CN111329994A - 与炎性肠病有关的抗原 - Google Patents

与炎性肠病有关的抗原 Download PDF

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Publication number
CN111329994A
CN111329994A CN202010149309.2A CN202010149309A CN111329994A CN 111329994 A CN111329994 A CN 111329994A CN 202010149309 A CN202010149309 A CN 202010149309A CN 111329994 A CN111329994 A CN 111329994A
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China
Prior art keywords
antibody
specific binding
binding member
fibronectin
domain
Prior art date
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Pending
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CN202010149309.2A
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English (en)
Chinese (zh)
Inventor
G·内里
K·施瓦格尔
M·鲁热克
D·奥哈拉
陈建清
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Philogen SpA
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Philogen SpA
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50435280&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN111329994(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Philogen SpA filed Critical Philogen SpA
Priority to CN202010149309.2A priority Critical patent/CN111329994A/zh
Publication of CN111329994A publication Critical patent/CN111329994A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2066—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6843—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202010149309.2A 2012-10-03 2012-10-03 与炎性肠病有关的抗原 Pending CN111329994A (zh)

Priority Applications (1)

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CN202010149309.2A CN111329994A (zh) 2012-10-03 2012-10-03 与炎性肠病有关的抗原

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010149309.2A CN111329994A (zh) 2012-10-03 2012-10-03 与炎性肠病有关的抗原
CN201280076034.8A CN104768563B (zh) 2012-10-03 2012-10-03 与炎性肠病有关的抗原
PCT/US2012/058574 WO2014055073A1 (en) 2012-10-03 2012-10-03 Antigens associated with inflammatory bowel disease

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CN201280076034.8A Division CN104768563B (zh) 2012-10-03 2012-10-03 与炎性肠病有关的抗原

Publications (1)

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CN111329994A true CN111329994A (zh) 2020-06-26

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CN202010149309.2A Pending CN111329994A (zh) 2012-10-03 2012-10-03 与炎性肠病有关的抗原

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EP (1) EP2903629B1 (enExample)
JP (1) JP6158933B2 (enExample)
KR (1) KR102011549B1 (enExample)
CN (2) CN104768563B (enExample)
AU (1) AU2012391490B2 (enExample)
CA (1) CA2886152C (enExample)
CO (1) CO7380754A2 (enExample)
DK (1) DK2903629T3 (enExample)
ES (1) ES2743423T3 (enExample)
HU (1) HUE044927T2 (enExample)
IL (1) IL237856B (enExample)
IN (1) IN2015DN03229A (enExample)
MX (1) MX364535B (enExample)
PH (1) PH12015500662B1 (enExample)
PL (1) PL2903629T3 (enExample)
PT (1) PT2903629T (enExample)
RU (1) RU2612878C2 (enExample)
SG (1) SG11201502404WA (enExample)
SI (1) SI2903629T1 (enExample)
WO (1) WO2014055073A1 (enExample)

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WO2017121880A1 (en) 2016-01-15 2017-07-20 Philogen S.P.A Intestinal antigens for pharmacodelivery applications
EP3634999A1 (en) 2017-06-07 2020-04-15 Philogen S.p.A. Vascular endothelial growth factor/anti-fibronectin antibody fusion proteins
WO2020181235A1 (en) * 2019-03-06 2020-09-10 Deka Biosciences, Inc. Il-10 variant molecules and methods of treating inflammatory disease and oncology
WO2020249757A1 (en) 2019-06-14 2020-12-17 Philogen S.P.A Immunoconjugates comprising a single chain diabody and interleukin-15 or interleukin-15 and a sushi domain of interleukin-15 receptor alpha
BR112023001187A2 (pt) 2020-07-20 2023-04-04 Deka Biosciences Inc Proteínas de fusão de citocina dupla compreendendo il -10
EP4185615A1 (en) 2020-07-22 2023-05-31 Philogen S.p.A. Treatment of pulmonary hypertension
US20250197485A1 (en) 2022-03-17 2025-06-19 Universitätsklinikum Jena Anti-ED-A Antibodies for the Treatment of Pulmonary Hypertension

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US20110250131A1 (en) * 2009-01-07 2011-10-13 Philogen S.P.A. Antigens Associated with Endometriosis, Psoriatic Arthritis and Psoriasis

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CO7380754A2 (es) 2015-09-10
IL237856B (en) 2019-11-28
EP2903629B1 (en) 2019-07-10
IL237856A0 (en) 2015-05-31
US20180044408A1 (en) 2018-02-15
JP2016500670A (ja) 2016-01-14
JP6158933B2 (ja) 2017-07-05
EP2903629A4 (en) 2016-07-27
RU2015115399A (ru) 2016-11-27
PT2903629T (pt) 2019-09-10
SG11201502404WA (en) 2015-05-28
CN104768563B (zh) 2020-02-28
PH12015500662A1 (en) 2015-05-18
WO2014055073A1 (en) 2014-04-10
KR102011549B1 (ko) 2019-08-16
IN2015DN03229A (enExample) 2015-10-02
KR20150061648A (ko) 2015-06-04
DK2903629T3 (da) 2019-08-05
AU2012391490B2 (en) 2018-02-15
SI2903629T1 (sl) 2019-09-30
CN104768563A (zh) 2015-07-08
CA2886152A1 (en) 2014-04-10
NZ631476A (en) 2017-06-30
PH12015500662B1 (en) 2019-05-31
MX364535B (es) 2019-04-29
PL2903629T3 (pl) 2019-12-31
US9695232B2 (en) 2017-07-04
CA2886152C (en) 2020-01-14
EP2903629A1 (en) 2015-08-12
HUE044927T2 (hu) 2019-11-28
AU2012391490A1 (en) 2015-04-30
ES2743423T3 (es) 2020-02-19
HK1212220A1 (en) 2016-06-10
MX2015003908A (es) 2015-08-05
US20150361161A1 (en) 2015-12-17
US10239939B2 (en) 2019-03-26
RU2612878C2 (ru) 2017-03-13

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