CN107233433A - Tinea pedis dissipates, preparation method and applications and herbal medicine immersion agent and preparation method thereof - Google Patents
Tinea pedis dissipates, preparation method and applications and herbal medicine immersion agent and preparation method thereof Download PDFInfo
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Abstract
Dissipated the invention provides a kind of tinea pedis, preparation method and applications and herbal medicine immersion agent and preparation method thereof, it is related to technical field of Chinese medicine, tinea pedis of the present invention is dissipated by the way that manufacture-yellow is connected, wilsonii, CORTEX PHELLODENDRI CHINENSE, tealeaves, hickory nut bark, yncaria stem with hooks, lycopodium calvatum, folium artemisiae argyi and Chinese ephedra carry out rational compatibility, the herbal medicine immersion agent that obtained tinea pedis dissipates and its further prepared has disinfection, it is antipruritic, dispelling wind and eliminating dampness, it is clearing heat and detoxicating, the effects such as restoring menstrual flow and invigorating blood circulation, there is good curative effect to the various skin diseases as caused by fungal infection, simultaneously, edible Cardia Salt is added in herbal medicine immersion agent of the present invention can also play a part of preventing hypertension and cardiovascular and cerebrovascular disease and auxiliary treatment.The present invention, which is effectively alleviated in existing treatment tinea pedis externally applied drug, contains glucocorticoid medicine, is also easy to produce skin disease after pharmacological dependence, deactivation and easily recurs, the problem of more refractory refractory.The tinea pedis, which dissipates, can be widely applied to prepare treatment dermopathic medicine as caused by fungal infection.
Description
Technical field
The present invention relates to technical field of Chinese medicine, dissipated more particularly, to a kind of tinea pedis, preparation method and applications and Chinese medicine
Soaking agent and preparation method thereof.
Background technology
Fungal dermatopathy, also known as dermatomycosis, refer to as human skin and mucous membrane, the hair caused by disease fungus
One major class infectious diseases of hair and first-class cutaneous appendages, is that dermatophyte invades epidermis, caused mycotic infection of superficial part
Property disease.The common feature of such disease is：The incidence of disease is high, with infectiousness, easily recurrence or infect again.Fungal dermatopathy is passed through
Normal recurrent exerbation, treat repeatedly, the quality of life of strong influence patient.
Modern society's work strain, pressure are big so that all kinds of tinea pedis, jock itch and ringworm of the body etc. caused by fungal dermatopathy into
For common disease frequently-occurring disease, the medicine of existing treatment fungal dermatopathy has a lot, is typically all coated by skin surface
Method, play sterilization, sterilization, analgesic effect, but there is also certain shortcoming for these treatment methods.Because, current market
The treatment fungal dermatopathy externally applied drug of circulation largely contains glucocorticoid, although glucocorticoid instant effect, and it has
There is obvious immunosuppressive action substantially, the local skin peripheral immunization ability of medication can be caused to decline, and longer-term is used
Glucocorticoid, then be also easy to produce dermatitis after pharmacological dependence, deactivation and easily recur, and has exacerbation trend, ultimately causes protopathy and disappears
There is healing is again secondary to cause steroid dependent dermatitis, it is more refractory refractory.
Therefore the medicine that tinea pedis made from a kind of utilization pure Chinese medicine raw material dissipates and its further prepared is researched and developed, can
There is good curative effect to the tinea pedis as caused by fungal infection, jock itch and ringworm of the body, and will not produce pharmacological dependence and toxic side effect,
Become it is very urgent with it is necessary.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is that providing a kind of tinea pedis dissipates, and the tinea pedis is dissipated by the way that manufacture-yellow company, wilsonii, river is yellow
The bulk drug reasonable compatibilities such as cypress, tealeaves, hickory nut bark, yncaria stem with hooks, lycopodium calvatum, folium artemisiae argyi and Chinese ephedra, obtained tinea pedis, which dissipates to have, to disappear
Poisoning bacterium, antipruritic, dispelling wind and eliminating dampness, it is clearing heat and detoxicating, the effects such as restore menstrual flow and invigorate blood circulation, have to the various skin diseases as caused by fungal infection
Good curative effect, alleviates in existing externally applied drug and contains glucocorticoid medicine, be also easy to produce skin disease after pharmacological dependence, deactivation
Easily recurrence, the problem of more refractory refractory.
The second object of the present invention is to provide a kind of tinea pedis scattered preparation method, and this method is by by each original in the present invention
Material medicine be dried and crush successively, the bulk drug after crushing is sufficiently mixed, be made tinea pedis dissipate, with prepare simply,
The advantage of simple operation.
The third object of the present invention is to provide a kind of tinea pedis, and to be dispersed in preparation treatment dermopathic as caused by fungal infection
Application in external used medicine.
The fourth object of the present invention is to provide a kind of herbal medicine immersion agent, and the main above-mentioned tinea pedis of the herbal medicine immersion agent, which dissipates, decocts
Cooking is prepared.
The fifth object of the present invention is to provide a kind of preparation method of herbal medicine immersion agent, and this method is using first dissipating tinea pedis
Decoct and decoction liquor is made, be separately added into that edible Cardia Salt is well mixed to be made after cooling, the herbal medicine immersion agent prepared has dense
Contracting degree is high, and the strong advantage of sterilization effect at utmost remains the medicinal efficacy of each medicinal material, meanwhile, eat low sodium
The addition of salt can also play enhancing disinfection effect and hypertension and cardiovascular and cerebrovascular disease be prevented and auxiliary is controlled
The effect for the treatment of.
A kind of tinea pedis that the present invention is provided dissipates, and includes the bulk drug of following parts by weight：Manufacture-yellow connects 6~136 parts, wilsonii 6
~126 parts, 5~120 parts of CORTEX PHELLODENDRI CHINENSE, 5~120 parts of tealeaves, 10~96 parts of hickory nut bark, 8~98 parts of yncaria stem with hooks, lycopodium calvatum 5~
3~86 parts of 96 parts, 6~96 parts of folium artemisiae argyi and Chinese ephedra.
