CN113577196A - Medicament for various skin diseases and preparation method and application thereof - Google Patents

Medicament for various skin diseases and preparation method and application thereof Download PDF

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CN113577196A
CN113577196A CN202110955768.4A CN202110955768A CN113577196A CN 113577196 A CN113577196 A CN 113577196A CN 202110955768 A CN202110955768 A CN 202110955768A CN 113577196 A CN113577196 A CN 113577196A
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parts
medicament
herba
skin diseases
ointment
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孔庆博
王丹
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/89—Cyperaceae (Sedge family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/614—Cnidaria, e.g. sea anemones, corals, coral animals or jellyfish
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234—Cnidium (snowparsley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532—Agastache, e.g. giant hyssop
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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Abstract

The invention discloses a medicament for treating various skin diseases, a preparation method and application thereof, wherein the medicament comprises the following raw materials: herba Carpesii Cernui, folium Artemisiae Argyi, herba Basellae Rubrae, herba Senecionis Cannabifolii, folium Artemisiae Argyi, herba Taraxaci, fructus Cnidii, herba Portulacae, rhizoma Bletillae, radix Ginseng Indici, herba Agastaches, Mentholum, semen Brassicae Pekinensis, and herba seu radix Cirsii Japonici. The feedstock preferably comprises: 30g of carex, 30g of artemisia anomala leaf, 30g of okra, 30g of senecio cannabifolius, 30g of folium artemisiae argyi, 50g of dandelion, 50g of fructus cnidii, 50g of purslane, 50g of rhizoma bletillae, 50g of wild ginseng, 50g of agastache rugosus, 50g of menthol, 50g of brassica campestris and 50g of setose thistle. The invention also provides application of the medicament, and the medicament is used for preparing external ointment for patients with skin diseases. The invention also provides a preparation method of the external ointment. The ointment prepared by the medicament has the effects of sterilizing, relieving itching, removing scars and scars, diminishing inflammation, relieving pain and the like, and can be used for various skin diseases.

Description

Medicament for various skin diseases and preparation method and application thereof
Technical Field
The invention relates to an external pharmaceutical composition, a preparation method and application thereof, in particular to a medicament for treating various skin diseases, a preparation method and application thereof.
Background
Skin diseases (dermatasis) are a general term for diseases occurring in the skin and its appendages. The skin is the largest organ of the human body, the skin diseases are not only various, but also diseases occurring in various internal organs can be shown on the skin. The skin diseases caused by various reasons, such as skin diseases caused by infection factors, such as leprosy, scabies, mycosis, skin bacterial infection and the like, have certain infectivity, not only affect the physical health, but also cause panic and social discrimination, but with the improvement of the living standard of people and the improvement of scientific and technological processes, the infectious diseases such as leprosy and the like are obviously controlled all over the world. Other internal and external factors causing skin diseases, such as mechanical, physical, chemical, biological, endocrine, and immune factors, are receiving more and more attention at present.
The skin is used as the first physiological defense line and the largest organ of the human body, constantly participates in the functional activities of the body, maintains the unity of opposition between the body and the natural environment, and the abnormal conditions of the body can be reflected on the surface of the skin. The skin has nearly perfect physiological protection function: such as barrier function, sensory function, body temperature regulation, absorption function, secretion and excretion function, etc., and plays an important role in maintaining the health of the body. The physiological function of the skin is impaired, causing skin diseases.
The most common causative factors of skin diseases are infectious diseases and allergic dermatitis, but degenerative changes with aging are also important skin diseases such as senile skin diseases and skin cancer, and various skin disorders causing side effects due to drug treatment of the diseases need to be noted.
The most used skin disease treatments are topical drugs. If the external medicine is not properly selected or used, the medicine is often ineffective and even aggravates the disease. The selection of the external medicine for treating the skin diseases can pay attention to the following aspects: the same medicine can be made into different dosage forms, such as solution, paste, powder, cream, lotion, ointment, tincture, emulsion, etc. Different formulations have different actions and indications, so the different formulations of external drugs should be selected correctly according to the clinical symptoms and skin lesions characteristics of different disease stages.
