It is indicated for dizziness, tinnitus, palpitation, insomnia, mania, fright epilepsy, hematemesis, epistaxis, and female metrorrhagia.

The folium Linderae Strychnifoliae is leaf of radix Linderae Strychnifoliae of Lauraceae. The radix linderae is distributed in Shaanxi, Anhui, Zhejiang, Jiangxi, Fujian, Taiwan, Hubei, Hunan, Guangxi, Sichuan and other places in China. Collected all the year round, cleaned, and used fresh or dried in the sun. Pungent flavor and warm nature. Enter spleen and kidney meridians. Has the effects of warming middle-jiao, regulating qi, relieving swelling and alleviating pain. It can be used for treating abdominal psychroalgia, frequent micturition, rheumatic arthralgia, traumatic injury, pain, and scald.

Cuttlefish bone is dried inner shell of Sepiella maindroni or Sepiella maindroni of Sepiidae. Collecting bone-shaped inner shell of cuttlefish, cleaning, and drying. Salty, astringent and warm in nature and taste. It enters spleen and kidney meridians. The main functional indications are as follows: astringe to stop bleeding, astringe essence to stop leucorrhea, relieve hyperacidity, heal wound. Can be used for treating ulcer, hyperchlorhydria, hematemesis, epistaxis, metrorrhagia, hematochezia, spermatorrhea, leucorrhea with red and white discharge, gastralgia, and acid regurgitation; it is used externally to treat wound bleeding, sore with pus. The traditional Chinese medicine is used as a hemostatic. Has antacid, analgesic, hemostatic, bone knitting, bone defect repairing, radioprotective, antitumor, and antiulcer effects.

Lignum Dalbergiae Odoriferae is dry heartwood of trunk and root of lignum Dalbergiae Odoriferae of Leguminosae. Collected all the year round, removed sapwood, dried in the shade. The product is in the form of quasi-cylindrical or irregular block. The surface is purplish red or reddish brown, and the section has compact texture. Hard and oily. Slightly fragrant smell and slightly bitter taste. Removing impurities, chopping into small pieces, and grinding into fine powder or making into tablet. Pungent and warm in nature and flavor. It enters liver and spleen meridians. Has effects of removing blood stasis, stopping bleeding, regulating qi-flowing and relieving pain. Can be used for treating hematemesis, epistaxis, traumatic hemorrhage, hypochondriac pain due to stagnation of liver-qi, thoracic obstruction, pain due to pricking, traumatic injury, emesis, and abdominal pain.

The radix Sangusorbae is dried root of sanguisorba officinalis or sanguisorba longifolia of Rosaceae. Picking and digging plants when sprouting or withering in autumn in spring, removing fibrous root, cleaning, and drying, or slicing and drying while fresh. Bitter, sour, astringent and slightly cold in nature. It enters liver and large intestine meridians. Has the effects of cooling blood, stopping bleeding, removing toxic substances and healing sore. Can be used for treating hematochezia, hemorrhoidal bleeding, bloody dysentery, metrorrhagia, scald due to hot water and fire, carbuncle, swelling, and sore.

The pollen Typhae is dried pollen of Typha angustifolia, Typha orientalis or plants of the same genus of Typhaceae. Collecting yellow male inflorescence at the upper part of the spike of cattail in summer, sun-drying, rolling, sieving to obtain fine powder, and unprocessed or stir-frying. Sweet and mild in nature and taste; it enters liver and pericardium meridians. Has hemostatic, blood stasis removing, and diuretic effects. It is mainly used for treating bleeding, blood stasis and pain, stranguria with blood and hematuria.

Herba et Gemma Agrimoniae is dry aerial part of Agrimonia pilosa Ledeb of Rosaceae. Bitter, astringent and mild in nature and taste; it enters heart and liver meridians. Has effects in astringing, stopping bleeding, stopping dysentery, preventing malaria, and tonifying deficiency. It can be used for treating hemorrhage, diarrhea, dysentery, malaria, cold and heat, traumatic injury, toxic materials clearing away, parasite killing, skin ulcer, furuncle, carbuncle, swelling, pruritus vulvae, and leukorrhagia.

The lignum Aquilariae Resinatum is resin-containing wood of Aquilaria of Thymelaeaceae and radix Aristolochice. Harvesting all the year round, cutting wood containing resin, removing resin-free part, drying in the shade, and crushing or filing. Unprocessed. Pungent, bitter and slightly warm in nature; it enters spleen, stomach and kidney meridians. Has effects of activating qi-flowing, relieving pain, warming middle-jiao, relieving vomit, and absorbing qi and relieving asthma. It can be used for treating abdominal distention and pain, stomach cold emesis, deficiency asthma.