Further, above-mentioned tinea pedis dissipates, and includes the bulk drug of following parts by weight：Manufacture-yellow connects 30~100 parts, wilsonii 30
~95 parts, 10~80 parts of CORTEX PHELLODENDRI CHINENSE, 10~80 parts of tealeaves, 30~60 parts of hickory nut bark, 30~60 parts of yncaria stem with hooks, lycopodium calvatum 20~
20~50 parts of 60 parts, 20~50 parts of folium artemisiae argyi and Chinese ephedra.
Further, above-mentioned tinea pedis dissipates, and includes the bulk drug of following parts by weight：Manufacture-yellow connect 65 parts, 60 parts of wilsonii, river
30 parts of 50 parts of golden cypress, 50 parts of tealeaves, 40 parts of hickory nut bark, 40 parts of yncaria stem with hooks, 35 parts of lycopodium calvatum, 35 parts of folium artemisiae argyi and Chinese ephedra.
The preparation method that a kind of tinea pedis that the present invention is provided dissipates, weighs bulk drug, by what is weighed by above-mentioned parts by weight
Bulk drug is dried and crushed, and the bulk drug after crushing is sufficiently mixed, and tinea pedis is made and dissipates.
Further, the water content of dried bulk drug is 7wt%~13wt%.
Further, the bulk drug after crushing was the powder after 10~20 mesh sieves.
A kind of tinea pedis that the present invention is provided is dispersed in preparation treatment dermopathic external used medicine as caused by fungal infection
Using.
Further, skin disease caused by above-mentioned fungal infection is tinea pedis, jock itch and ringworm of the body.
A kind of herbal medicine immersion agent that the present invention is provided, main dissipated by above-mentioned tinea pedis of the herbal medicine immersion agent decocts the system of preparation
.
Further, herbal medicine immersion agent raw material includes the scattered and edible Cardia Salt of above-mentioned tinea pedis.
A kind of preparation method for herbal medicine immersion agent that the present invention is provided, dissipates decoction by above-mentioned tinea pedis and obtains for 10~30 minutes
Decoction liquor, is cooled to 30~40 DEG C, then respectively with 150~200：1 weight is well mixed than adding edible Cardia Salt, is made
Herbal medicine immersion agent.
Compared with prior art, beneficial effects of the present invention are：
A kind of tinea pedis that the present invention is provided is dissipated, and the tinea pedis is dissipated by by manufacture-yellow company, wilsonii, CORTEX PHELLODENDRI CHINENSE, tealeaves, hickory nut
The bulk drug reasonable compatibility such as bark, yncaria stem with hooks, lycopodium calvatum, folium artemisiae argyi and Chinese ephedra, obtained tinea pedis dissipate with disinfection, it is antipruritic, dispel
Wind dehumidifying, it is clearing heat and detoxicating, the effects such as restore menstrual flow and invigorate blood circulation, have good curative effect to the various skin diseases as caused by fungal infection, delay
Solve in existing externally applied drug and contained glucocorticoid medicine, be also easy to produce skin disease after pharmacological dependence, deactivation and easily recur, refractory difficulty
More the problem of.
The preparation method that a kind of tinea pedis that the present invention is provided dissipates, this method is by the way that each bulk drug in the present invention is carried out successively
Dry and crush, the bulk drug after crushing is sufficiently mixed, be made tinea pedis dissipate, with prepare simply, simple operation, cost
Low advantage.
A kind of tinea pedis that the present invention is provided is dispersed in preparation treatment dermopathic external used medicine as caused by fungal infection
Using.
A kind of herbal medicine immersion agent that the present invention is provided, main dissipated by above-mentioned tinea pedis of the herbal medicine immersion agent decocts the system of preparation
.
A kind of preparation method for herbal medicine immersion agent that the present invention is provided, using first tinea pedis is dissipated, decoction is obtained to decoct this method
Edible Cardia Salt is separately added into after liquid, cooling well mixed obtained, the herbal medicine immersion agent prepared has concentrating degree high, sterilization
The strong advantage of bactericidal effect, at utmost remains the medicinal efficacy of each medicinal material, meanwhile, the addition for eating Cardia Salt can be with
Play a part of enhancing disinfection effect and hypertension and cardiovascular and cerebrovascular disease are prevented and auxiliary treatment.
Embodiment
Technical scheme is clearly and completely described below in conjunction with embodiment, it is clear that described reality
It is a part of embodiment of the invention to apply example, rather than whole embodiments.Based on the embodiment in the present invention, the common skill in this area
The every other embodiment that art personnel are obtained under the premise of creative work is not made, belongs to the model that the present invention is protected
Enclose.
According to an aspect of the present invention, a kind of tinea pedis dissipates, and includes the bulk drug of following parts by weight：Manufacture-yellow connects 6~136
Part, 6~126 parts of wilsonii, 5~120 parts of CORTEX PHELLODENDRI CHINENSE, 5~120 parts of tealeaves, 10~96 parts of hickory nut bark, 8~98 parts of yncaria stem with hooks,
3~86 parts of 5~96 parts of lycopodium calvatum, 6~96 parts of folium artemisiae argyi and Chinese ephedra.
The pharmacology and nature,taste and action of raw materials used explosive component in the present invention：
Manufacture-yellow connects：The coptis is Ranunculaceae, Coptis herbaceos perennial, and Traditional Chinese Medicine thinks that the coptis has heat-clearing dry
It is wet, the effect of purging intense heat and detonicating, to damp and hot feeling of fullness, vomit acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, blood
Hot hematemesis, hot eyes, toothache is quenched one's thirst, carbuncle swells furunculosis is effective in cure.The coptis is regard as main ingredient, its heat-clearing and damp-drying drug, purging intense heat in the present invention
Effect of removing toxic substances, to eczema, the disease such as wet sore, red swelling of the skin itch and skin ulcer has special effect.
In the present invention, the manufacture-yellow is linked as wine manufacture-yellow company.
In the present invention, the manufacture-yellow connects typical but non-limiting content and is：6 parts, 15 parts, 30 parts, 45 parts, 60 parts, 80
Part, 95 parts, 110 parts, 125 parts, 130 parts or 136 parts.