The existing biological agents, western medicines, traditional Chinese medicines and other products for treating skin diseases, sore and carbuncle swelling and pain cannot really and completely treat skin diseases, particularly fungal bacteria, and cannot leave no scars or fade scars, and further can eradicate sore and carbuncle swelling and pain, furuncle, eczema, dermatitis and the like. The purification of the medicine mode is not ideal enough, the medicine source cannot be kept true, and the fundamental technology and the solution have certain defects, so that the product cannot fundamentally solve the problems of patients and the public.
Disclosure of Invention
The invention aims to provide an external pharmaceutical composition, a preparation method and application thereof, which can solve the existing problems and effectively relieve the pain of patients.
In order to achieve the above object, the present invention provides a pharmaceutical preparation for various skin diseases, wherein the pharmaceutical preparation comprises the following raw materials: herba Carpesii Cernui, folium Artemisiae Argyi, herba Basellae Rubrae, herba Senecionis Cannabifolii, folium Artemisiae Argyi, herba Taraxaci, fructus Cnidii, herba Portulacae, rhizoma Bletillae, radix Ginseng Indici, herba Agastaches, Mentholum, semen Brassicae Pekinensis, and herba seu radix Cirsii Japonici.
The medicament for treating various skin diseases comprises the following raw materials in parts by weight: 25-35 parts of carex, 25-35 parts of artemisia leaf, 25-35 parts of abelmoschus manihot, 28-32 parts of senecio nobilis, 28-32 parts of folium artemisiae argyi, 45-55 parts of dandelion, 45-55 parts of fructus cnidii, 45-55 parts of purslane, 45-55 parts of rhizoma bletillae, 40-60 parts of wild ginseng, 40-60 parts of agastache rugosus, 40-60 parts of menthol, 40-60 parts of brassica alba seed and 40-60 parts of circium japonicum.
The medicament for treating various skin diseases comprises the following raw materials in parts by weight: 30g of carex, 30g of artemisia anomala leaf, 30g of okra, 30g of senecio cannabifolius, 30g of folium artemisiae argyi, 50g of dandelion, 50g of fructus cnidii, 50g of purslane, 50g of rhizoma bletillae, 50g of wild ginseng, 50g of agastache rugosus, 50g of menthol, 50g of brassica campestris and 50g of setose thistle.
The raw materials of the medicament for treating various skin diseases are all wild Chinese herbal medicines, and perennial medicinal materials for five years or more are adopted.
In the medicament for treating various skin diseases, the wild ginseng is twenty-five years or more.
The invention also provides application of the medicament for treating various skin diseases, wherein the medicament is used for preparing the external ointment for smearing the skin disease patients.
The invention also provides a preparation method of the external ointment, wherein the method comprises the following steps: weighing the medicines in proportion, grinding and crushing the medicines into powder, soaking and extracting the powder by alcohol, concentrating and purifying the powder, adding glycerol and white vaseline, uniformly mixing the mixture, heating and emulsifying the mixture, cooling the mixture to obtain an ointment in an oil emulsion state, and finally sterilizing, filling and packaging the ointment to obtain the ointment.
The preparation method of the external ointment comprises the step of grinding and crushing the ointment into powder with a granularity of 30-40 meshes.
The preparation method of the external ointment comprises the step of soaking the ointment in the alcohol for 24 hours or more.
The preparation method of the external ointment comprises the step of heating for emulsification, wherein the temperature is 75-95 ℃.