Myrrha is dried resin of herba Violae or herba corydalis Thalictrifoliae of Burseraceae. Is divided into natural myrrh and colloid myrrh. Distributed in somari, russian and south Arabian peninsula. Pungent and bitter in flavor and mild in nature. It enters heart, liver and spleen meridians. Has effects in removing blood stasis, relieving pain, eliminating swelling, and promoting granulation. Can be used for treating thoracic obstruction, cardialgia, gastralgia, dysmenorrhea, amenorrhea, puerperal stagnation, abdominal mass, rheumatic arthralgia, traumatic injury, carbuncle, swelling, and pyocutaneous disease.

The Olibanum is resin exuded from bark of Boswellia serrata belonging to Burseraceae and plants belonging to the same genus. The milk is classified into the species of frankincense somarie and the species of frankincense esophora, each of which is also in turn the same as the bead of frankincense and the original frankincense. Pungent, bitter and warm in nature. It enters heart, liver and spleen meridians. Has effects of promoting blood circulation, activating qi-flowing, relieving pain, eliminating swelling and promoting granulation. Can be used for treating thoracic obstruction, cardialgia, epigastralgia, dysmenorrhea, amenorrhea, puerperal blood stasis, abdominal pain, rheumatic arthralgia, spasm of muscles and tendons, traumatic injury, carbuncle, swelling, and pyocutaneous disease.

Preferably, the composition comprises the following raw materials in parts by weight: 45-55 parts of radix angelicae pubescentis, 35-45 parts of asarum, 55-65 parts of homalomena occulta, 55-65 parts of anisetree bark, 25-35 parts of safflower, 20-30 parts of scorpion, 25-35 parts of borneol, 25-35 parts of eucommia bark, 20-30 parts of black nightshade, 15-25 parts of white tea concentrated powder, 35-45 parts of garter snake, 30-40 parts of divaricate saposhnikovia root, 25-35 parts of rhizoma drynariae, 25-35 parts of lycopodium clavatum, 30-40 parts of garden balsam stem, 20-30 parts of nacre, 15-25 parts of combined spicebush leaf, 15-25 parts of cuttle bone, 8-12 parts of rosewood, 10-20 parts of garden burnet root, 15-25 parts of pollen typhae, 15-25 parts of hairyvein agrimony herb, 10-20 parts of agilawood, 15-20 parts of myrrh and 15-20 parts of frankincense.

The raw materials of the composition also comprise: one to two snow lotus and one to three long-noded pit vipers.

More preferably, the raw materials of the composition comprise by weight: 50g of radix angelicae pubescentis, 40g of asarum, 60g of homalomena occulta, 60g of anisetree bark, 30g of safflower, 25g of scorpion, 30g of borneol, 30g of eucommia bark, 25g of black nightshade, 20g of white tea concentrated powder, 40g of garter snake, 35g of divaricate saposhnikovia root, 30g of rhizoma drynariae, 30g of lycopodium clavatum, 35g of garden balsam stem, 25g of nacre, 20g of lindera aggregate leaf, 20g of cuttlebone bone, 10g of rosewood, 15g of sanguisorba officinalis, 20g of cattail pollen, 20g of hairyvein agrimony, 15g of agilawood, 18g of myrrh and 18g of frankincense.

The raw materials of the composition also comprise: one snow lotus and three long-noded pit vipers.

The raw materials are wild Chinese herbal medicines, and perennial Chinese herbal medicines are five years or more. The material is obtained from wild rare animals and plants, and can be artificially cultured and planted under the condition that conditions are not allowed, or other substitutes with equivalent and similar effects.

The invention also provides application of the composition for treating rheumatic bone pain and traumatic injury, and the composition is used for preparing external medicaments.

The invention also provides a preparation method of the medicament, which comprises the following steps: weighing the raw materials in proportion, cleaning and drying the washable raw materials, grinding and crushing all the raw materials, adding water, decocting, filtering to obtain liquid medicine, cooling in the air, filling into a container, sealing and packaging.

Other specific conditions and equipment, etc. employed in the process are known to those skilled in the art.

The prepared medicament is used as an external spray, and is filled into bottles, and the bottles are hermetically packaged, wherein each bottle contains 20-30 ml of the medicament.

The spray can be sprayed several times per day as required, and massaged for five to ten minutes after each spray.

The composition for treating rheumatic bone pain and traumatic injury, the use and the preparation method thereof provided by the invention are further described by combining the embodiment.