Wilsonii：Also known as bank bent stick, tiger are hasty and careless, 100 pins.The traditional Chinese medical science thinks that wilsonii has replenishing kidney, strengthening waist；QI invigorating is pacified
God；Promoting blood circulation and removing obstruction in channels the effect of, the insufficiency of both the spleen and the kindey is clinically used for, physically weak weak, poor appetite, soreness of waist and knee joint, the disease such as insomnia and dreamful sleep.Together
When, rich in a variety of glycoside active components such as glucosides, saponin(e, lignin in wilsonii, its leaf and containing in spending contains in flavones, fruit
There are a variety of water-soluble polysaccharides with immunizing composition.It is many containing vitamin B, vitamin C, vitamin D, vitamin E etc. in cauline leaf
Plant vitamin；Complete stool contains linoleic acid, volatile oil, and wilsonii is also containing micro members such as Ga, Zn, Na, Mg, Fe, Mn, Cu in addition
Element and mineral matter, rich in 16 kinds of amino acid, wherein 7 kinds are that human body is necessary.Wilsonii medically can anticancer, anti arteriosclerosis,
Antifatigue, protection is cardiovascular, improves diabetic symptom and can adjust body metabolism, treats neurosis.Improvement is slept
Sleep, increase the functions such as appetite.As health products, the intestines and stomach that can suppress alcohol absorb, reduce the alcohol concentration in blood, thorn
The injury of the skin whitening of slender acanthopanax energy, energy Green Tea Extract to human body, strengthen immunity plays a part of anti-aging.
In the present invention, the typical but non-limiting content of wilsonii is：6 parts, 15 parts, 30 parts, 45 parts, 60 parts, 80
Part, 95 parts, 110 parts or 126 parts.
CORTEX PHELLODENDRI CHINENSE：For the dry bark of rutaceae wampee, its is bitter in taste, trembles with fear, returns kidney, bladder warp, with heat-clearing
Eliminating dampness, purging intense heat, except steaming, effect of detoxification sore treatment is usually used in damp-heat dysentery, jaundice, with lower pruritus vulvae, puckery pain of heat gonorrhea, tinea pedis impotence
Preesed, hectic fever due to yin labor heat, night sweat is passed out semen, sore swollen toxin, the disease such as eczema wet sore.In the present invention, CORTEX PHELLODENDRI CHINENSE as external application can with heat-clearing,
Eliminating dampness, antipruritic, removing toxic substances, and medicine is nonirritant, relieves the pain of patient.
In the present invention, the typical but non-limiting content of CORTEX PHELLODENDRI CHINENSE is：5 parts, 15 parts, 30 parts, 45 parts, 60 parts, 80
Part, 95 parts, 110 parts or 120 parts.
Tealeaves：Chemical composition is made up of 3.5~7.0% inorganic matter and 93~96.5% organic matter, in tealeaves
Inorganic mineral substance element there are about 27 kinds, including phosphorus, potassium, sulphur, magnesium, manganese, fluorine, aluminium, calcium, sodium, iron, copper, zinc, selenium etc., in tealeaves
Organic compound mainly has protein, lipid, carbohydrate, amino acid, alkaloid, Tea Polyphenols, organic acid, pigment, fragrance
Composition, vitamin, saponin(e, sterol etc..Composition in tealeaves has a health-care effect, removes free radical, anti-bacteria and anti-virus, preventing decayed tooth, anti-
The anti-mutation of cancer, smelly eliminating, suppression atherosclerosis, reducing blood lipid, hypotensive, diuresis, hypoglycemic, treatment of vascular hardening, anticancer etc..
Tannic acid containing volume in tealeaves, it is especially especially effective to the der Pilz for causing tinea pedis with strong bactericidal action.
In the present invention, the typical but non-limiting content of tealeaves is：5 parts, 15 parts, 30 parts, 45 parts, 60 parts, 80 parts,
95 parts, 110 parts or 120 parts.
Hickory nut bark：For the root skin of juglandaceae plant hickory nut, exocarp.It is bitter；It is puckery；It is cool in nature.Hickory nut bark has one
Fixed toxicity, should not take orally.External application has good antipruritic effect of clearing heat and detoxicating, desinsection, it is wet to all types of toes itch and
Skin tinea demonstrate,proves excellent.
In the present invention, the typical but non-limiting content of tealeaves is：10 parts, 20 parts, 30 parts, 40 parts, 50 parts, 60
Part, 70 parts, 80 parts, 90 parts or 96 parts.
Yncaria stem with hooks：For the buckle stem branch of madder wort largeleaf gambirplant branchlet, containing rhynchophyllin, isorhynchophylline, effect be The flat liver of heat-clearing,
Dispelling wind and relieving convulsion, twitch for dizziness of having a headache, dysphoric cold, frightened dysentery, vascular hypertension, yncaria stem with hooks external application can be with dispelling wind and eliminating dampness.
In the present invention, the typical but non-limiting content of yncaria stem with hooks is：8 parts, 28 parts, 38 parts, 48 parts, 58 parts, 68 parts,
78 parts, 88 parts or 98 parts.
Lycopodium calvatum：It is lycopodium calvatum its mildly bitter flavor, temperature, pungent for the drying herb of lycopsid lycopod, it is attributed to liver,kidney,spleen
Through, with dispelling wind and eliminating dampness, stimulate the circulation of the blood and cause the muscles and joints to relax, cough-relieving, removing toxic substances, detumescence the effects such as.Clinically it is used for treatment joint joint stuffiness, wind
Cold-dampness numbness, painful swelling of joints, passages through which vital energy circulates arrested anxious, traumatic injury.
In the present invention, the typical but non-limiting content of lycopodium calvatum is：5 parts, 10 parts, 20 parts, 30 parts, 40 parts, 50
Part, 60 parts, 70 parts, 80 parts, 90 parts or 96 parts.
Folium artemisiae argyi：Wormwood is bitter in taste, pungent, temperature, enters spleen, liver, kidney.Folium artemisiae argyi have relieving asthma, antibechic and eliminating the phlegm, dispelling cold and removing dampness and anti-
Effect of blood coagulation.Modern experimental research has shown that external application is respectively provided with antibacterial and antivirus action in folium artemisiae argyi.
In the present invention, the typical but non-limiting content of folium artemisiae argyi is：6 parts, 10 parts, 20 parts, 30 parts, 40 parts, 50 parts,
60 parts, 70 parts, 80 parts, 90 parts or 96 parts.