The medicament for treating various skin diseases, the preparation method and the application thereof provided by the invention have the following advantages:
the invention selects more than five years or wild Chinese herbal medicines, combines the modern biotechnology and pharmaceutical technology after powdering, and is prepared into oil emulsion state ointment for coating after high concentration and purification. Has the effects of sterilizing, relieving itching, removing scar, diminishing inflammation, relieving pain, etc., can effectively treat dermatitis tinea, eliminate all damp toxin, kill parasites, stop pus, treat carbuncle, furuncle and various famous pyogenic infections, and also has the effect of treating skin diseases such as eczema, psoriasis, lupus erythematosus, etc. Can effectively recover various skin symptoms, relieve various symptoms, and pertinently solve various skin pruritus, bacterial infection, fungal infection and various inflammations and scars caused by the bacterial infection and the fungal infection.
The invention utilizes the uniqueness of the traditional Chinese medicine preparation, has better effect, can achieve the effect of treating skin diseases by the traditional Chinese medicine and the traditional Chinese medicine, and has the characteristics of reasonable formula, small dosage, obvious effect, no toxic or side effect, low recurrence rate and the like.
Detailed Description
The following further describes embodiments of the present invention.
The invention provides a medicament for treating various skin diseases, which comprises the following raw materials: herba Carpesii Cernui, folium Artemisiae Argyi, herba Basellae Rubrae, herba Senecionis Cannabifolii, folium Artemisiae Argyi, herba Taraxaci, fructus Cnidii, herba Portulacae, rhizoma Bletillae, radix Ginseng Indici, herba Agastaches, Mentholum, semen Brassicae Pekinensis, and herba seu radix Cirsii Japonici (root and leaf).
Wherein, the Meyer sedge is a plant of genus carex of family Cyperaceae of class Monocotyledonae, and mainly grows in the northeast Changbai mountain of China and in the south of Waxingan Ling. The carex meyeriana has the main effects of removing odor and odor, clearing and activating the channels and collaterals, eliminating fatigue, improving blood microcirculation and enhancing immunity.
The artemisia anomala leaf is the artemisia anomala leaf, and the part used as the medicine is the whole plant with flowers of the artemisia anomala of the Compositae. Is distributed in Henan, Jiangsu, Zhejiang, Anhui, Jiangxi, Fujian, Taiwan, Hubei, Hunan, Guangdong, Guangxi, Sichuan and Guizhou. Has the effects of clearing summer heat, promoting diuresis, promoting blood circulation, removing blood stasis, and relieving pain. It is used for treating sunstroke, headache, enteritis, dysentery, amenorrhea, abdominal pain, rheumatalgia, traumatic injury, traumatic hemorrhage, and mastitis.
The Abelmoschus manihot is the whole body of Abelmoschus manihot of family Hibiscus. Has the effects of astringing, inducing astringency, eliminating dampness and killing parasites. Can be used for treating hemorrhoid, proctoptosis, leucorrhea, tinea corporis, and enterobiasis.
Herba Selaginellae Doederleinii is dead nine, and the medicinal part is dried whole herb of herba Selaginellae Doederleinii or herba Selaginellae Doederleinii of Selaginellaceae. Collected all the year round, removed fibrous root and silt, dried in the sun. Distributed in most parts of the country. Has effects of promoting blood circulation and dredging channels. Can be used for treating amenorrhea, dysmenorrhea, abdominal mass, and traumatic injury. The herba Selaginellae charcoal has effects of removing blood stasis and stopping bleeding. Can be used for treating hematemesis, metrorrhagia, hematochezia, and rectocele.
The folium Artemisiae Argyi is leaf of Artemisia argyi of Compositae. Cultivating for 9 months and 2 nd month, cutting off aerial parts, picking off tender tips of leaves, and sun drying. Has effects of warming channels, stopping bleeding, dispelling cold, relieving pain, eliminating dampness, and relieving itching. It can be used for treating hematemesis, epistaxis, hemoptysis, hematochezia, metrorrhagia, gestational hemorrhage, menoxenia, dysmenorrhea, threatened abortion, psychroalgia of heart and abdomen, diarrhea, dysentery, cholera, spasm of muscle, leukorrhagia, eczema, scabies, tinea, hemorrhoid, and carbuncle.