Example 1

A composition for treating rheumatic bone pain and traumatic injury comprises the following raw materials in parts by weight:

50g of radix angelicae pubescentis, 40g of asarum, 60g of homalomena occulta, 60g of anisetree bark, 30g of safflower, 25g of scorpion, 30g of borneol, 30g of eucommia bark, 25g of black nightshade, 20g of white tea concentrated powder, 40g of garter snake, 35g of divaricate saposhnikovia root, 30g of rhizoma drynariae, 30g of lycopodium clavatum, 35g of garden balsam stem, 25g of nacre, 20g of lindera aggregate leaf, 20g of cuttlebone bone, 10g of rosewood, 15g of sanguisorba officinalis, 20g of cattail pollen, 20g of hairyvein agrimony, 15g of agilawood, 18g of myrrh and 18g of frankincense.

The embodiment also provides the application of the composition for treating rheumatic bone pain and traumatic injury, and the composition is used for preparing a medicament for external use.

The embodiment also provides a preparation method of the medicament, which comprises the following steps: weighing the raw materials in proportion, cleaning and drying the washable raw materials, grinding and crushing all the raw materials, adding water, decocting, filtering to obtain liquid medicine, cooling in the air, filling into a container, sealing and packaging.

The prepared medicament is used as an external spray, is filled into bottles, and is packaged in a sealing way, wherein each bottle contains 25ml of the medicament.

The spray is sprayed several times a day, and massages five to ten minutes after each spray.

Example 2

45g of radix angelicae pubescentis, 35g of asarum, 55g of homalomena occulta, 55g of anisetree bark, 25g of safflower, 20g of scorpion, 25g of borneol, 25g of eucommia bark, 20g of black nightshade, 15g of white tea concentrated powder, 35g of garter snake, 30g of divaricate saposhnikovia root, 25g of rhizoma drynariae, 25g of lycopodium clavatum, 30g of garden balsam stem, 20g of nacre, 15g of lindera aggregate leaf, 15g of cuttlebone bone, 8g of rosewood, 10g of sanguisorba officinalis, 15g of cattail pollen, 15g of hairyvein agrimony, 10g of agilawood, 15g of myrrh and 15g of frankincense.

The raw materials of the composition also comprise: half snow lotus and one long-noded pit viper.

The prepared medicament is used as an external spray, and is filled into bottles, sealed and packaged, wherein each bottle contains 20ml of the medicament.

Example 3

55g of radix angelicae pubescentis, 45g of asarum, 65g of homalomena occulta, 65g of anisetree bark, 35g of safflower, 30g of scorpion, 35g of borneol, 35g of eucommia bark, 30g of black nightshade, 25g of white tea concentrated powder, 45g of garter snake, 40g of divaricate saposhnikovia root, 35g of rhizoma drynariae, 35g of lycopodium clavatum, 40g of garden balsam stem, 30g of nacre, 25g of lindera aggregate leaf, 25g of cuttlebone bone, 12g of rosewood, 20g of sanguisorba, 25g of cattail pollen, 25g of hairyvein agrimony, 20g of agilawood, 20g of myrrh and 20g of frankincense.

The raw materials of the composition also comprise: two saussurea involucrata and two long-noded pit vipers.

The prepared medicament is used as an external spray, is filled into bottles, and is packaged in a sealing way, and each bottle contains 30ml of the medicament.

The raw materials adopted in the embodiments of the invention respectively accord with the corresponding national standards.

Clinical trials of the medicament prepared by the embodiments of the invention prove that the composition can rapidly achieve the effects of clearing away heat and toxic materials, relieving swelling and pain, dispelling wind and dredging collaterals, strengthening tendons and bones, removing blood stasis and stopping bleeding, promoting granulation and healing sore, repairing scars and the like, is used for treating rheumatic arthritis, traumatic injury, trauma and the like, has exact efficacy and small toxic and side effects, can help patients to recover quickly, and does not produce other sequelae.

The invention provides a composition for treating rheumatic ostealgia and traumatic injury, and application and a preparation method thereof. The preparation is also called as the preparation for hearing wind and getting early month.

The composition is a pure Chinese medicinal preparation, has small toxic and side effects, can help patients to recover quickly, has the effects of clearing heat and toxic materials, relaxing muscles and tendons, dredging collaterals, diminishing inflammation, sterilizing, stopping bleeding, astringing, repairing scars and the like, and can fundamentally start to enter liver and kidney, strengthen tendons and bones, treat wounds and relieve pain and condition organism states, so that the effect of the medicine on treating rheumatic arthritis, traumatic injury, trauma and the like is more obvious. The composition also has the characteristics of reasonable formula, small using amount, obvious effect, quick response, difficult relapse and the like, and has the advantages of simple and easily obtained components, convenient processing, low price, high quality, economy, practicability and the like.