Chinese ephedra：For the drying herbaceous stem stem of Ephedraceae plant ephedra sinica, epheday intermedia or ephedra equisetina, its is warm-natured, pungent, micro-
Hardship, Chinese ephedra have effects that sweating cold dispelling, freeing lung and relieving asthma, inducing diuresis for removing edema, available for treatment anemofrigid cold, it is uncomfortable in chest breath with cough, geomantic omen
The illness such as edema and bronchial astehma.Modern experimental research has shown that Chinese ephedra is rich in L- ephedrines, D-PSEUDOEPHEDRINE, L- demethyls
The compositions such as ephedrine, D- Nor pseudo ephedrines, L- methylephedrines, 2,3,5,6- Tetramethylpyrazines, with significantly having anti-
Bacterium, antiviral effect.
In the present invention, the typical but non-limiting content of Chinese ephedra is：3 parts, 10 parts, 20 parts, 30 parts, 40 parts, 50 parts,
60 parts, 70 parts, 80 parts or 86 parts.
In the present invention, above-mentioned each component medicine is respectively provided with to all kinds of tinea pedis, jock itch and ringworm of the body caused by fungal dermatopathy
Good therapeutic action.Traditional Chinese Medicine thinks that dermopathic produce is six external factors which cause diseases evil poison, directly or indirectly encroaches on human body, occurs
All kinds of surgical diseases.《Surgery opens profound》Say：" there is the gas of the six external factors which cause diseases in the world, is chill summer-heat and damp dryness-heat, the then stagnation of ying-qi of people's impression,
Become raw carbuncle swells malignant boil furuncle." six external factors which cause diseases evil poison virulence it is especially prosperous and powerful, exceeded the resistance against diseases of human normal, and then " change thermal burn cloudy,
Wind formation from blood dryness " triggers all kinds of surgical diseases.The treatment fungal dermatopathy skin disease for by above-mentioned medicinal material be made after compatibility
Tinea pedis dissipate, the medicinal material such as hickory nut bark, folium artemisiae argyi and Chinese ephedra contained by it has the effect of good anti-fungal infection；Manufacture-yellow connects
There can be good curative effect to skin disease caused by " changing thermal burn cloudy, wind formation from blood dryness " with heat-clearing and damp-drying drug, purging intense heat and detonicating with CORTEX PHELLODENDRI CHINENSE；
Wilsonii, yncaria stem with hooks, lycopodium calvatum can with dispelling wind and eliminating dampness, stimulate the circulation of the blood and cause the muscles and joints to relax；Meanwhile, it is aided with the tealeaves containing a large amount of tannic acid, it is sterilized
Effect is stronger, especially especially effective to various types of fungal dermatopathies.The tinea pedis that above-mentioned compatibility is prepared is dispersed in antimycotic
While infection, each medicine mutual reinforcement between be with also have effects that dispelling wind and eliminating dampness, it is clearing heat and detoxicating, restore menstrual flow and invigorate blood circulation, and then can improve
Body immunity, promotes the healing of fungal infection so that skin disease is uneasy to recur.
From the foregoing, the tinea pedis prepared of the present invention is dissipated with disinfection, antipruritic, dispelling wind and eliminating dampness, clearing heat and detoxicating, logical
The effects such as through promoting blood circulation, there is good curative effect to the various skin diseases as caused by fungal infection.Meanwhile, tinea pedis of the present invention is dissipated to be pure
Chinese medicine preparation will not produce pharmacological dependence also without any toxic side effect, solve and use glucocorticoid medicine, be also easy to produce
Skin disease easily recurs after pharmacological dependence, deactivation, and has exacerbation trend, ultimately causes primary affection and does not cure and secondary cause sharp
Plain dependence facial dermatitis, the problem of more refractory refractory.
To improve effect that tinea pedis of the present invention dissipates antibacterial anti-infection, the tealeaves during the present invention preferably tinea pedis dissipates is green tea, because
For the tannin acid content highest of green tea in various tealeaves, and black tea by fermentation, the content of tannic acid is with regard to much less.
In the preferred embodiment of the present invention, tinea pedis Bales Off includes the bulk drug of following parts by weight：Manufacture-yellow connects 30~
100 parts, 30~95 parts of wilsonii, 10~80 parts of CORTEX PHELLODENDRI CHINENSE, 10~80 parts of tealeaves, 30~60 parts of hickory nut bark, yncaria stem with hooks 30~
20~50 parts of 60 parts, 20~60 parts of lycopodium calvatum, 20~50 parts of folium artemisiae argyi and Chinese ephedra.
In above-mentioned preferred embodiment, tinea pedis Bales Off includes the bulk drug of following parts by weight：Manufacture-yellow connects 65 parts, wilsonii 60
30 parts of part, 50 parts of CORTEX PHELLODENDRI CHINENSE, 50 parts of tealeaves, 40 parts of hickory nut bark, 40 parts of yncaria stem with hooks, 35 parts of lycopodium calvatum, 35 parts of folium artemisiae argyi and Chinese ephedra.
In the present invention, by the further adjustment and optimization to each component raw material dosage ratio, so as to further optimize
The scattered drug effect of tinea pedis of the present invention.
According to an aspect of the present invention, a kind of scattered preparation method of tinea pedis, bulk drug is weighed by above-mentioned parts by weight, will
The bulk drug weighed is dried and crushed, and the bulk drug after crushing is sufficiently mixed, and tinea pedis is made and dissipates.
Preferably, the bulk drug weighed is first rinsed before it is dried.
Preferably, the scattered preparation process of above-mentioned tinea pedis is carried out under conditions of sterile, dustless.
In the present invention, the above method is dissipated by will be mixed after each raw material drying in the present invention and crushing with preparing this tinea pedis,
The medicinal efficacy of each medicinal material is farthest remained, has the advantages that to prepare simple, simple operation.
In the preferred embodiment of the present invention, the water content of dried bulk drug is 7wt%~13wt%.
In the present invention, the calculation formula of above-mentioned water content is：Water content (weight %)=(raw material weight-former material after drying
Material weight)/dry after raw material weight × 100%.
It should be noted that can not excessively dry bulk drug in above-mentioned drying process, in order to avoid causing bulk drug water content too low, lose
Go the situation of drug effect.