The herba Taraxaci is perennial herb of Compositae. Distributed in northeast, east, China, southwest, Shanxi, Gansu, Qinghai, etc. The medicinal part is dry whole plant of Taraxacum mongolicum hand-Mazz, Taraxacum sinicum hand-Mazz or plants of the same genus of Compositae, picked from spring to autumn when the flower begins to bloom, removed impurities, cleaned, cut into segments, and dried. Has the effects of clearing away heat and toxic materials, relieving swelling, dispersing pathogenic accumulation, inducing diuresis, and treating stranguria. It is mainly used for furuncle, swelling and toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, jaundice due to damp-heat pathogen, stranguria with heat and pain, etc.
Fructus Cnidii is dried mature fruit of cnidium monnieri (L.) DC of Umbelliferae, and has effects of eliminating dampness, dispelling pathogenic wind, killing parasites, relieving itching, warming kidney and tonifying yang. Can be used for treating pudendal pruritus, leukorrhagia, eczema, pruritus, lumbago due to damp arthralgia, sexual impotence due to kidney deficiency, and infertility due to cold womb.
Purslane is an annual herb of the purslane family. The part for administration is dried aerial part of herba Portulacae of Portulacaceae. Removing impurities, cleaning, moistening, cutting, and drying. Has the functions of clearing away heat and toxic material, cooling blood to stop bleeding and stopping dysentery. It can be used for treating toxic heat, dysentery with blood, carbuncle, furuncle, eczema, erysipelas, snake and insect bite, hematochezia, hemorrhoidal bleeding, metrorrhagia, and metrostaxis. Is distributed in various regions in China. The plant can be used as both medicine and food. The whole herb is used for medicine, and has the functions of clearing heat and promoting diuresis, detoxifying and reducing swelling, diminishing inflammation, quenching thirst and promoting urination; the seeds can improve eyesight.
The rhizoma Bletillae is tuber of bletilla striata of Orchidaceae. Collected in summer and autumn, removed fibrous root, cleaned, dried in the sun, unprocessed. Has effects of astringing, stopping bleeding, eliminating swelling, and promoting granulation. It can be used for treating hemorrhage, carbuncle, swelling, pyocutaneous disease, rhagadia manus et pedis, and scald due to hot water and fire.
The wild ginseng is a ginseng naturally grown in the deep mountain dense forest for more than 15 years. The world has three countries of China, Russia and Korea. Wild ginseng is a rare green natural tonic, wherein the natural wild ginseng grown in Changbai mountain and branch veins of Jilin in China is a rare ginseng. The succulent root of ginseng is a well-known tonic, is suitable for regulating blood pressure, recovering heart function, neurasthenia and asthenia, and also has expectorant, stomach invigorating, diuretic and exciting effects. It can be used for treating fatigue, asthenia, anorexia, listlessness, regurgitation, diarrhea, cough, asthma, spontaneous perspiration, palpitation, amnesia, vertigo, headache, sexual impotence, frequent micturition, diabetes, metrorrhagia, infantile pavor, and deficiency of both qi and blood.
Herba Agastaches is herba Agastaches of Labiatae family or aerial part of herba Agastaches; has effects in eliminating dampness, activating spleen, removing filth, regulating stomach, relieving summer-heat, and relieving exterior syndrome; can be used for treating syndrome of dampness obstruction of spleen and stomach, abdominal distention, early stage of damp-warm syndrome, emesis, diarrhea, summer-heat dampness, fever with aversion to cold, and chest and abdominal fullness.
The Mentholum is crystal extracted from whole plant of Mentha haplocalyx of Labiatae. Has effects in dispelling pathogenic wind and clearing away heat. Can be used for treating wind-heat type common cold, headache, conjunctival congestion, sore throat, toothache, and skin pruritus.