According to the composition for treating rheumatic ostealgia and traumatic injury, through traditional Chinese medicine syndrome differentiation, aiming at the etiology and pathogenesis of diseases and symptoms, the compatibility principle of medicines which are complementary is utilized, the medicines are purposefully and reasonably combined according to the monarch, minister, assistant and guide tissue structures, the medicines in the formula and the compatibility thereof are screwed into the pathogenesis of the diseases, and the comprehensive effect after the medicines are combined is highly unified with the established treatment method.

While the present invention has been described in detail with reference to the preferred embodiments, it should be understood that the above description should not be taken as limiting the invention. Various modifications and alterations to this invention will become apparent to those skilled in the art upon reading the foregoing description. Accordingly, the scope of the invention should be determined from the following claims.

Claims

1. A composition for rheumatic bone pain and traumatic injury, which is prepared from the following raw materials: radix angelicae pubescentis, asarum, homalomena occulta, anisetree bark, safflower, scorpion, saussurea involucrate, borneol, eucommia ulmoides, black nightshade, white tea, long-noded pit viper, garter snake, divaricate saposhnikovia root, rhizoma drynariae, lycopodium clavatum, garden balsam stem, nacre, combined spicebush leaf, cuttlebone, rosewood, garden burnet root, cattail pollen, hairyvein agrimony, agilawood, myrrh and frankincense.

2. The composition for rheumatic bone pain and traumatic injury according to claim 1, wherein the raw materials of the composition comprise concentrated powder of white tea.

3. The composition for rheumatic bone pain and traumatic injury according to claim 2, wherein the composition comprises the following raw materials in parts by weight: 45-55 parts of radix angelicae pubescentis, 35-45 parts of asarum, 55-65 parts of homalomena occulta, 55-65 parts of anisetree bark, 25-35 parts of safflower, 20-30 parts of scorpion, 25-35 parts of borneol, 25-35 parts of eucommia bark, 20-30 parts of black nightshade, 15-25 parts of white tea concentrated powder, 35-45 parts of garter snake, 30-40 parts of divaricate saposhnikovia root, 25-35 parts of rhizoma drynariae, 25-35 parts of lycopodium clavatum, 30-40 parts of garden balsam stem, 20-30 parts of nacre, 15-25 parts of combined spicebush leaf, 15-25 parts of cuttle bone, 8-12 parts of rosewood, 10-20 parts of garden burnet root, 15-25 parts of pollen typhae, 15-25 parts of hairyvein agrimony herb, 10-20 parts of agilawood, 15-20 parts of myrrh and 15-20 parts of frankincense.

4. The composition for rheumatic bone pain and traumatic injury according to claim 3, wherein the raw materials of the composition further comprise: one to two snow lotus and one to three long-noded pit vipers.

5. The composition for rheumatic bone pain and traumatic injury according to claim 3, wherein the raw materials of the composition comprise, by weight: 50g of radix angelicae pubescentis, 40g of asarum, 60g of homalomena occulta, 60g of anisetree bark, 30g of safflower, 25g of scorpion, 30g of borneol, 30g of eucommia bark, 25g of black nightshade, 20g of white tea concentrated powder, 40g of garter snake, 35g of divaricate saposhnikovia root, 30g of rhizoma drynariae, 30g of lycopodium clavatum, 35g of garden balsam stem, 25g of nacre, 20g of lindera aggregate leaf, 20g of cuttlebone bone, 10g of rosewood, 15g of sanguisorba officinalis, 20g of cattail pollen, 20g of hairyvein agrimony, 15g of agilawood, 18g of myrrh and 18g of frankincense.

6. The composition of claim 5, wherein the raw materials for the composition further comprise: one snow lotus and three long-noded pit vipers.

7. Use of a composition as claimed in any one of claims 1 to 6 for the preparation of a medicament for external use for rheumatic bone pain and traumatic injury.

8. A method of preparing the medicament of claim 7, wherein the method comprises: weighing the raw materials in proportion, cleaning and drying the washable raw materials, grinding and crushing all the raw materials, adding water, decocting, filtering to obtain liquid medicine, cooling in the air, filling into a container, sealing and packaging.

9. The preparation method of the medicament according to claim 8, wherein the medicament prepared by the method is used as an external spray, and is filled into bottles, and the bottles are hermetically packaged, wherein each bottle contains 20-30 ml of the medicament.

10. The method of claim 9, wherein the spray is sprayed several times a day and massaged for five to ten minutes after each spray.