In the preferred embodiment of the present invention, the bulk drug after crushing was the powder after 10~20 mesh sieves.
In the present invention, the tinea pedis that 10~20 mesh sieves are crossed after crushing dissipates fine powder to be easier to medicine in follow-up preparation process equal
Even mixing, while less particle also dissolution and is difficult to cause allergy anti-beneficial to the effective component of medicine during decoction
Should.
According to an aspect of the present invention, a kind of tinea pedis is dispersed in preparation treatment dermopathic external application as caused by fungal infection
Application in medicine.
In the preferred embodiment of the present invention, skin disease caused by above-mentioned fungal infection is tinea pedis, jock itch and body
Tinea.
According to an aspect of the present invention, a kind of herbal medicine immersion agent, main dissipated by above-mentioned tinea pedis of the herbal medicine immersion agent is decocted
Cooking is prepared.
In the present invention, herbal medicine immersion agent is main to be dissipated decoction by above-mentioned tinea pedis and prepares, with disinfection, it is antipruritic,
Dispelling wind and eliminating dampness, it is clearing heat and detoxicating, the effects such as restore menstrual flow and invigorate blood circulation, have good curative effect to the various skin diseases as caused by fungal infection.
In the preferred embodiment of the present invention, the herbal medicine immersion agent raw material dissipates and edible including above-mentioned tinea pedis
Cardia Salt.
In the present invention, edible Cardia Salt plays the role of good sterilizing, and its addition can not only play enhancing and disappear
Malicious biocidal efficacies, while can also play a part of preventing hypertension and cardiovascular and cerebrovascular disease and auxiliary treatment.
According to an aspect of the present invention, a kind of preparation method of herbal medicine immersion agent, by above-mentioned tinea pedis dissipate decoct 10~
Obtain decoction liquor within 30 minutes, 30~40 DEG C are cooled to, then respectively with 95~105：1 weight is than adding edible Cardia Salt mixing
Uniformly, herbal medicine immersion agent is made.
In above-mentioned preferred embodiment, first tinea pedis is dissipated and decocts obtained decoction liquor, is separately added into after cooling edible low
Sodium salt is well mixed to be made, and the herbal medicine immersion agent prepared has concentrating degree high, the strong advantage of sterilization effect, maximum journey
Degree remains the medicinal efficacy of each medicinal material.
It is described further below in conjunction with 1~12 pair of technical scheme of embodiment 1~10 and comparative example.
Embodiment 1
A kind of tinea pedis dissipates, and includes the bulk drug of following parts by weight：Manufacture-yellow connect 6 parts, 6 parts of wilsonii, 5 parts of CORTEX PHELLODENDRI CHINENSE, tealeaves 5
3 parts of part, 10 parts of hickory nut bark, 8 parts of yncaria stem with hooks, 5 parts of lycopodium calvatum, 6 parts of folium artemisiae argyi and Chinese ephedra.
The scattered preparation method of above-mentioned tinea pedis is：Bulk drug is weighed by above-mentioned parts by weight, the bulk drug weighed is advanced
Row drying, dried bulk drug water content is 7wt%, is then crushed, and bulk drug, which is crushed to, can cross the powder of 10 mesh sieves
Bulk drug after crushing, is then sufficiently mixed by end, and tinea pedis is made and dissipates.
Embodiment 2
A kind of tinea pedis dissipates, and includes the bulk drug of following parts by weight：Manufacture-yellow connect 6~136 parts, 126 parts of wilsonii, CORTEX PHELLODENDRI CHINENSE
86 parts of 120 parts, 120 parts of tealeaves, 96 parts of hickory nut bark, 98 parts of yncaria stem with hooks, 96 parts of lycopodium calvatum, 96 parts of folium artemisiae argyi and Chinese ephedra.
The scattered preparation method of above-mentioned tinea pedis is：Bulk drug is weighed by above-mentioned parts by weight, the bulk drug weighed is advanced
Row drying, dried bulk drug water content is 13wt%, is then crushed, and bulk drug, which is crushed to, can cross the powder of 20 mesh sieves
Bulk drug after crushing, is then sufficiently mixed by end, and tinea pedis is made and dissipates.
Embodiment 3
A kind of tinea pedis dissipates, and includes the bulk drug of following parts by weight：Manufacture-yellow connect 30 parts, 30 parts of wilsonii, 10 parts of CORTEX PHELLODENDRI CHINENSE, tea
20 parts of 10 parts of leaf, 30 parts of hickory nut bark, 30 parts of yncaria stem with hooks, 20 parts of lycopodium calvatum, 20 parts of folium artemisiae argyi and Chinese ephedra.
The scattered preparation method of above-mentioned tinea pedis is：Bulk drug is weighed by above-mentioned parts by weight, the bulk drug weighed is advanced
Row drying, dried bulk drug water content is 9wt%, is then crushed, and bulk drug, which is crushed to, can cross the powder of 12 mesh sieves
Bulk drug after crushing, is then sufficiently mixed by end, and tinea pedis is made and dissipates.
Embodiment 4
A kind of tinea pedis dissipates, and includes the bulk drug of following parts by weight：Manufacture-yellow connect 100 parts, 95 parts of wilsonii, 80 parts of CORTEX PHELLODENDRI CHINENSE,
50 parts of 80 parts of tealeaves, 60 parts of hickory nut bark, 60 parts of yncaria stem with hooks, 60 parts of lycopodium calvatum, 50 parts of folium artemisiae argyi and Chinese ephedra.
The scattered preparation method of above-mentioned tinea pedis is：Bulk drug is weighed by above-mentioned parts by weight, the bulk drug weighed is advanced
Row drying, dried bulk drug water content is 11wt%, is then crushed, and bulk drug, which is crushed to, can cross the powder of 18 mesh sieves
Bulk drug after crushing, is then sufficiently mixed by end, and tinea pedis is made and dissipates.
Embodiment 5
A kind of tinea pedis dissipates, and includes the bulk drug of following parts by weight：Manufacture-yellow connect 65 parts, 60 parts of wilsonii, 50 parts of CORTEX PHELLODENDRI CHINENSE, tea
30 parts of 50 parts of leaf, 40 parts of hickory nut bark, 40 parts of yncaria stem with hooks, 35 parts of lycopodium calvatum, 35 parts of folium artemisiae argyi and Chinese ephedra.