Semen Brassicae Capitatae is seed of Cleomis japonica of Cleomis family. Has effects of promoting blood circulation, relieving pain, dispelling pathogenic wind and dispelling cold. It can be used for invigorating stomach, promoting digestion, dispelling cold, relieving pain, and treating rheumatalgia, chronic arthritis, pyocutaneous disease, bone tuberculosis, hemorrhoid, and malaria. Ye can stop diarrhea and treat traumatic injury. Radically cure gonorrhea.
Herba seu radix Cirsii Japonici is dry aerial part of Cirsium japonicum of Compositae. Harvesting aerial parts when flowers bloom in summer and autumn, removing impurities, and drying in the sun. Has the effects of cooling blood, stopping bleeding, removing blood stasis and relieving swelling. Can be used for treating epistaxis, hematemesis, hematuria, hematochezia, metrorrhagia, traumatic hemorrhage, carbuncle, swelling, and skin ulcer.
Preferably, the raw materials comprise the following components in parts by weight: 25-35 parts of carex, 25-35 parts of artemisia leaf, 25-35 parts of abelmoschus manihot, 28-32 parts of senecio nobilis, 28-32 parts of folium artemisiae argyi, 45-55 parts of dandelion, 45-55 parts of fructus cnidii, 45-55 parts of purslane, 45-55 parts of rhizoma bletillae, 40-60 parts of wild ginseng, 40-60 parts of agastache rugosus, 40-60 parts of menthol, 40-60 parts of brassica alba seed and 40-60 parts of circium japonicum.
More preferably, the raw materials comprise by weight: 30g of carex, 30g of artemisia anomala leaf, 30g of okra, 30g of senecio cannabifolius, 30g of folium artemisiae argyi, 50g of dandelion, 50g of fructus cnidii, 50g of purslane, 50g of rhizoma bletillae, 50g of wild ginseng, 50g of agastache rugosus, 50g of menthol, 50g of brassica campestris and 50g of setose thistle.
The raw materials are all wild Chinese herbal medicines, and perennial Chinese herbal medicines are selected from five years or more.
The wild ginseng is selected from twenty-five years or more.
The invention also provides application of the medicament for treating various skin diseases, and the medicament is used for preparing an external ointment for smearing patients with skin diseases.
The invention also provides a preparation method of the external ointment, which comprises the following steps: weighing the medicines in proportion, grinding and crushing the medicines into powder, soaking and extracting the powder by alcohol, concentrating and purifying the powder, adding glycerol and white vaseline, uniformly mixing the mixture, heating and emulsifying the mixture, cooling the mixture to obtain an ointment in an oil emulsion state, and finally sterilizing, filling and packaging the ointment to obtain the ointment.
The particle size range of grinding and crushing is 30-40 meshes. The alcohol soaking time is 24 hr or more, and the alcohol dosage is adjusted according to the required dosage of the medicine. The alcohol is medical ethanol. The extraction adopts an ultrasonic method, a percolation method or a reflux method and the like. The concentration and purification are to recover ethanol by reduced pressure distillation. The temperature for heating and emulsifying is 75-95 ℃.
The pharmaceutical preparations for various skin diseases and the preparation method and use thereof according to the present invention will be further described with reference to the following examples.
Example 1
A medicament for various skin diseases, which comprises the following raw materials by weight: 30g of carex, 30g of artemisia anomala leaf, 30g of okra, 30g of senecio cannabifolius, 30g of folium artemisiae argyi, 50g of dandelion, 50g of fructus cnidii, 50g of purslane, 50g of rhizoma bletillae, 50g of wild ginseng, 50g of agastache rugosus, 50g of menthol, 50g of brassica campestris and 50g of setose thistle.
The raw materials are wild Chinese herbal medicines, wherein the perennial Chinese herbal medicines are respectively five years or more.
The wild ginseng is selected from twenty-five years or more.
The embodiment also provides application of the medicament for treating various skin diseases, and the medicament is used for preparing an external ointment for applying to a patient with the skin diseases.