The scattered preparation method of above-mentioned tinea pedis is：Bulk drug is weighed by above-mentioned parts by weight, the bulk drug weighed is advanced
Row drying, dried bulk drug water content is 10wt%, is then crushed, and bulk drug, which is crushed to, can cross the powder of 15 mesh sieves
Bulk drug after crushing, is then sufficiently mixed by end, and tinea pedis is made and dissipates.
Effect example 1
Tinea pedis, which dissipates, to illustrate the invention good curative effect to tinea pedis caused by fungal infection, and clinic is collected fungal infection and drawn
Tinea pedis patient 120 is played, male 60, women 60 is equally divided into 6 groups, wherein, the 1st~5 group is prepared using embodiment 1~5
Tinea pedis dissipate to suffer from foot be coated treatment；6th group is that control group only carries out spraying treatment using commercially available up to peaceful spray.Daily
Once in the morning and once at night, the course for the treatment of 60 days, and observed and counted 7 days, 30 days and 60 days therapeutic effects to patient respectively, it is tied
It is really as shown in the table：
As seen from the above table, dissipated using tinea pedis of the present invention after carrying out treatment 7 days, what 60% patients feet's Keratoderma was thickened
Symptom is relieved, and interphalangeal erosion, the phenomenon of sepage also have certain mitigation；After 30 days, 80% patients feet's skin angle
Change the symptom thickened to disappear substantially, interphalangeal erosion, the phenomenon of sepage have obvious mitigation；After 60 days, more than 90% patient
All types of tinea pedis symptoms disappear substantially, and the symptom of remaining patient also has clear improvement.And only controlled using commercially available up to peaceful spray
Though the control group for the treatment of has certain mitigation to tinea pedis symptom at 60 days, effect can not be consolidated, all kinds of tinea pedis recurrent exerbations.
Embodiment 6
A kind of preparation method of herbal medicine immersion agent：Tinea pedis described in embodiment 1 is dissipated to decoct and obtains decoction liquor within 10 minutes, it is cold
But to 30 DEG C, then respectively with 150：1 weight is well mixed than adding edible Cardia Salt, and herbal medicine immersion agent is made.
Embodiment 7
A kind of preparation method of herbal medicine immersion agent：Tinea pedis described in embodiment 2 is dissipated to decoct and obtains decoction liquor within 30 minutes, it is cold
But to 40 DEG C, then respectively with 200：1 weight is well mixed than adding edible Cardia Salt, and herbal medicine immersion agent is made.
Embodiment 8
A kind of preparation method of herbal medicine immersion agent：Tinea pedis described in embodiment 3 is dissipated to decoct and obtains decoction liquor within 15 minutes, it is cold
But to 32 DEG C, then respectively with 160：1 weight is well mixed than adding edible Cardia Salt, and herbal medicine immersion agent is made.
Embodiment 9
A kind of preparation method of herbal medicine immersion agent：Tinea pedis described in embodiment 4 is dissipated to decoct and obtains decoction liquor within 30 minutes, it is cold
But to 35 DEG C, then respectively with 180：1 weight is well mixed than adding edible Cardia Salt, and herbal medicine immersion agent is made.
Embodiment 10
A kind of preparation method of herbal medicine immersion agent：Tinea pedis described in embodiment 5 is dissipated to decoct and obtains decoction liquor within 15 minutes, it is cold
But to 35 DEG C, then respectively with 180：1 weight is well mixed than adding edible Cardia Salt, and herbal medicine immersion agent is made.
Comparative example 1
A kind of tinea pedis dissipates, and includes the bulk drug of following parts by weight：Manufacture-yellow connect 6 parts, 6 parts of wilsonii, 3 parts of CORTEX PHELLODENDRI CHINENSE, tealeaves 5
1 part of part, 7 parts of hickory nut bark, 8 parts of yncaria stem with hooks, 5 parts of lycopodium calvatum, 3 parts of folium artemisiae argyi and Chinese ephedra.
The preparation method of the scattered preparation method be the same as Example 5 of above-mentioned tinea pedis.
Comparative example 2
A kind of tinea pedis dissipates, and includes the bulk drug of following parts by weight：Manufacture-yellow connect 4 parts, 4 parts of wilsonii, 5 parts of CORTEX PHELLODENDRI CHINENSE, tealeaves 5
3 parts of part, 10 parts of hickory nut bark, 5 parts of yncaria stem with hooks, 3 parts of lycopodium calvatum, 6 parts of folium artemisiae argyi and Chinese ephedra.
The preparation method of the scattered preparation method be the same as Example 5 of above-mentioned tinea pedis.
Comparative example 3
A kind of tinea pedis dissipates, and includes the bulk drug of following parts by weight：Manufacture-yellow connect 136 parts, 126 parts of wilsonii, CORTEX PHELLODENDRI CHINENSE 130
100 parts of part, 120 parts of tealeaves, 110 parts of hickory nut bark, 98 parts of yncaria stem with hooks, 96 parts of lycopodium calvatum, 110 parts of folium artemisiae argyi and Chinese ephedra.
The preparation method of the scattered preparation method be the same as Example 5 of above-mentioned tinea pedis.
Comparative example 4
A kind of tinea pedis dissipates, and includes the bulk drug of following parts by weight：Manufacture-yellow connect 150 parts, 140 parts of wilsonii, CORTEX PHELLODENDRI CHINENSE 120
86 parts of part, 120 parts of tealeaves, 96 parts of hickory nut bark, 110 parts of yncaria stem with hooks, 110 parts of lycopodium calvatum, 96 parts of folium artemisiae argyi and Chinese ephedra.
The preparation method of the scattered preparation method be the same as Example 5 of above-mentioned tinea pedis.
Comparative example 5
A kind of tinea pedis dissipates, and includes the bulk drug of following parts by weight：6 parts of wilsonii, 5 parts of CORTEX PHELLODENDRI CHINENSE, 5 parts of tealeaves, hickory nut
3 parts of 10 parts of bark, 6 parts of folium artemisiae argyi and Chinese ephedra.
The preparation method of the scattered preparation method be the same as Example 5 of above-mentioned tinea pedis.