The embodiment also provides a preparation method of the external ointment, which comprises the following steps: the medicines are weighed according to the proportion, ground and crushed into powder, soaked and extracted by alcohol, concentrated and purified. The granularity of the ground and crushed particles is 30-40 meshes, and the time of alcohol soaking is 24 hours or more. Adding glycerol and white vaseline, mixing, heating for emulsification, and cooling to 75-95 deg.C. Obtaining ointment in an oil emulsion state, and finally sterilizing, filling and packaging.
Example 2
A medicament for various skin diseases, which comprises the following raw materials by weight: 25g of carex, 25g of artemisia anomala leaf, 25g of okra, 28g of senecio cannabifolius, 28g of folium artemisiae argyi, 45g of dandelion, 45g of fructus cnidii, 45g of purslane, 45g of rhizoma bletillae, 40g of wild ginseng, 40g of agastache rugosus, 40g of menthol, 40g of brassica campestris and 40g of setose thistle.
The raw materials are wild Chinese herbal medicines, wherein the perennial Chinese herbal medicines are respectively five years or more.
The wild ginseng is selected from twenty-five years or more.
The embodiment also provides application of the medicament for treating various skin diseases, and the medicament is used for preparing an external ointment for applying to a patient with the skin diseases.
The embodiment also provides a preparation method of the external ointment, which comprises the following steps: the medicines are weighed according to the proportion, ground and crushed into powder, soaked and extracted by alcohol, concentrated and purified. The granularity of the ground and crushed particles is 30-40 meshes, and the time of alcohol soaking is 24 hours or more. Adding glycerol and white vaseline, mixing, heating for emulsification, and cooling to 75-95 deg.C. Obtaining ointment in an oil emulsion state, and finally sterilizing, filling and packaging.
Example 3
A medicament for various skin diseases, which comprises the following raw materials by weight: 35g of carex, 35g of artemisia anomala leaf, 35g of okra, 32g of senecio cannabifolius, 32g of folium artemisiae argyi, 55g of dandelion, 55g of fructus cnidii, 55g of purslane, 55g of rhizoma bletillae, 60g of wild ginseng, 60g of agastache rugosus, 60g of menthol, 60g of brassica campestris and 60g of setose thistle.
The raw materials are wild Chinese herbal medicines, wherein the perennial Chinese herbal medicines are respectively five years or more.
The wild ginseng is selected from twenty-five years or more.
The embodiment also provides application of the medicament for treating various skin diseases, and the medicament is used for preparing an external ointment for applying to a patient with the skin diseases.
The embodiment also provides a preparation method of the external ointment, which comprises the following steps: the medicines are weighed according to the proportion, ground and crushed into powder, soaked and extracted by alcohol, concentrated and purified. The granularity of the ground and crushed particles is 30-40 meshes, and the time of alcohol soaking is 24 hours or more. Adding glycerol and white vaseline, mixing, heating for emulsification, and cooling to 75-95 deg.C. Obtaining ointment in an oil emulsion state, and finally sterilizing, filling and packaging.
The raw materials adopted in each embodiment respectively accord with the corresponding national standards.
Clinical trials of the externally-applied ointment prepared in each embodiment prove that the medicament has an obvious effect, and has the characteristics of reasonable formula, small dosage, remarkable effect, no toxic or side effect, quick response, difficult relapse and the like.
The medicament for various skin diseases and the preparation method and the application thereof provided by the invention have the advantages that through the differentiation of the traditional Chinese medicine, aiming at the etiology and pathogenesis of the disease, the compatibility principle of the auxiliary medicines is utilized, the medicines are reasonably combined according to the organization structure of monarch, minister, assistant and guide purposefully, the medicines in the formula and the compatibility thereof are screwed with the pathogenesis of the disease, and the comprehensive effect after the medicine is combined is highly unified with the established treatment method.
While the present invention has been described in detail with reference to the preferred embodiments, it should be understood that the above description should not be taken as limiting the invention. Various modifications and alterations to this invention will become apparent to those skilled in the art upon reading the foregoing description. Accordingly, the scope of the invention should be determined from the following claims.

Claims (10)

1. A medicament for various skin diseases is characterized in that the raw materials of the medicament comprise: herba Carpesii Cernui, folium Artemisiae Argyi, herba Basellae Rubrae, herba Senecionis Cannabifolii, folium Artemisiae Argyi, herba Taraxaci, fructus Cnidii, herba Portulacae, rhizoma Bletillae, radix Ginseng Indici, herba Agastaches, Mentholum, semen Brassicae Pekinensis, and herba seu radix Cirsii Japonici.
2. The medicament for treating various skin diseases according to claim 1, wherein the raw materials comprise, in parts by weight: 25-35 parts of carex, 25-35 parts of artemisia leaf, 25-35 parts of abelmoschus manihot, 28-32 parts of senecio nobilis, 28-32 parts of folium artemisiae argyi, 45-55 parts of dandelion, 45-55 parts of fructus cnidii, 45-55 parts of purslane, 45-55 parts of rhizoma bletillae, 40-60 parts of wild ginseng, 40-60 parts of agastache rugosus, 40-60 parts of menthol, 40-60 parts of brassica alba seed and 40-60 parts of circium japonicum.
3. The medicament for various skin diseases according to claim 2, wherein the raw materials comprise, by weight: 30g of carex, 30g of artemisia anomala leaf, 30g of okra, 30g of senecio cannabifolius, 30g of folium artemisiae argyi, 50g of dandelion, 50g of fructus cnidii, 50g of purslane, 50g of rhizoma bletillae, 50g of wild ginseng, 50g of agastache rugosus, 50g of menthol, 50g of brassica campestris and 50g of setose thistle.
4. The medicament for treating various skin diseases according to claim 4, wherein the raw materials are all wild Chinese herbal medicines, and perennial Chinese herbal medicines for five years or more are adopted.
5. The pharmaceutical preparation for various skin diseases according to claim 4, wherein the raw material includes wild ginseng for twenty-five years or more.
6. The use of the medicament for treating various skin diseases according to any one of claims 1 to 5, wherein the medicament is used for preparing an external ointment for smearing on skin patients.
7. A method of preparing the ointment for external use according to claim 6, which comprises: weighing the medicines in proportion, grinding and crushing the medicines into powder, soaking and extracting the powder by alcohol, concentrating and purifying the powder, adding glycerol and white vaseline, uniformly mixing the mixture, heating and emulsifying the mixture, cooling the mixture to obtain an ointment in an oil emulsion state, and finally sterilizing, filling and packaging the ointment to obtain the ointment.
8. The method for preparing an ointment for external use according to claim 7, wherein the particle size of the ground and crushed particles is in the range of 30 to 40 mesh.
9. The method for preparing an ointment for external use according to claim 7, wherein the alcohol is soaked for 24 hours or more.
10. The method for preparing an ointment for external use according to claim 7, wherein the temperature for emulsification is 75 to 95 ℃.
CN202110955768.4A 2021-08-19 2021-08-19 Medicament for various skin diseases and preparation method and application thereof Pending CN113577196A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104474076A (en) * 2014-12-06 2015-04-01 重庆市中医院 Traditional Chinese medicine composition for treating eczema
CN105106348A (en) * 2015-08-25 2015-12-02 俞凤鸣 Traditional Chinese medicine lotion
CN109223860A (en) * 2018-10-10 2019-01-18 刘振普 A kind of compound five-element grass spray

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104474076A (en) * 2014-12-06 2015-04-01 重庆市中医院 Traditional Chinese medicine composition for treating eczema
CN105106348A (en) * 2015-08-25 2015-12-02 俞凤鸣 Traditional Chinese medicine lotion
CN109223860A (en) * 2018-10-10 2019-01-18 刘振普 A kind of compound five-element grass spray

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