Comparative example 6
A kind of tinea pedis dissipates, and includes the bulk drug of following parts by weight：Manufacture-yellow connect 6 parts, 6 parts of wilsonii, 5 parts of CORTEX PHELLODENDRI CHINENSE, mountain core
3 parts of 10 parts of peach bark, 8 parts of yncaria stem with hooks, 5 parts of lycopodium calvatum, 6 parts of folium artemisiae argyi and Chinese ephedra.
The preparation method of the scattered preparation method be the same as Example 5 of above-mentioned tinea pedis.
Comparative example 7
A kind of preparation method of herbal medicine immersion agent：Tinea pedis made from comparative example 1 is dissipated to decoct and obtains decoction liquor within 15 minutes, it is cold
But to 35 DEG C, then respectively with 180：1 weight is well mixed than adding edible Cardia Salt, and herbal medicine immersion agent is made.
Comparative example 8
A kind of preparation method of herbal medicine immersion agent：Tinea pedis made from comparative example 2 is dissipated to decoct and obtains decoction liquor within 15 minutes, it is cold
But to 35 DEG C, then respectively with 180：1 weight is well mixed than adding edible Cardia Salt, and herbal medicine immersion agent is made.
Comparative example 9
A kind of preparation method of herbal medicine immersion agent：Tinea pedis made from comparative example 3 is dissipated to decoct and obtains decoction liquor within 15 minutes, it is cold
But to 35 DEG C, then respectively with 180：1 weight is well mixed than adding edible Cardia Salt, and herbal medicine immersion agent is made.
Comparative example 10
A kind of preparation method of herbal medicine immersion agent：Tinea pedis made from comparative example 4 is dissipated to decoct and obtains decoction liquor within 15 minutes, it is cold
But to 35 DEG C, then respectively with 180：1 weight is well mixed than adding edible Cardia Salt, and herbal medicine immersion agent is made.
Comparative example 11
A kind of preparation method of herbal medicine immersion agent：Tinea pedis made from comparative example 5 is dissipated to decoct and obtains decoction liquor within 15 minutes, it is cold
But to 35 DEG C, then respectively with 180：1 weight is well mixed than adding edible Cardia Salt, and herbal medicine immersion agent is made.
Comparative example 12
A kind of preparation method of herbal medicine immersion agent：Tinea pedis made from comparative example 6 is dissipated to decoct and obtains decoction liquor within 15 minutes, it is cold
But to 35 DEG C, then respectively with 180：1 weight is well mixed than adding edible Cardia Salt, and herbal medicine immersion agent is made.
Effect example 1
In order to illustrate that herbal medicine immersion agent of the present invention causes skin disease to have good curative effect to fungal infection, clinic collects fungi
Infection causes tinea pedis patient 240, male 120, women 120,5~60 years old age.
1st, treatment method：240 patients are divided into 12 groups, and wherein test group 1~5 is prepared using in embodiment 6~10 respectively
Herbal medicine immersion agent；Test group 6~11 is respectively using the herbal medicine immersion agent prepared in comparative example 7~12；Control group uses commercially available
Jiaoqiling for beriberi lotion, the constant temperature immersion at 30 DEG C of above-mentioned each test group and control group suffers from foot 30 minutes, daily once in the morning and once at night,
The course for the treatment of 60 days.
2nd, evaluation criterion：
Fully recover and all disappeared for the phenomenon of the red and swollen itch of pedal skin, skin ulcer and eczema, and without obvious scar.
The effective phenomenon for pedal skin ulcer and eczema disappears or mitigated, but the phenomenon of red swelling of the skin itch remains unchanged.
The invalid phenomenon for the red and swollen itch of pedal skin, skin ulcer and eczema is not cut down.
Calculate total effective rate=(recovery from illness case+effective case)/total case
3rd, clinical effectiveness is as shown in the table.
As can be seen from the above table, the herbal medicine immersion agent that 1~5 group of experimental group is prepared using embodiment 6~10 respectively is carried out
The patient of the treatment of 60 days, the symptom such as the red and swollen itch of its original pedal skin, skin ulcer and eczema has obvious improvement.
Herbal medicine immersion agent of the present invention is to the effective percentage of above-mentioned dermatosis patient up to more than 90%, and significantly larger than commercially available Jiaoqiling for beriberi is washed
Agent.
By being contrasted with comparative example 7, i.e., contrasted with test group 6, CORTEX PHELLODENDRI CHINENSE, mountain core in tinea pedis of the present invention dissipates
When the parts by weight of the components such as peach bark, folium artemisiae argyi and Chinese ephedra are less than parts by weight of the invention, the herbal medicine immersion agent pair prepared
The effective percentage of tinea pedis patient caused by fungal infection is 75% or so, and its effect is far below the medicine of the embodiment of the present invention 1~5.
By being contrasted with comparative example 8, i.e., contrasted with test group 7, when manufacture-yellow company, thorn in external-applied ointment of the present invention
When the parts by weight of the components such as slender acanthopanax, yncaria stem with hooks and lycopodium calvatum are less than parts by weight of the invention, the herbal medicine immersion agent pair prepared
The effective percentage of tinea pedis patient caused by fungal infection is 70% or so, and its effect is far below the medicine of the embodiment of the present invention 1~5.
By being contrasted with comparative example 9, i.e., contrasted with test group 8, when CORTEX PHELLODENDRI CHINENSE, mountain in external-applied ointment of the present invention
When the parts by weight of the components such as juglans regia, folium artemisiae argyi and Chinese ephedra are higher than parts by weight of the invention, the medicine prepared is to fungi
The effective percentage of tinea pedis patient is 90% or so caused by infection, and its effect reached is more or less the same with embodiment 1~5.Therefore, examine
Consider economy and security, when CORTEX PHELLODENDRI CHINENSE be 5~120 parts, hickory nut bark be 10~96 parts, folium artemisiae argyi be 6~96 parts, Chinese ephedra
During for 3~86 parts of parts by weight, you can reach good effect.
By being contrasted with comparative example 10, i.e., contrasted with test group 9, when in external-applied ointment of the present invention manufacture-yellow connect,
When the parts by weight of the components such as wilsonii, yncaria stem with hooks and lycopodium calvatum are higher than parts by weight of the invention, the medicine prepared is to fungi
The effective percentage of tinea pedis patient is 95% or so caused by infection, and its effect reached is more or less the same with embodiment 1~5.Therefore, examine
Consider economy and security, when manufacture-yellow be linked as 6~136 parts, wilsonii be 6~126 parts, yncaria stem with hooks be 8~98 parts, lycopodium calvatum be
During 5~96 parts by weight, you can reach good effect.
By the contrast with comparative example 11, i.e., contrasted with test group 10, although in comparative example 11 also containing wilsonii,
The medicines such as CORTEX PHELLODENDRI CHINENSE, tealeaves, hickory nut bark, folium artemisiae argyi and Chinese ephedra, but its medicine prepared is to red swelling of the skin itch, with skin
The effective percentage of skin ulcer and eczema patients is only 75% or so, and its effect is far below the medicine of the embodiment of the present invention 1~5, studies carefully it
Lack the traditional Chinese medicine ingredients such as manufacture-yellow company, yncaria stem with hooks, lycopodium calvatum in reason, its drug component.Manufacture-yellow even can be with heat-clearing and damp-drying drug, purging intense heat and detonicating
There is good curative effect to skin disease caused by " changing thermal burn cloudy, wind formation from blood dryness "；Yncaria stem with hooks, lycopodium calvatum can be with dispelling wind and eliminating dampness, relaxing muscles and tendons
It is active.It only has effects that anti-fungal infection for herbal medicine immersion agent prepared by comparative example 11, does not have dispelling wind and eliminating dampness, heat-clearing solution
Poison effect, it is treated to superficial phenomenon, to it is interior the cause of disease fail regulation, be easily caused tinea pedis Relapse rate, no
Easily recovery from illness.
By the contrast with comparative example 12, i.e., contrasted with test group 11, in herbal medicine immersion agent made from comparative example 12
Not comprising tea component, but its medicine prepared is only 80% or so to the effective percentage of tinea pedis patient caused by fungal infection,
Its effect is far below the medicine of the embodiment of the present invention 1~5.Trace it to its cause is because containing substantial amounts of tannic acid in tealeaves, to each
The fungal dermatopathy of type is especially effective.The scattered middle addition tealeaves of tinea pedis of the present invention can be remarkably reinforced fungal infection and cause skin
The therapeutic effect of skin disease.
In summary, tinea pedis produced by the present invention, which dissipates, has disinfection, antipruritic, dispelling wind and eliminating dampness, clearing heat and detoxicating, work of stimulating the menstrual flow
The effects such as blood, there is good curative effect to the various skin diseases as caused by fungal infection, alleviate in existing externally applied drug containing sugar
Corticoid medicine, is also easy to produce skin disease after pharmacological dependence, deactivation and easily recurs, the problem of refractory refractory.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, or which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme.
Claims (10)
1. a kind of tinea pedis dissipates, it is characterised in that main to be prepared by the following raw material according to the mass fraction：Manufacture-yellow connect 6~136 parts,
6~126 parts of wilsonii, 5~120 parts of CORTEX PHELLODENDRI CHINENSE, 5~120 parts of tealeaves, 10~96 parts of hickory nut bark, 8~98 parts of yncaria stem with hooks, stretch
3~86 parts of 5~96 parts of muscle grass, 6~96 parts of folium artemisiae argyi and Chinese ephedra.
2. tinea pedis according to claim 1 dissipates, it is characterised in that main to be prepared by the following raw material according to the mass fraction：
Manufacture-yellow connect 30~100 parts, 30~95 parts of wilsonii, 10~80 parts of CORTEX PHELLODENDRI CHINENSE, 10~80 parts of tealeaves, hickory nut bark 30~60
20~50 parts of part, 30~60 parts of yncaria stem with hooks, 20~60 parts of lycopodium calvatum, 20~50 parts of folium artemisiae argyi and Chinese ephedra.
3. tinea pedis according to claim 1 dissipates, it is characterised in that main to be prepared by the following raw material according to the mass fraction：
Manufacture-yellow connect 65 parts, 60 parts of wilsonii, 50 parts of CORTEX PHELLODENDRI CHINENSE, 50 parts of tealeaves, 40 parts of hickory nut bark, 40 parts of yncaria stem with hooks, 35 parts of lycopodium calvatum,
30 parts of 35 parts of folium artemisiae argyi and Chinese ephedra.
4. the scattered preparation method of a kind of tinea pedis according to any one of claims 1 to 3, it is characterised in that by each bulk drug
It is dried and crushes successively, the bulk drug after crushing is sufficiently mixed, tinea pedis is made and dissipates.
5. the scattered preparation method of tinea pedis according to claim 4, it is characterised in that the water content of dried bulk drug is
7wt%~13wt%.
6. the scattered preparation method of tinea pedis according to claim 4, it is characterised in that the bulk drug after crushing was 10~20
Powder after mesh sieve.
7. the tinea pedis according to any one of claims 1 to 3 is dispersed in dermopathic external application caused by preparation treatment fungal infection
Application in medicine；
It is preferred that, skin disease caused by the fungal infection is tinea pedis, jock itch or ringworm of the body.
8. a kind of herbal medicine immersion agent, it is characterised in that the herbal medicine immersion agent is main as described in any one of claims 1 to 3
Tinea pedis, which dissipates to decoct to prepare, to be made.
9. herbal medicine immersion agent according to claim 8, it is characterised in that the raw material of the herbal medicine immersion agent will including right
The tinea pedis described in 1~3 any one is asked to dissipate and edible Cardia Salt.
10. the preparation method of a kind of herbal medicine immersion agent according to claim 8 or claim 9, it is characterised in that by claim 1
Tinea pedis described in~3 any one, which dissipates to decoct, obtains decoction liquor in 10~30 minutes, is cooled to 30~40 DEG C, then respectively with 150~
200：1 weight is well mixed than adding edible Cardia Salt, and herbal medicine immersion agent is made.
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| CN111700989A (en) * | 2020-07-23 | 2020-09-25 | 湖南农达健康产业发展有限责任公司 | Traditional Chinese medicine composition for dispelling wind, eliminating dampness and treating tinea pedis and preparation method thereof |
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Application publication date: 20171010 |